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Lambert JC, Lizarraga L, Owens EO, et al. ORD Human Health Toxicity Value for Perfluoropropanoic Acid (CASRN 422-64-0|DTXSID8059970). Cincinnati (OH): U.S. Environmental Protection Agency; 2023 Jun.

Cover of ORD Human Health Toxicity Value for Perfluoropropanoic Acid (CASRN 422-64-0|DTXSID8059970)

ORD Human Health Toxicity Value for Perfluoropropanoic Acid (CASRN 422-64-0|DTXSID8059970).

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COMMONLY USED ABBREVIATIONS AND ACRONYMS

AIC

Akaike’s information criterion

ALP

alkaline phosphatase

ALT

alanine aminotransferase

AST

aspartate aminotransferase

BMCL

benchmark concentration lower confidence limit

BMD

benchmark dose

BMDL

benchmark dose lower confidence limit

BMDS

Benchmark Dose Software

BMR

benchmark response

BW

body weight

CASRN

Chemical Abstracts Service registry number

CBI

nonconfidential business information

CERI

Chemicals Evaluation and Research Institute

CPHEA

Center for Public Health and Environmental Assessment

DTXSID

DSSTox substance identifier

EPA

Environmental Protection Agency

FT3

free triiodothyronine

FT4

free thyroxine

GGT

γ-glutamyl transferase

GLP

Good Laboratory Practice

HbA1c

form of hemoglobin linked to sugar

HED

human equivalent dose

HERO

Health and Environmental Research Online

IRIS

Integrated Risk Information System

LOAEL

lowest-observed-adverse-effect level

NLM

National Library of Medicine

NOAEL

no-observed-adverse-effect level

NTP

National Toxicology Program

OECD

Organization for Economic Cooperation and Development

ORD

Office of Research and Development

PBPK

physiologically based pharmacokinetic

PECO

populations, exposures, comparators, and outcomes

PFAS

per- and polyfluoroalkyl substances

PFOA

perfluorooctanoic acid

PFOS

perfluorooctane sulfonic acid

PFPrA

perfluoropropanoic acid

POD

point of departure

PODHED

human equivalent

QA

quality assurance

RD

relative deviation

RfC

inhalation reference concentration

RfD

oral reference dose

SD

standard deviation

TGAb

thyroglobulin antibody

TIAB

title or abstract

TMAb

thyroid microsomal antibody

TSH

thyroid stimulating hormone

UF

uncertainty factor

UFA

interspecies uncertainty factor

UFC

composite uncertainty factor

UFD

database uncertainty factor

UFH

intraspecies uncertainty factor

UFL

LOAEL-to-NOAEL uncertainty factor

UFS

subchronic-to-chronic uncertainty factor

U.S.

United States of America

WoS

Web of Science

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