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Shekelle PG, Takata G, Newberry SJ, et al. Management of Acute Otitis Media: Update. Rockville (MD): Agency for Healthcare Research and Quality (US); 2010 Nov. (Evidence Reports/Technology Assessments, No. 198.)
This publication is provided for historical reference only and the information may be out of date.
Table 8Listing of Treatment Option Comparisons and Outcomes
| Comp# | Comparison | Author, Year | Tx success/failurea | Invasive infectionb | Bacteriologic cure | Disease recurrence | Adverse effects | Quality of life | Parent Satisfaction | Cost | Otherc |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 61 | 5 | 13 | 24 | 47 | 4 | 7 | 6 | 19 | |||
| 1 | Amox vs. Amox+Fenspiride | Zielnik- Jurkiewicz, 200565 | 1 | ||||||||
| 2 | Amox vs. Azithromycin | Arguedas, 200566 | 1 | 1 | 1 | ||||||
| 3 | Amox vs. Azithromycin | Morris, 201067 | 1 | 1 | |||||||
| 4 | Amox vs. Ceftriaxone | Zhang, 200368 | 1 | ||||||||
| 5 | Amox-clav vs. Amox-sulbactam | Casellas, 200569 | 1 | 1 | 1 | 1 | |||||
| 6 | Amox-clav vs. Azithromycin | Dagan, 20007 | 1 | 1 | 1 | ||||||
| 7 | Amox-clav vs. Azithromycin | Dunne, 200370 | 1 | 1 | |||||||
| 8 | Amox-clav vs. Azithromycin | Guven, 200652 | 1 | 1 | 1 | 1 | |||||
| 9 | Amox-clav vs. Azithromycin | Biner, 200771 | 1 | 1 | 1 | ||||||
| 10 | Amox-clav vs. Cefaclor | Subba Rao, 19985 | 1 | 1 | 1 | 1 | |||||
| 11 | Amox-clav vs. Cefdinir 7mg | Block, 200072 | 1 | 1 | 1 | ||||||
| 12 | Amox-clav vs. Cefdinir 14mg | Block, 200072 | 1 | 1 | 1 | ||||||
| 13 | Amox-clav vs. Cefdinir 7mg | Adler, 200073 | 1 | 1 | 1 | ||||||
| 14 | Amox-clav vs. Cefdinir 14mg | Adler, 200073 | 1 | 1 | 1 | ||||||
| 15 | Amox-clav vs. Cefdinir | Cifaldi, 200474 | 1 | 1 | 1 | ||||||
| 16 | Amox-clav vs. Cefdinir | Block, 200475 | 1 | 1 | 1 | 1 | 1 | ||||
| 17 | Amox-clav vs. Cefprozil | Hedrick, 200176 | 1 | 1 | |||||||
| 18 | Amox-clav vs. Ceftriaxone | Cohen, 199977 | 1 | 1 | 1 | 1 | 1 | ||||
| 19 | Amox-clav vs. Ceftriaxone | Wang, 200478 | 1 | 1 | |||||||
| 20 | Amox-clav vs. Ceftriaxone | Biner, 200771 | 1 | 1 | 1 | ||||||
| 21 | Amox-clav 40 mg vs. Cefuroxime | Pessey, 199979 | 1 | 1 | 1 | ||||||
| 22 | Amox-clav 80 mg vs. Cefuroxime | Pessey, 199979 | 1 | 1 | 1 | ||||||
| 23 | Amox-clav vs. Ciprodex drops | Dohar, 200680 | 1 | 1 | 1 | ||||||
| 24 | Azithromycin vs. Cefaclor | Dagan, 200081 | 1 | 1 | |||||||
| 25 | Azithromycin vs. Cefaclor | Oguz, 200382 | 1 | 1 | 1 | ||||||
| 26 | Azithromycin vs. Cefdinir | Block, 200583 | 1 | 1 | 1 | ||||||
| 27 | Azithromycin vs. Ceftriaxone | Biner, 200771 | 1 | 1 | 1 | ||||||
| 28 | Cefaclor vs. Cefprozil | Carvalho, 199884 | 1 | 1 | |||||||
| 29 | Cefdinir vs. Cefprozil | Block, 200085 | 1 | 1 | |||||||
| 30 | Cefaclor vs. Cefpodoxime | Tsai, 199886 | 1 | 1 | 1 | ||||||
| 31 | Amox vs. Wait- and-see | McCormick, 20053 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| 32 | PcV vs. Wait- and-see | Neumark, 200787 | 1 | 1 | 1 | 1 | |||||
| 33 | Amox vs. Placebo | Damoiseaux, 200088 | 1 | 1 | |||||||
| 34 | Amox vs. Placebo | Le Saux, 200589 | 1 | 1 | 1 | 1 | |||||
| 35 | Lidocaine drop vs. Placebo | Bolt, 200890 | 1 | 1 | |||||||
| 36 | Probiotic vs. Placebo | Hatakka, 200791 | 1 | 1 | |||||||
| 37 | Homeopathic vs. Placebo | Jacobs, 200192 | 1 | 1 | |||||||
| 38 | Amox vs. PrescriptionHold | Little, 20012 | 1 | 1 | 1 | 1 | |||||
| 39 | Amox vs. PrescriptionHold | Little, 200693 | 1 | 1 | |||||||
| 40 | Antibiotic vs. PrescriptionHold | Spiro, 200694 | 1 | 1 | 1 | 1 | 1 | ||||
| 41 | PrescriptionHold vs. Wait-and-see | Chao, 200895 | 1 | 1 | 1 | ||||||
| 42 | Amox high vs. low dose | Garrison, 200496 | 1 | 1 | 1 | 1 | |||||
| 43 | Amox-clav high vs. low dose | Pessey, 199979 | 1 | 1 | 1 | ||||||
| 44 | Amox-clav high vs. low dose | Bottenfield, 199897 | 1 | 1 | 1 | ||||||
| 45 | Amox-clav bid vs. tid | Damrikarnlert, 20006 | 1 | 1 | 1 | 1 | |||||
| 46 | Cefdinir high vs. low dose | Adler, 200073 | 1 | 1 | 1 | ||||||
| 47 | Cefdinir high vs. low dose | Block, 200072 | 1 | 1 | 1 | ||||||
| 48 | Amox-clav 5-day vs. 10-day | Cohen, 199898 | 1 | 1 | 1 | 1 | 1 | 1 | |||
| 49 | Cefaclor 5-day vs. 10-day | Catania, 200499 | 1 | 1 | 1 | ||||||
| 50 | Cefpodoxime 5- day vs. 10-day | Cohen, 2000100 | 1 | 1 | |||||||
| 51 | Ceftriaxone vs. Ceftriaxone+Prednisolone | Chonmaitree, 2003101 | 1 | 1 | 1 | ||||||
| 52 | Ceftriaxone vs. Ceftriaxone+Antihistamine | Chonmaitree, 2003101 | 1 | 1 | 1 | ||||||
| 53 | Ceftriaxone vs. Ceftriaxone+Prednisolone+Antihistamine | Chonmaitree, 2003101 | 1 | 1 | 1 | ||||||
| 54 | Ceftriaxone+Prednisolone vs. Cetriaxone+Antihistamine | Chonmaitree, 2003101 | 1 | 1 | 1 | ||||||
| 55 | Ceftriaxone+Prednisolone vs. Ceftriaxone+Predinisolone+Antihistamine | Chonmaitree, 2003101 | 1 | 1 | 1 | ||||||
| 56 | Ceftriaxone+Antihistamine vs. Ceftriaxone+Predinisolone+Antihistamine | Chonmaitree, 2003101 | 1 | 1 | 1 | ||||||
| 57 | Otikon drops vs. Topical Anesthetic | Sarrell, 2001102 | 1 | 1 | 1 | ||||||
| 58 | Anesthetic vs. Anesthetic+Amox | Sarrell, 2003103 | 1 | 1 | |||||||
| 59 | Anesthetic vs. NHED | Sarrell, 2003103 | 1 | 1 | |||||||
| 60 | Anesthetic vs. NHED+Amox | Sarrell, 2003103 | 1 | 1 | |||||||
| 61 | Anesthetic+Amox vs. NHED | Sarrell, 2003103 | 1 | 1 | |||||||
| 62 | Anesthetic+Amox vs. NHED+Amox | Sarrell, 2003103 | 1 | 1 | |||||||
| 63 | NHED vs. NHED+Amox | Sarrell, 2003103 | 1 | 1 |
- a
Included success/failure defined by improvement of signs and/or symptoms
- b
Included otologic complications
- c
Included healthcare utilization, compliance, tolerability, PE tube placement, need for change of treatment, duration of AOM
- Table 8, Listing of Treatment Option Comparisons and Outcomes - Management of Ac...Table 8, Listing of Treatment Option Comparisons and Outcomes - Management of Acute Otitis Media: Update
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