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Butler M, Urosevic S, Desai P, et al. Treatment for Bipolar Disorder in Adults: A Systematic Review [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2018 Aug. (Comparative Effectiveness Review, No. 208.)

Cover of Treatment for Bipolar Disorder in Adults: A Systematic Review

Treatment for Bipolar Disorder in Adults: A Systematic Review [Internet].

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Appendix ASearch Strategies

Database: Ovid MEDLINE(R)

Search Strategy: RCTs

------------------------------------------------------------

  1. meta analysis as topic/ (13510)
  2. meta-analy$.tw. (52680)
  3. metaanaly$.tw. (1203)
  4. meta-analysis/ (45541)
  5. (systematic adj (review$1 or overview$1)).tw. (43341)
  6. exp Review Literature as Topic/ (7347)
  7. or/1-6 (104864)
  8. cochrane.ab. (25132)
  9. embase.ab. (23427)
  10. (psychlit or psyclit).ab. (849)
  11. (psychinfo or psycinfo).ab. (8872)
  12. or/8-11 (39709)
  13. reference list$.ab. (8541)
  14. bibliograph$.ab. (10454)
  15. hand search.ab. (775)
  16. relevant journals.ab. (639)
  17. manual search$.ab. (2034)
  18. or/13-17 (20943)
  19. selection criteria.ab. (18005)
  20. (data adj2 (extract* or abstract*)).ab. (26471)
  21. 19 or 20 (37021)
  22. review/ (1843638)
  23. 21 and 22 (21523)
  24. Comment/ (528055)
  25. Letter/ (802670)
  26. editorial/ (333012)
  27. animal/ (5241748)
  28. human/ (13252793)
  29. 27 not (28 and 27) (3807921)
  30. or/24-26,29 (4993696)
  31. 7 or 12 or 18 or 23 (130774)
  32. 31 not 30 (122020)
  33. randomized controlled trials as topic/ (90815)
  34. randomized controlled trial/ (366322)
  35. random allocation/ (79441)
  36. double blind method/ (124067)
  37. single blind method/ (18635)
  38. clinical trial/ (484436)
  39. clinical trial, phase i.pt. (13833)
  40. clinical trial, phase ii.pt. (22208)
  41. clinical trial, phase iii.pt. (8628)
  42. clinical trial, phase iv.pt. (905)
  43. controlled clinical trial.pt. (87769)
  44. randomized controlled trial.pt. (366322)
  45. multicenter study.pt. (167455)
  46. clinical trial.pt. (484436)
  47. exp clinical trials as topic/ (276232)
  48. or/33-47 (1007391)
  49. (clinical adj trial$).tw. (193529)
  50. ((singl$ or doubl$ or treb$ or tripl$) adj (blind$3 or mask$3)).tw. (121456)
  51. placebos/ (32313)
  52. placebo$.tw. (148340)
  53. randomly allocated.tw. (15301)
  54. (allocated adj2 random$).tw. (17733)
  55. or/49-54 (386436)
  56. 48 or 55 (1124628)
  57. case report.tw. (180193)
  58. case report.tw. (180193)
  59. letter/ (802670)
  60. historical article/ (298584)
  61. or/57-60 (1270322)
  62. 56 not 61 (1095429)
  63. exp cohort studies/ (1320622)
  64. cohort$.tw. (244490)
  65. controlled clinical trial.pt. (87769)
  66. epidemiological methods/ (29547)
  67. limit 66 to yr=1971-1983 (5333)
  68. or/63-65,67 (1486088)
  69. (ae or to or po or co).fs. (3071650)
  70. side effect$.ti,ab. (162368)
  71. side effect$.ti,ab. (162368)
  72. ((adverse or undesireable or harm$ or serious or toxic) adj3 (effect$ or reaction$ or event$ or outcome$)).ti,ab. (277104)
  73. exp product surveillance, postmarketing/ (10888)
  74. exp adverse drug reaction reporting systems/ (5477)
  75. exp clinical trials, phase iv/ (221)
  76. exp poisoning/ (129396)
  77. exp substance-related disorders/ (220844)
  78. exp drug toxicity/ (86909)
  79. exp abnormalities, drug induced/ (13732)
  80. exp drug monitoring/ (13980)
  81. exp drug hypersensitivity/ (37576)
  82. (toxicity or complication$ or noxious or tolerability).ti,ab. (807144)
  83. exp postoperative complication/ (410502)
  84. exp intraoperative complications/ (39444)
  85. or/69-84 (4065205)
  86. exp Bipolar disorder/ (30924)
  87. bipolar*.ti. (15477)
  88. cyclothymia.ti. (77)
  89. (rapid adj cycl*).ti. (416)
  90. (mania or hypomania or manic or hypomanic).ti. (5588)
  91. or/86-90 (35187)
  92. 32 and 91 (799)
  93. 62 and 91 (4169)
  94. 68 and 85 and 91 (1916)
  95. limit 92 to yr="1994-Current" (788)
  96. limit 93 to yr="1994-Current" (3286) RCTs
  97. limit 94 to yr="1994-Current" (1518)
  98. 95 not 96 (522) Systematic reviews
  99. 97 not (95 or 96) (989) Cohort harms
  100. (68 and 91) not 85 (3060)
  101. limit 100 to yr="1994-Current" (2188) Cohort benefits
  102. 101 not (95 or 96 or 97) (1704)
  103. limit 96 to “all child (0 to 18 years)” (726)
  104. limit 96 to “all adult (19 plus years)” (2056)
  105. 103 and 104 (474)
  106. 103 not 105 (252)
  107. 96 not 106 (3034) RCTs without pediatric-only
  108. limit 98 to “all child (0 to 18 years)” (70)
  109. limit 98 to “all adult (19 plus years)” (161)
  110. 108 and 109 (46)
  111. 108 not 110 (24)
  112. 98 not 111 (498) Systematic reviews without pediatric-only
  113. limit 99 to “all child (0 to 18 years)” (274)
  114. limit 99 to “all adult (19 plus years)” (843)
  115. 113 and 114 (208)
  116. 113 not 115 (66)
  117. 99 not 116 (923) Cohort harms without pediatric-only
  118. limit 102 to “all child (0 to 18 years)” (607)
  119. limit 102 to “all adult (19 plus years)” (1360)
  120. 118 and 119 (459)
  121. 118 not 120 (148)
  122. 102 not 121 (1556) Cohort benefits without pediatric-only
  123. (resection or prostate or radiofrequency or sealer or ablation or hip or fibrillation).ab. (396573)
  124. 107 not 123 (2855) RCTs without pediatric-only or resection, ablation, etc.
  125. 112 not 123 (495) Systematic reviews without pediatric-only or resection, ablation, etc.
  126. 117 not 123 (800) Cohort harms without pediatric-only or resection, ablation, etc.
  127. 122 not 123 (1515) Cohort benefits without pediatric-only or resection, ablation, etc.

Database: Embase Classic+Embase

------------------------------------------------------------

  1. retracted article/ (6992)
  2. (random$ or placebo$ or single blind$ or double blind$ or triple blind$).ti,ab. (964464)
  3. (animal$ not human$).sh,hw. (3892889)
  4. (book or conference paper or editorial or letter or review).pt. not exp randomized controlled trial/ (4026686)
  5. 1 or 2 (971306)
  6. 5 not (3 or 4) (788381)
  7. exp cohort analysis/ (159852)
  8. exp longitudinal study/ (65122)
  9. exp prospective study/ (251233)
  10. exp follow up/ (749090)
  11. cohort$.tw. (363883)
  12. 7 or 8 or 9 or 10 or 11 (1281760)
  13. exp case-control study/ (90165)
  14. (case$ and control$).tw. (421076)
  15. 13 or 14 (455349)
  16. (case$ and series).tw. (156704)
  17. exp review/ (2051725)
  18. (literature adj3 review$).ti,ab. (210224)
  19. exp meta analysis/ (76123)
  20. exp “Systematic Review”/ (64783)
  21. 17 or 18 or 19 or 20 (2235229)
  22. (medline or embase or pubmed or cinahl or amed or psychlit or psychinfo or scisearch or cochrane).ti,ab. (99517)
  23. retracted article/ (6992)
  24. 22 or 23 (106462)
  25. 21 and 24 (78850)
  26. (systematic$ adj2 (review$ or overview)).ti,ab. (66304)
  27. (meta?anal$ or meta anal$ or metaanal$ or metanal$).ti,ab. (75185)
  28. 25 or 26 or 27 (159362)
  29. (ae or si or to or co).fs. (3025512)
  30. (safe or safety).ti,ab. (597602)
  31. side effect$.ti,ab. (238444)
  32. ((adverse or undesireable or harm$ or serious or toxic) adj3 (effect$ or reaction$ or event$ or outcome$)).ti,ab. (406794)
  33. exp adverse drug reaction/ (358463)
  34. exp drug toxicity/ (77722)
  35. exp intoxication/ (328776)
  36. exp drug safety/ (221042)
  37. exp drug monitoring/ (40454)
  38. exp drug hypersensitivity/ (49258)
  39. exp postmarketing surveillance/ (22410)
  40. exp phase iv clinical trial/ (1496)
  41. (toxicity or complication$ or noxious or tolerability).ti,ab. (1146485)
  42. exp postoperative complication/ (478856)
  43. exp peroperative complication/ (19583)
  44. or/29-43 (4747913)
  45. exp *bipolar disorder/ (21744)
  46. (manic and depress*).ti. (2122)
  47. (bipolar and (disorder or depress*)).ti. (14239)
  48. 45 or 46 or 47 (25031)
  49. 28 and 48 (966)
  50. 49 not (3 or 4) (463)
  51. limit 50 to yr=“2010 -Current” (238)
  52. limit 51 to (book or conference abstract or conference proceeding or “conference review” or editorial or erratum or letter or note or short survey or trade journal) (105)
  53. 51 not 52 (133) Systematic Reviews
  54. 6 and 48 (1987)
  55. 54 not 52 (1952) RCTs
  56. 12 and 48 (2527)
  57. 56 not (3 or 4) (2224)
  58. 57 not 51 (2195)
  59. 44 and 48 (5891)
  60. 58 and 59 (417) Cohort Harms

Database: PsycINFO

Search Strategy: RCTs

------------------------------------------------------------

  1. retracted article/ (6992)
  2. (random$ or placebo$ or single blind$ or double blind$ or triple blind$).ti,ab. (964464)
  3. (animal$ not human$).sh,hw. (3892889)
  4. (book or conference paper or editorial or letter or review).pt. not exp randomized controlled trial/ (4026686)
  5. 1 or 2 (971306)
  6. 5 not (3 or 4) (788381)
  7. exp cohort analysis/ (159852)
  8. exp longitudinal study/ (65122)
  9. exp prospective study/ (251233)
  10. exp follow up/ (749090)
  11. cohort$.tw. (363883)
  12. 7 or 8 or 9 or 10 or 11 (1281760)
  13. exp case-control study/ (90165)
  14. (case$ and control$).tw. (421076)
  15. 13 or 14 (455349)
  16. (case$ and series).tw. (156704)
  17. exp review/ (2051725)
  18. (literature adj3 review$).ti,ab. (210224)
  19. exp meta analysis/ (76123)
  20. exp “Systematic Review”/ (64783)
  21. 12 or 13 or 14 (2235229)
  22. (medline or embase or pubmed or cinahl or amed or psychlit or psychinfo or scisearch or cochrane).ti,ab. (99517)
  23. retracted article/ (6992)
  24. 16 or 17 (106462)
  25. 15 and 18 (78850)
  26. (systematic$ adj2 (review$ or overview)).ti,ab. (66304)
  27. (meta?anal$ or meta anal$ or metaanal$ or metanal$).ti,ab. (75185)
  28. 19 or 20 or 21 (159362)
  29. (ae or si or to or co).fs. (3025512)
  30. (safe or safety).ti,ab. (597602)
  31. side effect$.ti,ab. (238444)
  32. ((adverse or undesireable or harm$ or serious or toxic) adj3 (effect$ or reaction$ or event$ or outcome$)).ti,ab. (406794)
  33. exp adverse drug reaction/ (358463)
  34. exp drug toxicity/ (77722)
  35. exp intoxication/ (328776)
  36. exp drug safety/ (221042)
  37. exp drug monitoring/ (40454)
  38. exp drug hypersensitivity/ (49258)
  39. exp postmarketing surveillance/ (22410)
  40. exp phase iv clinical trial/ (1496)
  41. (toxicity or complication$ or noxious or tolerability).ti,ab. (1146485)
  42. exp postoperative complication/ (478856)
  43. exp peroperative complication/ (19583)
  44. or/23-27(4747913)
  45. exp *bipolar disorder/ (21744)
  46. (manic and depress*).ti. (2122)
  47. (bipolar and (disorder or depress*)).ti. (14239)
  48. 29 or 30 or 31 (25031)
  49. 22 and 32 (966)
  50. 33 not (3 or 4) (463)
  51. limit 34 to yr="2015" (238)
  52. limit 35 to (book or conference abstract or conference proceeding or “conference review” or editorial or erratum or letter or note or short survey or trade journal) (105)
  53. 35 not 36 (133) Systematic Reviews
  54. 6 and 32 (1987)
  55. 38 not 36 (1952) RCTs
  56. 9 and 32 (2527)
  57. 40 not (3 or 4) (2224)
  58. 41 not 35 (2195)
  59. 28 and 32 (5891)
  60. 42 and 43 (417) Cohort Harms

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