α2u-g

alpha 2u-globulin

ACGIH

American Conference of Governmental Industrial Hygienists

AIC

Akaike’s information criterion

ALD

approximate lethal dosage

ALT

alanine aminotransferase

AR

androgen receptor

AST

aspartate aminotransferase

atm

atmosphere

ATSDR

Agency for Toxic Substances and Disease Registry

BMC

benchmark concentration

BMCL

benchmark concentration lower confidence limit

BMD

benchmark dose

BMDL

benchmark dose lower confidence limit

BMDS

Benchmark Dose Software

BMR

benchmark response

BUN

blood urea nitrogen

BW

body weight

CA

chromosomal aberration

CAS

Chemical Abstracts Service

CASRN

Chemical Abstracts Service registry number

CBI

covalent binding index

CHO

Chinese hamster ovary (cell line cells)

CL

confidence limit

CNS

central nervous system

CPHEA

Center for Public Health and Environmental Assessment

CPN

chronic progressive nephropathy

CYP450

cytochrome P450

DAF

dosimetric adjustment factor

DEN

diethylnitrosamine

DMSO

dimethylsulfoxide

DNA

deoxyribonucleic acid

EPA

Environmental Protection Agency

ER

estrogen receptor

FDA

Food and Drug Administration

FEV₁

forced expiratory volume of 1 second

GD

gestation day

GDH

glutamate dehydrogenase

GGT

γ-glutamyl transferase

GSH

glutathione

GST

glutathione-S-transferase

Hb/g-A

animal blood-gas partition coefficient

Hb/g-H

human blood-gas partition coefficient

HEC

human equivalent concentration

HED

human equivalent dose

i.p.

intraperitoneal

IRIS

Integrated Risk Information System

IVF

in vitro fertilization

LC₅₀

median lethal concentration

LD₅₀

median lethal dose

LOAEL

lowest-observed-adverse-effect level

MN

micronuclei

MNPCE

micronucleated polychromatic erythrocyte

MOA

mode of action

MTD

maximum tolerated dose

NAG

N-acetyl-β-D-glucosaminidase

NCI

National Cancer Institute

NOAEL

no-observed-adverse-effect level

NTP

National Toxicology Program

NZW

New Zealand White (rabbit breed)

OCT

ornithine carbamoyl transferase

ORD

Office of Research and Development

PBPK

physiologically based pharmacokinetic

PCNA

proliferating cell nuclear antigen

PND

postnatal day

POD

point of departure

POD_ADJ

duration-adjusted POD

QSAR

quantitative structure-activity relationship

RBC

red blood cell

RDS

replicative DNA synthesis

RfC

inhalation reference concentration

RfD

oral reference dose

RGDR

regional gas dose ratio

RNA

ribonucleic acid

SAR

structure activity relationship

SCE

sister chromatid exchange

SD

standard deviation

SDH

sorbitol dehydrogenase

SE

standard error

SGOT

serum glutamic oxaloacetic transaminase, also known as AST

SGPT

serum glutamic pyruvic transaminase, also known as ALT

SSD

systemic scleroderma

TCA

trichloroacetic acid

TCE

trichloroethylene

TWA

time-weighted average

UF

uncertainty factor

UF_A

interspecies uncertainty factor

UF_C

composite uncertainty factor

UF_D

database uncertainty factor

UF_H

intraspecies uncertainty factor

UF_L

LOAEL-to-NOAEL uncertainty factor

UF_S

subchronic-to-chronic uncertainty factor

U.S.

United States of America

WBC

white blood cell

Abbreviations and acronyms not listed on this page are defined upon first use in the PPRTV document.