Evaluates the carcinogenic risk to humans posed by the ingestion of several naturally occurring substances. Separate monographs are presented for two food items (salted fish and pickled vegetables), two naturally occurring plant substances (caffeic acid and d-limonene), four heterocyclic aromatic amines found in cooked meat and fish, and selected mycotoxins, including aflatoxins.

The monograph on salted fish concentrates on fish as traditionally prepared in southern China, where very high rates of nasopharyngeal carcinoma have been linked to the consumption of salted fish prepared in a manner which involves putrefaction. The monograph concludes that Chinese-style salted fish is carcinogenic to humans. The second monograph concludes that pickled vegetables, prepared according to traditional Asian methods, are possibly carcinogenic to humans. Caffeic acid was judged to be possibly carcinogenic to humans. The report was unable to classify the carcinogenicity of d-limonene. For the heterocyclic aromatic amines present in cooked meat and fish, IQ was classified as probably carcinogenic to humans; MeIQ, MeIQx, and PhIP were classified as possibly carcinogenic.

The most extensive monograph, on aflatoxins, concludes that naturally occurring mixtures of aflatoxins are carcinogenic to humans and that aflatoxin M1 occurring in milk is possibly carcinogenic. Toxins derived from Fusarium moniliforme and ochratoxin A, which has been linked to Balkan endemic nephropathy, were classified as possibly carcinogenic to humans. The remaining mycotoxins could not be classified.

Contents

• NOTE TO THE READER
• LIST OF PARTICIPANTS
• PREAMBLE
• GENERAL REMARKS
• THE MONOGRAPHS
  • Food items and constituents
    • SALTED FISH
      • 1. Exposure Data
      • 2. Studies of Cancer in Humans
      • 3. Studies of Cancer in Experimental Animals
      • 4. Other Relevant Data
      • 5. Summary of Data Reported and Evaluation
      • 6. References
    • PICKLED VEGETABLES
      • 1. Exposure Data
      • 2. Studies of Cancer in Humans
      • 3. Studies of Cancer in Experimental Animals
      • 4. Other Relevant Data
      • 5. Summary of Data Reported and Evaluation
      • 6. References
    • CAFFEIC ACID
      • 1. Exposure Data
      • 2. Studies of Cancer in Humans
      • 3. Studies of Cancer in Experimental Animals
      • 4. Other Relevant Data
      • 5. Summary of Data Reported and Evaluation
      • 6. References
    • d-LIMONENE
      • 1. Exposure Data
      • 2. Studies of Cancer in Humans
      • 3. Studies of Cancer in Experimental Animals
      • 4. Other Relevant Data
      • 5. Summary of Data Reported and Evaluation
      • 6. References
  • Heterocyclic aromatic amines
    • IQ (2-AMINO-3-METHYLIMIDAZO[4,5-f]QUINOLINE)
      • 1. Exposure Data
      • 2. Studies of Cancer in Humans
      • 3. Studies of Cancer in Experimental Animals
      • 4. Other Relevant Data
      • 5. Summary of Data Reported and Evaluation
      • 6. References
    • MeIQ (2-AMINO-3,4-DIMETHYLIMIDAZO[4,5-f]QUINOLINE)
      • 1. Exposure Data
      • 2. Studies of Cancer in Humans
      • 3. Studies of Cancer in Experimental Animals
      • 4. Other Relevant Data
      • 5. Summary of Data Reported and Evaluation
      • 6. References
    • MeIQx (2-AMINO-3,8-DIMETHYLIMIDAZO[4,5.f]QUINOXALINE)
      • 1. Exposure Data
      • 2. Studies of Cancer in Humans
      • 3. Studies of Cancer in Experimental Animals
      • 4. Other Relevant Data
      • 5. Summary of Data Reported and Evaluation
      • 6. References
    • PhIP (2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-b]PYRIDINE)
      • 1. Exposure Data
      • 2. Studies of Cancer in Humans
      • 3. Studies of Cancer in Experimental Animals
      • 4. Other Relevant Data
      • 5. Summary of Data Reported and Evaluation
      • 6. References
  • Mycotoxins
    • AFLATOXINS
      • 1. Exposure Data
      • 2. Studies of Cancer in Humans
      • 3. Studies of Cancer in Experimental Animals
      • 4. Other Relevant Data
      • 5. Summary of Data Reported and Evaluation
      • 6. References
    • TOXINS DERIVED FROM FUSARIUM GRAINEARUM, F. CULMORUM AND F. CROOKWELLENSE: ZEARALENONE, DEOXYNIVALENOL, NIVALENOL AND FUSARENONE X
      • 1. Exposure Data
      • 2. Studies of Cancer in Humans
      • 3. Studies of Cancer in Experimental Animals
      • 4. Other Relevant Data
      • 5. Summary of Data Reported and Evaluation
      • 6. References
    • TOXINS DERIVED FROM FUSARIUM MONILIFORME: FUMONISINS B₁ AND B₂ AND FUSARIN C
      • 1. Exposure Data
      • 2. Studies of Cancer in Humans
      • 3. Studies of Cancer in Experimental Animals
      • 4. Other Relevant Data
      • 5. Summary of Data Reported and Evaluation
      • 6. References
    • TOXINS DERIVED FROM FUSARIUM SPOROTRICHIOIDES: T-2 TOXIN
      • 1. Exposure Data
      • 2. Studies of Cancer in Humans
      • 3. Studies of Cancer in Experimental Animals
      • 4. Other Relevant Data
      • 5. Summary of Data Reported and Evaluation
      • 6. References
    • OCHRATOXIN A
      • 1. Exposure Data
      • 2. Studies of Cancer in Humans
      • 3. Studies of Cancer in Experimental Animals
      • 4. Other Relevant Data
      • 5. Summary of Data Reported and Evaluation
      • 6. References
• SUMMARY OF FINAL EVALUATIONS
• APPENDIX 1
• APPENDIX 2
• PUBLICATIONS OF THE INTERNATIONAL AGENCY FOR RESEARCH ON CANCER
• IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC RISKS TO HUMANS
• IARC TECHNICAL REPORTS

Corrigenda to the IARC Monographs are published online at http://monographs.iarc.fr/ENG/Publications/corrigenda.php.

Corrigenda to Volume 56. (PDF, 35K)

LIBRARY CATALOGUING DATA

This publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 9–16 June 1992

Lyon, France - 1993