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O'Connor EA, Whitlock EP, Gaynes B, et al. Screening for Depression in Adults and Older Adults in Primary Care: An Updated Systematic Review [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2009 Dec. (Evidence Syntheses, No. 75.)
Screening for Depression in Adults and Older Adults in Primary Care: An Updated Systematic Review [Internet].
Show detailsKey Question 1 and 1a-Screening trials
Inclusion Criteria:
- Screening: study of depression screening; outcomes same as those listed above.
Exclusion Criteria:
- Focus on inpatient, residential treatment, psychiatric, or community settings.
- Focus on interventions that are not primary care feasible or referable (e.g. ECT).
- Does not meet quality criteria, including follow-up of less than 6 weeks.
- Focus on children or adolescents.
- None of the outcomes listed above.
- Focus on pregnancy-related screening.
- Examination of genetic modifiers.
- Does not meet any inclusion criterion.
- Not a general primary care population.
- Not English language or non-developed country.
- Non-comparative study/excluded design.
- Comparative-effectiveness study.
- Missing both depression-specific screener and depression-specific outcome
- Use as source document.
- Screen not used in clinical care.
Key Question 2-Harms of screening
Inclusion Criteria:
- Study addressing adverse events associated with depression screening.
Exclusion Criteria:
- Setting limits generalizability to general adult primary care population.
- Focus on interventions other than antidepressants
- Does not meet quality criteria, including follow-up of less than 6 weeks
- Focus on children or adolescents.
- Focus on pregnancy-related screening.
- Examination of genetic modifiers.
- Does not meet any inclusion criterion.
- Not generalizable to primary care population
- Not English language or non-developed country
- Non-comparative study/excluded design.
- Use as source document
Key Question 3-Treatment with antidepressants in the elderly
Inclusion Criteria: Study of depression treatment with antidepressants in the elderly, meeting all of the following criteria:
- Setting: primary care, outpatient mental health, community setting if intervention is PC-feasible or referable.
- Intervention: antidepressant for acute treatment of depression
- Quality: fair-good quality per USPSTF standards, with follow-up of at least 6 weeks.
- Design: Meta-analysis or systematic evidence review
- Outcomes: depressive symptomatology, quality of life ratings, assessments of functioning, depressive illness diagnosis, suicidality (attempts or ideation), or change in health status (e.g., death, improvement in co-morbid disorders, reduction in physical complaints).
- Population: Exclusively or primarily (> 80%) ages 65 and older
- Context/Environment: Conducted in US, UK, Canada, Australia, New Zealand
- Language: Published in English
Exclusion Criteria:
- Focus on inpatient, residential treatment, psychiatric, or community settings.
- Focus on interventions that are not primary-care feasible or referable
- Does not meet quality criteria, including follow-up of less than 6 weeks
- Focus on children or adolescents
- None of the outcomes listed above.
- Examination of genetic modifiers
- Does not meet any inclusion criterion.
- Not a general primary care population
- Not English language or one of included countries
- Non-comparative study.
- Comparative-effectiveness study.
- Use as source document
- Focus on non-elderly adults.
- Depression prevention or treatment maintenance interventions.
- Not a treatment outcomes study.
- Article is an individual trial (rather than synthesized review), or it is a SER/MA with content area covered more comprehensively or recently in one of the Included reviews.
Key Question 3-Treatment with psychotherapy in the elderly
Inclusion Criteria: Study of depression treatment with psychotherapy in the elderly, meeting all of the following criteria:
- Setting: primary care, outpatient mental health, community setting if intervention is PC-feasible or referable.
- Intervention: cognitive-behavioral, interpersonal therapy, or problem-solving type intervention
- Quality: fair-good quality per USPSTF standards, with follow-up of at least 6 weeks.
- Design: Systematic evidence review or meta-analysis
- Outcomes: depressive symptomatology, quality of life ratings, assessments of functioning, depressive illness diagnosis, suicidality (attempts or ideation), or change in health status (e.g., death, improvement in co-morbid disorders, reduction in physical complaints).
- Population: Exclusively or primarily (> 80%) ages 65 and older
- Context/Environment: Conducted in US, UK, Canada, Australia, New Zealand
- Language: Published in English
Exclusion Criteria, any of the following:
- Focus on inpatient, residential treatment, psychiatric, or community settings.
- Focus on interventions that are not primary-care feasible or referable
- Does not meet quality criteria, including follow-up of less than 6 weeks
- Focus on children or adolescents
- None of the outcomes listed above.
- Examination of genetic modifiers
- Does not meet any inclusion criterion.
- Not a general primary care population
- Not English language or one of included countries
- Non-comparative study.
- Comparative-effectiveness study.
- Use as source document
- Focus on interventions that are not primarily CBT-related or IPT in nature (e.g., pharmacotherapy, reminiscence, psychodynamic)
- Focus on non-elderly adults.
- Depression prevention or treatment maintenance interventions.
- Not a treatment outcomes study.
- Article is an individual trial (rather than synthesized review), or it is a SER/MA with content area covered more comprehensively or recently in one of the Included reviews.
Key Question 4-Harms of Depression Treatment with Antidepressants
Inclusion Criteria:
- Systematic review, regulatory review, large cohort, or large prospective observational study addressing adverse events associated with depression treatment or screening.
- For studies of suicidality:
- Minimum n=10,000 for cohort or observational study
- Minimum follow-up=6 months
- For studies of non-suicidality harms
- Minimum n=1,000 for cohort or observational studies
- Minimum follow-up=3 months
- May include comparative effectiveness without control group if provides absolute rates of harms in an understudied population
Exclusion Criteria:
- Focus on inpatient, residential treatment, psychiatric, or community settings.
- Focus on interventions that are not primary care feasible or referable (e.g. ECT)
- Does not meet quality criteria, including follow-up of less than 6 weeks
- Focus on children or adolescents
- None of the adverse effects of interest to our review above.
- Focus on pregnancy-related screening.
- Updated/covered by another more recent MA/SR
- Does not meet any inclusion criterion.
- Not a general primary care population
- Not English language or non-developed country
- Not a study design specified above.
- Comparative-effectiveness study.
- Use as source document
- Use as a discussion document only.
- Inclusion and exclusion criteria for key questions - Screening for Depression in...Inclusion and exclusion criteria for key questions - Screening for Depression in Adults and Older Adults in Primary Care
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