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Carson S, Lee N, Thakurta S. Drug Class Review: Newer Antihistamines: Final Report Update 2 [Internet]. Portland (OR): Oregon Health & Science University; 2010 May.
This publication is provided for historical reference only and the information may be out of date.
Original Report and Update 1
| Author | Agents | Characteristics |
|---|---|---|
| Placebo-controlled trials | ||
| Bernstein 1997 | Fexofenadine 60, 120, 240 mg bid | SAR, mc, r db, pc, 57 pts late summer 2 wks |
| Casale 1999 | Fexofenadine 120 or 180 mg qd | SAR mc, r, pc, 861 pts. 2 wks |
| Ciprandi 2001 | Fexofenadine 120 180mg | PAR, db, pc, 31 pts 4 wks |
| Dolovich 1994 | Loratadine 10 mg qd | SAR, db, pc, 180 pts 6 weeks |
| Juhlin 1991 | Cetirizine 10 or 20 mg qd | CIU, db, pc, 30 pts 2 wks |
| Juhlin 1988 | Cetirizine 10 mg qd | CIU, r, db, pc, 30 pts 2 wks |
| Mansmann 1991 | Cetirizine 10, 20 mg qd | PAR, db, pc, 215 pts 4 wk |
| Meltzer 1999 | Fexofenadine 120 or 180 mg qd | SAR, r, db, pc, QoL |
| Monroe 2003 | Desloratadine 5mg qd | CIU, r, db, pc, 6 wk |
| Monroe 1998 | Loratadine 10 mg qd | CIU, mc, db, pc, 169 pts. 4 wks |
| Murray 2002 | Cetirizine | SAR mc, r, db, pc, , 865 pts. 2 wks |
| Nelson 2000 | Fexofenadine 20, 60, 120, or 240mg | CIU, r, db, pc, 4 wks |
| Raptopoulou 1993 | Loratadine 10 mg | SAR, db, pc, 48 pts. 4 wks |
| Salmun 2002 | Desloratadine 2.5, 5, 7.5, 10, or 20 mg qd | SAR, r, db, pc, 1026 pts 2 wks |
| Thompson 2000 | Fexofenadine 60 mg twice daily | CUI mc, r db, pc 160 & 165 pt trials 4 wks |
| Vena 2002 | Fexofenadine 180 mg qd | CIU, open, 20 pts. 4 wks. |
| Wasserman 1991 | Cetirizine 10 mg and 5mg qd | SAR, db, pc, 88 pts spring 2 wks |
| Zuberbier 1995 | Cetirizine 10 or 20 mg qd | CIU, r, db, 24 pts 3wks |
| Zuberbier 1996 | Cetirizine 20 mg qd | CIU, db, pc, 11 pts. 3 wks |
Abbreviations: bid, twice daily; CIU, chronic idiopathic urticaria; db, double blind; PAR, perennial allergic rhinitis; pts, patients; qd, once daily; QoL, quality-of-life; mc, SAR, seasonal allergic rhinitis; tid; 3 times daily; wks, weeks.
Update 2
| Amat P, Novella A, Roma J, Valero A, Lluch M, Malet A. Treatment of perennial allergic rhinitis with cetirizine. Allergol Immunopathol. 1992;20(4):139–143. |
| Berlin JM, Golden SJ, Teets S, Lehman EB, Lucas T, Craig TJ. Efficacy of a steroid nasal spray compared with an antihistamine nasal spray in the treatment of perennial allergic rhinitis. J Am Osteopath Assoc.2000;100(7 Suppl):S8–13. |
| Bruttmann G, Arendt C, Bernheim J. Double-blind, placebo controlled comparison of cetirizine 2HC1 and terfenadine in atopic perennial rhinitis. Acta Therapeutica.1989;15(1):99–109. |
| Ciprandi G, Cirillo I, Vizzaccaro A, et al. Desloratadine and levocetirizine improve nasal symptoms, airflow, and allergic inflammation in patients with perennial allergic rhinitis: a pilot study. International Immunopharmacology.2005;5(13–14):1800–1808. |
| Dorow P, Aurich R, Petzold U. Efficacy and tolerability of azelastine nasal spray in patients with allergic rhinitis compared to placebo and budesonide. Arzneimittelforschung.1993;43(8):909–912. |
| Hampel FC, Jr., Ratner PH, Amar NJ, et al. Improved quality of life among seasonal allergic rhinitis patients treated with olopatadine HCl nasal spray 0.4% and olopatadine HCl nasal spray 0.6% compared with vehicle placebo. Allergy Asthma Proc.2006;27(3):202–207. |
| Mahmoud F, Arifhodzic N, Haines D, Novotney L. Levocetirizine modulates lymphocyte activation in patients with allergic rhinitis. Journal of Pharmacological Sciences.2008;108(2):149–156. |
| Potter PC, Paediatric Levocetirizine Study G. Efficacy and safety of levocetirizine on symptoms and health-related quality of life of children with perennial allergic rhinitis: a double-blind, placebo-controlled randomized clinical trial. Ann Allergy Asthma Immunol.2005;95(2):175–180. |
- Poor-quality studies - Drug Class Review: Newer AntihistaminesPoor-quality studies - Drug Class Review: Newer Antihistamines
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