| Aripiprazole (Ability)1 |
Cardiovascular: Cardiorespiratory arrest (0.1% to 1%), Cardiorespiratory failure (0.1% to 1%), Myocardial infarction (0.1% to 1%), Prolonged QT interval (0.1% to 1%) Endocrine metabolic: Diabetic ketoacidosis (Less than 0.1%) Gastrointestinal: Pancreatitis Hematologic: Agranulocytosis, Leukopenia (Less than 1%), Neutropenia (Less than 1%) Musculoskeletal: Rhabdomyolysis (Less than 0.1%) Neurologic: Cerebrovascular accident, Seizure (Up to 0.3%), Tardive dyskinesia, Transient ischemic attack Psychiatric: At risk for suicide, Suicidal behavior Other: Angioedema (0.1% to less than 1%), Increased body temperature, Neuroleptic malignant syndrome Neurologic: Akathisia (2% to 25%), Dizziness (4% to 10%), Extrapyramidal sign (2% to 27.3%), Headache (10% to 27%), Insomnia (8% to 18%), Sedated (3% to 21%), Somnolence (6% to 26.3%), Tremor (2% to 11.8%)
|
| Asenapine (Saphris)1 |
Cardiovascular: Prolonged QT interval Endocrine metabolic: Hyperglycemia (Adult, 1.7% to 15.8%; pediatric up to 1.8%), Serum cholesterol abnormal (Adult, 0% to 14.7%; pediatric, 0% to 9.6%), Serum triglycerides raised, Or altered (Adult, 1.6% to 8.3%; pediatric, 1.9% to 4%), Weight increased (Adult, 1% to 22%; pediatric, 2% to 12%) Hematologic: Agranulocytosis, Decreased blood leukocyte number, Neutropenia Immunologic: Hypersensitivity reaction Neurologic: Somnolence (Adult, 13% to 26%; pediatric, 46% to 53%) Psychiatric: Suicidal thoughts (1% to 4%) Other: Angioedema, Death, Neuroleptic malignant syndrome Neurologic: Akathisia (Adult, 4% to 15%; pediatric, 1% to 2%), Dizziness (Adult, 3% to 8%; pediatric, 5% to 10%), Extrapyramidal disease (6% to 12%)
|
| Carbamazepine (Carbetrol, Epitol, Equetro, Tegretol, Teril)1 |
Cardiovascular: Atrioventricular block, Cardiac dysrhythmia, Congestive heart failure, Eosinophilic myocarditis, Hypersensitivity, Syncope Dermatologic: Stevens-Johnson syndrome, Toxic epidermal necrolysis Endocrine metabolic: Hypocalcemia, Hyponatremia (Oral, 4% to 21.7%; IV, less than 2%), Water intoxication syndrome Gastrointestinal: Pancreatitis Hematologic: Agranulocytosis, Aplastic anemia, Bone marrow depression, Eosinophil count raised, Leukopenia, Pancytopenia, Thrombocytopenia Hepatic: Hepatitis, Liver damage, Liver failure, Vanishing bile duct syndrome Immunologic: Drug reaction with eosinophilia and systemic symptoms Neurologic: Acute intermittent porphyria Renal: Azotemia, Renal failure Respiratory: Pulmonary hypersensitivity Other: Angioedema Neurologic: Asthenia (8%), Ataxia (15%), Dizziness (Bipolar disorder, 44%; seizures, 9%), Somnolence (Bipolar disorder, 32%; seizures, 5%)
|
| Cariprazine (Vraylar)1 |
Cardiovascular: Ischemic stroke (Up to 0.1%), Orthostatic hypotension Endocrine metabolic: Diabetes mellitus, Dyslipidemia, Hyperglycemia Gastrointestinal: Esophageal dysmotility Hematologic: Leukopenia, Neutropenia Musculoskeletal: Tardive dyskinesia Neurologic: Seizure Psychiatric: At risk for suicide (Up to 1%), Loss of judgement Respiratory: Pulmonary aspiration Other: Body temperature finding, Body temperature dysregulation, Neuroleptic malignant syndrome Neurologic: Akathisia (Schizophrenia, 9%; bipolar, 20%), Extrapyramidal sign (Schizophrenia, 15%; bipolar, 26%), Somnolence (5% to 8%)
|
| Lamotrigine (Lamictal)1 |
Dermatologic: Erythema multiforme (less than 0.1%), Rash, Serious (0.08% to 0.8%), Stevens-Johnson syndrome, Toxic epidermal necrolysis Hematologic: Anemia (immediate release, less than 0.1%), Disseminated intravascular coagulation, Eosinophil count raised (immediate release, less than 0.1%), Leukopenia (immediate release, 0.1% to 1%), Thrombocytopenia (immediate release, less than 0.1%) Hepatic: Liver failure Immunologic: Drug reaction with eosinophilia and systemic symptoms Neurologic: Aseptic meningitis Other: Angioedema (less than 0.1%), Neuroleptic malignant syndrome Neurologic: Asthenia (immediate-release, 2% to 8%; extended-release, 6%), Ataxia (immediate-release, 2% to 11%), Coordination problem (immediate-release, 6% to 7%; extended-release, 3%), Dizziness (immediate-release, 7% to 54%; extended release, 14%), Headache (immediate-release, 29%), Insomnia (immediate-release, 5% to 10%), Somnolence (immediate-release, 9% to 17%; extended-release, 5%), Tremor (immediate-release, 4% to 10%; extended-release, 6%), Vertigo (immediate-release, 2%; extended-release, 3%)
|
| Lithium3 |
Black Box Warning: Lithium toxicity can occur at doses close to therapeutic levels. Keep all appointments to check response to lithium. unusual tiredness or weakness excessive thirst frequent urination slow, jerky movements movements that are unusual or difficult to control blackouts seizures fainting dizziness or lightheadedness fast, slow, irregular, or pounding heartbeat shortness of breath chest tightness confusion hallucinations (seeing things or hearing voices that do not exist) crossed eyes painful, cold, or discolored fingers and toes headache pounding noises inside the head swelling of the feet, ankles, or lower legs
|
| Olanzapine (Zyprexa)1 |
Cardiovascular: Sudden cardiac death Endocrine metabolic: Diabetes mellitus, Diabetic coma with ketoacidosis, Diabetic ketoacidosis, Hyperglycemic hyperosmolar state Gastrointestinal: Acute hemorrhagic pancreatitis Hematologic: Leukopenia, Venous thromboembolism Immunologic: Drug reaction with eosinophilia and systemic symptoms, Hypersensitivity reaction Neurologic: Cerebrovascular disease, Dystonia (2% to 3%), Seizure (0.9%), Status epilepticus Psychiatric: Suicidal intent (0.1% to 1%) Respiratory: Pulmonary embolism Neurologic: Akathisia (5% to 27%), Asthenia (2% to 20%), Dizziness (Adult, 1.6% to 18%; adolescent, 7% to 8%), Somnolence (IM, 6%; oral, 20% to 52%), Tremor (1% to 23%)
|
| Quetiapine2
(Seroquel) |
Changes in mood or behavior, agitation, anxiety, restlessness, or thoughts of hurting yourself or others Constant muscle movement that you cannot control (often in your lips, tongue, jaw, arms, or legs) Fast, slow, pounding, or uneven heartbeat Fever, chills, cough, sore throat, and body aches Fever, sweating, confusion, uneven heartbeat, muscle stiffness Increase in how much or how often you urinate, increased thirst, increased hunger, or weakness Lightheadedness, dizziness, fainting, or clumsiness Seizures Vision changes
|
| Risperidone (Risperdal)1 |
Cardiovascular: Prolonged QT interval, Sudden cardiac death, Syncope (oral, up to 1%; IM, up to 2%) Endocrine metabolic: Diabetic ketoacidosis, Hypothermia Gastrointestinal: Pancreatitis Hematologic: Agranulocytosis, Leukopenia, Neutropenia, Thrombocytopenia, Thrombotic thrombocytopenic purpura Neurologic: Cerebrovascular accident, Seizure (0.3%), Tardive dyskinesia (oral, less than 5%; IM, less than 4%) Reproductive: Priapism Respiratory: Pulmonary embolism Other: Neuroleptic malignant syndrome Neurologic: Akathisia (oral, up to 10%; IM, 4% to 11%), Dizziness (oral, 4% to 16%; IM, 3% to 11%), Dystonia (oral, adult, 3% to 5%; pediatric, 2% to 6%; IM, adult, less than 4%), Parkinsonism (oral, 6% to 28%; IM, 8% to 15%), Sedated (5% to 63%), Tremor (oral, 2% to 12%; IM, 3% to 24%)
|
| Valproic acid (Depakene, Stavzor, Valproic)1 |
Cardiovascular: Palpitations (1% to less than 5%), Tachycardia (1% to less than 5%) Endocrine metabolic: Hyperammonemia Gastrointestinal: Hematemesis (1% to less than 5%) Hematologic: Myelodysplastic syndrome, Thrombocytopenia, Dose-related (1% to 27%) Immunologic: Hypersensitivity reaction (rare) Neurologic: Coma, Hyperammonemia-induced, Encephalopathy, Hyperammonemic encephalopathy Otic: Ototoxicity - deafness (1% to less than 5%) Respiratory: Pleural effusion (rare) Neurologic: Amnesia (4% to 7%), Asthenia (10% to 27%), Ataxia (8%), Dizziness (12% to 25%), Headache (5% to 31%), Insomnia (9% to 15%), Somnolence (17% to 30%), Tremor (9% to 57%) Neurologic: Amnesia (4% to 7%), Asthenia (10% to 27%), Ataxia (8%), Dizziness (12% to 25%), Headache (5% to 31%), Insomnia (9% to 15%), Somnolence (17% to 30%), Tremor (9% to 57%)
|
| Divalproex (Depakote)1 |
Cardiovascular: Palpitations (greater than 1% to less than 5%), Tachycardia (greater than 1% to less than 5%) Endocrine metabolic: Hyperammonemia Gastrointestinal: Pancreatitis (greater than 1% to less than 5%) Hematologic: Myelodysplastic syndrome, Thrombocytopenia, Dose-related (1% to 27%) Hepatic: Liver failure Immunologic: Drug reaction with eosinophilia and systemic symptoms (rare) Neurologic: Hyperammonemic encephalopathy Otic: Ototoxicity - deafness (greater than 1% to less than 5%) Neurologic: Asthenia (6% to 27%), Dizziness (up to 25%), Feeling nervous (up to 11%), Headache (31%), Insomnia (up to 15%), Somnolence (Adult, 7% to 30%; pediatric, greater than 5%), Tremor (1% to 57%)
|
| Valproate (Depacon)1 |
Endocrine metabolic: Hyperammonemia Gastrointestinal: Pancreatitis Hematologic: Myelodysplastic syndrome, Thrombocytopenia (27%) Hepatic: Liver failure Immunologic: Drug reaction with eosinophilia and systemic symptoms Neurologic: Hyperammonemic encephalopathy
|
| Ziprasidone3
(Geodon) |
unusual movements of your face or body that you cannot control fast, irregular, or pounding heartbeat rash or hives itching blisters or peeling of skin mouth sores swollen glands fever or chills shaking muscle stiffness confusion sweating loss of consciousness painful erection of the penis that lasts for hours
|
| Allopurinol1
(Aloprim, Zyloprim) |
Dermatologic: Drug reaction with eosinophilia and systemic symptoms, Rash (up to 3%), Stevens-Johnson syndrome (less than 1%), Toxic epidermal necrolysis (less than 1%) Hematologic: Agranulocytosis, Aplastic anemia, Eosinophil count raised, Myelosuppression, Thrombocytopenia (0.6%) Hepatic: Granulomatous hepatitis (less than 1%), Hepatic necrosis (less than 1%), Hepatotoxicity Immunologic: Hypersensitivity reaction Renal: Renal failure (less than 1%)
|
| Bupropion2
(Aplenzin, Wellbutrin, Zyban) |
Blistering, peeling, or red skin rash Chest pain, trouble breathing, fast, slow, or uneven heartbeat Muscle or joint pain, fever with rash Seeing or hearing things that are not there, feeling like people are against you Seizures or tremors Sudden increase in energy, racing thoughts, trouble sleeping Thoughts of hurting yourself, worsening depression, severe agitation or confusion
|
| Celecoxib (Celebrex)1 |
Cardiovascular: Myocardial infarction (Osteoarthritis or rheumatoid arthritis, 0.1% to 1.9%), Torsades de pointes, Ventricular hypertrophy (familial adenomatous polyposis, 0.1% to 1%) Dermatologic: Erythema multiforme, Erythroderma, Generalized exanthematous pustulosis, acute, Stevens-Johnson syndrome, Toxic epidermal necrolysis Endocrine metabolic: Hyperkalemia Gastrointestinal: Gastrointestinal hemorrhage (Osteoarthritis or rheumatoid arthritis, less than 0.1%), Gastrointestinal perforation (Osteoarthritis or rheumatoid arthritis, less than 0.1%), Gastrointestinal ulcer, Inflammatory disorder of digestive tract Hematologic: Hemorrhage, Thrombosis (familial adenomatous polyposis, 1.2%) Hepatic: Fulminant hepatitis, Hepatotoxicity (Rare), Increased liver enzymes (Osteoarthritis or rheumatoid arthritis, 0.1% to 1.9%), Liver failure Immunologic: Anaphylactoid reaction, Drug reaction with eosinophilia and systemic symptoms Neurologic: Cerebrovascular accident Renal: Acute renal failure, Injury of kidney Respiratory: Asthma, Bronchospasm (arthritis, 0.1% to 1.9%)
|
| Citalopram2
(Celexa) |
Anxiety, restlessness, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there Chest pain, trouble breathing Confusion, weakness, and muscle twitching Fast, pounding, or uneven heartbeat Feeling more excited or energetic than usual, trouble sleeping, racing thoughts Eye pain, vision changes, seeing halos around lights Lightheadedness, dizziness, fainting Painful, prolonged erection of your penis Thoughts of hurting yourself or others, unusual behavior Unusual bleeding or bruising
|
| Dipyridamole (Persantine)1 |
Cardiovascular: Angina pectoris, Cardiac arrest, Myocardial infarction (IV, 0.1%), Myocardial ischemia, Ventricular fibrillation, Ventricular tachycardia (IV, 0.2%) Hepatic: Liver failure Immunologic: Hypersensitivity reaction Neurologic: Cerebrovascular accident, Seizure Respiratory: Bronchospasm (IV, 0.2%)
|
| Donepezil2
(Aricept) |
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing Bloody or black, tarry stools Change in how much or how often you urinate Chest pain, slow or uneven heartbeat, trouble breathing Lightheadedness, dizziness, fainting Seizures Severe stomach pain Unusual bleeding, bruising, or weakness Vomiting of blood or material that looks like coffee grounds
|
| Fluoxetine2
(Prozac, Sarafem) |
Anxiety, restlessness, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there Confusion, weakness, and muscle twitching Eye pain, trouble seeing, blurry vision Fast, pounding, or uneven heartbeat, dizziness Seizures Skin rash, blisters, peeling, or redness Trouble breathing Unusual behavior, thoughts of hurting yourself or others, feeling more excited or energetic than usual, trouble sleeping Unusual bleeding or bruising
|
| Gabapentin (Gralise, Horizant, Neurontin)1 |
Dermatologic: Stevens-Johnson syndrome Endocrine metabolic: Hypoglycemia Immunologic: Anaphylaxis, Drug reaction with eosinophilia and systemic symptoms Neurologic: Dizziness (Adults, 28%; adults and adolescents, 17%; pediatrics, 3%), Somnolence (Adults, 21%; adults and adolescents, 19%; pediatrics, 8%) Psychiatric: Disorder of form of thought (Pediatric, 1.7%), Disturbance in thinking (2% to 3%), Hostile behavior (Pediatric, 5.2%), Hyperactive behavior (Pediatric, 4.7%), Mood swings (Pediatric, 6%), Suicidal thoughts Other: Angioedema Neurologic: Ataxia (Adult, 3%; adult and adolescent, 13%), Nystagmus (Adult and adolescent, 8%)
|
| Haloperidol (Haldol)1 |
Cardiovascular: Prolonged QT interval, Sudden cardiac death, Torsades de pointes Gastrointestinal: Paralytic ileus Hematologic: Agranulocytosis Neurologic: Dystonia, Neuroleptic malignant syndrome, Seizure, Tardive dyskinesia Reproductive: Priapism Neurologic: Akathisia, Extrapyramidal disease (Frequent), Somnolence
|
| Memantine2
(Namenda) |
Change in how much or how often you urinate. Chest pain. Lightheadedness, dizziness, or fainting. Seeing or hearing things that are not there. Severe sleepiness, restlessness, or confusion. Sudden or severe headache.
|
| Oxcarbazepine (Trileptal)1 |
Dermatologic: Erythema multiforme, Stevens-Johnson syndrome, Toxic epidermal necrolysis Endocrine metabolic: Hyponatremia (1% to 5%) Hematologic: Agranulocytosis, Leukopenia, Pancytopenia Immunologic: Anaphylaxis, Hypersensitivity reaction, Multiorgan Neurologic: Status epilepticus Psychiatric: Suicidal thoughts Other: Angioedema Neurologic: Abnormal gait (Up to 17%), Ataxia (Adult, 1% to 31%; pediatric, 13%), Dizziness (Adult, 8% to 49%; pediatric, 28%), Headache (Adult, 8% to 32%; pediatric, 31%), Impairment of balance (5% to 7%), Somnolence (Adult, 5% to 36%; pediatric, 31% to 34.8%), Tremor (1% to 16%)
|
| Paliperidone (Invega)1 |
Cardiovascular: Prolonged QT interval (7%) Hematologic: Agranulocytosis, Leukopenia Neurologic: Dysphagia, Tardive dyskinesia Reproductive: Priapism Neurologic: Akathisia (3% to 17%), Dyskinesia (1% to 6%), Dystonia (1% to 14%), Extrapyramidal disease (4% to 23%), Parkinsonism (Up to 14%), Somnolence (6% to 26%), Tremor (2% to 12%)
|
| Paroxetine2
(Brisdelle, Paxil, Pexeva) |
Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there Bone pain, tenderness, swelling, or bruising Changes in behavior, thoughts of hurting yourself or others Confusion, weakness, and muscle twitching Eye pain, vision changes, seeing halos around lights Trouble keeping still, feeling restless and agitated, racing thoughts, excessive energy, trouble sleeping Unusual bleeding or bruising
|
| Perphenazine (Trilafon)1 |
Cardiovascular: Prolonged QT interval, Torsades de pointes Gastrointestinal: Obstipation (rare), Paralytic ileus (rare) Hematologic: Agranulocytosis (rare), Disorder of hematopoietic structure (rare), Leukopenia (rare), Thrombocytopenia (rare) Immunologic: Drug-induced lupus erythematosus, Systemic (rare) Neurologic: Ineffective thermoregulation, Heatstroke or hypothermia (rare), Neuroleptic malignant syndrome (rare), Seizure (rare) Reproductive: Priapism (rare) Other: Death Neurologic: Akathisia, Dizziness, Drug-induced tardive dystonia, Dystonia, Extrapyramidal disease, Parkinsonian, Somnolence, Tardive dyskinesia
|
| Ramelteon (Rozerem)1 |
|
| Tamoxifen2
(Nolvadex, Soltamox) |
Chest pain, shortness of breath, or coughing up blood. Dark-colored urine or pale stools. Fever, chills, cough, sore throat, and body aches. Heavy or abnormal vaginal bleeding, pelvic pain or pressure. Nausea, vomiting, loss of appetite, or pain in your upper stomach. New breast lumps. Numbness or weakness in your arm or leg, or on one side of your body. Pain in your lower leg (calf). Sudden or severe headache, or problems with vision, speech, or walking. Swelling in your hands, ankles, or feet. Unusual bleeding, bruising, or weakness. Yellowing of your skin or the whites of your eyes.
|
| Topiramate (Qudexy, Topamax)1 |
Dermatologic: Erythema multiforme, Stevens-Johnson syndrome, Toxic epidermal necrolysis Endocrine metabolic: Hyperammonemia (Adolescents, 26%), Hypohidrosis, Increased body temperature, Metabolic acidosis (Adult, 14% to 44%; pediatric, 9% to 77%) Hepatic: Liver failure Neurologic: Drug-induced encephalopathy Ophthalmic: Angle-closure glaucoma, Glaucoma, Myopia, Visual field defect (epilepsy, 0.1% to 1%) Psychiatric: Suicidal thoughts Renal: Nephrolithiasis (adults, 1% to 3%) Other: Withdrawal sign or symptom Neurologic: Confusion (3% to 11%), Dizziness (4% to 25%), Impaired cognition (2% to 7%), Impaired psychomotor performance (2% to 13%), Memory impairment (3% to 12%), Paresthesia (1% to 51%), Reduced concentration span (2% to 10%), Somnolence (6% to 29%)
|
| Venlafaxine2
(Effexor) |
Anxiety, restlessness, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there Blistering, peeling, red skin rash Chest pain, cough, trouble breathing Confusion, weakness, and muscle twitching Eye pain, vision changes, seeing halos around lights Fast or pounding heartbeat Feeling more excited or energetic than usual Headache, trouble concentrating, memory problems, unsteadiness Seizures Unusual behavior, thoughts of hurting yourself or others, trouble sleeping, nervousness, unusual dreams Unusual bleeding or bruising
|
| Verapamil2
(Calan, Covera-HS, Verelan) |
Chest pain Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes Fast, slow, uneven, or pounding heartbeat Lightheadedness, dizziness, fainting Rapid weight gain, swelling in your legs, feet, or ankles Trouble breathing Unusual tiredness or weakness
|
