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Urologic Cancers
Editors
Editors: Neil Barber, MBBS, FRCS1 and Ahmed Ali, MBChB, MSc, FRCS1.Affiliations
Urologic cancers are an umbrella term for cancers of the prostate, kidney, bladder, penis, and testis. Routine use of advanced imaging modalities for various reasons has increased the incidental detection of some of these cancers at an early stage. Robot-assisted surgery for nephrectomy, prostatectomy, cystectomy, and retroperitoneal lymph node dissection has improved surgical outcomes of localized disease. The introduction of targeted therapies since 2006 has revolutionized the management of metastatic kidney cancer. Despite these advances, the five-year survival of patients with advanced renal cancer is still poor and we need a better understanding of the disease. The book Urologic Cancers brings together an international team of clinicians and basic scientists to provide an up-to-date overview of a wide spectrum of topics that comprise epidemiological, pathological, clinical, and biological aspects of urologic cancers. From the epidemiological spectrum, the most recent information on the epidemiology of testicular cancer and penile cancer are presented. From the clinical spectrum, the characteristics and management of divergent urothelial neoplasms, the role of surgery in the management of testicular and kidney cancer, biopsy approaches for better detection and diagnosis of prostate cancer, the role of family history and germline genetics in prostate cancer disease profiling and screening, and the need for the implementation of quality assurance programs to improve prostate cancer care discussed. The biological aspects of disease mechanisms focus on various emerging molecular pathways and how these can be targeted to develop novel therapeutics. The contents of the book will be of interest to healthcare professionals, basic scientists and clinicians interested in urologic cancers.
Contents
- Foreword
- Preface
- List of Contributors
- 1. Invasive Urothelial Carcinoma: Subtypes and Divergent Differentiation
- 2. Papillary Urothelial Neoplasms: Clinical, Histologic, and Prognostic Features
- 3. The Etiology of Bladder Cancer
- 4. The Role of MicroRNA in the Metastatic Phenotype of Bladder Cancer
- 5. Implications of Chromatin Modifier Mutations in Epigenetic Regulation of Bladder Cancer
- 6. The Etiology of Renal Cell Carcinoma and Upper Tract Urothelial Carcinoma
- 7. MetastamiRs in Renal Cell Carcinoma: An Overview of MicroRNA Implicated in Metastatic Kidney Cancer
- 8. New Trends in Robotic Retroperitoneal Partial Nephrectomy
- 9. The Epidemiology of Testicular Cancer
- 10. Organ Sparing Surgery in Testicular Cancer
- 11. The Epidemiology of Penile Cancer
- 12. Prostate Cancer Diagnosis: Biopsy Approaches
- 13. Prostate Cancer: Advances in Radiation Oncology, Molecular Biology, and Future Treatment Strategies
- 14. Improving Prostate Cancer Care through Quality Assurance Programs
- 15. The Role of Family History and Germline Genetics in Prostate Cancer Disease Profile and Screening
Neil Barber, MBBS, FRCS is a Consultant Urological Surgeon at Frimley Park Hospital, Clinical Lead for Urology at Frimley Health NHS Foundation Trust, and Director of the Frimley Renal Cancer Centre. Dr. Barber Leads the tertiary referral center for renal cancer Surgery at Frimley Health NHS Foundation Trust. He also created a very successful Royal College of Surgeons of England certified fellowship program to train Urologist on all renal surgeries including robotic and minimally invasive renal surgery. Dr. Barber provides the full breadth of Urological care, including issues ranging from prostate cancer, urinary tract infections, prostatitis, and penoscrotal conditions. Dr. Barber is recognized as a Key Opinion Leader and clinical advisor both to industry and to NICE.
Ahmed Ali, MBChB, MSc, FRCS is a Consultant Urological Surgeon at Frimley Health Foundation NHS Trust, UK. Dr. Ali leads the bladder cancer services and is a core member of the Urology Department at Frimley Park Hospital. After receiving Master’s degree in Urology from University College of London in 2013, Dr. Ali continued to gain his expertise in managing urological oncology while undertaking a fellowship post at Addenbrookes hospital in Cambridge. Recently, Dr. Ali introduced multiple new treatments for bladder cancer at Frimley Health such as Enbloc resection of a bladder tumor, Transurethral laser ablation/resection of bladder tumor, and hyperthermic mitomycin treatment for BCG failure patients. Dr. Ali is currently involved in NIHR-funded trial to investigate the role of novel markers in overactive bladder syndrome.
Urologic Cancers
ISBN: 978-0-6453320-5-6
DOI: https://doi.org/10.36255/exon-publications-urologic-cancers
Edited by
Neil Barber, MBBS, FRCS and Ahmed Ali, MBChB, MSc, FRCS, Frimley Park Hospital, Frimley Health NHS Foundation Trust, Camberley, UK
Published by
Exon Publications, Brisbane, Australia
Copyright© 2022 Exon Publications
Copyright of individual chapters belongs to the respective authors. The authors grant unrestricted publishing and distribution rights to the publisher. The electronic versions of the chapters are published under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). https://creativecommons.org/licenses/by-nc/4.0/. Users are allowed to share and adapt the chapters for any non-commercial purposes as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source. The book in its entirety is subject to copyright by the publisher. The reproduction, modification, replication and display of the book in its entirety, in any form, by anyone, for commercial purposes are strictly prohibited without the written consent of the publisher.
Notice to the user
The views and opinions expressed in this book are believed to be accurate at the time of publication. The publisher, editors or authors cannot be held responsible or liable for any errors, omissions or consequences arising from the use of the information contained in this book. The publisher makes no warranty, implicit or explicit, with respect to the contents of this book, or its use.
First Published in September 2022