We wish to thank Kaci Parson, who helped as a research assistant; Jeannie Ouellette and Cheryl Cole-Hill for their help with editing and producing this report; James D. Neaton for his expertise in clinical trials and biostatics with regard to antipsychotics; and Aysegul Gozu and her colleagues at AHRQ for their helpful comments during the writing process. Special gratitude for Robert L. Kane in memoriam.