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D’Anci KE, Lynch MP, Leas BF, et al. Effectiveness and Safety of Bronchial Thermoplasty in Management of Asthma [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2017 Dec. (Comparative Effectiveness Reviews, No. 202.)

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Effectiveness and Safety of Bronchial Thermoplasty in Management of Asthma [Internet].

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Appendix DMinimally Important Differences for Asthma Study Outcomes

It is important to evaluate whether a measured change in an asthma outcome is clinically meaningful as well as statistically significant. Thresholds for determining clinically significant improvement have been established for some measures of asthma control, asthma-related quality of life, pulmonary physiology, and healthcare utilization, and are presented in Table E-1. The data in this table are reproduced with permission from the AHRQ EPC report, “Systematic Review of Intermittent Inhaled Corticosteroids and of Long-acting Muscarinic Antagonists for Asthma,” by the University of Connecticut Evidence-based Practice Center.

Table D-1. Thresholds for clinical significance.

Table D-1

Thresholds for clinical significance.

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