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Viswanathan M, Treiman KA, Doto JK, et al. Folic Acid Supplementation: An Evidence Review for the U.S. Preventive Services Task Force [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2017 Jan. (Evidence Synthesis, No. 145.)

  • This publication is provided for historical reference only and the information may be out of date.

This publication is provided for historical reference only and the information may be out of date.

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Folic Acid Supplementation: An Evidence Review for the U.S. Preventive Services Task Force [Internet].

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References

1.
National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development. Neural Tube Defects (NTDs): Condition Information. Bethesda, MD: USA​.gov; Nov 30, 2012. [May 2, 2014]. http://www​.nichd.nih​.gov/health/topics/ntds​/conditioninfo/Pages/default.aspx.
2.
Centers for Disease Control and Prevention (CDC). CDC Grand Rounds: additional opportunities to prevent neural tube defects with folic acid fortification. MMWR Morb Mortal Wkly Rep. 2010 Aug 13;59(31):980–4. [PubMed: 20703205]
3.
National Institute of Neurological Disorders and Stroke. NINDS Anencephaly Information Page. Bethesda, MD: NINDS; Apr 16, 2014. [July 23, 2012]. http://www​.ninds.nih​.gov/disorders/anencephaly/anencephaly​.htm.
4.
National Institute of Neurological Disorders and Stroke. Cephalic disorders fact sheet. Bethesda, MD: NINDS; Apr 16, 2012. 2014. [July 23, 2012]. http://www​.ninds.nih​.gov/disorders/cephalic_disorders​/detail_cephalic_disorders​.htm.
5.
Rasmussen SA, Olney RS, Holmes LB, et al. Guidelines for case classification for the National Birth Defects Prevention Study. Birth Defects Res A Clin Mol Teratol. 2003 Mar;67(3):193–201. [PubMed: 12797461]
6.
Rasmussen SR, Frais JL. Genetics of syndromic neural tube defects. In: Wyszynski DF, editor. Neural Tube Defects: From Origin to Treatment. New York, NY: Oxford University Press; 2006.
7.
Williams J, Mai CT, Mulinare J, et al. Updated estimates of neural tube defects prevented by mandatory folic acid fortification - United States, 1995-2011. MMWR Morb Mortal Wkly Rep. 2015 Jan 16;64(1):1–5. [PMC free article: PMC4584791] [PubMed: 25590678]
8.
American College of Obstetricians and Gynecologists. Neural tube defects. ACOG Practice Bulletin No. 44. Obstet Gynecol. 2003;102:203–13.
9.
Agopian AJ, Tinker SC, Lupo PJ, et al. Proportion of neural tube defects attributable to known risk factors. Birth Defects Res A Clin Mol Teratol. 2013 Jan;97(1):42–6. [PMC free article: PMC4482342] [PubMed: 23427344]
10.
Elwood JM, Little J, Elwood JH. Epidemiology and control of neural tube defects. Oxford, UK: Oxford University Press; 1992.
11.
Ahrens K, Yazdy MM, Mitchell AA, et al. Folic acid intake and spina bifida in the era of dietary folic acid fortification. Epidemiology. 2011 Sep;22(5):731–7. [PMC free article: PMC4813305] [PubMed: 21659881]
12.
van der Put NM, Eskes TK, Blom HJ. Is the common 677C-->T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis. QJM. 1997 Feb;90(2):111–5. [PubMed: 9068801]
13.
Tsang BL, Devine OJ, Cordero AM, et al. Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies. Am J Clin Nutr. 2015 Jun;101(6):1286–94. [PubMed: 25788000]
14.
Botto LD, Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol. 2000 May 1;151(9):862–77. [PubMed: 10791559]
15.
van der Put NM, Steegers-Theunissen RP, Frosst P, et al. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet. 1995 Oct 21;346(8982):1070–1. [PubMed: 7564788]
16.
Shin M, Besser LM, Siffel C, et al. Prevalence of spina bifida among children and adolescents in 10 regions in the United States. Pediatrics. 2010 Aug;126(2):274–9. [PubMed: 20624803]
17.
Goldman P, Peppercorn MA. Drug therapy: sulfasalazine. N Engl J Med. 1975 Jul 3;293(1):20–3. [PubMed: 236516]
18.
Williams LJ, Rasmussen SA, Flores A, et al. Decline in the prevalence of spina bifida and anencephaly by race/ethnicity: 1995-2002. Pediatrics. 2005 Sep;116(3):580–6. [PubMed: 16140696]
19.
Aneji CN, Northrup H, Au KS. Deep sequencing study of the MTHFR gene to identify variants associated with myelomeningocele. Birth Defects Res A Clin Mol Teratol. 2012 Feb;94(2):84–90. [PMC free article: PMC3327553] [PubMed: 22241680]
20.
Centers for Disease Control and Prevention (CDC). Racial/ethnic differences in the birth prevalence of spina bifida - United States, 1995-2005. MMWR Morb Mortal Wkly Rep. 2009 Jan 9;57(53):1409–13. [PubMed: 19129744]
21.
Mitchell LE. Epidemiology of neural tube defects. Am J Med Genet C Semin Med Genet. 2005 May 15;135C(1):88–94. [PubMed: 15800877]
22.
Suarez L, Hendricks KA, Cooper SP, et al. Neural tube defects among Mexican Americans living on the US-Mexico border: effects of folic acid and dietary folate. Am J Epidemiol. 2000 Dec 1;152(11):1017–23. [PubMed: 11117610]
23.
Suarez L, Felkner M, Brender JD, et al. Neural tube defects on the Texas-Mexico border: what we've learned in the 20 years since the Brownsville cluster. Birth Defects Res A Clin Mol Teratol. 2012 Nov;94(11):882–92. [PubMed: 22945287]
24.
Hamner HC, Mulinare J, Cogswell ME, et al. Predicted contribution of folic acid fortification of corn masa flour to the usual folic acid intake for the US population: National Health and Nutrition Examination Survey 2001-2004. Am J Clin Nutr. 2009 Jan;89(1):305–15. [PubMed: 19056605]
25.
da Silva VR, Hausman DB, Kauwell GP, et al. Obesity affects short-term folate pharmacokinetics in women of childbearing age. Int J Obes (Lond). 2013 Dec;37(12):1608–10. [PubMed: 23567925]
26.
McMahon DM, Liu J, Zhang H, et al. Maternal obesity, folate intake, and neural tube defects in offspring. Birth Defects Res A Clin Mol Teratol. 2013 Feb;97(2):115–22. [PubMed: 23404872]
27.
Flegal KM, Carroll MD, Kit BK, et al. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA. 2012 Feb 1;307(5):491–7. [PubMed: 22253363]
28.
Correa A, Gilboa SM, Botto LD, et al. Lack of periconceptional vitamins or supplements that contain folic acid and diabetes mellitus-associated birth defects. Am J Obstet Gynecol. 2012 Mar;206(3):218.e1–13. [PMC free article: PMC4915337] [PubMed: 22284962]
29.
Dheen ST, Tay SS, Boran J, et al. Recent studies on neural tube defects in embryos of diabetic pregnancy: an overview. Curr Med Chem. 2009;16(18):2345–54. [PubMed: 19519395]
30.
Yerby MS. Management issues for women with epilepsy: neural tube defects and folic acid supplementation. Neurology. 2003 Sep 1;61(6 Suppl 2):S23–6. [PubMed: 14504306]
31.
Shaer CM, Chescheir N, Schulkin J. Myelomeningocele: a review of the epidemiology, genetics, risk factors for conception, prenatal diagnosis, and prognosis for affected individuals. Obstet Gynecol Surv. 2007 Jul;62(7):471–9. [PubMed: 17572919]
32.
Chen CP. Syndromes, disorders and maternal risk factors associated with neural tube defects (VII). Taiwan J Obstet Gynecol. 2008 Sep;47(3):276–82. [PubMed: 18935989]
33.
Milunsky A, Ulcickas M, Rothman KJ, et al. Maternal heat exposure and neural tube defects. JAMA. 1992 Aug 19;268(7):882–5. [PubMed: 1640616]
34.
Parker SE, Mai CT, Canfield MA, et al. Updated National Birth Prevalence estimates for selected birth defects in the United States, 2004-2006. Birth Defects Res A Clin Mol Teratol. 2010 Dec;88(12):1008–16. [PubMed: 20878909]
35.
Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academies Press; 1998. [PubMed: 23193625]
36.
Wolff T, Witkop CT, Miller T, et al. Folic Acid Supplementation for the Prevention of Neural Tube Defects: An Update of the Evidence for the U.S. Preventive Services Task Force. Rockville MD: Agency for Healthcare Research and Quality; May, 2009. (Evidence Synthesis No. 70). AHRQ Publication No. 09-051132-EF-1. [PubMed: 20722169]
37.
Food and Drug Administration (FDA). Food standards: amendment of standards of identity for enriched grain products to require addition of folic acid. Final Rule. Fed Regist. 1996;61(44):8781–97.
38.
Honein MA, Paulozzi LJ, Mathews TJ, et al. Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA. 2001 Jun 20;285(23):2981–6. [PubMed: 11410096]
39.
National Birth Defects Prevention Network. Neural tube defect ascertainment project 2010. 2004. [9 May 2015]. http://www​.nbdpn.org​/current/resources/ntd_fa_info.html.
40.
World Health Organization. Guideline: optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects. Geneva: World Health Organization; 2015. [PubMed: 25996016]
41.
Shane B. Folate status assessment history: implications for measurement of biomarkers in NHANES. Am J Clin Nutr. 2011 Jul;94(1):337S–42S. [PMC free article: PMC3127515] [PubMed: 21593497]
42.
Crider KS, Devine O, Hao L, et al. Population red blood cell folate concentrations for prevention of neural tube defects: bayesian model. BMJ. 2014;349:g4554. [PMC free article: PMC4115151] [PubMed: 25073783]
43.
U.S. Department of Health and Human Services. Food standards: amendment of standards of identity for enriched grain products to require addition of folic acid. Fed Regist. 1996 March 5;61(44):8781–97.
44.
Yang Q, Cogswell ME, Hamner HC, et al. Folic acid source, usual intake, and folate and vitamin B-12 status in US adults: National Health and Nutrition Examination Survey (NHANES) 2003-2006. Am J Clin Nutr. 2010 Jan;91(1):64–72. [PubMed: 19828716]
45.
Tinker SC, Hamner HC, Qi YP, et al. U.S. women of childbearing age who are at possible increased risk of a neural tube defect-affected pregnancy due to suboptimal red blood cell folate concentrations, National Health and Nutrition Examination Survey 2007 to 2012. Birth Defects Res A Clin Mol Teratol. 2015 Jun;103(6):517–26. [PMC free article: PMC4515959] [PubMed: 25884850]
46.
Siega-Riz AM, Bodnar LM, Savitz DA. What are pregnant women eating? Nutrient and food group differences by race. Am J Obstet Gynecol. 2002 Mar;186(3):480–6. [PubMed: 11904611]
47.
Gahche J, Bailey R, Burt V, et al. Dietary supplement use among U.S. adults has increased since NHANES III (1988-1994). NCHS Data Brief. 2011 Apr;(61):1–8. [PubMed: 21592424]
48.
Robbins CL, Zapata LB, Farr SL, et al. Core state preconception health indicators - pregnancy risk assessment monitoring system and behavioral risk factor surveillance system, 2009. MMWR Surveill Summ. 2014 Apr 25;63(3):1–62. [PubMed: 24759729]
49.
McDowell MA, Lacher DA, Pfeiffer CM, et al. Blood folate levels: the latest NHANES results. NCHS Data Brief. 2008 May;(6):1–8. [PubMed: 19389320]
50.
Crider KS, Bailey LB, Berry RJ. Folic acid food fortification-its history, effect, concerns, and future directions. Nutrients. 2011 Mar;3(3):370–84. [PMC free article: PMC3257747] [PubMed: 22254102]
51.
Marchetta CM, Devine OJ, Crider KS, et al. Assessing the association between natural food folate intake and blood folate concentrations: a systematic review and Bayesian meta-analysis of trials and observational studies. Nutrients. 2015 Apr;7(4):2663–86. [PMC free article: PMC4425166] [PubMed: 25867949]
52.
Daly LE, Kirke PN, Molloy A, et al. Folate levels and neural tube defects. Implications for prevention. JAMA. 1995 Dec 6;274(21):1698–702. [PubMed: 7474275]
53.
Berry RJ, Li Z, Erickson JD, et al. Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med. 1999 Nov 11;341(20):1485–90. [PubMed: 10559448]
54.
Hao L, Yang QH, Li Z, et al. Folate status and homocysteine response to folic acid doses and withdrawal among young Chinese women in a large-scale randomized double-blind trial. Am J Clin Nutr. 2008 Aug;88(2):448–57. [PubMed: 18689382]
55.
Crider KS, Zhu JH, Hao L, et al. MTHFR 677C->T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation. Am J Clin Nutr. 2011 Jun;93(6):1365–72. [PubMed: 21508090]
56.
Chuang CH, Hillemeier MM, Dyer AM, et al. The relationship between pregnancy intention and preconception health behaviors. Prev Med. 2011 Jul-Aug;53(1-2):85–8. [PMC free article: PMC3143280] [PubMed: 21539855]
57.
Dott M, Rasmussen SA, Hogue CJ, et al. Association between pregnancy intention and reproductive-health related behaviors before and after pregnancy recognition, National Birth Defects Prevention Study, 1997-2002. Matern Child Health J. 2010 May;14(3):373–81. [PubMed: 19252975]
58.
Goldberg BB, Alvarado S, Chavez C, et al. Prevalence of periconceptional folic acid use and perceived barriers to the postgestation continuance of supplemental folic acid: survey results from a Teratogen Information Service. Birth Defects Res A Clin Mol Teratol. 2006 Mar;76(3):193–9. [PubMed: 16511885]
59.
Rosenberg KD, Gelow JM, Sandoval AP. Pregnancy intendedness and the use of periconceptional folic acid. Pediatrics. 2003 May;111(5 Pt 2):1142–5. [PubMed: 12728127]
60.
Finer LB, Zolna MR. Unintended pregnancy in the United States: incidence and disparities, 2006. Contraception. 2011 Nov;84(5):478–85. [PMC free article: PMC3338192] [PubMed: 22018121]
61.
Robbins CL, Zapata LB, Farr SL, et al. Core state preconception health indicators - pregnancy risk assessment monitoring system and behavioral risk factor surveillance system, 2009. MMWR Surveill Summ. 2014 Apr 25;63 Suppl 3:1–62. [PubMed: 24759729]
62.
Centers for Disease Control and Prevention. Preconception Care and Health Care. Atlanta, GA: Centers for Disease Control and Prevention; Feb 1, 2013. [31 July 2015]. http://www​.cdc.gov/preconception​/showyourlove/
63.
Lynch MM, Squiers LB, Lewis MA, et al. Understanding women's preconception health goals: audience segmentation strategies for a preconception health campaign. Soc Mar Q. 2014;20:148–64. [PMC free article: PMC6058727] [PubMed: 30057489]
64.
Squiers L, Mitchell EW, Levis DM, et al. Consumers' perceptions of preconception health. Am J Health Promot. 2013 Jan-Feb;27(3 Suppl):S10–9. [PMC free article: PMC4487640] [PubMed: 23286658]
65.
Lewis MA, Mitchell EW, Levis DM, et al. Couples' notions about preconception health: implications for framing social marketing plans. Am J Health Promot. 2013 Jan-Feb;27(3):S20–S7. PMID: WOS:000323479400009. [PMC free article: PMC4487636] [PubMed: 23286659]
66.
Rofail D, Colligs A, Abetz L, et al. Factors contributing to the success of folic acid public health campaigns. J Public Health (Oxf). 2012 Mar;34(1):90–9. [PMC free article: PMC3285116] [PubMed: 21727078]
67.
March of Dimes. Improving Preconception Health: Women's Knowledge and Use of Folic Acid. White Plains, NY: Dec, 2008. March of Dimes Foundation Item # 50-2392-08. http://www​.marchofdimes​.com/peristats/pdfdocs​/2008FolicAcidSurveyReport.pdf.
68.
American College of Obstetricians and Gynecologists. The importance of preconception care in the continuum of women's health care. Washington, DC: American College of Obstetricians and Gynecologists; Sep, 2005. Committee Opinion Number 313. [PubMed: 16135611]
69.
Callegari LS, Ma EW, Schwarz EB. Preconception care and reproductive planning in primary care. Med Clin North Am. 2015 May;99(3):663–82. [PubMed: 25841606]
70.
American Congress of Obstetricians and Gynecologists. ACOG practice bulletin. Clinical management guidelines for obstetrician-gynecologists. Number 44, July 2003. (Replaces Committee Opinion Number 252, March 2001). Obstet Gynecol. 2003 Jul;102(1):203–13. [PubMed: 12850637]
71.
American Academy of Pediatrics; Committee on Genetics. Folic acid for the prevention of neural tube defects. Pediatrics. 1999 Aug;104(2 Pt 1):325–7. [PubMed: 10429019]
72.
Centers for Disease Control and Prevention. From the Centers for Disease Control and Prevention. Recommendations for use of folic acid to reduce number of spina bifida cases and other neural tube defects. JAMA. 1993 Mar 10;269(10):1233, 6–8. [PubMed: 8437292]
73.
American Academy of Family Physicians. Summary of Recommendations for Clinical and Preventive Services. Neural Tube Defects, Prevention, Folic Acid Supplementation, Women. Lakewood, KS: AAFP; 2009. [2 May 2014]. www​.aafp.org/patient-care​/clinical-recommendations​/all/neural-tube-defects.html.
74.
National Institute for Health and Care Excellence. NICE public health guidance: PH11 Maternal and child nutrition. London: NICE; 2008. [2 May 2014]. http://publications​.nice​.org.uk/maternal-and-child-nutrition-ph11​/recommendations#folic-acid-2on.
75.
Quality Standards Subcommittee of the American Academy of Neurology. Practice parameter: management issues for women with epilepsy (summary statement). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Epilepsia. 1998 Nov;39(11):1226–31. [PubMed: 9821989]
76.
Sterne JAC, Hernán MA, Reeves BC, et al. ROBINS-I: a tool for assessing risk of bias in non-randomized studies of interventions. BMJ (Online). in press. [PMC free article: PMC5062054] [PubMed: 27733354]
77.
Higgins JP, Altman DG, Gotzsche PC, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011;343(d5928):d5928. [PMC free article: PMC3196245] [PubMed: 22008217]
78.
Whiting P, Savovic J, Higgins JP, et al. ROBIS: A new tool to assess risk of bias in systematic reviews was developed. J Clin Epidemiol. 2016 Jan;69:225–34. [PMC free article: PMC4687950] [PubMed: 26092286]
79.
Harris RP, Helfand M, Woolf SH, et al. Current methods of the US Preventive Services Task Force: a review of the process. Am J Prev Med. 2001 Apr;20(3 Suppl):21–35. [PubMed: 11306229]
80.
West SL, Gartlehner G, Mansfield AJ, et al. Comparative Effectiveness Review Methods: Clinical Heterogeneity. Rockville, MD: Agency for Healthcare Research and Quality; 2010. Methods Research Report AHRQ Publication No. 10-EHC070-EF. http:​//effectivehealthcare.ahrq.gov/ [PubMed: 21433337]
81.
Czeizel AE, Dobo M, Vargha P. Hungarian cohort-controlled trial of periconceptional multivitamin supplementation shows a reduction in certain congenital abnormalities. Birth Defects Res A Clin Mol Teratol. 2004 Nov;70(11):853–61. [PubMed: 15523663]
82.
Shaw GM, Schaffer D, Velie EM, et al. Periconceptional vitamin use, dietary folate, and the occurrence of neural tube defects. Epidemiology. 1995 May;6(3):219–26. [PubMed: 7619926]
83.
Vollset SE, Gjessing HK, Tandberg A, et al. Folate supplementation and twin pregnancies. Epidemiology. 2005 Mar;16(2):201–5. [PubMed: 15703534]
84.
Goh YI, Bollano E, Einarson TR, et al. Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis. J Obstet Gynaecol Can. 2006 Aug;28(8):680–9. [PubMed: 17022907]
85.
Thompson SJ, Torres ME, Stevenson RE, et al. Periconceptional multivitamin folic acid use, dietary folate, total folate and risk of neural tube defects in South Carolina. Ann Epidemiol. 2003 Jul;13(6):412–8. [PubMed: 12875798]
86.
Wolff T, Witkop CT, Miller T, et al. Folic acid supplementation for the prevention of neural tube defects: an update of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2009 May 5;150(9):632–9. [PubMed: 19414843]
87.
Mosley BS, Cleves MA, Siega-Riz AM, et al. Neural tube defects and maternal folate intake among pregnancies conceived after folic acid fortification in the United States. Am J Epidemiol. 2009 Jan 1;169(1):9–17. [PMC free article: PMC3139973] [PubMed: 18953063]
88.
Czeizel AE, Dudas I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med. 1992 Dec 24;327(26):1832–5. [PubMed: 1307234]
89.
Czeizel AE. Prevention of congenital abnormalities by periconceptional multivitamin supplementation. BMJ. 1993 Jun 19;306(6893):1645–8. [PMC free article: PMC1678103] [PubMed: 8324432]
90.
Czeizel AE, Dudas I, Metneki J. Pregnancy outcomes in a randomised controlled trial of periconceptional multivitamin supplementation. Final report. Arch Gynecol Obstet. 1994;255(3):131–9. [PubMed: 7979565]
91.
Czeizel AE, Metneki J, Dudas I. The higher rate of multiple births after periconceptional multivitamin supplementation: an analysis of causes. Acta Genet Med Gemellol (Roma). 1994;43(3-4):175–84. [PubMed: 8588492]
92.
Czeizel AE. Controlled studies of multivitamin supplementation on pregnancy outcomes. Ann N Y Acad Sci. 1993 Mar 15;678:266–75. [PubMed: 8257482]
93.
Czeizel AE. Periconceptional folic acid containing multivitamin supplementation. Eur J Obstet Gynecol Reprod Biol. 1998 Jun;78(2):151–61. [PubMed: 9622312]
94.
Czeizel AE. Reduction of urinary tract and cardiovascular defects by periconceptional multivitamin supplementation. Am J Med Genet. 1996 Mar 15;62(2):179–83. [PubMed: 8882400]
95.
Hernandez-Diaz S, Werler MM, Walker AM, et al. Neural tube defects in relation to use of folic acid antagonists during pregnancy. Am J Epidemiol. 2001 May 15;153(10):961–8. [PubMed: 11384952]
96.
Mills JL, Rhoads GG, Simpson JL, et al. The absence of a relation between the periconceptional use of vitamins and neural-tube defects. National Institute of Child Health and Human Development Neural Tube Defects Study Group. N Engl J Med. 1989 Aug 17;321(7):430–5. [PubMed: 2761577]
97.
Milunsky A, Jick H, Jick SS, et al. Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. JAMA. 1989 Nov 24;262(20):2847–52. [PubMed: 2478730]
98.
Moore LL, Bradlee ML, Singer MR, et al. Folate intake and the risk of neural tube defects: an estimation of dose-response. Epidemiology. 2003 Mar;14(2):200–5. [PubMed: 12606886]
99.
Werler MM, Shapiro S, Mitchell AA. Periconceptional folic acid exposure and risk of occurrent neural tube defects. JAMA. 1993 Mar 10;269(10):1257–61. [PubMed: 8437302]
100.
Bekkers MB, Elstgeest LE, Scholtens S, et al. Maternal use of folic acid supplements during pregnancy, and childhood respiratory health and atopy. Eur Respir J. 2012 Jun;39(6):1468–74. [PubMed: 22034647]
101.
Crider KS, Cordero AM, Qi YP, et al. Prenatal folic acid and risk of asthma in children: a systematic review and meta-analysis. Am J Clin Nutr. 2013 Nov;98(5):1272–81. [PMC free article: PMC5369603] [PubMed: 24004895]
102.
Haberg SE, London SJ, Stigum H, et al. Folic acid supplements in pregnancy and early childhood respiratory health. Arch Dis Child. 2009 Mar;94(3):180–4. [PMC free article: PMC3612898] [PubMed: 19052032]
103.
Kiefte-de Jong JC, Timmermans S, Jaddoe VW, et al. High circulating folate and vitamin B-12 concentrations in women during pregnancy are associated with increased prevalence of atopic dermatitis in their offspring. J Nutr. 2012 Apr;142(4):731–8. [PubMed: 22399526]
104.
Magdelijns FJ, Mommers M, Penders J, et al. Folic acid use in pregnancy and the development of atopy, asthma, and lung function in childhood. Pediatrics. 2011 Jul;128(1):e135–44. [PubMed: 21690114]
105.
Martinussen MP, Risnes KR, Jacobsen GW, et al. Folic acid supplementation in early pregnancy and asthma in children aged 6 years. Am J Obstet Gynecol. 2012 Jan;206(1):72.e1–7. [PMC free article: PMC3246127] [PubMed: 21982024]
106.
Whitrow MJ, Moore VM, Rumbold AR, et al. Effect of supplemental folic acid in pregnancy on childhood asthma: a prospective birth cohort study. Am J Epidemiol. 2009 Dec 15;170(12):1486–93. [PubMed: 19880541]
107.
Granell R, Heron J, Lewis S, et al. The association between mother and child MTHFR C677T polymorphisms, dietary folate intake and childhood atopy in a population-based, longitudinal birth cohort. Clin Exp Allergy. 2008 Feb;38(2):320–8. [PubMed: 18070159]
108.
Yang L, Jiang L, Bi M, et al. High dose of maternal folic acid supplementation is associated to infant asthma. Food Chem Toxicol. 2015 Jan;75:88–93. [PubMed: 25449200]
109.
Wang T, Zhang HP, Zhang X, et al. Is folate status a risk factor for asthma or other allergic diseases? Allergy Asthma Immunol Res. 2015 Nov;7(6):538–46. [PMC free article: PMC4605926] [PubMed: 26333700]
110.
Dunstan JA, West C, McCarthy S, et al. The relationship between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhood. Allergy. 2012 Jan;67(1):50–7. [PubMed: 21923665]
111.
Tinker SC, Cogswell ME, Devine O, et al. Folic acid intake among U.S. women aged 15-44 years, National Health and Nutrition Examination Survey, 2003-2006. Am J Prev Med. 2010 May;38(5):534–42. [PubMed: 20347553]
112.
Dietary Guidelines Advisory Committee. Scientific Report of the 2015 Dietary Guidelines Advisory Committee: Advisory Report to the Secretary of Health and Human Services. Rockville, MD: U.S. Departments of Health and Human Services (HHS) and Agriculture (USDA); 2015. http://health​.gov/dietaryguidelines​/2015-scientific-report​/PDFs​/Scientific-Report-of-the-2015-Dietary-Guidelines-Advisory-Committee.pdf.
113.
Khodr ZG, Lupo PJ, Agopian AJ, et al. Preconceptional folic acid-containing supplement use in the national birth defects prevention study. Birth Defects Res A Clin Mol Teratol. 2014 Apr 7; [PubMed: 24706436]
114.
Centers for Disease Control and Prevention. Preconception health indicators among women--Texas, 2002-2010. MMWR Morb Mortal Wkly Rep. 2012 Jul 27;61(29):550–5. [PubMed: 22832936]
115.
Kim H, Cain R, Viner-Brown S, et al. Multivitamin use prior to pregnancy in Rhode Island. Med Health R I. 2011 Sep;94(9):276–8. [PubMed: 22010325]
116.
March of Dimes. Improving preconception health: women's knowledge and use of folic acid. 2008.
117.
March of Dimes. Improving preconception health: knowledge and use of vitamins and folic acid among Spanish-language-dominant Hispanic women. 2009.
118.
Bentley TG, Willett WC, Weinstein MC, et al. Population-level changes in folate intake by age, gender, and race/ethnicity after folic acid fortification. Am J Public Health. 2006 Nov;96(11):2040–7. [PMC free article: PMC1751812] [PubMed: 17018833]
119.
Centers for Disease Control and Prevention (CDC). Use of supplements containing folic acid among women of childbearing age--United States, 2007. MMWR Morb Mortal Wkly Rep. 2008 Jan 11;57(1):5–8. [PubMed: 18185493]
120.
Centers for Disease Control and Prevention. Trends in folic acid supplement intake among women of reproductive age--California, 2002-2006. MMWR Morb Mortal Wkly Rep. 2007 Oct 26;56(42):1106–9. [PubMed: 17962802]
121.
Correa A, Stolley A, Liu Y. Prenatal tea consumption and risks of anencephaly and spina bifida. Ann Epidemiol. 2000 Oct 1;10(7):476–7. [PubMed: 11018418]
122.
Parker SE, Yazdy MM, Tinker SC, et al. The impact of folic acid intake on the association among diabetes mellitus, obesity, and spina bifida. Am J Obstet Gynecol. 2013 Sep;209(3):239.e1–8. [PMC free article: PMC3989866] [PubMed: 23711668]
123.
Kaplan JS, Iqbal S, England BG, et al. Is pregnancy in diabetic women associated with folate deficiency? Diabetes Care. 1999 Jul;22(7):1017–21. [PubMed: 10388960]
124.
Kim H, Lee YA, Hwang JY, et al. Relationship between body-mass index and serum folate concentrations in pregnant women: Mothers and Children's Environmental Health (MOCEH). FASEB J. 2011;25
125.
Jentink J, Bakker MK, De Jong-van Den Berg LTW. Effect of correct folic acid use on spina bifida in pregnancies exposed to valproic acid or carbamazepine in the Netherlands. Pharmacoepidemiol Drug Saf. 2009;18(S1):S13.
126.
Jentink J, Bakker MK, Nijenhuis CM, et al. Does folic acid use decrease the risk for spina bifida after in utero exposure to valproic acid? Pharmacoepidemiol Drug Saf. 2010 Aug;19(8):803–7. [PubMed: 20680999]
127.
Van Allen MI, Boyle E, Thiessen P, et al. The impact of prenatal diagnosis on neural tube defect (NTD) pregnancy versus birth incidence in British Columbia. J Appl Genet. 2006;47(2):151–8. [PubMed: 16682757]
128.
Kirke PN, Daly LE, Elwood JH. A randomised trial of low dose folic acid to prevent neural tube defects. The Irish Vitamin Study Group. Arch Dis Child. 1992 Dec;67(12):1442–6. [PMC free article: PMC1793975] [PubMed: 1489222]
129.
Central Technical Co-Ordinating Unit. Multicentric study of efficacy of periconceptional folic acid containing vitamin supplementation in prevention of open neural tube defects from India. Indian J Med Res. 2000;112:206–11. PMID: CN-00328155. [PubMed: 11247198]
130.
MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet. 1991 Jul 20;338(8760):131–7. [PubMed: 1677062]
131.
De-Regil LM, Fernandez-Gaxiola AC, Dowswell T, et al. Effects and safety of periconceptional folate supplementation for preventing birth defects. Cochrane Database Syst Rev. 2010;(10) Cd007950. [PMC free article: PMC4160020] [PubMed: 20927767]
132.
Lassi Zohra S, Salam Rehana A, Haider Batool A, et al. Folic acid supplementation during pregnancy for maternal health and pregnancy outcomes. Cochrane Database of Syst Rev. 2013;(3) PMID: CD006896. [PMC free article: PMC10069458] [PubMed: 23543547]
133.
Finer LB, Zolna MR. Shifts in intended and unintended pregnancies in the United States, 2001-2008. Am J Public Health. 2014 Feb;104(Suppl 1):S43–8. [PMC free article: PMC4011100] [PubMed: 24354819]
134.
Panel on Micronutrients, Subcommittees on Upper Reference Levels of Nutrients and of Interpretation and Use of Dietary Reference Intakes, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington DC: National Academy Press; 2001. [PubMed: 25057538]
135.
O'Keefe CA, Bailey LB, Thomas EA, et al. Controlled dietary folate affects folate status in nonpregnant women. J Nutr. 1995 Oct;125(10):2717–25. [PubMed: 7562109]
136.
Herbert V. Experimental nutritional folate deficiency in man. Trans Assoc Am Physicians. 1962;75:307–20. [PubMed: 13953904]
137.
Eichner ER, Pierce HI, Hillman RS. Folate balance in dietary-induced megaloblastic anemia. N Engl J Med. 1971 Apr 29;284(17):933–8. [PubMed: 5551802]
138.
Hoffbrand AV, Newcombe BF, Mollin DL. Method of assay of red cell folate activity and the value of the assay as a test for folate deficiency. J Clin Pathol. 1966;19:17–28. [PMC free article: PMC473152] [PubMed: 5904976]
139.
Varadi S, Abbott D, Elwis A. Correlation of peripheral white cell and bone marrow changes with folate levels in pregnancy and their clinical significance. J Clin Pathol. 1966;19(1):33. -&. PMID: WOS:A19667336800005. [PMC free article: PMC473154] [PubMed: 5904979]
140.
Yoon PW, Rasmussen SA, Lynberg MC, et al. The National Birth Defects Prevention Study. Public Health Rep. 2001;116(Suppl 1):32–40. [PMC free article: PMC1913684] [PubMed: 11889273]
141.
Bailey RL, Dodd KW, Gahche JJ, et al. Total folate and folic acid intake from foods and dietary supplements in the United States: 2003-2006. Am J Clin Nutr. 2010 Jan;91(1):231–7. [PMC free article: PMC2793110] [PubMed: 19923379]
142.
U.S. Department of Agriculture. Scientific Report of the 2015 Dietary Guidelines Advisory Committee. Appendix E-2: Supplementary Documentation to the 2015 DGAC Report. Washington, DC: U.S. Department of Agriculture; Feb, 2015.
143.
Brown SB, Reeves KW, Bertone-Johnson ER. Maternal folate exposure in pregnancy and childhood asthma and allergy: a systematic review. Nutr Rev. 2014 Jan;72(1):55–64. [PubMed: 24551950]
144.
Abe M. Folic acid supplementation during pregnancy affects food allergy risk in offspring depending on parental allergies. Allergy. 2014;69:152.
145.
Abe M. The effect of maternal folic acid intake during pregnancy on incidence of child food allergy. Allergy. 2013;68:559–60.
146.
Abe M. The effect of folic acid supplementation before conception on the onset of food allergies in infants. Allergy. 2015;70:266.
147.
Berry RJ, Kihlberg R, Devine O. Impact of misclassification of in vitro fertilisation in studies of folic acid and twinning: modelling using population based Swedish vital records. BMJ. 2005 Apr 9;330(7495):815. [PMC free article: PMC556070] [PubMed: 15722370]
148.
Botto LD, Erickson JD, Mulinare J, et al. Maternal fever, multivitamin use, and selected birth defects: evidence of interaction? Epidemiology. 2002 Jul;13(4):485–8. [PubMed: 12094106]
149.
Bower C, Stanley FJ. Dietary folate as a risk factor for neural-tube defects: evidence from a case-control study in Western Australia. Med J Aust. 1989 Jun 5;150(11):613–9. [PubMed: 2725375]
150.
Bower C, Stanley FJ. Periconceptional vitamin supplementation and neural tube defects; evidence from a case-control study in Western Australia and a review of recent publications. J Epidemiol Community Health. 1992 Apr;46(2):157–61. [PMC free article: PMC1059526] [PubMed: 1583432]
151.
Brescianini S, Cotichini R, Nistico L, et al. Folic acid supplementation before conception and chance of a twin pregnancy: Preliminary results from an italian case-control study. Twin Res Hum Genet. 2012;15(2):177.
152.
Carmichael SL, Yang W, Shaw GM. Periconceptional nutrient intakes and risks of neural tube defects in California. Birth Defects Res A Clin Mol Teratol. 2010 Aug;88(8):670–8. [PMC free article: PMC2929981] [PubMed: 20740594]
153.
Chandler AL, Hobbs CA, Mosley BS, et al. Neural tube defects and maternal intake of micronutrients related to one-carbon metabolism or antioxidant activity. Birth Defects Res A Clin Mol Teratol. 2012 Nov;94(11):864–74. [PMC free article: PMC3518275] [PubMed: 22933447]
154.
Charles D, Ness AR, Campbell D, et al. Taking folate in pregnancy and risk of maternal breast cancer. BMJ. 2004 Dec 11;329(7479):1375–6. [PMC free article: PMC535452] [PubMed: 15591563]
155.
Charles DH, Ness AR, Campbell D, et al. Folic acid supplements in pregnancy and birth outcome: re-analysis of a large randomised controlled trial and update of Cochrane review. Paediatr Perinat Epidemiol. 2005 Mar;19(2):112–24. [PubMed: 15787886]
156.
Taylor CM, Atkinson C, Penfold C, et al. Folic acid in pregnancy and mortality from cancer and cardiovascular disease: further follow-up of the Aberdeen folic acid supplementation trial. J Epidemiol Community Health. 2015 Aug;69(8):789–94. [PMC free article: PMC4515996] [PubMed: 25855124]
157.
Czeizel AE, Vargha P. Periconceptional folic acid/multivitamin supplementation and twin pregnancy. Am J Obstet Gynecol. 2004 Sep;191(3):790–4. [PubMed: 15467542]
158.
Czeizel AE, Toth M, Rockenbauer M. Population-based case control study of folic acid supplementation during pregnancy. Teratology. 1996 Jun;53(6):345–51. [PubMed: 8910980]
159.
De Marco P, Merello E, Calevo MG, et al. Maternal periconceptional factors affect the risk of spina bifida-affected pregnancies: an Italian case-control study. Childs Nerv Syst. 2011 Jul;27(7):1073–81. [PubMed: 21207040]
160.
Desoto MC, Hitlan RT. Synthetic folic acid supplementation during pregnancy may increase the risk of developing autism. J Pediatr Biochem. 2012;2(4):251–61.
161.
Ericson A, Kallen B, Aberg A. Use of multivitamins and folic acid in early pregnancy and multiple births in Sweden. Twin Res. 2001 Apr;4(2):63–6. [PubMed: 11665336]
162.
Gildestad T, Nordtveit TI, Nilsen RM, et al. Maternal folic acid and multivitamin supplementation and risk of neural tube defects: a population-based registry study. Eur J Epidemiol. 2013;28(1):S242–S3.
163.
Haberg SE. Folic acid supplements in pregnancy and respiratory health in early childhood. J Allergy Clin Immunol. 2009;123(2):S18.
164.
Kallen B. Use of folic acid supplementation and risk for dizygotic twinning. Early Hum Dev. 2004 Nov;80(2):143–51. [PubMed: 15500994]
165.
Kallen B. Congenital malformations in infants whose mothers reported the use of folic acid in early pregnancy in Sweden. A prospective population study. Congenit Anom (Kyoto). 2007 Dec;47(4):119–24. [PubMed: 17988253]
166.
Kondo A, Morota N, Date H, et al. Awareness of folic acid use increases its consumption, and reduces the risk of spina bifida. Br J Nutr. 2015 Jul 14;114(1):84–90. [PubMed: 25999131]
167.
Medveczky E, Puho E. Parental employment status and neural-tube defects and folic acid/multivitamin supplementation in Hungary. Eur J Obstet Gynecol Reprod Biol. 2004 Aug 10;115(2):178–84. [PubMed: 15262352]
168.
Mulinare J, Cordero JF, Erickson JD, et al. Periconceptional use of multivitamins and the occurrence of neural tube defects. JAMA. 1988 Dec 2;260(21):3141–5. [PubMed: 3184392]
169.
Ohya Y, Yonemoto J, Ogata T, et al. Influence of environmental chemicals and drugs taken before and during pregnancy on onset of childhood asthma and eczema. Allergy. 2011;66:554.
170.
Shaw GM, Nelson V, Carmichael SL, et al. Maternal periconceptional vitamins: interactions with selected factors and congenital anomalies? Epidemiology. 2002 Nov;13(6):625–30. [PubMed: 12410002]
171.
Veeranki SP, Gebretsadik T, Dorris SL, et al. Association of folic acid supplementation during pregnancy and infant bronchiolitis. Am J Epidemiol. 2014 Apr 15;179(8):938–46. [PMC free article: PMC3966719] [PubMed: 24671071]
172.
Veeranki SP, Gebretsadik T, Mitchel EF, et al. Timing of prenatal folic acid supplementation and risk of allergic rhinitis in early childhood. Am J Respir Crit Care Med. 2014;189
173.
Di Renzo GC, Spano F, Giardina I, et al. Iron deficiency anemia in pregnancy. Womens Health (Lond Engl). 2015 Oct 16; [PubMed: 26472066]
174.
Locksmith GJ, Duff P. Preventing neural tube defects: the importance of periconceptional folic acid supplements. Obstet Gynecol. 1998 Jun;91(6):1027–34. [PubMed: 9611019]
175.
Kallen BA, Olausson PO. Use of folic acid and delivery outcome: a prospective registry study. Reprod Toxicol. 2002 Jul-Aug;16(4):327–32. [PubMed: 12220592]
176.
Lumley J, Watson L, Watson M, et al. Periconceptional supplementation with folate and/or multivitamins for preventing neural tube defects. Cochrane Database Syst Rev. 2001;(3) Cd001056. [PubMed: 11686974]
177.
Shaw GM, Rozen R, Finnell RH, et al. Maternal vitamin use, genetic variation of infant methylenetetrahydrofolate reductase, and risk for spina bifida. Am J Epidemiol. 1998 Jul 1;148(1):30–7. [PubMed: 9663401]
178.
Shaw GM, Todoroff K, Carmichael SL, et al. Lowered weight gain during pregnancy and risk of neural tube defects among offspring. Int J Epidemiol. 2001 Feb;30(1):60–5. [PubMed: 11171858]
179.
Shaw GM, Velie EM, Schaffer D. Risk of neural tube defect-affected pregnancies among obese women. JAMA. 1996 Apr 10;275(14):1093–6. [PubMed: 8601928]

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