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Nausea and vomiting are major concerns for patients undergoing chemotherapy and radiotherapy. Nausea and vomiting are also frequent complications associated with surgery and are commonly associated with pregnancy. Earlier pharmacologic agents commonly used as antiemetics included histamine-1 blockers, anticholinergics, and dopamine antagonists. A discovery that type 3 serotonin receptor-blocking properties were contributing to the effect of one of the dopamine antagonists, metoclopramide, eventually led to the development of the newer antiserotoninergic drugs. The purpose of this review is to compare the benefits and harms of these newer drugs in treating or preventing nausea and vomiting.
Contents
- Introduction
- Methods
- Results
- Summary
- References
- Appendixes
- Appendix A. Search Strategy
- Appendix B. Quality assessment methods for drug class reviews for the Drug Effectiveness Review Project
- Appendix C. Placebo-controlled and active-controlled trials for prevention of chemotherapy-related nausea and vomiting
- Appendix D. Placebo-controlled and active-controlled trials for prevention of PONV
- Appendix E. Abbreviations Used in Report
- Evidence Tables
Suggested citation:
Peterson K, McDonagh MS, Carson, S, Lopez S. Drug Class Review on Newer Antiemetics. Final Report. 2006
The purpose of this report is to make available information regarding the comparative effectiveness and safety profiles of different drugs within pharmaceutical classes. Reports are not usage guidelines, nor should they be read as an endorsement of, or recommendation for, any particular drug, use or approach. Oregon Health & Science University does not recommend or endorse any guideline or recommendation developed by users of these reports.
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