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IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Some Chemicals Used as Solvents and in Polymer Manufacture. Lyon (FR): International Agency for Research on Cancer; 2017. (IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, No. 110.)
6.1. Cancer in humans
There is inadequate evidence in humans for the carcinogenicity of 1,3-propane sultone.
6.2. Cancer in experimental animals
There is sufficient evidence in experimental animals for the carcinogenicity of 1,3-propane sultone.
6.3. Overall evaluation
1,3-Propane sultone is probably carcinogenic to humans (Group 2A).
6.4. Rationale
In making this overall evaluation, the Working Group took into account that 1,3-propane sultone is a strong, direct-acting alkylating agent that reacts with DNA and proteins and that, as a result, is genotoxic in virtually all test systems examined, both in vitro and in vivo. Results of studies of cancer in experimental animals are consistent with this mechanism because tumours arose both at the site of exposure and at distant sites. In the absence of adequate data on cancer in humans, the overall evaluation of 1,3-propane sultone was upgraded from Group 2B to Group 2A on the basis of strong evidence for genotoxicity.
- Evaluation - Some Chemicals Used as Solvents and in Polymer ManufactureEvaluation - Some Chemicals Used as Solvents and in Polymer Manufacture
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