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Sanders GD, Coeytaux R, Dolor RJ, et al. Angiotensin-Converting Enzyme Inhibitors (ACEIs), Angiotensin II Receptor Antagonists (ARBs), and Direct Renin Inhibitors for Treating Essential Hypertension: An Update [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011 Jun. (Comparative Effectiveness Reviews, No. 34.)

Cover of Angiotensin-Converting Enzyme Inhibitors (ACEIs), Angiotensin II Receptor Antagonists (ARBs), and Direct Renin Inhibitors for Treating Essential Hypertension: An Update

Angiotensin-Converting Enzyme Inhibitors (ACEIs), Angiotensin II Receptor Antagonists (ARBs), and Direct Renin Inhibitors for Treating Essential Hypertension: An Update [Internet].

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Summary and Discussion

A succinct summary of the results of this review of the comparative long-term benefits and harms of angiotensin-converting enzyme inhibitor(s) (ACEIs), angiotensin II receptor blocker(s)/antagonist(s) (ARBs), or direct renin inhibitors for adults with essential hypertension is provided in three tables. First, we give an aggregated view of the strength of evidence and brief conclusions (Table 27). Second, we further describe the nature and quality of the evidence (Table 28). Finally, we summarize the quantitative analyses of outcomes, offering an estimate of the comparative outcomes for ACEIs (Table 29).

Table 27. Summary of evidence on comparative long-term benefits and harms of ACEIs, ARBs, and direct renin inhibitors for essential hypertension.

Table 27

Summary of evidence on comparative long-term benefits and harms of ACEIs, ARBs, and direct renin inhibitors for essential hypertension.

Table 28. Quality of evidence summary table.

Table 28

Quality of evidence summary table.

Table 29. GRADE balance sheet.

Table 29

GRADE balance sheet.

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