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Hatef E, Wilson RF, Hannum SM, et al. Use of Telehealth During the COVID-19 Era [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2023 Jan.

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Use of Telehealth During the COVID-19 Era [Internet].

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3Results

3.1. Results of the Search

Our searches identified a total of 9,987 unique citations, of which 764 were eligible and applicable to at least one of the four Key Questions (KQs) (Figure 2). We identified 406 studies applicable to KQ1, of which 11 were selected to directly address the question; 165 studies applicable to KQ2, of which 63 provided comparative data and were included in the synthesis; 412 studies applicable to KQ3, of which 187 were included in the qualitative evidence synthesis along with 138 surveys; and 51 studies addressing KQ4. (Of note, this field is moving rapidly and our updated search in May 2022 identified an additional 410 eligible citations, of which 124 were added to our synthesis.) See Appendix B for a list of excluded studies.

3.2. Results of Key Question 1

Key Question 1.

What are the characteristics of patient, provider, and health systems using telehealth during the COVID-19 era?

3.2.1. Key Points and Summary

  • Patients using telehealth were more likely to be people who were young to middle-aged, female, White, of higher socioeconomic status, and living in urban settings.
  • Visits for mental and behavioral health conditions were more frequent than visits for other conditions, and mental or behavioral care was also more likely to be delivered via telehealth than care for other conditions.
  • There was an increase in the use of telehealth for primary care, specialty care, and diagnostic/ancillary care.

We identified a total of 406 studies that provided information about the characteristics of patients, providers, and health systems using telehealth during the COVID-19 era (see Appendix C, list of KQ1 studies). Many of the studies were conducted in a small patient population or in a small health system with few providers and, so, were not generalizable to the U.S. population. Thus, we selected 11 studies to provide the descriptive characteristics of use of telehealth. These studies analyzed eight different nationally representative databases, which represented millions of telehealth visits in the United States (Table 1; Appendix C, List of Key Question 1 Studies).

Each of the data sources was very large, with wide and slightly different coverage:

  • Two studies used the IQVIA National Disease and Therapeutic Index,38 a nationally representative audit of outpatient practice in the United States (Appendix D, Table D.1).39, 40 In 2020, the total number of telehealth encounters was 117.9 million in quarter 1 and 99.3 million in quarter 2.39
  • The Centers for Disease Control and Prevention (CDC) used data from four large national telehealth providers.41 In the first three months of 2020, this dataset reported about 1.63 million telehealth visits.
  • Castlight Health aggregates medical and pharmaceutical claims from self-insured employers and health plans.42 The data from Castlight included claims from 6.8 million individuals in 2020.

This figure depicts the results of the searches conducted in this review. Four databases were searched: PubMed, CINHL, PsycINFO, and Cochrane; along with a handsearch. After deduplication 9,987 abstracts were eligible for screening. 7,911 abstracts were excluded, leaving 2,076 full text articles for screening. After full text screening 764 articles (1,312 full texts excluded) were eligible for data abstraction and inclusion in the report: Key Question (KQ) 1: 452; KQ2: 128; KQ3: 360; KQ4: 51. 310 of these full text articles were included for the syntheses: KQ1: 11; KQ2: 63; KQ3: 187; KQ4: 51.

Figure 2

Results of the search and screening. KQ=Key Question * Sum of included articles exceeds 764 because studies could be applicable to more than one KQ.

Table 1. Summary of studies analyzing characteristics of patients, providers, and health systems using telehealth during the COVID-19 era (N=11 studies).

Table 1

Summary of studies analyzing characteristics of patients, providers, and health systems using telehealth during the COVID-19 era (N=11 studies).

  • Two studies used Blue Health Intelligence data repository which includes data from most Blue Cross Blue Shield Association health insurance plans. The analysis included over 36 million patients.2, 3 The first study assessed a wide range of care patterns and factors through June 2020, and the second through December 2022.
  • One study used healthcare claims provided by Change Healthcare, representing more than 50 percent of private insurance claims in the United States.43 Submitted telehealth claims in this dataset were a modest 524,670 in February 2020 and then spiked to 12,626,363 telehealth claims in April 2020.
  • One study focusing on mental health services only made use of data from large electronic claims submission service (Office Ally) and assessed telehealth patterns for over 25 million behavioral health encounters through December 2020.44
  • Two studies made use of United Healthcare / Optum data (one from Optum Labs and the other from Optum Clinformatics). The first46 looked at all ambulatory services for 16.7 million people through June 2020; the second45 focused on 2.1 million children in the early part (January–March) of 2021.
  • Finally, one study used Veterans Affairs (VA) encounters and veteran patient data from the VA Corporate Data Warehouse, a repository for VA electronic health records.47 This study analyzed over 42 million outpatient healthcare encounters.

As noted, studies analyzed either the early COVID-19 era (from March through June 2020) or later pandemic periods (from July 2020 through March 2021) and all but one provided comparative data from a 2018 and/or 2019 pre-Covid period (Appendix D, Table D.1).

3.2.2. Results of Key Question 1a

Key Question 1a.

What are the characteristics of patients using telehealth during the COVID-19 era?

3.2.2.1. Age

Nine studies provided details about the ages of patients using telehealth.2, 3, 3941, 4447 A study of outpatient practices reported that patients 19 to 35 years of age and 36 to 55 years of age accounted for 12.4 percent and 19.8 percent of in-person visits, respectively, in the early COVID-19 era, but accounted for 17.8 percent and 26.1 percent of telehealth visits, respectively, during the early COVID-19 era. This indicates substantial adoption of telehealth of those 19 to 55 years of age compared with both younger and older patients (15.6 percent of telehealth visits were individuals <19 years and 15.2 percent and 25.3 percent of visits were individuals 56 to 65 years and 66+ years, respectively).39 Using the same dataset, another study presented similar results, reporting that, compared with the same quarter of the pre-COVID-19 era, those patients who were 39 years of age and younger accounted for more of the telehealth visits for behavioral and psychiatric conditions in the first and second quarter of 2020, while those 40 years of age and older accounted for fewer of the telehealth visits in the first and second quarter of 2020.40 At the same time, the proportion of office visits decreased for the younger age groups and stayed the same or increased for those 40 years of age and older (Appendix D, Table D.1).

An analysis from CDC reported that most telehealth visits were for adults 18 to 49 years of age, both before and during the COVID-19 era (66 percent in 2019 and 69 percent in 2020).41 During the early COVID-19 era, the percentage of telehealth visits for persons 18 to 49 years of age increased slightly, from 68 percent during the first week of January 2020 to 73 percent during the last week of March (p<0.05). Conversely, the percentage of telehealth visits for children during the early COVID-19 era remained similar or slightly decreased compared with the same period in 2019. An average of 3.5 percent of telehealth visits were for children aged <5 years in 2020 (compared with 4.0 percent in 2019), and an average of 8.6 percent for those aged 5–17 years in 2020 (compared with 10.0 percent in 2019).

A study using electronic records from the VA reported that age was only slightly associated with the use of virtual care in the pandemic period.47 However, patients using telehealth delivered via video were on average 10 years younger than those who never used video care (57 versus 67 years of age). Older veterans 45 to 64 years of age and 65 years of age and older were substantially less likely to use video care compared with veterans 18 to 44 years of age (Risk Ratio 0.80 [95% confidence interval (CI), 0.79 to 0.82] and 0.50 [95% CI, 0.48 to 0.52], respectively). Patients with high levels of pre-COVID-19 use of care were more likely to be new users of any type of telehealth.

Both studies of ambulatory care using a Blue Health Intelligence dataset across two COVID-19 time periods reported that, compared with those who had in-person visits only, those who had one or more telehealth visits during the COVID-19 era were more likely to be patients with two or more chronic conditions and those 18 to 49 years of age.2, 3

The one study that focussed only on children45 suggested that telehealth visits were highest among infants and toddlers compared with other pediatric age groups.

3.2.2.2. Gender

Seven studies provided details about the gender of patients using telehealth.3, 3941, 44, 46, 47 One of the studies, using a nationally representative audit of outpatient practices, compared characteristics of users in 2020 with those of users in 2018 and 2019, noting that the proportion of office visits by gender remained consistent between 2019 and 2020 (51 percent males versus 49 percent females) but that the proportion of females using telehealth increased (49.6 percent in 2019 to 52.2 percent in 2020).39 Using the same dataset to analyze telehealth visits for behavioral and psychiatric conditions, another study also noted that females represented a larger proportion of telehealth visits before and during the COVID-19 era.40 For instance, in quarter 2 of 2018 and 2019, females represented 60 percent of telehealth visits, which decreased to 57 percent in quarter 2 of 2020. The CDC analysis similarly reported that female patients represented more of the telehealth visits both before and during the COVID-19 era (63 percent in both 2019 and 2020).41 The VA study reported that females had a marginally increased likelihood of using telehealth compared with males (1.02 [95% CI, 1.02 to 1.03]) and reported that a greater proportion of new users of video care were female (17 percent) than those who never used video care (8 percent) (Appendix D, Table D.1).47

3.2.2.3. Race/Ethnicity

Five studies provided information about patient race/ethnicity and use of telehealth.39, 40, 42, 46, 47 A study of visit types in eight quarters of 2018–2020, reported that increases in telehealth visits during the COVID-19 era were similar among White patients (1.5 percent of visits in 2019 versus 19.3 percent in 2020) and Black patients (0.7 percent of visits in 2019 versus 20.5 percent in 2020).39 A study using the same dataset to examine mental and behavioral health visits similarly reported no change in the percentage of telehealth visits by patient race/ethnicity; White patients represented 75 percent of telehealth visits in quarter 2 of 2020, Black patients represented 12 percent, and Hispanic patients 7 percent (Appendix D, Table D.1).40

The VA study reported minor, and likely not meaningful, differences in the use of telehealth by race or ethnicity.47 Black veterans had a marginally increased likelihood of using any telehealth (1.02 [95% CI, 1.01 to 1.03]) and a slightly decreased likelihood of using video care compared with White veterans (0.96 [95% CI, 0.94 to 0.97]). However, the study reported that veterans who used telehealth before and/or during the COVID-19 era were more likely to be non-White, Hispanic, single, urban, disabled, and experiencing homelessness compared with veterans who never used telehealth.

Another study reported lower rates of telehealth use in zip codes with predominately racial/ethnic minority populations.42 Compared with those in zip codes with 80 percent or more White residents, patients in zip codes with 80 percent or more residents who belong to racial/ethnic minority groups had smaller reductions in the use of in-person office visits (absolute difference: 200.0 per 10,000 [95% CI, 128.9 to 270.1]) and also smaller increases in the use of telehealth (absolute difference: −71.6 per 10,000 [95% CI, −87.6 to −55.5]).

3.2.2.4. Socioeconomic Status and Education

Four studies assessed the economic status of patients using telehealth.2, 3, 42, 46 All studies of claims data reported lower rates of telehealth use among patients residing in zip codes with lower income.42 For example, one study of ambulatory care using commercial health insurance plans reported higher use of telehealth in the most versus least socially advantaged neighborhoods (27.4 percent [1.42 contacts per person] versus 19.9 percent [1.24 contacts per person]) (Appendix D, Table D.1).2 No study assessed the educational level of users of telehealth.

3.2.2.5. Urban/Rural Location

Four studies provided details about urban versus rural location of patients receiving telehealth.2, 3, 46, 47 In each study, patients living in urban settings represented a larger proportion of patients using telehealth. In the VA study, those living in rural areas had similar likelihood of using virtual care compared with those in urban areas (1.00 [95% CI, 0.99 to 1.00]). However, users of video care during the COVID-19 era were more likely to be urban-dwelling compared with veterans who never used virtual care (75 percent versus 65 percent).47 Similarly, a study of ambulatory care reported higher use of telehealth in urban versus rural locations (24.2 percent [1.35 contacts per person] versus 14.2 percent [1.15 contacts per person]) (Appendix D, Table D.1).2

3.2.3. Results for Key Question 1b

Key Question 1b.

What are the characteristics of provider and health systems using telehealth during the COVID-19 era?

3.2.3.1. Specialty

Seven studies provided details about the conditions of patients and, thus, indirectly, the type of provider specialty using telehealth.2, 3, 4347 Generally, mental and behavioral health represented the largest proportion of telehealth visits.

The VA study noted that, as before the COVID-19 era, mental health care had the largest percentage of its encounters provided through telehealth and the largest absolute number of visits; however, visits for mental health care had the smallest increase during the COVID-19 era (6.4-fold increase in the first 3 months of COVID-19).47 In comparison, primary care had a 15.6-fold increase, specialty care had a 14.2-fold increase, and diagnostic/ancillary care had an 8-fold increase in video-based encounters.

Another study also reported that mental health visits were far more likely than medical visits to be delivered via telehealth (46.1 percent [0.23 visits per person] versus 22.1 percent [0.86 visits per person])2. Further, this study noted that the use of telehealth for acute conditions (14.1 percent [0.63 visits per person]) was lower than that for chronic conditions (21.5 percent [0.24 visits per person]).

The one study of the later COVID-19 era reported similar findings: the frequency of telehealth claims for behavioral and mental health disorders far exceeded all other clinical issues and were 4 to 5 times more frequent than for other common conditions, such as circulatory and endocrine disorders.43

The selected studies did not provide data to allow for description of characteristics of practice setting or community versus hospital-based settings.

3.2.4. Results for Key Question 1c

Key Question 1c.

How do the characteristics of patients, providers, and health systems differ between the first 4 months of the COVID-19 era versus the remainder of the COVID-19 era?

Seven of the 11 studies reported characteristics of patients and providers for the early COVID-19 era. Most of the four studies in the later COVID-19 era (July 2020 through March 2021) indicated that the patterns seen in the earlier period were, in general, sustained, with similar levels and patterns of telehealth care, even as in-person visits increased to approach their pre-pandemic levels. Two studies assessed the relative rates of telehealth use in the later period3, 43 and the distribution was similar to that found in the earlier period. For example, psychiatry/behavioral health continued to represent the highest specialty making use of telehealth.3, 43

3.3. Results for Key Question 2

Key Question 2.

What are the benefits and harms of telehealth during the COVID-19 era?

3.3.1. Key Points and Summary

  • For adult patients who receive general medical care unrelated to COVID-19, those who receive an initial telehealth visit have similar hospitalization rates compared with those who receive in-person care.
  • Patients seeking care for women’s health (including prenatal care) who receive an initial telehealth visit may have higher emergency department (ED) visit and hospitalization rates compared with those who receive in-person care, however, differences, if any, for healthcare utilization rates between in-person and telehealth care were small and/or not clinically meaningful.
  • Patients with COVID-19 receiving telehealth care may be more likely to be hospitalized or visit the ED.
  • Clinical outcomes were similar and any differences between in-person and telehealth care varied by the type of outcome: the mortality rates and reported adverse events between in-person and telehealth care were small and/or not clinically meaningful; patients who receive an initial telehealth visit may have better patient-reported outcomes compared with those who receive in-person care.
  • Among the process measures, evidence supported a mostly lower rate of missed visits, lower rate of change in therapy/medication, higher rates of therapy/medication adherence, but lower rate of up-to-date labs and paraclinical assessment among patients receiving an initial telehealth visit. Among patients who receive general medical care or surgical care for an acute condition, those who receive telehealth care may have lower rates of care resolution in their initial visit, thus higher rates of followup visits. However, among patients who receive general medical care or surgical care for a chronic condition, those who receive telehealth care may have higher rates of care resolution in their initial visit, thus lower rates of followup visits. Among patients who receive care for specific conditions (excluding COVID-19 and pregnancy/prenatal/gynecological care), those who receive an initial telehealth visit may have higher rates of case resolution.
  • Few studies conducted subgroup analyses. In studies that conducted subgroup analysis, Non-Hispanic Black, Asian, and Hispanic patients had lower adverse events (i.e., medication-related problems) and higher appointment adherence when receiving telehealth compared with those receiving in-person care. However, not surprisingly, among patients in both in-person and telehealth groups, those patients who were older and/or had more complex conditions had higher rates of hospitalization.

We identified a total of 165 studies reporting outcomes of telehealth visits. Table 2 provides an overview of all studies by type of outcomes and clinical area. We synthesized 63 studies that provided data comparing telehealth with in-person visits. Details of study, participant, and provider characteristics can be found in Appendix C, Results Table C.2 and Appendix D Evidence Tables D.2, D.3, and D.4. Studies that did not include data comparing telehealth with in-person visits are briefly described (Appendix D Evidence Tables D.2 through D.8.2) but were excluded from the synthesis.

We categorized outcomes into three categories: healthcare utilization, clinical outcomes, and process outcomes. Healthcare utilization outcomes include emergency department (ED) visits, hospitalization, and readmission. The clinical outcome category includes mortality, patient-reported outcomes, condition-specific clinical outcomes, and adverse events. Process outcomes include missed visits, case resolution or duplication of services, change in therapy or medication, therapy or medication adherence, and up-to-date laboratory and paraclinical assessments. We did not identify any studies evaluating the cost of telehealth care as an outcome. We considered an effect or difference clinically meaningful if it would result in a change in the clinical practice or care plan for the patient.

Because the outcomes of interest were reported across a very wide range of clinical areas, we categorized the clinical areas into five main categories: care for general medical conditions, care for specific conditions, surgical care, care for general behavioral/mental health conditions, and physical rehabilitation or care for functional impairment (see Figure 3).

This figure outlines the organization of the Key Question 2 section. Outcomes were categorized into three categories: healthcare utilization, clinical outcomes, and process outcomes. Healthcare utilization outcomes include emergency department visits, hospitalization, and readmission. The clinical outcome category includes mortality, patient-reported outcomes, condition specific clinical outcomes, and adverse events. Process outcomes include missed visits, case resolution or duplication of services, change in therapy or medication, therapy or medication adherence, and up-to-date laboratory and paraclinical assessments. Because the outcomes of interest were reported across a very wide range of clinical areas, we categorized the clinical areas into five main categories: care of general medical conditions, care for specific conditions, surgical care, care for general behavioral/mental health conditions, and physical rehabilitation or functional impairment.

Figure 3

Organization of Key Question 2: What are the benefits and harms of telehealth during the COVID-19 era? ED= emergency department

3.3.2. Healthcare Utilization

3.3.2.1. Emergency Department Visits

We identified twelve observational studies that compared ED visit rates for in-person versus telehealth care (see Appendix D, Evidence Table D.5.1). For the majority of the studies, the differences, if any, of ED visit rates between in-person and telehealth care were small and not clinically meaningful (i.e., would not result in a change in the clinical practice or care plan for the patient). We were unable to make a general statement about the performance of telehealth versus in-person visits, as the clinical conditions, patient/provider characteristics, and type of assessment performed during the visits varied across the small number of studies included in this evidence synthesis. All these factors impacted the outcome of the initial visit and the need for a followup ED visit. Our confidence in our conclusions across the clinical conditions is low owing to weak study designs, issues with risk of bias, and the limited number of studies (see Table 3 and Figure 4).

Another eight studies reported ED visit rates for patients who received telehealth care (with no comparison to in-person).4855 These studies generally reported ED visit rates of 0 percent to 21 percent among study participants who received telehealth care. Studies varied in their patient and provider characteristics and clinical conditions, resulting in the wide range of ED visit rates (see Appendix D, Evidence Tables D.5.1 and D.5.2).

Table 2. Summary of key findings for the effects of telehealth versus in-person care by clinical conditions (N=124 studies).

Table 2

Summary of key findings for the effects of telehealth versus in-person care by clinical conditions (N=124 studies).

Table 3. Summary of findings: emergency department visits for patients receiving telehealth versus in-person care (N=12 studies).

Table 3

Summary of findings: emergency department visits for patients receiving telehealth versus in-person care (N=12 studies).

This figure depicts a forest plot presenting emergency department outcomes for patients with an initial telehealth visit versus an in-person visit. The data are presented as odds ratios. The forest plot is subdivided by patient’s clinical condition category: COVID-19 specialized care, general medical care-all ages, pregnant and prenatal conditions, other specialized care, and surgical care.

Figure 4

Forest plot presenting emergency department visits for patients who had an initial telehealth visit versus an initial in-person visit. CI = confidence interval; HHT = hereditary hemorrhagic telangiectasia; N = sample size; NR = not reported; OBGYN = obstetrics (more...)

3.3.2.2. General Medical Care, All Ages

Among patients of all ages who received care for general medical conditions, two observational studies reported ED visit rates after an in-person or telehealth visit. One cohort study, with serious risk of bias owing to possible selection bias and issues with intervention classification, among adults with a median age of 64 years reported ED visit rates after an in-person or telehealth visit for general medical care (all ages). The study enrolled 741 patients who had in-person visits and 564 patients who had telehealth visits.56 It identified lower ED visit rates among those who had an initial in-person visit than those who had an initial telehealth visit (29 ED visits [3.9 percent] among those in the in-person group versus 28 ED visits [5 percent] among those in telehealth group, p=0.36). The study only identified ED visits that occurred within 14 days after the initial visit, which may have contributed to the small difference between the two groups. Another cohort study, with a low risk of bias, reported ED visit rates for patients with general medical care (all ages) with a diagnosis of acute or chronic ambulatory care sensitive conditions (i.e., conditions that would avoid healthcare utilization with proper ambulatory management of the disease). Among patients with acute ambulatory care conditions, the study analyzed claims data on 493,716 patients who had in-person visits and 113,857 patients who had telehealth visits and reported higher ED visit rates among those who had an initial telehealth visit than those who had an initial in-person visit (odds ratio (OR): 1.11; 95% confidence intervals [CI], 1.06 to 1.16, with in-person visit as the reference). 3 Among patients with chronic ambulatory care conditions, the study analyzed claims data on 410,743 patients who had in-person visits and 94,481 patients who had telehealth visits and reported lower ED visit rates among those who had an initial telehealth visit than those who had an initial in-person visit (OR: 0.96; 95% CI, 0.92 to 1.01, with in-person visit as the reference). The study only included ED visits that occurred within 14 days after the initial visit, which may have contributed to a modest difference between the two groups.

The two studies showed conflicting results. The difference in the type of clinical conditions that they assessed may have resulted in the conflicting results between two studies. The study favoring telehealth care for a sub-population of patients3 was much bigger and assessed ED visits separately for those with acute and chronic ambulatory care sensitive conditions, which may have resulted in more accurate parsing out of the difference in ED visit patterns (Table 3). For patients of all ages who receive care for general medical conditions, those who receive an initial telehealth visit for an acute condition may have higher rates of ED visits compared with those who receive in-person care, and those who receive an initial telehealth visit for a chronic condition may have lower rates of ED visits compared with those who receive in-person care (Strength of Evidence (SOE): Moderate) (Table 3).

3.3.2.3. Care for Specific Conditions, COVID-19

Among patients with COVID-19 who received care, three observational studies reported ED visit rates after an in-person or telehealth visit. One cohort with moderate risk of bias among patients with COVID-19 (mean age of 58 years) assessed ED visit rates after an in-person primary care visit or telehealth encounter. The study enrolled 593 patients who had in-person visits and 192 patients who had telehealth visits.58 This study reported higher ED visit rates among those who had an initial in-person visit compared with those who had an initial telehealth visit (167 ED visits [28.2 percent] among those in the in-person group versus 24 ED visits [12.5 percent] among those in the telehealth group, p<0.001) in the 30 days following the initial assessment. Another cohort study among patients with COVID-19 (patients’ age not reported) assessed ED visit rates after an in-person primary care visit or telehealth visit. This study was at serious risk of bias owing to potentially inadequate adjustment for confounding factors and possible selection bias. This study enrolled 3,197 patients who had in-person visits and 1,187 patients who had telehealth visits.57 The study identified lower ED visit rates among those who had an initial in-person visit (227 ED visits [7.1 percent] among those in the in-person group versus 307 ED visits [25.9 percent] among those in the telehealth group, p<0.001) in the 68 days following the initial assessment. A third cohort study with moderate risk of bias among adult and elderly patients with COVID-19 (mean age of 46.03 years) assessed ED visit rates after an in-person primary care visit or telehealth visit. This study enrolled 154 patients who had in-person visits and 139 patients who had telehealth visits.59 The study reported lower ED visit rates among those who had an initial telehealth visit compared with those who had an initial in-person visit (24 ED visits [15.6 percent] among those in the in-person group versus 13 ED visits [10.1 percent] among those in the telehealth group, p=0.117) in the 30 days following the initial assessment. The three studies showed conflicting results. The difference in the followup period (68 days versus 30 days) and the data collection period (later period in the COVID-19 era [starting December 20, 2020]57 versus the early months of the pandemic [starting March 23 and April 7, 2020]58, 59) may have resulted in conflicting results among three studies. The study favoring in-person care is a larger study (N=4,384 versus N=785 and N=293) with a longer followup period (Table 3). For patients who receive specialized COVID-19 care, those who receive an initial telehealth visit may have higher ED visit rates compared with those who receive in-person care (SOE: Low).

3.3.2.4. Care for Specific Conditions, Pregnancy/Prenatal/Gynecological Care

One cohort study with a moderate risk of bias among patients in a family planning clinic (mean age of 28 years) assessed ED visit rates among those who received an in-person versus telehealth medical abortion service. This study enrolled 94 patients who had in-person visits, 124 patients who had telehealth visits and picked up their medication from the clinic, and 69 patients who had telehealth visits and received their medication in the mail.60 The study identified lower ED visit rates among those who had an initial in-person visit than among either telehealth group (2 ED visits [2.1 percent] among those in the in-person group versus 5 ED visits [4 percent] among those in telehealth group who picked up their medication from the clinic and 4 ED visits [5.8 percent] in the telehealth group who received their medication in the mail). For patients who receive specialized pregnancy/prenatal/gynecological care, those who receive an initial telehealth visit may have slightly higher ED visit rates compared with those who receive in-person care (SOE: Low) (Table 3).

3.3.2.5. Other Conditions

Among patients who received care for specific conditions, excluding COVID-19 and pregnancy/prenatal/ gynecological care, five observational studies reported ED visit rates after an in-person versus a telehealth visit. One was a cohort study with moderate risk of bias among patients with hereditary hemorrhagic telangiectasia (mean age of 57 years) enrolling 45 patients who had in-person visits and 45 who had telehealth visits.61 The study identified lower ED visit rates among those who had an initial telehealth visit compared with those who had an initial in-person visit (11 ED visits [24.4 percent] among those in the in-person group versus 9 ED visits [20 percent] among those in the telehealth group, p>0.05) in 244 days after the initial visit. The long followup time helped to identify the difference between the two groups in this small population.

The second study, a cohort study with critical risk of bias owing to substantial concerns about how baseline and time-varying confounders were addressed, was conducted in Portugal. This study assessed ED visit rates among elderly patients with chronic heart failure (mean age of 71 years) and compared rates from the pre-COVID-19 era (mainly in-person visits) with rates from the COVID-19 era (mainly telehealth visits).62 The study identified a lower ED visit rate among patients who had an initial telehealth visit (214 ED visits among 160 patients in the in-person group [1.3 visits per person] versus 52 visits among 43 patients in the telehealth group [1.2 visits per person], p=0.27). The ED visits were assessed within 497 days after the initial visit in the in-person group and 70 days in the telehealth group.

The third study, a cohort study with serious risk of bias owing to lack of information on adjusting for confounders, assessed ED visit rates among adult and elderly patients with cancer (median age of 60 years) and compared the care prior to and during transition to telehealth (mainly in-person visits) with the post-transition period (mainly telehealth visits).63 The study identified a lower ED visit rate among patients who had an initial visit in the 1 week during the transition and in the 4 weeks after the transition compared with those who had an initial visit in the 4 weeks prior to the transition (24 of 763 patients [3.1 percent] in the pre-transition group versus 2 of 168 [1.2 percent] patients in the during-transition group and 7 of 813 patients [0.9 percent] in the post-transition group, p=0.0031).

The fourth study was a cross-sectional study conducted in Australia, with serious risk of bias owing to lack of information on confounders. This study assessed ED visit rates among adult and elderly patients with cancer (mean age of 62.77 years) and compared rates from the pre-COVID-19 era (mainly in-person visits) with rates from the later-COVID-19 era (mainly telehealth visits).65 The study identified a higher ED visit rate among patients who had an initial telehealth visit (3 of 814 patients [0.37 percent] in the in-person group versus 4 of 910 patients [0.44 percent] in the telehealth group, in 24 hours after the first visit, p=1; and 3 of 814 patients [0.37 percent] in the in-person group versus 7 of 910 patients [0.77 percent] in the telehealth group, in 7 days after the first visit, p=0.343).

The fifth study was a cohort study with low risk of bias. This study assessed ED visit rates among adult and elderly patients with asthma (mean age not reported) and compared rates from the pre-COVID-19 era (mainly in-person visits) with rates from the later-COVID-19 era (mainly telehealth visits).64 The study identified a lower mean of ED visits among patients who had an initial telehealth visit (mean of 0.048, standard error [SE] 0.012 among patients in the in-person group versus mean of 0, SE 0 among patients in telehealth-only group, p comparing the two groups not reported).

The five studies showed conflicting results. The difference in the followup periods (ranging from 7 to 497 days) and the data collection period (early period in the COVID-19 era 63 versus comparison of the pre-COVID-19 era to the COVID-19 era 61, 62, 64, 65) may have resulted in conflicting results among these studies. Moreover, there were other critical confounders, like COVID-19 infection as a risk of an ED visit among the telehealth group (COVID-19 era), and no risk in the in-person group (pre-COVID-19 era), that have not been taken into consideration in the reported comparison. While the study favoring in-person care 65 is a large study (N=1,724) it has a short followup period of 7 days compared with longer followup periods reported for studies in favor of telehealth (Table 3). For patients who receive specialized care (excluding COVID-19 and pregnancy/prenatal/gynecological care), those who receive an initial telehealth visit may have lower ED visit rates compared with those who receive in-person care (SOE: Low) (Table 3).

3.3.2.6. Surgical Care

One cohort study with serious risk of bias owing to no information on confounders assessed ED visit rates among patients who underwent abdominal surgery (median age of 49 years) and had either an in-person visit or a telehealth visit for post-operation followup. The study enrolled 113 patients who had in-person visits and 106 patients who had telehealth visits.66 The study identified lower ED visit rates among those who had an initial telehealth visit than among those who had an in-person visit (2 ED visits [1.9 percent] among those in telehealth group versus 7 ED visits [6.2 percent] among those in the in-person group). For patients receiving surgical care, those who receive an initial telehealth visit may have lower ED visit rates compared with those who receive in-person care (SOE: Low) (Table 3).

3.3.3. Hospitalization

We identified 18 observational studies that compared in-person care with telehealth care and evaluated hospitalization rates (see Appendix D, Evidence Table D.5.3). As shown in Figure 5, for the majority of the studies, the differences in hospitalization rates for in-person versus telehealth care were small. We are unable to make a general statement about the relative performance of in-person or telehealth care because the clinical conditions, patient/provider characteristics, and types of assessment performed during the visits varied across the small number of studies included in this evidence synthesis. All these factors impacted the outcome of the initial visit and the need for followup hospitalization. Our confidence in our conclusions across the clinical conditions is generally low, owing to weak study designs, issues with risk of bias, and a limited number of studies (see Table 4, and Figure 5).

There were 14 other studies reporting hospitalization rates for patients receiving telehealth (with no comparison).4952, 55, 6775 These studies generally reported hospitalization rates after receipt of telehealth care of 0.01 percent to 37 percent. Studies varied in their patient and provider characteristics and clinical conditions, resulting in a wide range of hospitalization rates (see Appendix D, Evidence Tables D.5.3 and D.5.4).

3.3.3.1. General Medical Care, Adults

Among adult patients who received care for general medical conditions, two observational studies reported hospitalization rates after an in-person or telehealth visit. One was a cohort study with a moderate risk of bias among older adults (mean age of 75 years) enrolling 6,792 patients who had in-person visits and 10,311 who had telehealth visits.76 The study identified significantly lower hospitalization rates among those who had an initial telehealth visit and for all diagnoses, as well as among those with an ambulatory care sensitive condition (OR: 0.72; 95% CI, 0.57 to 0.9, p=0.004 for all diagnoses and OR: 0.78; 95% CI, 0.61 to 1, p=0.049 for those with ambulatory care sensitive conditions)

The other study, a retrospective cohort study, with a serious risk of bias owing to lack of proper adjustment for confounders and handling of missing data, assessed transfer rate to in-patient care (i.e., hospitalization) among younger, mostly white females in the United States (mean age of 38 years).77 The study identified a lower hospitalization rate among patients who had an initial telehealth visit (2.9 in-patient transfers for 207 patients [1.4 percent] in the telehealth group versus 7.0 for 207 patients [3.4 percent] in the in-person group, p>0.05). The difference in hospitalization rates was smaller in this population compared with the other study. The younger patient population, with fewer clinical comorbidities, might have resulted in a smaller difference between those who had in-person versus telehealth visits. Considering the consistent results and the demographic difference in populations, we conclude that for adult patients who receive care for general medical conditions, those who receive an initial telehealth visit have similar hospitalization rates compared with those who receive in-person care (SOE: Moderate) (Figure 5, Table 4).

3.3.3.2. General Medical Care, All Ages

Among patients of all ages who received care for general medical conditions, two observational studies reported hospitalization rates after an in-person or telehealth visit. One cohort study, with serious risk of bias owing to possible selection bias and intervention classification bias, among adults (median age of 42 years) reported hospitalization rates after an in-person or telehealth visit for care addressing general medical conditions. The study enrolled 741 patients who had in-person visits and 564 patients who had telehealth visits.56 Lower hospitalization rates were reported among those who had an initial telehealth visit (11 hospitalization events [2 percent]) compared with those who had in-person visits (21 hospitalization events [2.8 percent)], p=0.31). The study only identified hospitalization events within the 14 days after the initial visit, which may have contributed to the small difference between the two groups. Another cohort study, with low risk of bias, reported hospitalization rates for patients with general medical care (all ages) with a diagnosis of acute or chronic ambulatory care sensitive conditions (i.e., conditions that would avoid healthcare utilization with proper ambulatory management of the disease). Among patients with acute ambulatory care sensitive conditions, the study enrolled claims data on 493,716 patients who had in-person visits and 113,857 patients who had telehealth visits.3 It identified higher hospitalization rates among those who had an initial telehealth visit than those who had an initial in-person visit (OR: 1.03; 95% CI, 0.98 to 1.08, with in-person visit as the reference). Among patients with chronic ambulatory care conditions, the study enrolled claims data on 410,743 patients who had in-person visits and 94,481 patients who had telehealth visits. It identified lower hospitalization rates among those who had an initial telehealth visit than those who had an initial in-person visit (OR: 0.94; 95% CI, 0.90 to 0.99, with in-person visit as the reference).

The study only identified hospitalization events that occurred within 14 days after the initial visit, which may have contributed to a modest difference between the two groups. The two studies showed conflicting results. The difference in the type of clinical conditions that they assessed may have resulted in conflicting results between two studies. The study favoring in-person care for a sub-population of patients 3 was much larger and assessed hospitalization rates separately for those with acute and chronic ambulatory care sensitive conditions, which may have resulted in more accurate parsing out of the difference in hospitalization patterns (Table 4). For patients of all ages who receive care for general medical conditions, those who receive an initial telehealth visit for an acute condition may have higher hospitalization rates compared with those who receive in-person care and those receive an initial telehealth visit for a chronic condition may have lower hospitalization rates compared with those who receive in-person care (SOE: Moderate) (Figure 5, Table 4).

Table 4. Summary of findings: hospitalization rates for patients receiving telehealth versus in-person care (N=18 studies).

Table 4

Summary of findings: hospitalization rates for patients receiving telehealth versus in-person care (N=18 studies).

This figure depicts a forest plot presenting hospitalization outcomes for patients with an initial telehealth visit versus an in-person visit. The data are presented as odds ratios. The forest plot is subdivided by patient’s clinical condition category: COVID-19 specialized care, general medical care-adults, general medical care-all ages (not specified in the study), pregnancy and prenatal conditions, other specialized care, and surgical care.

Figure 5

Forest plot presenting hospitalization for patients who had an initial telehealth visit versus an initial in-person visit. ACSC = ambulatory care sensitive conditions; CI = confidence interval; N = sample size; NR = not reported; OBGYN = obstetrics and (more...)

3.3.3.3. Care for Specific Conditions, COVID-19

Among patients with COVID-19 who received care, two observational studies reported hospitalization rates after an in-person or telehealth visit. One cohort study, with serious risk of bias owing to potentially inadequate adjustment for confounding factors and possible selection bias, assessed hospitalization rates after an in-person primary care visit or telehealth visit among patients with COVID-19 (patients’ ages not reported). The study enrolled 3,197 patients who had in-person visits and 1,187 patients who had telehealth visits.57 It identified lower hospitalization rates among those who had an initial in-person visit (65 hospitalization events [2 percent] among those in the in-person group versus 184 hospitalization events [15.5 percent] among those in the telehealth group, p<0.001) in the 68 days following the initial assessment. The monitoring of COVID-19 symptoms via telehealth and the lack of physical examination, as well as assessment of disease severity during the telehealth visit, might have contributed to the meaningful difference between the hospitalization rates in the two groups. Another cohort study among adult and elderly patients with COVID-19 (mean age of 46.03 years) assessed hospitalization rates after an in-person primary care visit or telehealth visit. The study enrolled 154 patients who had in-person visits and 139 patients who had telehealth visits.59 This study reported lower hospitalization rates among those who had an initial telehealth visit compared with those who had an initial in-person visit (10 hospitalization events [6.5 percent] among those in the in-person group versus 6 events [4.3 percent] among those in the telehealth group, hazard ratio (HR): 0.578, 95% CI: 0.29 to 1.13, p=0.452) in the 30 days following the initial assessment.

The two studies showed conflicting results. The difference in the followup period (68 days versus 30 days) and the data collection period (later period in the COVID-19 era [starting December 20, 2020]57 versus the early months of the pandemic [starting March 23, 2020]59) may have resulted in conflicting results between two studies. The study favoring in-person care is a larger study (N=4,384 versus N= 293) with a longer followup period (Table 3). For patients who receive care for COVID-19, those who receive an initial telehealth visit may have higher hospitalization rates compared with those who receive in-person care (SOE: Low) (Figure 5, Table 4).

3.3.3.4. Care for Specific Conditions, Pregnancy/Prenatal/Gynecological Care

Among patients who received specialized care for pregnancy/prenatal/gynecological care, two observational studies reported hospitalization rates after an in-person versus a telehealth visit. One cohort study, with serious risk of bias owing to possible issues with confounders, assessed neonatal intensive care unit (NICU) admission rates for full-term newborns of patients who received in-person or telehealth prenatal care (mean age of 28 years). The study enrolled 6,559 patients who had in-person visits and 6,084 patients who had telehealth visits.78 It identified slightly lower hospitalization rates among those who had an initial in-person visit (98 NICU admissions [1.5 percent] among those in the in-person group versus 94 NICU admissions [1.6 percent] among those in the telehealth group, p<0.001), but the difference in NICU admissions was not meaningful. Another cohort study, with moderate risk of bias, assessed neonatal intensive care nursery admission rates for patients who received in-person or telehealth postpartum care (median age of 30.35 years). The study enrolled 780 patients who had in-person visits and 799 patients who had telehealth visits.79 It identified slightly lower hospitalization rates among those who had an initial in-person visit (102 admissions [13.1 percent] among those in the in-person group versus 115 admissions [14.4 percent] among those in the telehealth group, p=0.45).

For patients who receive specialized pregnancy/prenatal/gynecological care, using telehealth may result in slightly higher hospitalization rates compared with those who receive in-person care (SOE: Low) (Figure 5, Table 4).

3.3.3.5. Care for Specific Conditions, Other Conditions

Among patients who received care for specific conditions, excluding COVID-19 and pregnancy/prenatal/gynecological care, nine observational studies reported hospitalization rates after an in-person or telehealth visit. One was a cohort study with a moderate risk of bias among older adults with heart failure (mean age of 71 years) enrolling 39 patients who had in-person visits and 43 patients who had telehealth visits.80 The study identified slightly lower hospitalization rates among those who had an initial in-person visit (0 hospitalization events among those in the in-person group versus 2 hospitalization events among those in the telehealth group).

The second study, a cohort study with critical risk of bias owing to substantial concerns about baseline and time-varying confounders, was conducted in Portugal. This study assessed hospitalization rates among elderly patients with chronic heart failure (mean age of 71 years) and compared rates from the pre-COVID-19 era (mainly in-person visits) with rates from the COVID-19 era (mainly telehealth visits).62 The study identified a lower hospitalization rate among patients who had an initial telehealth visit (71 hospitalization events among 160 patients in the in-person group [44.3 percent] versus 11 hospitalization events among 43 patients in the telehealth group [25.6 percent]). The hospitalization event was assessed in the 497 days after the initial visit in the in-person group and 70 days in the telehealth group. Different followup periods might have contributed to this difference between the two groups.

The third study, a cohort study with a serious risk of bias owing to inadequate reporting for adjustment of confounding factors, assessed hospitalization rates among adult patients with irritable bowel syndrome (age range from 22 to 76 years of age; median age of 36 years).81 The study identified a lower hospitalization rate among patients who had an initial telehealth visit (17 hospitalization events among 1,036 patients in the in-person group [1.6 percent] versus 3 hospitalization events among 334 patients in the telehealth group [0.9 percent]).

The fourth study, a cohort study with serious risk of bias owing to concerns regarding inadequate adjustment for confounders, assessed hospitalization rates among rheumatology patients (mean age of 55 years).82 The study identified a lower hospitalization rate among patients who had an initial telehealth visit (33 hospitalization events among 1,286 patients in the in-person group [2.6 percent] versus 15 hospitalization events among 1,493 patients in the telehealth group [1 percent], p=0.002).

The fifth study, a cross-sectional study with serious risk of bias owing to issues with patient selection, assessed the hospitalization rates among adult patients with chest pain (median age of 44 years) in primary care clinics during the COVID-19 era.85 The study identified a lower hospitalization rate among patients who had an initial in-person visit (27 hospitalization events among 455 patients in the in-person group [5.9 percent] versus 29 hospitalization events among 455 patients in the telehealth group [6.4 percent]).

The sixth study, a cohort study with serious risk of bias owing to concerns with addressing confounders, was conducted in the United Kingdom. This study assessed hospitalization rates among adult and elderly patients with stroke (median age of 65 years) and compared rates from the pre-COVID-19 era (mainly in-person visits) with rates from the COVID-19 era (mainly telehealth visits).83 The study identified a slightly lower hospitalization rate among patients who had an initial telehealth visit (3 hospitalization events owing to recurrent transient ischemic attack or stroke among 180 patients in the in-person group [1.67 percent] versus 2 hospitalization events among 136 patients in the telehealth group [1.47 percent], p=0.445).

The seventh study, a cohort study with critical risk of bias owing to issues with confounders and reporting bias, assessed hospitalization rates among adult and elderly patients with stroke (mean age of 66.7 years) and compared rates from the pre-COVID-19 era (mainly in-person visits) with rates from the COVID-19 era (mainly telehealth visits).84 The study identified a higher hospitalization rate among patients who had an initial telehealth visit (66 hospitalization events for inpatient thrombolytic treatment among 15,226 patients in the in-person group [4 percent] versus 70 hospitalization events among 11,105 patients in the telehealth group [5.7 percent], p=0.033).

The eighth study, a cross-sectional study with serious risk of bias because of concerns with confounders, was conducted in Australia. This study assessed hospitalization rates among adult and elderly patients with cancer (mean age of 62.77 years) and compared rates from the pre-COVID-19 era (mainly in-person visits) with rates from the COVID-19 era (mainly telehealth visits).65 The study identified a slightly higher hospitalization rate among patients who had an initial telehealth visit (18 of 814 patients [2.21 percent] in the in-person group versus 22 of 910 patients [2.42 percent] in the telehealth group, in 24 hours after the first visit, p=0.531).

The ninth study was a cohort study with moderate risk of bias. This study assessed hospitalization rates among adult and elderly patients with asthma (mean age not reported) and compared rates from the pre-COVID-19 era (mainly in-person visits) with rates from the COVID-19 era (mainly telehealth visits).64 The study identified a slightly lower mean of hospitalization events among patients who had an initial telehealth visit (mean of <0.001, SE 0.062 among patients in the in-person group versus mean of 0, SE 0 among patients in telehealth-only group, p comparing the two groups not reported), but the difference was not clinically meaningful.

The nine studies showed conflicting results. Different patient populations, clinical conditions, followup periods (ranging from 1 to 497 days), and data collection periods (early period in the COVID-19 era 82 versus the comparison between pre-COVID-19 and the COVID-19 era62, 64, 65, 80, 81, 83, 84) may have resulted in conflicting results among these studies. Moreover, there were other critical confounders, such as COVID-19 infection as a risk of hospitalization event among the telehealth group (the COVID-19 era), and no risk in the in-person group (pre-COVID-19 era), that have not been taken into consideration in the reported comparison. The difference in hospitalization rates was much larger in one study than in the others. For patients who receive care for specific conditions (excluding COVID-19 and pregnancy/prenatal/gynecological care care), those who receive an initial telehealth visit may have lower hospitalization rates compared with those who receive in-person care (SOE: Low) (Figure 5, Table 4).

3.3.3.6. Surgical Care

One cohort study with moderate risk of bias assessed hospitalization rates among adult and elderly patients who underwent surgery (mean age of 56.6 years) and compared an in-person versus telehealth visit for post-operation followup. This study enrolled 437 patients who had in-person visits and 98 patients who had telehealth visits.86 The study identified slightly lower hospitalization rates among those who had an initial telehealth visit than among those with an in-person visit (2 postoperative intensive care unit [ICU] admissions [0.5 percent] among those in the in-person group versus 0 postoperative ICU admissions [0 percent] among those in telehealth group). For patients receiving surgical care, those who receive an initial telehealth visit may have lower hospitalization rates compared with those who receive in-person care (SOE: Low) (Table 4).

3.3.4. Readmission

We identified six observational studies that compared in-person with telehealth care and evaluated readmission rates (see Appendix D, Evidence Table D.5.5). The difference in readmission rates between in-person and telehealth care reported in these studies was not meaningful. Our confidence in our conclusions across the clinical conditions is low owing to weak study designs, issues with risk of bias, and a limited number of studies (see Table 5 and Figure 6). We also identified one study with no comparison that reported a readmission rate of 0.3 percent among patients with COVID-19 who received telehealth care (see Appendix D, Evidence Tables D.5.5 and D.5.6).75

3.3.4.1. Care for Specific Conditions, COVID-19

Among patients with COVID-19, two observational studies reported readmission rates after an in-person or telehealth visit. One cohort with moderate risk of bias assessed readmission rates for patients in in-person and telehealth groups (mean age of 58 years).58 This study reported slightly lower readmission rates among those in the telehealth group compared with those in the in-person group (26 readmission events [4.4 percent] among 593 patients in the in-person group versus 4 events [3.5 percent] among 114 patients in the telehealth group, p=0.67) in the 30 days following the initial assessment. The much smaller sample size for the telehealth group may have resulted in the detection of fewer readmission events in this group.

Another cohort study, with a serious risk of bias owing to concern about the handling of confounders and missing data, assessed readmission rates among patients with COVID-19 (mean age of 39 years) after an in-person or telehealth visit.87 The study identified lower readmission rates related to COVID-19 complications among those who had an initial telehealth visit (1 readmission event [8 percent] among those in the in-person group versus 0 events among those in telehealth group) in the 72 hours following the initial assessment, but the difference was not meaningful. The short followup period may have resulted in the detection of fewer readmission events. For patients who receive specialized COVID-19 care, those who receive an initial telehealth visit may have similar readmission rates compared with those who receive in-person care (SOE: Low) (Table 5).

3.3.4.2. Care for Specific Conditions, Pregnancy/Prenatal/Gynecological Care

One cohort study, with moderate risk of bias, assessed 6-week readmission rates among patients with hypertensive disorder of pregnancy who received in-person or telehealth prenatal care (mean age of 30 years) and compared the pre-COVID-19 era (mainly in-person visits) with the COVID-19 era (mainly telehealth visits).88 The study enrolled 215 patients who had in-person visits and 258 patients who had telehealth visits and reported slightly lower readmission rates among those who had an initial telehealth visit (38 readmissions [17.8 percent] among those in the in-person group versus 45 readmissions [17.4 percent] among those in the telehealth group, p=0.91). For patients who receive specialized pregnancy/prenatal/gynecological care, readmission rates may be similar for those receiving telehealth compared with those who receive in-person care (SOE: Low) (Table 5).

Table 5. Summary of findings: readmission rates for patients receiving telehealth versus in-person care (N=6 studies).

Table 5

Summary of findings: readmission rates for patients receiving telehealth versus in-person care (N=6 studies).

This figure depicts a forest plot presenting readmission outcomes for patients with an initial telehealth visit versus an in-person visit. The data are presented as odds ratios. The forest plot is subdivided by patient’s clinical condition category: COVID-19 specialized care, pregnancy and prenatal conditions, and surgical care.

Figure 6

Forest plot presenting readmissions for patients who had an initial telehealth visit versus an initial in-person visit. CI = confidence interval; N = sample size; NR = not reported; OBGYN = obstetrics and gynecology; OR = odds ratio.

3.3.4.3. Surgical Care

Among patients who received surgical care, three observational studies reported readmission rates after an in-person or telehealth visit. One cohort study with serious risk of bias, owing to issues with confounders, assessed readmission rates among adult and elderly patients who underwent thyroid/parathyroid surgery (mean age of 47.1 years) and had an in-person versus telehealth visit for post-operation followup. This study enrolled 66 patients who had in-person visits and 23 patients who had telehealth visits.89 The study identified no difference in readmission rates among those who had an initial telehealth visit than among those with an in-person visit (0 readmission [0 percent] among those in the in-person group versus 0 [0 percent] among those in telehealth group). Another cohort study with serious risk of bias, owing to concerns with lack of adjustment for confounders, was conducted in Chile. It assessed readmission rates among adult and elderly patients who underwent abdominal surgery (mean age of 49 years) and had an in-person versus telehealth visit for post-operation followup. The study enrolled 113 patients who had in-person visits and 106 patients who had telehealth visits.66 The study identified lower readmission rates for elective surgery among those who had an initial telehealth visit than among those who had an in-person visit (2 readmission events [1.9 percent] among those in the in-person group versus 6 [5.3 percent] among those in telehealth group, p=0.32). But the readmission rates for urgent/emergency surgery among those who had an initial telehealth visit was higher than among those who had an in-person visit (3 readmission events [2.7 percent] among those in the in-person group versus 4 readmission events [3.8 percent] among those in telehealth group, p=0.32]. The third study was a cohort study with moderate risk of bias that assessed readmission rates among adult and elderly surgical patients (mean age of 56.6 years) that had an in-person versus telehealth visit for post-operation followup. This study enrolled 437 patients who had in-person visits and 98 patients who had telehealth visits.86 The study identified slightly lower 90-day readmission rates among those who had an initial telehealth visit than among those who had an in-person visit [OR: 0.89; 95% CI, 0.43 to 1.7, p=0.77].

Different patient populations, clinical conditions, and followup periods may have resulted in conflicting results among these studies. The difference in readmission rates was larger in the study and in clinical setting favoring telehealth, however these were not meaningful. For patients receiving surgical care, those who receive an initial telehealth visit may have similar readmission rates compared with those who receive in-person care (SOE: Low) (Table 5).

3.3.5. Clinical Outcomes

3.3.5.1. Mortality

We identified seven observational studies that compared in-person and telehealth care and evaluated mortality rates (see Appendix D, Evidence Table D.6.1). For five of the studies, the differences of mortality rates between in-person and telehealth care were small and not clinically meaningful. For patients with cardiac conditions, telehealth seemed to have lower mortality rates compared with in-person care. For surgical patients using telehealth for post-operation followup, telehealth seemed to result in higher mortality rates compared with in-person care. Our confidence in our conclusions across the clinical conditions is low owing to weak study designs, issues with risk of bias, and a limited number of studies (see Table 6 and Figure 7).

There were another nine studies that reported mortality rates for patients who received telehealth care (with no comparison).49, 51, 54, 6872, 90 These studies generally reported mortality rates of 0.3 percent to 12.5 percent after receipt of telehealth care. Studies varied in their patient and provider characteristics and clinical conditions which resulted in a wide range of mortality rates (see Appendix D, Evidence Tables D.6.1 and D.6.2).

3.3.5.1.1. Care for Specific Conditions, Pregnancy/Prenatal/Gynecological Care

Among patients who received specialized care for pregnancy/prenatal/gynecological care, two observational studies reported mortality rates after an in-person versus a telehealth visit. One cross-sectional study with a moderate risk of bias assessed successful medical abortion rates among patients who received an in-person versus a telehealth medical abortion visit (mean age of 28 years). This study enrolled 22,158 patients who had in-person visits and 29,984 patients who had telehealth visits.91 The study identified no difference in mortality rates between the two groups (no deaths in the 59 days after the visit in the in-person group and no deaths in the 85 days after the visit in the telehealth group). A cohort study with a moderate risk of bias assessed neonatal intensive care nursery mortality rates for infants of patients who received in-person versus telehealth postpartum care (median age of 30.35 years). The study enrolled 780 patients who had in-person visits and 799 patients who had telehealth visits.79 It identified slightly lower mortality rates among those who had an initial in-person visit (11 deaths [1.4 percent] among those in the in-person group versus 13 deaths [1.6 percent] among those in the telehealth group, p=0.72).

For patients who receive specialized pregnancy/prenatal/gynecological care, those who receive an initial telehealth visit may have similar mortality rates compared with those who receive in-person care (SOE: Low) (Table 6).

3.3.5.1.2. Care for Specific Conditions, Other Conditions

Among patients who received care for specific conditions, excluding COVID-19 and pregnancy/prenatal/gynecological care, three observational studies reported mortality rates after an in-person versus a telehealth visit. One study, a cohort study with critical risk of bias owing to substantial concerns about how time-varying confounders were addressed, was conducted in Portugal. This study assessed mortality rates among elderly patients with chronic heart failure (mean age of 71 years) and compared rates from the pre-COVID-19 era (mainly in-person visits) with rates from the COVID-19 era (mainly telehealth visits).62 The study identified a lower mortality rate among patients who had an initial telehealth visit (20 deaths among 160 patients in the in-person group [12.5 percent] versus 1 death among 43 patients in the telehealth group [2.3 percent]). The death events were assessed in the 497 days after the initial visit in the in-person group and in the 70 days after the initial visit in the telehealth group. A small sample size and a much shorter followup period for the telehealth group may have contributed to the detection of fewer death events in this group.

Table 6. Summary of findings: mortality for patients receiving telehealth versus in-person care (N=7 studies).

Table 6

Summary of findings: mortality for patients receiving telehealth versus in-person care (N=7 studies).

This figure depicts a forest plot presenting mortality outcomes for patients with an initial telehealth visit versus an in-person visit. The data are presented as odds ratios. The forest plot is subdivided by patient’s clinical condition category: pregnancy and prenatal conditions, other specialized care, and surgical care.

Figure 7

Forest plot presenting mortality outcomes for patients who had an initial telehealth visit versus an initial in-person visit. CI = confidence interval; N = sample size; NR = not reported; OBGYN = obstetrics and gynecology; OR = odds ratio.

The second study was a cohort study with a moderate risk of bias among older adults with heart failure (mean age of 71 years) enrolling 39 patients who had in-person visits and 43 who had telehealth visits.80 The study identified lower mortality rates among those who had an initial telehealth visit (5.1 percent mortality rate among those in the in-person group versus 2.33 percent mortality rate among those in the telehealth group, p=0.60).

The third study, a cross-sectional study with serious risk of bias owing to lack of information on adjusting for confounders, was conducted in Australia. This study assessed mortality rates among adult and elderly patients with cancer (mean age of 62.77 years) and compared rates from the pre-COVID-19 era (mainly in-person visits) with rates from the COVID-19 era (mainly telehealth visits).65 The study identified a slightly higher mortality rate among patients who had an initial in-person visit (7 death events among 814 patients [0.86 percent] in the in-person group versus 0 death events among 910 patients [0 percent] in the telehealth group in 30 days after the first visit, p=0.008). A short followup period may have resulted in the small difference in death events between the two groups. For patients who receive care for specific conditions (excluding COVID-19 and pregnancy/prenatal/gynecological care), those who receive an initial telehealth visit may have lower mortality rates compared with those who receive in-person care (SOE: Low) (Table 6).

3.3.5.1.3. Surgical Care

Among patients who received surgical care, two observational studies reported mortality rates after an in-person versus a telehealth visit. One cohort study with serious risk of bias, owing to concerns with confounders, assessed mortality rates among patients who underwent abdominal surgery (median age of 49 years) and had an in-person versus telehealth visit for post-operation followup. This study enrolled 113 patients who had in-person visits and 106 patients who had telehealth visits.66 The study identified no difference in mortality rates between the two groups [0 death events among those in the in-person group versus 0 death events among those in telehealth group].

Another cohort study with moderate risk of bias assessed mortality rates among adult and elderly patients who underwent surgery (mean age of 56.6 years) and had an in-person versus telehealth visit for post-operation followup. This study enrolled 437 patients who had in-person visits and 98 patients who had telehealth visits.86 The study identified higher mortality rates among those who had an initial telehealth visit compared with those who had an in-person visit [OR: 2.26; 95% CI, 0.48 to 7.72, p=0.32]. The study favoring in-person visits was larger and the mortality rates were assessed in the 90 days after the surgery, which may have contributed to the detection of a clinically meaningful difference between the two groups. For patients receiving surgical care, those who receive an initial telehealth visit may have higher mortality rates compared with those who receive in-person care (SOE: Low) (Table 6).

3.3.6. Patient-Reported Outcomes

We identified five observational studies that compared in-person care with telehealth care and evaluated patient-reported outcomes (see Appendix D, Evidence Table D.6.3). For three of the studies, the differences in patient-reported outcomes between in-person and telehealth care were small and not clinically meaningful. For patients who receive weight management care, those who receive an initial telehealth visit may have better patient-reported outcomes compared with those who receive in-person care. For patients receiving pregnancy/postnatal care, those who receive an initial telehealth visit may have worse patient-reported outcomes compared with those who receive in-person care. Our confidence in our conclusion is low, owing to weak study design, issues with risk of bias, and a limited number of studies (see Table 7 and Figure 8).

Another four studies reported patient-reported outcomes for patients who received telehealth (with no comparisons).9295 These studies generally reported changes in different types of pain (i.e., headache, neuropathic, and shoulder pain), mobility, and self-care from baseline. The change in pain scores ranged considerably from 0.2 to −28.9. Patients showed higher rates of full mobility and ability for self-care after participating in a telehealth home-based program versus before participation (see Appendix D, Evidence Tables D.6.2 and D.6.3).95

3.3.6.1. Care for Specific Conditions, Pregnancy/Prenatal/Gynecological Care

Among patients who received pregnancy/prenatal/gynecological care, one cohort study with moderate risk of bias, performed postpartum depression screening among patients who received in-person or telehealth postpartum care (median age of 30.35 years). The study enrolled 780 patients who had in-person visits and 799 patients who had telehealth visits.79 It identified higher rates of postpartum depression among those who had an initial telehealth visit (368 patients [65.1 percent] in the in-person group versus 571 patients [86.3 percent] in the telehealth group, OR: 4.61; 95% CI, 3.38 to 6.28, p=0.32]. p<0.001). For patients who receive pregnancy/prenatal/gynecological care, those who receive an initial telehealth visit may have worse patient-reported outcomes compared with those who receive in-person care (SOE: Low) (Table 7).

3.3.6.2. Care for Specific Conditions, Other Conditions

Among patients who received care for specific conditions (excluding COVID-19 and pregnancy/prenatal/gynecological care), one observational study reported patient-reported outcomes after an in-person versus a telehealth visit. The prospective cohort, with a serious risk of bias owing to concerns about adjustment for confounders and missing data, assessed weight loss among patients who received telehealth versus in-person visits in a weight management clinic.96 The study enrolled 228 obese patients in the in-person group and 51 obese patients in the telehealth group. It identified lower rates of deterioration in the dietary habit score among patients in the telehealth group (97 of 228 patients [42.54 percent] in the in-person group versus 17 of 51 patients [33.33 percent] in the telehealth group). The smaller sample size in the telehealth group compared with the in-person group may have resulted in the detection of fewer patients with deterioration in their dietary habit score. For patients who receive care for specific conditions (excluding COVID-19 and pregnancy/prenatal/gynecological care), those who receive an initial telehealth visit may have better patient-reported outcomes compared with those who receive in-person care (SOE: Low) (Table 7).

Table 7. Summary of findings: patient-reported outcomes for patients receiving telehealth care versus in-person care (N=5 studies).

Table 7

Summary of findings: patient-reported outcomes for patients receiving telehealth care versus in-person care (N=5 studies).

This figure depicts a forest plot presenting patient reported outcomes for patients with an initial telehealth visit versus an in-person visit. The data are presented as odds ratios. The forest plot is subdivided by patient’s clinical condition category: Specific conditions, and pregnancy and prenatal conditions.

Figure 8

Forest plot presenting patient-reported outcomes for patients who had an initial telehealth visit versus an initial in-person visit. CI = confidence interval; N = sample size; NR = not reported; OBGYN = obstetrics and gynecology; OR = odds ratio.

3.3.6.3. Care for General Behavioral and Mental Health Conditions

Among patients who received care for general behavioral and mental health conditions, three observational studies reported patient-reported outcomes after an in-person versus a telehealth visit. One cohort, with serious risk of bias owing to serious concerns with addressing confounders, assessed eating disorders among adult patients (mean age of 24.52 years) enrolled in a multidisciplinary intensive outpatient program receiving care through in-person (N=60) or telehealth (N=33) visits.97 Patients who had an in-person visit experienced more improvement in their eating disorder (larger change in the overall score of the Eating Disorder Examination Questionnaire v4 comparing the followup to baseline score) than those who had a telehealth visit (mean of 4.1; standard deviation (SD) 1.07 in the overall score at baseline and mean of 2.37; SD 1.24 in the followup for patients in the in-patient group versus mean of 3.56; SD 1.42 in the overall score at baseline and mean of 2.56; SD 1.14 in the followup for patients in the telehealth group). On average, the patients stayed in this eating disorder program for 11.32 weeks (SD 7.64) and the mean of stay did not differ between the two groups (p=0.762).

A second cohort study with moderate risk of bias among adult patients (age range of 18 to 87 years) assessed overall psychological functioning and adjustment among patients with psychiatric diseases and compared those from the pre-COVID-19 era (mainly in-person visits) with those from the COVID-19 era (mainly telehealth visits).98 This study reported that patients who had a telehealth visit experienced better general psychological adjustment (a lower score in the Brief adjustment scale-6; a 6-item self-report scale designed to address overall psychological functioning and adjustment) than those who had an in-person visit (mean of 23.91 in the scale for 196 patients in the in-patient group versus mean of 21.01 for 196 patients in the telehealth group, p=<0.00).

A third cohort study, with serious risk of bias owing to issues with addressing confounders, assessed general mental health among caregivers and children (mean age of 47.17 years for caregivers and 11.08 for children) and compared data from the pre-COVID-19 era (mainly in-person visits) with data from the COVID-19 era (mainly telehealth visits).99 It identified that, among the 12 patients enrolled in the study, general mental health improved 20 weeks after enrolling in the focused group parenting intervention via telehealth compared with mental health before enrollment (baseline mean of the Patient Health Questionnaire–9 [PHQ-9] score 7.8; SD 5.96 versus followup mean of the PHQ-9 score 3.1; SD 2.02, Cohen’s d: −0.75; 95% CI: −0.62 to 8.78, with higher PHQ-9 score indicating greater severity of depressive symptoms).

Different patient populations, clinical conditions, and followup periods may have resulted in conflicting results among these studies. The studies also used different questionnaires with varying degrees of accuracy to assess the mental health status of their patients. The sample size and difference between in-person and telehealth groups were small in the study favoring in-person visits.97 For patients receiving care for general behavioral and mental health conditions, those who receive an initial telehealth visit may have better patient-reported outcomes compared with those who receive in-person care (SOE: Low) (Table 7).

3.3.7. Condition-Specific Clinical Outcomes

We identified 11 observational studies that compared in-person care with telehealth care and evaluated a variety of condition-specific clinical outcomes (see Appendix D, Evidence Table D.6.5). Our confidence in our conclusions across the clinical conditions is low owing to weak study designs, issues with risk of bias, and a limited number of studies (see Table 8 and Figure 9). There were also two studies with no comparison: one study that included 663 patients reported a successful, complete abortion in 650 patients (98 percent) who received medical abortion through telehealth visits;74 one study assessed rotator cuff–related shoulder pain and identified improvement in 40 percent of 11 patients who received only advice during their telehealth visit, in 50 percent of 12 patients who received care and exercise recommendations during their telehealth visit, and in 75 percent of 12 patients who received telerehabilitation in addition to care and exercise recommendations during their telehealth visit (see Appendix D, Evidence Tables D.6.5 and D.6.6).93

3.3.7.1. Care for Specific Conditions, Pregnancy/Prenatal/Gynecological Care

Among patients who received specialized care for pregnancy/prenatal/gynecological care, two observational studies reported clinical outcomes after an in-person versus a telehealth visit. One cross-sectional study, with a moderate risk of bias, assessed successful medical abortion rates among patients who received an in-person (N=22,158) or telehealth visit (N=29,984) (mean age of 28 years).91 This study identified a slightly higher success rate for patients in the telehealth group compared with those in the in-person group (21,769 [98.2 percent] successful abortions among those in the in-person group in the 59 days after the initial visit versus 29,618 [98.8 percent] successful abortions among those in the telehealth group in the 85 days after the initial visit, p=1.0), but the difference was not clinically meaningful. The shorter followup period for the in-person group may have resulted in the identification of a slighter lower success rate in this group. Another cohort study, with moderate risk of bias, assessed breast feeding practice among patients who received in-person (N=780) versus telehealth (N=799) postpartum care (median age of 30.35 years).79 It identified slightly higher rates of breast feeding among those who had an initial in-person visit (420 [75.3 percent] patients in the in-person group versus 473 [72.3 percent] patients in the telehealth group practicing breast feeding, p=0.45 OR: 0.09; 95% CI: 0.68 to 1.18, p=0.25). Different patient populations and clinical conditions may have resulted in conflicting results between the two studies. The difference between in-person and telehealth groups was larger and clinically more meaningful in the study favoring in-person visits.79 For patients who receive specialized pregnancy/prenatal/gynecological care, those who receive an initial in-person visit may have slightly better clinical outcomes compared with those who receive telehealth care (SOE: Low) (Table 8).

3.3.7.2. Care for Specific Conditions, Other Conditions

We identified seven observational studies that reported different condition-specific outcomes among patients who received care for specific conditions. Four of the studies reported results favoring telehealth compared with in-person care. One was a cohort study, with serious risk of bias owing to concerns regarding inadequate adjustment for confounders and missing data, among children with epilepsy (mean age not reported) enrolling 101 patients who had in-person visits and 16 who had telehealth visits.100 The study identified a higher remission rate among those who had an initial telehealth visit compared with those who had an in-person visit (70 percent remission rate in 1 month and 75 percent in 3 months in the in-person group versus 88 percent remission rate in 1 and 3 months in the telehealth group). The second study, a cohort study with serious risk of bias owing to concerns regarding adjustment for confounders and missing data, assessed weight loss among patients who had in-person visits versus those who had telehealth visits in a weight management clinic. This study, which enrolled 228 obese patients in the in-person group and 51 obese patients in the telehealth group, reported significantly higher weight loss among patients in the telehealth group (OR: 2.79; 95% CI, 1.04 to 7.48, p=0.042).96 The third study with results favoring telehealth was a cohort study with moderate risk of bias that assessed disease remission rates among rheumatology patients (mean age of 55 years).101 This study identified a higher remission rate among patients who had an initial telehealth visit (162 of 210 patients [77.1 percent] who had an initial in-person visit and 291 of 340 patients [85.6 percent] who had an initial telehealth visit, with the difference in risk of: 0.08; 95% CI, 0.02 to 0.15, p<0.05). The fourth study, a cohort study with serious risk of bias owing to serious concerns about addressing confounders, assessed weight management among overweight/obese patients who received wellness and health education (median age of 49 years).102 This study identified a higher rate of at least 5 precent weight loss among patients who had an initial telehealth visit compared with those who had an in-person visit (32 of 69 patients [46.4 percent] with an initial in-person visit and 54 of 91 patients [59.3 percent] with an initial telehealth visit, p=0.26). The difference was also clinically meaningful. The weight loss was assessed 6 months after receiving the education.

Table 8. Summary of findings: condition-specific clinical outcomes for patients receiving telehealth versus in-person care (N=11 studies).

Table 8

Summary of findings: condition-specific clinical outcomes for patients receiving telehealth versus in-person care (N=11 studies).

This figure depicts a forest plot presenting condition specific outcomes for patients with an initial telehealth visit versus an in-person visit. The data are presented as odds ratios. The forest plot is subdivided by patient’s clinical condition category: pregnancy and prenatal conditions, and specific conditions.

Figure 9

Forest plot presenting condition specific outcomes for patients who had an initial telehealth visit versus an initial in-person visit. CI = confidence interval; N = sample size; NR = not reported; OBGYN = obstetrics and gynecology; OR = odds ratio. (more...)

The remaining three studies were larger and reported results favoring in-person compared with telehealth care. A cohort study with moderate risk of bias assessed meeting the “controlling high blood pressure quality measure” among patients with hypertension (mean age of 65.4 years).103 This study compared patients who had an in-person visit (N=20,745) with those who had one telehealth visit (N=6,878) and those who had two or more telehealth visits (N=5,104). The study identified a higher rate of patients not meeting the “controlling high blood pressure quality measures” among patients who had an initial telehealth visit (OR: 2.06; 95% CI, 1.94 to 2.18, p=<0.001 for those with one telehealth visit and OR: 2.49; 95% CI, 2.31 to 2.68, p=<0.001 for those with two or more telehealth visits compared with those with an in-person visit). This difference was also clinically meaningful.

Another cohort study with low risk of bias assessed asthma exacerbations among adult and elderly patients and compared data from the pre-COVID-19 era (mainly in-person visits) with data from the COVID-19 era (mainly telehealth visits).64 The study identified a lower mean of exacerbation events among patients who had an initial in-person visit (mean of 0.127, SE 0.015 among patients in the in-person group [N=1792] versus mean of 0.161, SE 0.018 among patients in telehealth group [N=1952], p comparing the two groups not reported). Finally, a cohort study with 204 patients with keratoconus (mean age of 29.36 years), and with serious risk of bias owing to issues with confounders, assessed the diagnostic accuracy and reliability of telehealth visits in detecting keratoconus progression compared with in-person visits.104 This study found that the telehealth visit was not suitable as a substitute to an in-person visit, with the telehealth visit having lower rates of detection of keratoconus progression (Specificity: 95.8, Sensitivity: 69.2, Positive Predictive Value: 52.9, and Negative Predictive Value: 97.9 comparing telehealth to in-person visit).

Different patient populations and clinical conditions may have resulted in conflicting results among these studies. The difference between in-person and telehealth groups was larger and clinically meaningful in studies favoring in-person visits. For patients who receive care for specific conditions (excluding COVID-19 and pregnancy/prenatal/gynecological care), those who receive an initial telehealth visit may have worse condition-specific clinical outcomes compared with those who receive in-person care (SOE: Low) (Table 8).

3.3.7.3. Surgical Care

Among patients who received surgical care, one cohort study, with serious risk of bias owing to lack of information on adjusting for confounders, was conducted among adult and elderly patients who underwent thyroid/parathyroid surgery (mean age of 47.1 years) and had an in-person versus telehealth visit for post-operation followup.89 The study reported that patients in the telehealth group (N=28) experienced less intraoperative blood loss compared with those in the in-person group (N=66) (mean: 35.5; SD 56.7 among those in the in-person group versus mean: 19.4; SD 26.4 among those in telehealth group, p=0.06). For patients receiving surgical care, those who receive an initial telehealth visit may have better condition-specific clinical outcomes compared with those who receive in-person care (SOE: Low) (Table 8).

3.3.7.4. Care for General Behavioral and Mental Health Conditions

Among patients who received care for general behavioral and mental health conditions, one cohort study, with serious risk of bias owing to concerns about addressing confounders and patient selection, assessed eating disorders among adult patients (mean age of 24.52 years) enrolled in a multidisciplinary intensive outpatient program and receiving care through in-person (N=60) or telehealth (N=33) visits. 97 It identified that patients who had a telehealth visit experienced more improvement in their eating disorder (weight gain presented as an increased body mass index [BMI]) than those with an in-person visit (BMI mean of 24.78; SD 7.63 for patients in the in-patient group versus BMI mean of 26.26; SD 10.39 for patients in the telehealth group). On average the patients stayed in this eating disorder program for 11.32 weeks (SD 7.64) and the mean of stay did not differ between two groups (p=0.762). For patients receiving care for general behavioral and mental health conditions, those who receive an initial telehealth visit may have better condition-specific clinical outcomes compared with those who receive in-person care (SOE: Low) (Table 8).

3.3.8. Adverse Events

We identified nine observational studies and one randomized controlled trial (RCT) that compared in-person and telehealth care and reported adverse events (see Appendix D, Evidence Table D.6.7). For the majority of the studies, the differences of reported adverse events between in-person and telehealth care were small. We were unable to make a general statement about performance of in-person versus telehealth, as the clinical conditions, patient/ provider characteristics, and type of assessment performed during the visit varied across the small number of studies included in this evidence synthesis. All of these factors impacted the outcome of the visit and the possibility of an adverse event being reported. Our confidence in our conclusions across the clinical conditions is low owing to weak study designs, issues with risk of bias, and a limited number of studies (see Table 9 and Figure 10). Another four studies reported adverse events for patients who received telehealth care (with no comparison).93, 105107 These studies reported adverse events rates after receipt of telehealth care of 13 percent to 86 percent. Studies varied in their patient and provider characteristics and clinical conditions, which resulted in a wide range of adverse event rates (see Appendix D, Evidence Tables D.6.7 and D.6.8).

Table 9. Summary of findings: adverse events for patients receiving telehealth versus in-person care (N=10 studies).

Table 9

Summary of findings: adverse events for patients receiving telehealth versus in-person care (N=10 studies).

This figure depicts a forest plot presenting adverse events for patients with an initial telehealth visit versus an in-person visit. The data are presented as odds ratios. The forest plot is subdivided by patient’s clinical condition category: pregnancy and prenatal conditions, behavioral and mental health conditions, and surgical conditions.

Figure 10

Forest plot presenting adverse events for patients who had an initial telehealth visit versus an initial in-person visit. CI = confidence interval; N = sample size; NR = not reported; OBGYN = obstetrics and gynecology; OR = odds ratio.

3.3.8.1. General Medical Care, Adults

One cohort study with moderate risk of bias assessed adverse events among adult and elderly patients (mean age of 62.52 years) who had an in-person (N=341) or telehealth pharmacy visit (N=151).108 This study identified higher average medication related problems per visit among patients who had an initial in-person visit (mean: 1.65; SD 1.56 in the in-person group versus 1.06; SD 1.21 among patients in the telehealth group, p=<0.01). For adult patients receiving general medical conditions, patients who receive an initial in-patient visit may have higher rates of adverse events compared with those who receive in-person care (SOE: Low) (Table 9).

3.3.8.2. Care for Specific Conditions, Pregnancy/Prenatal/Gynecological Care

Among patients who received specialized pregnancy/prenatal/gynecological care, three observational studies reported adverse events rates after an in-person or telehealth visit. One cohort study with a moderate risk of bias among patients in a family planning clinic (mean age of 28 years) assessed adverse event rates among those who received an in-person or telehealth medical abortion service in the 249-251 days after the medical abortion. This study enrolled 94 patients who had in-person visits, 124 patients who had telehealth visits and picked up their medication from the clinic, and 69 patients who had telehealth visits and received their medication in the mail.60 The study identified no adverse events among those who had an initial in-person visit and those who had a telehealth visit and received their medication in the mail. Patients who received a telehealth visit and picked up their medication from the clinic experienced adverse events (2 patients [1.6 percent] required blood transfusion).

The second study was a cohort study, with a serious risk of bias owing to possible issues with confounders, that assessed adverse events among pregnant individuals (mean age of 28 years) who received in-person or telehealth prenatal care. This study enrolled 6,559 patients who had in-person visits and 6,084 patients who had telehealth visits.78 The study identified slightly lower adverse events rates among those who had an initial telehealth visit compared with those who had an initial in-person visit (26 patients [0.4 percent] who needed hysterectomies in the in-person group versus 13 patients [0.2 percent] who needed hysterectomies in telehealth group, and 279 patients [0.43 percent] who needed blood transfusion in the in-person group versus 216 patients [0.36 percent] in the telehealth group, p-0.07).

The third study was a cross-sectional study, with a moderate risk of bias, which assessed successful medical abortion rates among patients who received an in-person or telehealth medical abortion visit (mean age of 28 years).91 This study enrolled 22,158 patients who had in-person visits and 29,984 patients who had telehealth visits and reported slightly higher adverse event rates for patients in the in-person group compared with those in the telehealth group (8 hemorrhagic events that required transfusion [0.04 percent] among those in the in-person group in 59 days after the initial visit versus 7 [0.02 percent] among those in telehealth group in 85 days after the initial visit, p=0.56), but the difference was neither significantly nor clinically meaningful. The shorter followup period for the in-person group may have resulted in the study missing some adverse events in this group.

Even though the first cohort study60 showed slightly higher adverse event rates in one of the telehealth groups (the group who received a telehealth visit and picked up their medication from the clinic), we found the results to be consistent overall, as the other telehealth group in this study (those who had a telehealth visit who received their medication in the mail) had similar adverse events rates compared with the in-person group; and, the other studies with much larger patient populations found lower adverse events rates for those in the telehealth group. For patients who receive specialized pregnancy/prenatal/gynecological care, those who receive an initial telehealth visit may have slightly lower adverse events rates compared with those who receive in-person care (SOE: Low) (Table 9).

3.3.8.3. Care for Specific Conditions, Other Conditions

Among patients who received care for specific conditions (excluding COVID-19 and pregnancy/prenatal/gynecological care), one cohort study, with serious risk of bias owing to concerns about inadequate adjustment for confounders and selection of results, reported adverse events for patients who received in-person training about an insulin pump in a diabetic center versus virtual training via telehealth visit (the type of adverse event not reported).109 This study followed 14,284 patients in the in-person group and 8,984 patients in the telehealth group. Patients in the telehealth group had slightly fewer adverse events compared with those in the in-person group (mean number of adverse events: 0.04; SD 0.24 for patients in the in-person group and 0.03; SD 0.2 for those in the telehealth group, p=0.003), but the difference was not clinically meaningful. For patients who receive care for specific conditions (excluding COVID-19 and pregnancy/prenatal/gynecological care), those who receive an initial telehealth visit may have a slightly lower adverse events rate compared with those who receive in-person care (SOE: Low) (Table 9).

3.3.8.4. Surgical Care

Among patients who received surgical care, one RCT and three observational studies reported adverse events. One RCT with some concerns for risk of bias, owing to concerns with baseline differences between comparison arms, was conducted among adult patients who underwent dental surgery (mean age of 51.6 years) and had an in-person (N=35) versus telehealth (N=60) visit for post-operation followup.110 The study reported that patients in the telehealth group experienced fewer adverse events compared with those in the in-person group [3.3 percent taste of blood and 6.7 percent swelling of surgical area among those in the in-person group versus 0 percent taste of blood and 3.3 percent swelling of surgical among those in telehealth group, p=0.317 and 0.557, respectively). Other adverse events such as fever, chills with sweat, and dysphagia or difficulty breathing were not detected in either group.

One cohort study, with serious risk of bias owing to concerns with confounders, was conducted among adult and elderly patients who underwent thyroid/parathyroid surgery (mean age of 47.1 years) and had an in-person or telehealth visit for post-operation followup.89 The study reported that patients in the telehealth group (N=23) experienced fewer postoperative complications compared with those in the in-person group (N=66) (6 patients [9.1 percent] among those in the in-person group versus 2 patients [7.1 percent] among those in telehealth group, p=1).

A second cohort study, with serious risk of bias owing to concerns with confounders, was conducted among patients who underwent abdominal surgery (median age of 49 years) and had an in-person (N=113) or telehealth (N=106) visit for post-operation followup.66 The study reported lower rates of adverse events among those who had an initial telehealth visit than among those with an in-person visit (9 patients [7.9 percent] with postoperative morbidity, 9 patients [7.9 percent] with minor complications, and 1 patient [0.9 percent] with major complications among those in the in-person group versus 6 patients [5.7 percent] with postoperative morbidity, 7 patients [6 percent] with minor complications, and 0 patients [0 percent] with major complications among those in telehealth group, p=0.5, 0.79, =>0.99). But, patients in the telehealth group experienced higher rates of perioperative COVID-19 infection (6 patients [5.3 percent] among those in the in-person group versus 9 patients [8.5 percent] among those in the telehealth group, p=0.35), which may have contributed to patients receiving more telehealth care than in-person care.

A third cohort study with moderate risk of bias was conducted among adult and elderly patients who underwent surgery (mean age of 56.6 years) and had an in-person (N=437) or telehealth (N=98) visit for post-operation followup.86 The study reported slightly lower rates of adverse events in the 90 days after the surgery among those who had an initial telehealth visit than among those who had an in-person visit (the following rates for in-person versus telehealth, respectively, apply: 8 patients [1.8 percent] versus 1 patient [1 percent] for anastomic leak, 7 patients [1.6 percent] versus 1 patient [1 percent] for acute kidney injury, 6 patients [1.4 percent] versus 0 patients [0 percent] for venous thrombosis, 5 patients [1.1 percent] versus 0 patients [0 percent] for pancreatic leak, 3 patients [0.7 percent] versus 0 patients [0 percent] for cardiopulmonary, 3 patients [0.7 percent] versus 0 patients [0 percent] for bleeding, and 1 patient [0.2 percent] versus 0 patients [0 percent] for stroke; none of the differences were statistically significant). Other adverse events were reported as slightly higher among those who had a telehealth visit (the following rates for in-person versus telehealth, respectively, apply: 3 patients [0.7 percent] for bowel obstruction versus 1 patient [1 percent], 5 patients [1.1 percent] versus 2 patients [2 percent] for wound infection, 4 patients [0.9 percent] versus 2 patients [2 percent] for other infection; none of the differences were statistically significant). The differences were not clinically meaningful.

Studies varied in their patient populations and clinical conditions and the difference between in-person and telehealth groups were small and clinically not meaningful. For patients receiving surgical care, those who receive an initial telehealth visit may have similar rates of adverse events compared with those who receive in-person care (SOE: Low) (Table 9).

3.3.8.5. Care for General Behavioral and Mental Health Conditions

One cohort study, with serious risk of bias owing to concerns on addressing confounders, assessed any adverse events, including nonfatal suicide-related behaviors, suicides, psychiatric hospitalizations, emergency room visits, and any other behaviors resulting in crisis intervention among U.S. Veterans 24 weeks after receiving mental health treatment (mean age of 41.8 years) through in-person (N=29) or telehealth (N=45) visits.111 This study reported no adverse events among patients who had a telehealth visit or with an in-person visit. For patients receiving care for general behavioral and mental health conditions, those who receive an initial telehealth visit may have similar rates of adverse events compared with those who receive in-person care (SOE: Low) (Table 9).

3.3.9. Process Outcomes

3.3.9.1. Missed Visits

We identified seven observational studies that compared in-person care with telehealth care and evaluated missed visits (see Appendix D, Evidence Table D.7.1). The difference in missed visit rates between in-person and telehealth care reported in these studies was large. Our confidence in our conclusions across the clinical conditions is low owing to weak study designs, issues with risk of bias, and a limited number of studies (see Table 10 and Figure 11). We identified an additional study with no comparison group that reported a missed visit rate of 8.3 percent to 22.3 percent for patients who received telehealth care for different types of outpatient visits (e.g., clinical visits, ultrasounds, laboratory workups) among patients who received telehealth care (see Appendix D, Evidence Tables D.7.1 and D.7.2).112

3.3.9.2. Care for Specific Conditions, Pregnancy/Prenatal/Gynecological Care

Among patients who received specialized care for pregnancy/prenatal/gynecological care, one cohort study, with moderate risk of bias, assessed the postpartum visit attendance rates among patients who received in-person (N= 780) versus telehealth (N= 799) postpartum care (median age of 30.35 years).79 The study reported higher postpartum attendance rates among those who had an initial in-person visit (565 [72.4 percent] among those in the in-person group versus 662 [82.9 percent] among those in the telehealth group, OR: 1.9; CI, 1.47 to 2.46, p=<0.001 for all postpartum visits). In addition, for patients diagnosed with a hypertensive disorder during pregnancy, the study reported a higher postpartum cardiology follow-up attendance rates among those who had an initial in-person visit (29 of 56 patients [51.8 percent] among those in the in-person group versus 36 of 59 [61 percent] among those in the telehealth group, OR: 1.8; CI, 0.79 to 4.11, p=0.32).

For patients who receive specialized pregnancy/prenatal/gynecological care, those who receive an initial telehealth visit may have higher attendance rates compared with those who receive in-person care (SOE: Low) (Table 10).

3.3.9.3. Care for Specific Conditions, Other Conditions

Among patients who received care for specific conditions (excluding COVID-19 and pregnancy/prenatal/gynecological care), four observational studies reported missed visits rates. The first study, a cohort study with serious risk of bias owing to concerns with confounders, assessed missed visits rates among rheumatology patients (mean age of 55 years).82 The study reported a lower missed visit rate among patients who had an initial telehealth visit (157 missed visits [10.9 percent] among 1,443 patients in the in-person group versus 104 [6.5 percent] among 1,597 patients in the telehealth group, OR: 0.57; 95% CI, 0.44 to 0.74, p<0.001). A smaller cohort study, with serious risk of bias owing to concerns with confounding, assessed missed visits rates among adult patients with thyroid cancer (mean age of 46 years) and compared rates from the pre-COVID-19 era (mainly in-person visits) with rates from the COVID-19 era (mainly telehealth visits).113 The study identified higher missed visit rates during the COVID-19 era compared with the pre-COVID-19 era (15 percent drop in outpatient visits during the COVID-19 era indicated higher missed visit rates for telehealth visits compared with in-person visits). The third study, a cohort study with serious risk of bias owing to concerns about addressing confounders, assessed cancellation rates for a colonoscopy appointment among adult and elderly patients with inflammatory bowel disease (mean age of 47.6 years) and compared rates from the pre-COVID-19 era (mainly in-person visits) with rates from the COVID-19 era (mainly telehealth visits).114 The study reported a slightly higher cancellation rate among patients who had an initial telehealth visit (13 of 814 patients [1.5 percent] in the in-person group versus 22 of 910 patients [2.5 percent] in the telehealth group, p=0.14). The last study, a cross-sectional study with moderate risk of bias, assessed appointment adherence rates for adult patients with HIV (mean age of 44.2 years).115 The study reported higher appointment adherence rates, thus lower missed visit rates, among patients who had an initial telehealth visit (332 visits [70.8 percent] in the in-person group versus 246 visits [79.2 percent] in the telehealth group, p=<0.001). The difference in missed visit rates was much larger in the small study favoring in-person visits.113 Different patient populations and clinical conditions may have resulted in the difference among these studies. For patients who receive care for specific conditions (excluding COVID-19 and pregnancy/prenatal/gynecological care), those who receive an initial telehealth visit may have lower missed visit rates compared with those who receive in-person care (SOE: Low) (Table 10).

Table 10. Summary of findings: missed visits for patients receiving telehealth versus in-person care (N=7 studies).

Table 10

Summary of findings: missed visits for patients receiving telehealth versus in-person care (N=7 studies).

This figure depicts a forest plot presenting missed events for patients with an initial telehealth visit versus an in-person visit. The data are presented as odds ratios. The forest plot is subdivided by patient’s clinical condition category: pregnancy and prenatal conditions, specific conditions, and surgical care.

Figure 11

Forest plot presenting missed events for patients who had an initial telehealth visit versus an in-person visit. CI = confidence interval; N = sample size; NR = not reported; OBGYN = obstetrics and gynecology; OR = odds ratio. †The odds ratio (more...)

3.3.9.4. Surgical Care

One cross-sectional study, with moderate risk of bias, assessed missed visit rates among adult patients (mean age of 55.6 years) that had an in-person (N= 3,810) or telehealth (N= 4,387) visit for post-operation followup after an orthopedic spine surgery.116 The study reported lower missed visit rates among those who had an initial telehealth visit than among those with an in-person visit (1,953 patients [51.3 percent] in the in-person group versus 1,080 [24.7 percent] in the telehealth group, OR: 0.311; 95% CI, 0.284 to 0.342, p=<0.001), and this difference is clinically meaningful. For patients receiving surgical care, those who receive an initial telehealth visit may have lower missed visit rates compared with those who receive in-person care (SOE: Low) (Table 10).

3.3.9.5. Care for General Behavioral and Mental Health Conditions

A small cohort study (N=12) with serious risk of bias owing to concerns about addressing confounders, assessed general mental health among caregivers and children (mean age of 47.17 years for caregivers and 11.08 for children) and compared data from the pre-COVID-19 era (mainly in-person visits) with data from the COVID-19 era (mainly telehealth visits).99 This study reported that the mean no-show rates for those in the telehealth group was higher than those in the in-person group 20 weeks after enrolling in the focused group parenting intervention (mean no-show rate of 0.23; SD 0.23 among patients in the in-person group versus mean no-show rate of 0.32; SD 0.25 among patients in the telehealth group, indicating higher missed visit rates for telehealth visits compared with in-person visits).

For patients receiving care for general behavioral and mental health conditions, evidence was insufficient to draw conclusions owing to the existence of only one study with a small sample size and concerns with risk of bias (Table 10).

3.3.9.6. Case Resolution/Duplication of Services

We defined case resolution as a patient’s chief complaint being addressed in an initial visit and duplication of service as the need for a followup visit immediately after an initial visit (e.g., telehealth followed immediately by in-person visit). We identified 12 observational studies that compared in-person care with telehealth care and evaluated case resolution/duplication of services (see Appendix D, Evidence Table D.7.3). We are unable to make a general statement about relative performance of in-person or telehealth care, as the clinical conditions, patient/provider characteristics, and type of assessment performed during the visit varied across the small number of studies included in this evidence synthesis. All these factors impacted the case resolution during the initial visits and the need for duplication of services. Our confidence in our conclusions across the clinical conditions is low owing to weak study designs, issues with risk of bias, and a limited number of studies (see Table 11 and Figure 12).

We identified an additional 12 studies with no comparison groups that reported case resolution/duplication of services for patients who received telehealth care (with no comparison). These studies reported the need for followup visits (duplication of services) from 3 percent to 69 percent of patients (see Appendix D, Evidence Tables D.7.3 and D.7.4).48, 50, 68, 71, 90, 117123

3.3.9.6.1. General Medical Care, All Ages

Among patients of all ages who received care for general medical conditions, two observational studies reported case resolution/duplication of services rates after an in-person or telehealth visit. One cross-sectional study, with serious risk of bias owing to concerns about potential confounders, among adults (median age of 26 years) reported the need for a followup visit with the health system for those who received an in-person, outpatient primary care visit versus those who received a telephone or video telehealth primary care visit.124 This study identified higher rates of followup visits among those who had an initial telehealth visit than those with an in-person visit (e.g., mean number of followup telephone calls of 3.56, SD 2.46 in the in-person group versus 5.29, SD 2.6 in the telephone telehealth group and 4.39, SD 2.5 in the video telehealth group, p=0.002).

A cohort study with low risk of bias reported followup visits of any kind for patients with general medical care (all ages) with a diagnosis of acute or chronic ambulatory care sensitive conditions (i.e., conditions that would avoid healthcare utilization with proper ambulatory management of the disease). Among patients with acute ambulatory care sensitive conditions, the study analyzed claims data on 493,716 patients who had in-person visits and 113,857 patients who had telehealth visits.3 The study reported higher followup visit rates among those who had an initial telehealth visit than those who had an initial in-person visit (OR: 1.44; 95% CI, 1.42 to 1.46, with in-person visit as the reference). Among patients with chronic ambulatory care sensitive conditions, the study analyzed claims data on 410,743 patients with in-person visits and 94,481 patients with telehealth visits, reporting lower followup visit rates among those who had an initial telehealth visit than those who had an initial in-person visit (OR: 0.94; 95% CI: 0.92 to 0.95, with in-person visit as the reference). The study only identified followup visits that occurred within 14 days after the initial visit, which may have contributed to the modest difference between the two groups.

The two studies showed conflicting results. The difference in the type of clinical conditions that the studies assessed may have resulted in the conflicting results between the two studies. The study favoring telehealth care for a sub-population of patients (lower rates of followup visits for patients with chronic ambulatory care sensitive conditions)3 was larger and assessed followup visits separately for those with acute and chronic ambulatory care sensitive conditions, which may have resulted in more accurate parsing out of the difference in followup visit patterns. For patients of all ages who receive care for general medical conditions, those who receive an initial telehealth visit for an acute condition may have higher rates of followup visits compared with those who receive in-person care, and those who receive an initial telehealth visit for a chronic condition may have lower rates of followup visits compared with those who receive in-person care (SOE: Moderate) (Table 11).

Table 11. Summary of findings: case resolution/duplication of services for patients receiving telehealth versus in-person care (N=12 studies).

Table 11

Summary of findings: case resolution/duplication of services for patients receiving telehealth versus in-person care (N=12 studies).

This figure depicts a forest plot presenting case resolution for patients with an initial telehealth visit versus an in-person visit. The data are presented as odds ratios. The forest plot is subdivided by patient’s clinical condition category: COVID-19 specialized care, general medical care-all ages, pregnancy and prenatal conditions, specific conditions, and surgical care.

Figure 12

Forest plot presenting case resolution for patients who had an initial telehealth visit versus an in-person visit. CI = confidence interval; N = sample size; NR = not reported; OBGYN = obstetrics and gynecology; OR = odds ratio.

3.3.9.6.2. Care for Specific Conditions, COVID-19

One cohort study, with serious risk of bias owing to concern about the handling of confounders and missing data, assessed case resolution/duplication of services among patients with COVID-19 (mean age of 39 years) after an in-person or telehealth visit.87 The study reported lower rates of followup visits (i.e., duplication of services) among those who had an initial telehealth visit (7 of 132 patients [5.3 percent] in the in-person group versus 6 of 153 patients [3.9 percent] in the telehealth group returned to the health system in the 72 hours following the initial assessment). The short followup period may have resulted in the detection of fewer followup events in both groups. Owing to the limited number of studies, small sample size, and concerns with risk of bias, there is insufficient evidence that patients who receive an initial telehealth visit may have different rates of case resolution and followup visits compared with those who receive in-person care (SOE: Insufficient) (Table 11).

3.3.9.6.3. Care for Specific Conditions, Pregnancy/Prenatal/Gynecological Care

One cohort study with a moderate risk of bias among patients in a family planning clinic (mean age of 28 years) assessed case resolution/duplication of services among those who received an in-person or telehealth medical abortion service. This study enrolled 94 patients who had in-person visits, 124 patients who had telehealth visits and picked up their medication from the clinic, and 69 patients who had telehealth visits and received their medication in the mail.60 The study reported higher rates of case resolution (i.e., completed medical abortion with no need for surgery) among those in the telehealth group compared with those in the in-person group (88 of 94 patients [93.6 percent] who received an in-person visit versus 120 of 124 patients [96.8 percent] who received a telehealth visit and picked up their medication from the clinic and 67 of 69 patients [97.1 percent] who received a telehealth visit and received their medication in the mail). The small sample size across the three groups may have resulted in small differences in case resolutions among them. Owing to the limited number of studies, small sample size, and some concerns with risk of bias, there is insufficient evidence that those who receive an initial telehealth visit may have different rates of case resolution compared with those who receive in-person care (SOE: Insufficient) (Table 11).

3.3.9.6.4. Care for Specific Conditions, Other Conditions

Among patients who received care for specific conditions, excluding COVID-19 and pregnancy/prenatal/gynecological care, seven observational studies reported case resolution/duplication of services after an in-person or telehealth visit.

Three studies reported findings favoring in-person visits. One was a cohort with a serious risk of bias owing to concerns with confounders. This study assessed followup telephone visits among rheumatology patients (mean age of 55 years old).82 The study reported a lower rate of followup phone calls among patients who had an initial in-person visit compared with those who had a telehealth visit (29 of 1,286 patients [2.3 percent] in the in-person group versus 48 of 1,493 patients [3.2 percent] in the telehealth group, p=0.13). Another cohort study, with serious risk of bias owing to concerns about confounding and intervention classification, among adult patients (median age of 67 years) in a cardiology clinic, assessed the need for followup appointments after an in-person or telehealth visit.54 This study identified a lower rate of followup appointments among those who received in-person visits (196 of 1,118 patients [16.5 percent] in the in-person group versus 79 of 327 patients [24.2 percent] in the telehealth group, p=0.015). The difference in followup visit rate was much larger in one study than in the other. Different patient populations and clinical conditions, as well as different followup periods, might have resulted in this wide range of followup visits between the two studies. A third cohort study, with serious risk of bias owing to concerns with adjusting for confounders, was conducted in Sweden. This study assessed unplanned telephone contact with the physician among adult and elderly patients with inflammatory bowel disease (mean age of 47.6 years) and compared data from the pre-COVID-19 era (mainly in-person visits) with data from the COVID-19 era (mainly telehealth visits).114 The study reported a slightly higher number of unplanned telephone contacts among patients who had an initial telehealth visit (mean of 0.88; SD 1.89 contacts per patient among 814 patients in the in-person group versus mean of 0.9; SD 1.9 contacts per patient among 910 patients in the telehealth group, p=0.379).

Four studies reported findings in favor of telehealth visits. One was a cohort study, with serious risk of bias owing to concerns with adequate adjustment for confounders, among children with epilepsy (mean age not reported) enrolling 101 patients who had in-person visits and 16 patients who had telehealth visits.100 The study reported a higher rate of case resolution among those who had an initial telehealth visit (75 percent of patients in the in-person group required a followup counseling visit in the 1 month after the initial visit versus 35 percent of patients in the telehealth group) and the difference was clinically meaningful. The much smaller sample size in the telehealth group compared with the sample size in the in-person group might have resulted in the identification of a smaller number of patients with followup visits in the telehealth group. The second study was a cohort study, with serious risk of bias owing to concerns with inadequate adjustment for confounders, among children in an otolaryngology clinic (mean age of 24 months) enrolling 50 patients who had in-person visits and 50 patients who had telehealth visits.125 This study identified lower rates of recommended followups among those who had an initial telehealth visit compared with those who had an initial in-person visit (16 followup visits [32 percent] among those in the in-person group versus 10 followup visits [20 percent] among those in telehealth group, p=0.25). The third study, a cohort study with serious risk of bias owing to concerns with inadequate adjustment for confounders, was conducted in an eye hospital. This study assessed the need for an in-person ophthalmology assessment among patients who were triaged in-person or via telehealth for an ophthalmic issue (median age of 49 years).126 The study identified a lower rate of followup visits among patients who had an initial telehealth visit (40 followup visits among 451 patients [88.7 percent] in the in-person group versus 220 among 403 patients [54.6 percent] in the telehealth group, p<0.001). The fourth study, a cohort study with serious risk of bias owing to concerns with adjusting for confounders and patient selection, was conducted among patients with cardiac diseases in Ireland. This study assessed the return to clinic among adult and elderly patients who received in-person care (N=1,220) or telehealth care (N= 496) (mean age of 60 years).127 The study reported a lower rate of return to clinic among patients who had an initial telehealth visit (980 patients [80.3 percent] in the in-person group versus 353 patients [71.2 percent] in the telehealth group, p=0.0003).

Studies varied in their patient populations and clinical conditions, which may have resulted in this wide range of followup visits among the studies. Although three studies showed higher case resolution in the in-person group, the four studies favoring telehealth presented more consistent results and clinically meaningful differences between the two groups (Table 11). For patients who receive care for specific conditions (excluding COVID-19 and pregnancy/prenatal/gynecological care), those who receive an initial telehealth visit may have higher rates of case resolution and a lower rate of duplicated services compared with those who receive in-person care (SOE: Low).

3.3.9.7. Surgical Care

One cohort study, with serious risk of bias owing to lack of information about adjusting for confounders, reported case resolution/duplication of services among patients who underwent abdominal surgery (median age of 49 years) and had an in-person (N= 113) or telehealth (N= 106) visit for post-operation followup.66 The study reported higher rates of 30-day followup visits among those who had an initial telehealth visit than among those with an in-person visit (4 in-person followup visits [3.5 percent] and 7 telehealth followup visits [6.2 percent] among those in the in-person group versus 3 in-person followup visits [2.8 percent] and 16 telehealth followup visits [14.9 percent] among those in telehealth group). For patients receiving surgical care, those who receive an initial telehealth visit may have lower rates of case resolution and a higher rate of duplicated services compared with those who receive in-person care (SOE: Low) (Table 11).

3.3.9.8. Change in Therapy/Medication

We identified eight observational studies that compared in-person with telehealth care and reported changes in therapy/medication (see Appendix D, Evidence Table D.7.5). The difference between in-person and telehealth care reported in these studies was mainly small and not clinically meaningful. Across the eight studies, changes in therapy/medication happened more often for patients in the in-person group compared with those in the telehealth group. Our confidence in our conclusions across the clinical conditions is low owing to weak study designs, issues with risk of bias, and a limited number of studies (see Table 12 and Figure 13). Another two studies reported changes in therapy/medication for patients receiving telehealth (with no comparison). These studies reported the change in therapy/medication for 13 percent to 58 percent of patients (see Appendix D, Evidence Tables D.7.5 and D.7.6).90, 106

3.3.9.8.1. General Medical Care, Adults

Among adult patients who received care for general medical conditions, two observational studies reported changes in therapy/medication after an in-person or telehealth visit. One cohort study, with low risk of bias conducted in Australia, assessed change in therapy/medication among adult and elderly patients who received professional general practitioner consultations for standard attendance, chronic disease management, and/or mental health service in an in-person (N=8,303,233) or telehealth visit (N=5,304,983).128 This study reported higher rates of change in medication among patients who had an initial in-person visit, compared with patients who had a telehealth visit, presented as the number of consultations with at least one prescribed medication (3,264,748 patients [39.3 percent] in the in-person group versus 1,751,878 patients [33 percent] in the telehealth group, OR: 1.38; 95% CI, 1.379 to 1.381). Another cohort study with moderate risk of bias assessed change in therapy/medication among adult and elderly patients (mean age of 62.52 years) who had an in-person (N=341) or telehealth pharmacy visit (N=151).108 This study reported higher average additional or different medications per visit among patients who had an initial in-person visit than among those who had a telehealth visit (mean: 0.37; SD 0.7 in the in-person group versus 0.12; SD 0.4 among patients in the telehealth group, p=0.527 for needing additional medications and mean: 0.09; SD 0.31 in the in-person group versus 0.06; SD 0.23 among patients in the telehealth group, p=0.423 for needing different medications). The two studies were different in their patient populations and clinical conditions. For adult patients receiving general medical conditions, patients who receive an initial in-person visit may have higher rates of change in therapy/medication compared with those who receive telehealth care (SOE: Moderate) (Table 12).

Table 12. Summary of findings: change in therapy/medication for patients receiving telehealth versus in-person care (N=8 studies).

Table 12

Summary of findings: change in therapy/medication for patients receiving telehealth versus in-person care (N=8 studies).

This figure depicts a forest plot presenting change in therapy outcomes for patients with an initial telehealth visit versus an in-person visit. The data are presented as odds ratios. The forest plot is subdivided by patient’s clinical condition category: general medical care-adults, and specific conditions.

Figure 13

Forest plot presenting change in therapy outcomes for patients who had an initial telehealth visit versus an in-person visit. CI = confidence interval; N = sample size; NR = not reported; OBGYN = obstetrics and gynecology; OR = odds ratio.

3.3.9.8.2. Care for Specific Conditions, Other Conditions

Among patients who received care for specific conditions (excluding COVID-19 and pregnancy/prenatal/gynecological care), six observational studies reported changes in therapy/medication after an in-person or telehealth visit.

One cohort study with moderate risk of bias assessed changes in therapy/medication among rheumatology patients (mean age of 55 years).101 This study reported a higher rate of change in therapy/medication among patients who had an initial in-person visit (22 of 210 patients [10.5 percent]) compared with patients who had an initial telehealth visit (20 of 340 patients [5.9 percent]) for those patients who had a new disease-modifying antirheumatic drug started for them, with the following difference in proportion: −0.05 (95% CI, −0.1 to 0, p>0.05); the study also reported a higher rate of change in therapy/medication among patients who had an initial in-person visit (12 of 210 [5.7 percent] and patients who had an initial telehealth visit (11 of 340 [3.2 percent]) for those patients who had an increase in the dose of their disease-modifying antirheumatic drug, with the following difference in proportion: −0.02 (95% CI, −0.07 to 0.01, p>0.05).

Another cohort study, with a serious risk of bias owing to concerns regarding inadequate adjustment for confounders, assessed changes in therapy/medication among rheumatology patients (mean age of 55 years).82 The study reported a higher rate of change in therapy/medication among patients who had an initial in-person visit compared with those who had a telehealth visit (352 of 1,286 patients [27.4 percent] in the in-person group versus 338 of 1,493 patients [22.6 percent] in the telehealth group had a change in their immunosuppressive therapy, p=0.004, and 96 of 1,286 patients [7.5 percent] in the in-person group versus 79 of 1,493 patients [5.3 percent] in the telehealth group had a change in their analgesic medication, p=0.019).

The third study, a cohort study with serious risk of bias owing to inadequate reporting for adjustment of confounding factors, assessed change in therapy/medication among adult patients with irritable bowel syndrome (age range from 22 to 76 years; median age of 36 years).81 This study reported a higher rate of change in therapy/medication among patients who had an initial telehealth visit (19 of 50 patients [38 percent] in the in-person group versus 29 of 45 patients [64 percent] in the telehealth group had a biologic agent started for them, p=0.01; and, 8 of 50 patients [16 percent] in the in-person group versus 8 of 45 patients [18 percent] in the telehealth group had a dose escalation in their medication, p>0.99.)

The fourth study, a cohort study with serious risk of bias owing to concerns with adjusting for confounders and patient selection, was conducted in Ireland among patients with cardiac diseases. This study assessed changes in medication or management of disease among adult and elderly patients who had an initial in-person visit (N= 1,220) or telehealth visit (N= 496) (mean age of 60 years old).127 This study reported a higher rate of change among patients who had an initial in-person visit (470 patients [38.5 percent] in the in-person group versus 99 patients [19.9 percent] in the telehealth group had at least one change in the clinical management of their disease, p=<0.00001, and 390 patients [31.9 percent] in the in-person group versus 80 patients [16.1 percent] in the telehealth group had a medication change, p=<0.00001).

The fifth study, a cohort study with serious risk of bias owing to concerns about addressing confounders, was conducted among patients with inflammatory bowel disease and assessed changes in medication or management of disease among adult patients who had an initial in-person visit (N= 868) or telehealth visit (N= 891) (mean age of 47.6 years old).114 The study reported a higher rate of change in medication among patients who had an initial telehealth visit (21.3 percent in the in-person group versus 22.2 percent in the telehealth group had a medication increase, p=0.641; 6.1 percent in the in-person group versus 5.9 percent in the telehealth group had a medication decrease, p=0.914; and 76.1 percent in the in-person group versus 75.3 percent in the telehealth group had no change in medication, p=0.713). The difference between the two groups was small and clinically not meaningful.

The sixth study was a cohort study, with serious risk of bias owing to concerns about addressing confounders, conducted in Spain. This study assessed the mean number of prescribed medications among patients with multiple sclerosis (mean age not reported).129 The study reported a higher number of prescribed medications among patients who had an initial in-person visit (mean of 30.0, SE 7 among patients in the in-person group versus mean of 23.2, SD 5.5 among patients in telehealth group, p=0.805). The difference was small and not clinically meaningful.

The six studies were different in their patient populations, clinical conditions, and the type of treatment/medication. One of the studies favoring telehealth was conducted in the later months of the pandemic (January 1 to May 31, 2021) when telehealth utilization was stabilized across healthcare systems.129 Four of the studies showing a lower rate of change in therapy or medication in the telehealth group were larger studies, with one study assessed as a moderate risk of bias. For patients who receive care for specific conditions (excluding COVID-19 and pregnancy/prenatal/gynecological care), those who receive an initial telehealth visit may have lower rates of change in therapy/medication compared with those who receive in-person care (SOE: Low) (Table 12).

3.3.9.9. Therapy/Medication Adherence

We identified nine observational studies that compared in-person and telehealth care and reported therapy/medication adherence (see Appendix D, Evidence Tables D.7.7). The difference, if any, between in-person and telehealth care reported in these studies was mostly small. Our confidence in our conclusions across the clinical conditions is low owing to weak study designs, issues with risk of bias, and a limited number of studies (see Table 13 and Figure 14). There was another study reporting therapy/medication adherence (i.e., exercise adherence) for patients who received telehealth care (with no comparison). This study reported an exercise adherence rate of 67 percent to 92 percent for patients who received internet-based recommendations or telerehabilitation (see Appendix D, Evidence Tables D.7.7 and D.7.8).93

3.3.9.9.1. General Medical Care, Adults

Among adult patients who received care for general medical conditions, two observational studies reported therapy/medication adherence after an in-person or telehealth visit.

Table 13. Summary of findings: therapy/medication adherence for patients receiving telehealth versus in-person care (N=9 studies).

Table 13

Summary of findings: therapy/medication adherence for patients receiving telehealth versus in-person care (N=9 studies).

This figure depicts a forest plot presenting treatment adherence outcomes for patients with an initial telehealth visit versus an in-person visit. The data are presented as odds ratios. The forest plot is subdivided by patient’s clinical condition category: general medical care-adults, specific conditions, and behavioral and mental health conditions.

Figure 14

Forest plot presenting treatment adherence for patients who had an initial telehealth visit versus an in-person visit. CI = confidence interval; N = sample size; NR = not reported; OBGYN = obstetrics and gynecology; OR = odds ratio.

A cohort study, with serious risk of bias owing to lack of proper adjustment for confounders and handling of missing data, assessed therapy/medication adherence among younger, mostly White females in the United States (mean age of 38 years).77 This study identified a higher rate of therapy/medication adherence among patients who had an initial telehealth visit (129 of 207 patients [62.3 percent] in the in-person group versus 151 of 207 patients [72.9 percent] in the telehealth group, p<0.05), and the difference was clinically meaningful.

Another cohort study with moderate risk of bias assessed therapy/medication adherence among adult and elderly patients (mean age of 62.52 years) who had an in-person (N=341) or telehealth pharmacy visit (N=151).108 This study reported that the average therapy/medication adherence per visit among patients who had an initial in-person visit was the same as those who had a telehealth visit (mean: 0.01; SD 0.14 for non-adherence in the in-person group versus 0.01; SD 0.08 among patients in the telehealth group, p=1). Between the two studies, the study favoring a telehealth visit identified a large and clinically meaningful difference between the two groups. For adult patients receiving care for general medical conditions, patients who receive an initial telehealth visit may have higher rates of therapy/medication adherence compared with those who receive in-person care (SOE: Low) (Table 13).

3.3.9.9.2. Care for Specific Conditions, Other Conditions

Among patients who received care for specific conditions (excluding COVID-19 and pregnancy/prenatal/gynecological care), four studies assessed therapy/medication adherence after an in-person or telehealth visit. A cohort study, with moderate risk of bias, assessed therapy/medication adherence (i.e., continuous positive airway pressure [CPAP] compliance) among patients with sleep apnea (mean age not reported).130 This study reported similar rates of CPAP compliance among 193 patients in the in-person group and 77 patients in the telehealth group (p=0.099).

A second cohort study, with moderate risk of bias, assessed therapy/medication adherence among adult and elderly patients with diabetes (mean age of 62 years) who had an initial in-person (N= 54,872) or telehealth (N= 8,850) visit.131 This study reported higher rates of medication adherence among those in the in-patient group (33,053 patients [60.2 percent] in the in-person group versus 4,960 patients [56 percent] patients in the telehealth group p=<0.001). The medication adherence rates were also slightly higher among patients with and without type 2 diabetes who had an initial in-person visit (19,775 patients [68.1 percent] in the in-person group versus 2,904 patients [60.2 percent] patients in the telehealth group, p=<0.001, among those with type 2 diabetes; and 13,278 patients [51.4 percent] in the in-person group versus 2,056 patients [51 percent] patients in the telehealth group, p=0.64, among those without type 2 diabetes). The outcomes were assessed 6 months after the initial visits.

The third cohort study, with low risk of bias, assessed the adherence to inhaled corticosteroids, which was defined as the proportion of days covered (a proportion between 0.0 and 1.0) among adult and elderly patients with asthma (mean age not reported).64 The study reported slightly higher adherence among patients who had an initial telehealth visit (mean of 0.446, SE 0.008 among 1,792 patients in the in-person group versus mean of 0.476, SE 0.008 among 1,952 patients in the telehealth-only group, p comparing the two groups not reported). The difference was small and not clinically meaningful.

The fourth study was a cross-sectional study, with serious risk of bias owing to concerns with addressing confounders, that reported the number of physician recommended surgeries that were completed after a telehealth or in-person visit among pediatric otolaryngology patients (mean age of 6.15 years).132 The study reported a slightly higher adherence to physician recommendation among patients who had an initial telehealth visit (41 patients [36.3 percent] in the in-person group vs 24 patients [40.7 percent] in the telehealth group, p-value not reported).

The four studies were different in their patient populations, clinical conditions, and the type of treatment/medication. They also used different definitions of medication adherence. The study favoring in-person visits had a much larger sample size and the difference between two groups in the whole population was slightly bigger than the other studies.131 For patients who receive care for specific conditions (excluding COVID-19 and pregnancy/prenatal/gynecological care), those who receive an initial telehealth visit may have lower rates of therapy/medication adherence compared with those who receive in-person care (SOE: Low) (Table 13).

3.3.9.10. Care for General Behavioral and Mental Health Conditions

Among patients receiving care for general behavioral and mental health conditions, three observational studies assessed therapy/medication adherence after an in-person or telehealth visit. One cohort study with moderate risk of bias assessed completed followup visits among children in a developmental behavioral pediatric practice (mean age of 9.3) through in-person (N=1,077) or telehealth (N=354) visits.133 The study reported higher rates of completed visits among patients in the telehealth group (OR: 1.57; 95% CI: 1.23 to 2, p=<0.001).

Another cohort study, with serious risk of bias owing to concerns about confounding, assessed therapy/medication adherence among U.S. Veterans 24 weeks after receiving mental health treatment (mean age of 41.8 years) through in-person (N=29) or telehealth (N=45) visits.111 The study reported higher rates of treatment completion among patients in the telehealth group (22 patients [76 percent] among patients in the in-person group versus 37 patients [82 percent] among patients in the telehealth group, p=0.506).

The last cohort study, with serious risk of bias owing to concerns with addressing confounders, assessed therapy/medication adherence among adult and elderly patients with opioid use disorder (mean age of 46.9 years).134 The study reported higher rates of 90-day treatment retention among patients in the telehealth group (24 of 72 patients [33.3 percent] in the in-person group versus 17 of 35 patients [48.6 percent] in the telehealth group).

The three studies were different in their patient populations, clinical conditions, and the type of treatment/medication. They also used different definitions of therapy/medication adherence. All three studies identified clinically meaningful differences between in-person and telehealth groups. For patients receiving care for general behavioral and mental health conditions, those who receive an initial telehealth visit may have higher rates of therapy/medication adherence compared with those who receive in-person care (SOE: Low) (Table 13).

3.3.9.11. Up-to-Date Labs and Paraclinical Assessment

We identified seven observational studies that compared in-person and telehealth care and reported rates of up-to-date labs and paraclinical assessment, including imaging and pathology assessment (see Appendix D, Evidence Tables D.7.9). The difference between in-person and telehealth care reported in these studies was mostly large. Among the seven studies, up-to-date labs and paraclinical assessment were mostly at a higher rate among patients in the telehealth group compared with those in the in-person group. Our confidence in our conclusions across the clinical conditions is low owing to weak study designs, issues with risk of bias, and a limited number of studies (see Table 14 and Figure 15). There was another study that reported up-to-date labs (i.e., COVID-19 test) for patients receiving telehealth (with no comparison) and a COVID-19 test rate of 33 percent to 62 percent for patients triaged in a respiratory clinic (see Appendix D, Evidence Tables D.7.9 and D.7.10).51

Table 14. Summary of findings: up-to-date labs and paraclinical assessment for patients receiving telehealth versus in-person care (N=7 studies).

Table 14

Summary of findings: up-to-date labs and paraclinical assessment for patients receiving telehealth versus in-person care (N=7 studies).

This figure depicts a forest plot presenting laboratory and assessment outcomes for patients with an initial telehealth visit versus an in-person visit. The data are presented as odds ratios. The forest plot is subdivided by patient’s clinical condition category: specific conditions, and pregnancy and prenatal conditions.

Figure 15

Forest plot presenting up-to-date laboratory and assessment outcome for patients who had an initial telehealth visit versus an in-person visit. CI = confidence interval; N = sample size; NR = not reported; OBGYN = obstetrics and gynecology; OR = odds (more...)

3.3.9.11.1. Care for Specific Conditions, Pregnancy/Prenatal/Gynecological Care

Among patients who received specialized pregnancy/prenatal/gynecological care, one cohort study, with moderate risk of bias, assessed completion of postpartum glucose tolerance test among patients with diabetes who received in-person (N= 45) or telehealth (N= 59) postpartum care (median age of 30.35 years).79 The study reported slightly lower rates of completed glucose tolerance test among patients who had an initial telehealth visit compared with those who had an in-person visit (12 patients [26.7 percent] among those in the in-person group versus 15 patients [25.4 percent] among those in the telehealth group, OR: 0.99; 95% CI: 0.37 to 2.68, p=0.89), but the difference was not clinically meaningful. For patients receiving specialized pregnancy/prenatal/gynecological care, those who receive an initial telehealth visit may have similar rates of up-to-date labs and paraclinical assessment compared with those who receive in-person care (SOE: Low) (Table 14).

3.3.9.11.2. Care for Specific Conditions, Other Conditions

Among patients who received care for specific conditions (excluding COVID-19 and pregnancy/prenatal/gynecological care), six observational studies reported rates of up-to-date labs and paraclinical assessment after an in-person or telehealth visit.

One cohort study, with serious risk of bias owing to concerns about handling confounders and missing data, included patients in a diabetes care center (mean age of 37 years).135 Patients in the telehealth group had a higher rate of continuous glucose monitoring compared with those in the in-person group (7 of 43 patients [16 percent] in the in-person group versus 155 of 166 patients [93.4 percent] in the telehealth group, p<0.001).

A second study was a cohort study, with serious risk of bias owing to concerns about handling confounders and missing data, among patients in a gastroenterology/rheumatology clinic (mean age of 55 years).136 Patients in the in-person group had a higher rate of completion of pathology consults and radiology assessments ordered for them compared with those in the telehealth group (426 of 492 patients [86.6 percent] in the in-person group versus 443 of 582 patients [76.1 percent] in the telehealth group completed their pathology consult, p<0.001; and 247 of 295 patients [83.7 percent] in the in-person group versus 229 of 345 patients [66.4 percent] in the telehealth group completed the radiology assessment, p<0.001), and the difference between the two groups was clinically meaningful.

The third cohort study, with serious risk of bias owing to issues with addressing confounders, assessed up-to-date labs and paraclinical assessment among adult and elderly patients with cancer (median age of 60 years) compared the care prior to (N= 763) and during transition to telehealth (mainly in-person visits) (N=168) with the post-transition period (mainly telehealth visits) (N= 813).63 The study reported a lower rate of up-to-date labs and paraclinical assessment among patients who had an initial visit in 1 week during the transition and in 4 weeks after the transition compared with those who had an initial visit in 4 weeks prior to the transition (265 patients [34.7 percent] in the pre-transition group versus 58 patients [34.5 percent] in the during transition group and 105 patients [12.9 percent] in the post-transition group, p=<0.0001, for up-to-date laboratory testing; 112 patients [14.7 percent] in the pre-transition group versus 17 patients [10.1 percent] in the during-transition group and 40 patients [4.9 percent] in the post-transition group, p=<0.0001, for up-to-date diagnostic imaging; and 16 patients [2.1 percent] in the pre-transition group versus 1 patient [0.6 percent] in the during-transition group and 5 patients [0.6 percent] in the post-transition group, p=0.0223, for up-to-date procedures such biopsy, paracentesis, acupuncture, endoscopy, and catheter exchanges).

The fourth cohort study, with serious risk of bias owing to concerns with addressing confounders, was conducted in Spain. This study assessed the completion of magnetic resonance (MR) scan among patients with multiple sclerosis (mean age not reported).129 The study reported higher monthly number of MR scans performed among patients who had an initial in-person visit versus patients who had telehealth care (mean of 196, SD 17.5 among patients in the in-person group versus mean of 183.5, SD 68.9 among patients in telehealth group, p=0.538).

The fifth study, a cross-sectional study with serious risk of bias owing to concerns with patient selection, assessed the number of lab and imaging orders placed in the system for adult patients with chest pain (median age of 44 years) in primary care clinics during the COVID-19 era.85 The study identified similar rates of placed orders between the two groups (median of 1; interquartile rate (IQR): 0 to 1 for imaging in the in-person group versus median of 1; IQR: 1 to 1 in the telehealth group, p=0.006; and median of 6; IQR: 4 to 8 orders for labs in the in-person group versus median of 6; IQR: 5 to 8 in the telehealth group, p=0.02). But it did not report the completion rates of the placed orders between the two groups.

The sixth study was a cohort study with serious risk of bias owing to concerns with confounders that assessed the proportion of inflammatory bowel disease patients with surveillance or activity control colonoscopies (mean age of 47.6 years).114 The study reported a higher proportion of surveillance colonoscopies performed among patients who had an initial in-person visit (76 of 814 patients [15 percent] in the in-person group versus 49 of 910 patients [9.4] in the telehealth group, p=0.007).

The six studies were different in their patient populations, clinical conditions, and the type of lab/paraclinical assessment. For patients receiving care for specific conditions (excluding COVID-19 and pregnancy/prenatal/gynecological care), those who receive an initial telehealth visit may have lower rates of up-to-date labs and paraclinical assessment compared with those who receive in-person care (SOE: Low) (Table 14).

3.3.10. Results for Key Question 2a

Key Question 2a.

Do the benefits and harms of telehealth during the COVID-19 era vary by type of telehealth intervention?

One study directly compared types of telehealth for ED visits and mortality in cardiology patients.54 This study compared patients receiving either a telephone-only or a video intervention. The study reported higher rates of ED visits in the telephone-only group compared with the video intervention group (9.9 percent versus 5.5 percent, respectively, p=0.165). Similar results were reported for mortality, with higher rates in the telephone group compared with the video intervention group (all-cause mortality: 0.35 percent versus 0.30 percent, respectively, p=0.759; cardiac mortality: 1.1 percent versus 0.6 percent, respectively, p=0.806).54 Although both outcomes were not statistically significant, the difference in ED visits may be meaningful, showing lower rates in patients who received a video intervention and suggesting telehealth care via video visits as a more appropriate mode of care delivery for complex conditions such as cardiovascular diseases. Owing to the low number of events reported for mortality, we cannot determine if there is a meaningful difference between telephone-only and video interventions (For further details, see Appendix D, Evidence Table D.5.2).

In studies that compared in-person with telehealth visits, most studies did not directly address the association of benefits and harms outcomes of telehealth by the type of telehealth intervention or conduct a subgroup analysis by telehealth type. We only saw an inconsistency of results, which may be associated with the different types of telehealth assessed, in the eight studies that reported hospitalization rates in patients who needed care for specific conditions (excluding COVID-19 and pregnancy, prenatal, and gynecological care patients).62, 64, 65, 8083, 85 Three studies included both a telephone and a video component in their protocol,64, 80, 85 with results favoring the in-person arm, whereas four studies that used only telephone calls reported results favoring the telehealth care62, 81, 83 or showed no difference with in-person visits.65 The eighth study did not specify the type of telehealth used but also showed lower hospitalization rates among those who had telehealth care compared with those who had in-person care (for further details, see Appendix D, Evidence Table D.5.3).82

We identified no studies that provided information about the association of telehealth type for most of the outcomes of interest and there are inconsistent results in the studies that are available. We cannot determine if benefits and harms outcomes vary by type of telehealth.

3.3.11. Results for Key Question 2b

Key Question 2b.

Do the benefits and harms of telehealth during the COVID-19 era vary by patient characteristics?

Four studies that reported on ED, hospitalization rates, readmission, adverse events, and missed visits provided subgroup analysis on patient characteristics.52, 56, 59, 67, 76, 88, 108, 115 Three studies were conducted in patients undergoing care for general medical conditions,56, 76, 108 three studies were conducted in patients being treated for COVID-19,52, 59, 67 one study was conducted among pregnant patients,88 and one study was conducted in a specific HIV population.115 Seven of the eight studies were cohort observational studies, and one was a cross-sectional study.115

3.3.11.1. Patient Characteristics: Age

Seven studies provided some information about differences in benefits or harms from telehealth by age of the patient.52, 56, 59, 67, 76, 108, 115 Six of the studies were retrospective cohort studies and one was a cross-sectional study.115 Outcomes reported were ED visits, hospitalization, adverse events, and missed visits.

Two cohort studies examined the number of ED visits for patients who received telehealth versus in-person care.56, 59 One cohort study looking at patients receiving care for general medical conditions found no significant association between age and ED visits when the initial visit was telehealth (OR: 1.00; 95% CI, 0.99 to 1.02).56 The other study looked at rate of ED visits for COVID-19 patients, showing a statistically significant lower number of ED visits in patients below the age of 30 (p=0.04).59 This is in contrast to the other age groups the study investigated ranging from 31 years to 80 years and older, which showed no statistical difference between in-person and telehealth visits.59

Five studies reported on age subgroups and hospitalization events. Two studies assessed hospitalization events for patients receiving care for general medical conditions. One cohort study found a significant association between increasing age of the patient who received telehealth care and hospitalizations (OR: 1.04; 95% CI, 1.01 to 1.06).56 The other cohort care study investigated the impact of age on hospitalizations, but only among older patients (ages 65 to 84 years and 85 years and older).76 Although this study did not find a statistically significant difference when it compared patients who were 75 to 84 years of age (OR: 1.02; 95% CI, 0.79 to 1.30) or 85 years of age and older (OR: 1.26; 95% CI, 0.91 to 1.73) with those between 65 to 74 years of age, there was a noticeable increase in hospitalization rates for older patients compared with the reference group. This study only analyzed the impact of age in the telehealth group, and the analysis was not repeated for in-person care.

Of the three cohort studies investigating hospitalization rates for COVID-19 patients, one of the studies found a significant increase in hospitalization rates in the age group older than 60 years in comparison to patients 30 to 39 years of age (HR: 4.89; 95% CI, 1.42 to 16.79).67 Comparing other age groups to patients who were 30 to 39 years of age, the study did not find a statistically significant difference. Another cohort study showed a statistically significant difference, with lower hospitalization in the telehealth group, for patients with COVID-19 who were ages 60 to 69 years (p=0.032).59 Other age groups in the analysis, ranging from below 30 years of age to above 80 years of age, did not show any significant difference between in-person and telehealth visits. The third study of COVID-19 patients found a non-statistically significant difference between age groups (OR: 1.09; 95% CI, 0.77 to 1.54).52

Two studies investigated age subgroups: one cohort study for adverse events and one cross-sectional study for missed visits. For adverse events, the cohort study that compared in-person versus telehealth visits for care addressing general medical conditions found a significantly lower average of medication-related problems per visit in the telehealth group compared with in-person care for patients younger than 65 years of age (p≤0.01) but not for patients older than 65 years of age (p=0.24).108 For the outcome of missed visits, the cross-sectional study of HIV patients showed appointment adherence was significantly higher in the telehealth group compared with the in-person group for patients 25 to 34 years of age (p=0.046), patients 45 to 54 years of age (p=0.01), and for patients 65 years of age and older (p=0.027).115

The results from these studies suggest that age may have an effect on health outcomes among patients utilizing telehealth. Telehealth reduced ED visits and adverse events, and increased appointment adherence, but only for certain age groups and there was no direct comparison between age groups. For direct comparison between age groups, in hospitalization, older patients with COVID-19 receiving telehealth care may have higher rates of hospitalization (for further outcome details, see Appendix D, Evidence Tables D.5.1 and D.5.3).

3.3.11.2. Patient Characteristics: Gender

Seven studies provided gender subgroup analyses.52, 56, 59, 67, 76, 108, 115 Six of the studies were retrospective cohort studies and one was a cross-sectional study.115 Outcomes reported were ED visits, hospitalization, adverse events, and missed visits.

Of the two studies reporting on ED visits, one cohort study that assessed in-person versus telehealth visits for care addressing general medical conditions found no significant association between gender and ED visits (OR: 0.61; 95% CI, 0.33 to 1.13) when the initial visit was telehealth.56 The other cohort study that assessed in-person versus telehealth visits for COVID-19 patients found no significant association between in-person versus telehealth visits and ED visits for either males (OR: 0.29; 95% CI, 0.08 to 1.1) or females (OR: 0.75; 95% CI, 0.31 to 1.82).59

Five studies reported on gender and hospitalization events. Of the two studies that assessed in-person versus telehealth visits for care addressing general medical conditions, one cohort study found no significant association with gender (OR: 0.61; 95% CI, 0.33 to 1.13) when the initial visit was telehealth.56 The other study also found no statistically significant difference in hospitalization rates for patients based on their gender (OR: 0.96; 95% CI, 0.76 to 1.21).76 Similarly, three studies that investigated patients with COVID-19 showed no statistically different rate of hospitalization based on gender: one cohort study compared in-person with telehealth visits (males: OR 0.23; 95% CI, 0.03 to 2.00; females: OR 1.01; 95% CI, 0.28 to 3.64),59 and two cohort studies compared patients who all received an intervention with a telehealth component (HR: 1.76; 95% CI, 0.91 to 3.4367 and OR: 0.7; 95% CI, 0.22 to 2.2552).

One study analyzed gender subgroups for adverse events and missed visits. For adverse events, a cohort study looking at in-person or telehealth visits for care addressing general medical conditions found a significantly lower average of medication-related problems per visit in the telehealth group compared with the in-person group for males (p≤0.01) and for females (p=0.01).108 For the outcome of missed visits, one cross-sectional study of HIV patients showed appointment adherence was higher in the telehealth group compared with the in-person group for both males (p=0.029) and females (p≤0.0001).115

Overall, the results from these seven studies suggest that there is not a difference for those who receive telehealth in ED visits, hospitalization, adverse events, or missed visits based on gender (For further outcome details, see Appendix D, Evidence Table D.5.1).

3.3.11.3. Patient Characteristics: Race and Ethnicity

Seven studies provided data and analysis on gender subgroups.52, 59, 67, 76, 88, 108, 115 Six of the studies were retrospective cohort studies and one was a cross-sectional study.115 Outcomes reported were ED visits, hospitalization, readmission, adverse events, and missed visits.

One cohort study reported on ED visits and assessed in-person versus telehealth visits for the care of COVID-19 patients. This study found no significant association between telehealth and ED visits for patients who were White, non-Hispanic (OR: 0.66; 95% CI, 0.31 to 1.41); Black, non-Hispanic (OR: 0.80; 95% CI, 0.05 to 13.81); other race (0 events, in-person care and telehealth); and Hispanic (0 events, in-person care and telehealth).59 There was no direct comparison between the race and ethnicity subgroups.

Four studies reported subgroup analyses for race and ethnicity on hospitalization, one of patients receiving care for general medical conditions and three of patients being treated for COVID-19.52, 59, 67, 76 The study of people receiving general medical care found no statistically significant difference in hospitalization rates for patients by race and ethnicity: compared with patients who were White, patients who were Black (OR: 1.01; 95% CI, 0.79 to 1.29), Asian (OR: 0.97; 95% CI, 0.42 to 2.25), or Other races (OR: 1.1; 95% CI, 0.64 to 1.91) showed non-statistically significant difference in hospitalization rates when receiving telehealth visits.76 For patients who were Hispanic, compared with those who were non-Hispanic, there was also no statistically significant difference in hospitalization rates (OR: 1.79; 95% CI, 0.94 to 3.41). Two of the studies in patients with COVID-19 similarly reported non-statistically significant differences based on race/ethnicity: patients who were White or African-American compared with Other races (White: HR: 2.59; 95% CI, 0.96 to 7.01; African-American: HR: 1.5; 95% CI, 0.63 to 4.01);67 and patients who were White, non-Hispanic compared with patients who were African-American, non-Hispanic (OR: 0.85; 95% CI, 0.28 to 2.6), Hispanic (OR: 1.19; 95% CI, 0.14 to 9.8), or Other races (OR: 1.17; 95% CI, 0.14 to 9.67).52

The third study on COVID-19 patients showed no statistical difference between in-person and telehealth groups for patients who were White non-Hispanic, Black non-Hispanic, Other races, and Hispanic. No direct comparison of race and ethnicity subgroups was conducted.59

One cohort study reported on readmission and assessed in-person or telehealth visits for care of pregnant patients. This study found no significant association between telehealth and readmission for patients who were White, non-Hispanic (OR: 0.85; 95% CI, 0.16 to 4.64) and Black, non-Hispanic (OR: 1.01; 95% CI, 0.6 to 1.71).88

For both adverse events and missed visits outcomes, the included studies showed a statistical difference between the in-person and telehealth arms by race and ethnicity. One cohort study looking at patients receiving care for general medical conditions showed a statistically significant lower average of medication-related issues in the telehealth group for people who were Black (p≤0.01), Asian (p=0.03), and Hispanic (p=0.02).108 One cross-sectional study looking at HIV patients showed a statistically significant higher appointment adherence rate among people who were Black (0.001) or Hispanic (0.015) and had a telehealth visit.115

Benefits and harms of telehealth may vary by race and ethnicity for adverse events and missed visits, but we were unable to make a determination for ED visits, hospitalization, and readmission (for further outcome details, see Appendix D, Evidence Table D.5.3).

3.3.11.4. Patient Characteristics: Presence of Comorbidities

Five cohort studies reported a subgroup analysis of outcomes from telehealth visits and the number of patients’ comorbidities and reported on ED visits, hospitalizations, and adverse events. Three studies were conducted among patients receiving care for general medical conditions,56, 76, 108 and two studies reported this analysis among patients with COVID-19.59, 67

For ED visits, one study on care for general medical conditions reported that an increase in the number of comorbidities among telehealth patients was associated with an increase in ED visits, although no statistically significant difference was observed (ED visits [OR: 1.09; 95% CI: 0.89 to 1.33].56 Comorbidity subgroup analysis was not repeated for patients receiving in-person care. The second study that reported ED visits among patients with COVID-19 showed a lower rate of ED visits in the telehealth arm compared with the in-person arm for overweight and obese patients; however, the results were not statistically significant (overweight: p=0.10; obese: p=0.14).59

Four studies reported on hospitalization outcomes for patient subgroups with comorbidities. In the care for general medical conditions, one cohort study reported that an increase in the number of comorbidities among telehealth patients was associated with an increase in hospitalization, although no statistically significant difference was observed (OR: 1.09; 95% CI: 0.85 to 1.38]).56 Comorbidity subgroup analysis was not repeated for patients receiving in-person care. The second study on care for general medical conditions, using the Charlson Comorbidity Index, reported higher rates of hospitalization for those receiving telehealth for patients with more comorbidities (OR: 1.74; 95% CI, 1.67 to 1.81).76 Comorbidity subgroup analysis was not repeated for patients receiving in-person care. The two studies conducted among patients with COVID-19 included analysis of overweight and obese subgroups. One study compared hospitalization rates of obese patients who received telehealth care versus non-obese patients who received telehealth, finding a significantly higher rate of hospitalization in obese patients (HR: 2.27; 95% CI, 1.17 to 4.41).67 This analysis was not repeated for patients receiving in-person care however. The second study that reported hospitalization among patients with COVID-19 showed a slightly lower rate of hospitalization in the telehealth arm compared with the in-person arm for overweight and obese patients; however, the results were not statistically significant (overweight: p=0.21; obese: p=0.47).59

One study analyzed comorbidity subgroups for adverse events and compared in-person care with telehealth care for patients with general medical conditions. This cohort study reported a statistically significant lower average of medication-related issues in the telehealth group compared with the in-person group on several comorbidity subgroups: patients with high blood pressure (in-person: mean 2.1 [SD 1.78]; telehealth: mean 0.86 [SD 0.94], p≤0.01), diabetes (in-person: mean 2.1 [SD 1.61]; telehealth: mean 1.29 [SD 1.11], p≤0.01), end-organ damage (in-person: mean 2.09 [SD 1.61]; telehealth: mean 1.11 [SD 1.02], p≤0.01), and chronic kidney disease (in-person: mean 2.92 [SD 1.38]; telehealth: mean 0.75 [SD 0.71], p≤0.01).108 Similar effects were seen for other comorbidities reported but were not statistically significant: patients on dialysis, and those with acquired immunodeficiency syndrome, congestive heart failure, chronic obstructive pulmonary disease, dementia, connective tissue disorder, and malignant lymphoma.108

The benefits and harms of using telehealth care did not show a significant difference for ED visits. Among patients receiving telehealth care, patients with more comorbidities may have higher hospitalization rates but a lower average of medication-related issues for certain comorbidities (for further outcome details, see Appendix D, Evidence Tables D.5.1 and D.5.2).

3.3.12. Results for Key Question 2c

Key Question 2c.

Do the benefits and harms of telehealth during the COVID-19 era vary by provider and health system characteristics?

The providers represented a variety of specialties treating a wide range of clinical conditions. These services included clinical care for abortion and antenatal care, cardiology, diabetes, irritable bowel disease, rheumatology, primary care, and multidisciplinary clinics, as well as home-care services, to name a few. Among the 63 studies that compared in-person and telehealth interventions, three studies were conducted in nationally representative populations, 10 studies were conducted at a large regional health network, 24 were conducted at a large single center, 29 were conducted at single centers but did not specify if they were part of a larger health system, and one study did not provide enough information to determine the type of health system (see Appendix C, Results Table C.2 for further details). No studies directly addressed the association of benefits and harms outcomes of telehealth with provider or health system characteristics. Most of the reported outcomes were consistent for the specific clinical area or there was not any inconsistency in results that may be associated with provider or healthcare system characteristics.

3.4. Results for Key Question 3

Key Question 3.

What is considered a successful telehealth intervention, and what are the barriers and facilitators of these interventions during the COVID-19 era:

  • From the patient or caregiver perspective?
  • From the provider perspective?

3.4.1. Key Points and Summary

  • Both patients and providers reported that telehealth is more convenient, provides greater access for many patients, provides patient and provider flexibility, is more efficient in terms of time and utilization of office space, allows for remote work, supports greater inclusion of family caregivers, and increases patient appointment compliance.
  • Patients and providers felt that telehealth may not be suitable for specific patient populations, such as those who are more difficult to reach and engage via telehealth or those requiring complex care.
  • Telehealth raises concerns about maintaining privacy and confidentiality in the digital environment, especially if patients access telehealth in public places or multi-person homes.
  • Access to telehealth is felt by patients and providers to be unequally distributed and is especially inaccessible for patients of low socio-economic status, vulnerable populations, those with digital literacy problems, older adults, and non-native English speakers.
  • Some patients perceive telehealth as a barrier to improved health outcomes owing to the absence of a physical exam and challenges in developing rapport and communicating with their care team, potentially resulting in delayed or missed diagnoses.
  • Providers noted that the cost of telehealth can be a barrier to care owing to limits of insurance reimbursement.
  • Providers felt that future use of telehealth should be considered in combination with traditional, in-person visits to ensure regular and appropriate followups, especially for specific patient populations (e.g., those who live far away from in-person care).
  • Providers reported being more exhausted by telehealth and noted a potential drop in productivity as a result.

We identified 412 studies that addressed what we considered to be successful telehealth interventions (measured as user satisfaction or dissatisfaction) and barriers and facilitators of use of these interventions during the COVID-19 era. One hundred and eighty-seven studies were synthesized and included qualitative data from interviews, focus groups, and open-ended survey questions. One hundred and thirty-eight studies included quantitative data from surveys. Thirty-seven studies included both qualitative and quantitative data. For the draft report, we synthesized the qualitative research and considered whether the survey data supported or was in contrast with the findings from the qualitative research. For the update, we synthesized qualitative studies which added new information or identified new themes, but did not include new surveys (Appendix D, Evidence Table D.11, and Evidence Tables D.12 through D.17, Tables 15 and 16).

Table 15. Overview of synthesized qualitative studies (N=187 studies).

Table 15

Overview of synthesized qualitative studies (N=187 studies).

Table 16. Overview of surveys (N=138 studies).

Table 16

Overview of surveys (N=138 studies).

We classified information in each individual qualitative study into the major themes of barriers or facilitators and satisfaction or dissatisfaction. We also classified subthemes, such as ease of use, access, and communication. Facilitators are considered factors that make a process, such as using telehealth, easier to initiate or use. Barriers are considered obstacles that make a process, such as using telehealth, more difficult to initiate or use. We defined satisfaction as the fulfillment of a want or need and dissatisfaction as not having a want or need fulfilled or being discontent with something, such as telehealth (Appendix D, Evidence Tables D.18 through D.21).

3.4.2. Barriers and Facilitators to Telehealth

3.4.2.1. Patient Perspective of Barriers and Facilitators to Telehealth

3.4.2.1.1. Telehealth Literacy

Three qualitative studies conducted in the United States, Canada, and Australia described the patient perspective, highlighting the limitations of using technology as a barrier to use,137 as well as general lack of skill reducing the comfort level of using newer technology.138 Specifically, two studies highlighted that older individuals may have difficulty with new technology.138, 139

A small survey of 34 patients in the United States identified telehealth as convenient and well-integrated, with a few survey respondents noting that the system was unnecessarily complex.140 The survey data differ from the qualitative data in that the populations are from different countries; the survey included heart failure patients versus general care in the qualitative study; and the qualitative data were collected in the later COVID-19 era, whereas the survey data were collected during the general COVID-19 era (Appendix C, Results Table D.11).

We have high confidence, based on three studies with minor methodological concerns, that telehealth literacy among patients is a barrier to care. This statement is supported by a survey with similar results (Appendix C, Results Table C.4; Appendix D, Evidence Table D.22; Table 17).

3.4.2.1.2. Cost

No studies described cost from the perspective of patients as a barrier or a facilitator to telehealth.

3.4.2.1.3. Privacy

Seven qualitative studies described issues of privacy from patient perspectives. Patients raised concerns about confidentiality and privacy during the virtual visit,141147 describing concerns about not having caller ID, being overheard, and issues of background noise. Because of these types of noted issues, there was a preference for telephone consultations that would allow patients to write notes.

Two surveys of patients noted shorter waiting periods, and participants felt that their privacy was secured and respected.148, 149 The survey data may differ from the qualitative data as the specific type of telehealth was not reported in the surveys; patient conditions or clinical needs were different between the two types of studies; and the qualitative data were collected primarily during the early and general COVID-19 eras, whereas the surveys were conducted in the early COVID-19 era (Appendix C, Results Table C.3.).

Table 17. Summary of the evidence for patient perspectives of barriers and facilitators (N=23).

Table 17

Summary of the evidence for patient perspectives of barriers and facilitators (N=23).

We have moderate confidence, based on the seven qualitative studies, that issues surrounding privacy are a patient-perceived barrier to care via telehealth. Our confidence is not high owing to the limited information available across the studies and the overall heterogeneity of the populations (Appendix C, Results Table C.4; Appendix D, Evidence Table D.22; Table 17). Information collected from surveys, in contrast, suggests that privacy is not a patient-perceived barrier to care via telehealth.

3.4.2.1.4. Health Outcomes

Five qualitative studies described health outcomes associated with telehealth from the patient perspective. Patients felt that telehealth compromised their healthcare by letting their care “fall through the cracks” as a result of not having a physical exam, missed diagnoses, and discomfort discussing symptoms over the telephone.143, 151, 152 Patients expressed concerns about possible disease progression,142 citing challenges with remote assessment that included decreased clinical monitoring and ability to develop rapport – both of which could undermine the therapeutic relationship, exacerbate ‘secretive’ disorders (e.g., anorexia nervosa), and decrease overall clinical efficacy.153

There were no surveys of patients that collected data about telehealth as being a barrier or facilitator to better health outcomes.

We have moderate confidence that patients perceive telehealth as a barrier to improved health outcomes. Our confidence is limited owing to inadequate description of qualitative methods in 40 percent of the studies, as well as the overall heterogeneity of the populations (Appendix C, Results Table C.4; Appendix D, Evidence Table D.22; Table 17).

3.4.2.1.5. Communication

Six qualitative studies addressed communication barriers and facilitators from the patient perspective. When compared with in-person evaluations, patient participants cited communication via telehealth as limited142, 147 and not as effective or resulting in reduced confidence in the provider’s expertise.137 In particular, patients perceived telehealth as less thorough and more rushed147 and impersonal.155 Patients reported difficulties building rapport, especially via telephone, owing to the lack of eye-to-eye contact and physical examination,142 and they expressed dislike for the formality of telephone appointments and the lack of nonverbal communication.154 Patients described facilitators, such as the use of video conferencing, as more beneficial than a telephone appointment, as it allows the use of nonverbal communication.154 Patients valued the ‘step-by-step’ approach staff took in explaining the process; they also emphasized that it was important that information be presented clearly, without the use of medicalized language, and that ample time be provided to ask questions.150

One survey176 noted that, when accessing telehealth, patients felt they had a better understanding of their need for a consultation and had adequate opportunity to discuss their concerns with the doctor. This survey differs from the qualitative studies in that the intervention was via telephone, only, rather than via telephone plus video. Populations also differed between this survey and the qualitative studies with the survey data focused on older (65+ years) patients (Appendix C, Results Table C.3).

We have high confidence that telehealth can act as both a barrier and a facilitator to communication from a patient perspective. We have minor concerns related to the adequacy of the findings in the studies, as well as the possibly skewed population providing input on outcomes in one study; however, we did not feel that these concerns sufficiently biased the findings in this area (Appendix C, Results C.4; Appendix D, Evidence Table D.22; Table 17). The survey pointed to telehealth having a positive impact on communication between patients and providers.

3.4.2.1.6. Technical Issues

We identified nine qualitative studies that addressed technical issues. From the patient perspective, technology-related barriers137, 147, 155, 158 included joining the online appointment159 and utilizing the technology.142, 160 Patients felt intimidated by the technology; many were concerned that online technological aspects would be too difficult, 156 and this was further affected by the abrupt transition to telehealth.157 Other issues that patients noted were difficulties obtaining prescriptions and pathology results, reduced confidence in the doctor, and an added burden for complex medical care.137 Other patient groups described issues with having to take their own vitals or an overall preference for in-person visits.140 Concerns specific to the method of telehealth included feeling that communication was not as effective,137 feeling like it was hard to hear during the appointment,142 and lack of access to the Internet or a video-conferencing device.142

Fourteen surveys provided patient perspectives on technical issues with telehealth.140, 149, 176187 Although many participants rated video and audio quality as “good,” greater than 15 percent of populations surveyed were neutral-to-negative about video and audio quality.149, 180, 181 One survey reported that 28 percent of the participants required technical assistance with the telehealth visit.184 The survey data are similar to the qualitative data in that video (audio-visual appointments) was the primary mode of delivery and at least half of the data were from a U.S. population. However, the survey and qualitative data differ in patient health concern (Appendix C, Results Table C.3).

We have moderate confidence that patients perceive technical issues as a barrier to telehealth care. There was a lack of methodologic rigor and description of findings across studies, resulting in a lack of clarity about and confidence in the findings. Additionally, there was overall heterogeneity of the populations (Appendix C, Results Table C.4; Appendix D, Evidence Table D.22; Table 17). Information collected via patient survey supported the finding that technical issues can be a barrier to telehealth care from the patient perspective.

3.4.2.1.7. Inequity

We identified five qualitative studies that addressed inequity and its impact on access to telehealth care. Access was noted as problematic by patients with low socio-economic status or those lacking adequate resources, such as a stable internet connection.143, 157, 188 One study pointed to technology experience and lack of support surrounding it as an issue.188 These issues were especially problematic for specific subgroups, presenting an issue of health equity.141, 142 These subgroups included vulnerable populations, those with digital literacy problems, older adults, and non-native English speakers.143, 174

Two surveys178, 183 asked patients about telehealth access inequity. One survey highlighted that, while most patients have access to laptops, smartphones, or other devices that are video conference compatible, patients who are retired (i.e., older) have less access to these devices.178 The other survey reported that patients often opt for telephone rather than video visits owing to a lack of access to video-capable devices.183 These surveys differ from the qualitative studies in the populations studied. Additionally, all qualitative data were gathered in the early COVID-19 era, whereas survey data were collected in both the early and later COVID-19 eras. When reported, the mode of telehealth delivery was audio-visual for nine of the 15 surveys, and six of the qualitative studies (Appendix C, Results Table C.3).

We have moderate confidence that access to telehealth is problematic for patients in specific subgroups, including those of low socioeconomic status, vulnerable populations, older adults, and non-native English speakers. There were poor descriptions of qualitative data collection and analyses and heterogeneity in the populations studied (Appendix C, Results Table C.4; Appendix D, Evidence Table D.22; Table 17). Information collected via patient surveys supports our conclusion that access to telehealth can be a source of inequity.

3.4.2.1.8. Suggestions

We identified five qualitative studies from the patient perspective that included suggestions for better telehealth implementation, including greater technology integration support, as well as a provision for larger screens or better bandwidth.163, 164 Providing technical instruction or assistance to improve adoption of virtual care for elderly clients and others who struggled with this technology was suggested,157 as was training for staff so they could provide support to patients.157 Mental health and physical health were noted as important to patients, particularly for pre-, ante-, and postnatal populations; this population in particular felt that mental health was not addressed well by telehealth, and suggested that mental health care be included as a standard of care during telehealth visits.165 Further, some patients receiving mental health prior to the COVID-19 era wanted additional online services, such as group therapy via video and more options for online counseling.158

There were no surveys that collected patient suggestions on telehealth implementation.

We have moderate confidence that patients provided suggestions that are useful for better telehealth implementation. We had concerns with poor reporting of methodology and descriptions of findings. Additionally, there is overall heterogeneity of the populations studied (Appendix C, Results C.4; Appendix D, Evidence Table D.22; Table 17).

3.4.2.1.9. Advantages

Four qualitative studies identified some of the positive aspects of telehealth noted by patients: improved access to care,145, 166 availability of services during the pandemic,142, 167 convenience and cost savings associated with accessing care,166 and easier access to general practice services.167

There were no surveys that reported patient perspectives on the advantages of telehealth.

We have moderate confidence that patients perceive that telehealth improves access to care, services, and convenience. Our confidence was lower primarily owing to limited details on methodology and descriptions of findings and heterogeneity of the populations studied (Appendix C, Results C.4; Appendix D, Evidence Table D.22; Table 17).

3.4.2.1.10. Appropriateness of Fit

We identified seven qualitative studies addressing appropriateness of fit (i.e., whether telehealth is a good fit for end users based on abilities and understanding). While some patients noted a preference for in-person visits in general,141, 162 they also acknowledged the need for telehealth during the pandemic. Staying at home was the primary reason that telehealth was cited as a good fit, including preferring the comfort and convenience of home,168, 169 the care and home-life balance,168, 170 and relief of financial stress owing to travel.168 One study noted that patients reported an ease of effectively communicating their concerns with their providers during phone appointments; they did not perceive any decrease in quality of care.141 There were situations where patients felt that telehealth was not a good fit, including first appointments, appointments for new symptoms, or long-term management of chronic conditions.162, 171 Patients described not feeling comfortable using tele-mental health, not being able to connect to their provider, feeling that there was a decrease in the number of sessions, and that the phone was less effective.158, 169

There were no surveys that collected data on appropriateness of fit.

We have moderate confidence in the varying opinions patients have about the appropriateness of telehealth. The seven qualitative studies provided findings both in favor of and against the use of telehealth for their specific concerns. The primary methodological concerns of these studies were insufficient detail about how the data were collected or analyzed. (Appendix C, Results C.4; Appendix D, Evidence Table D.22; Table 17).

3.4.2.1.11. Changes to Practice

One study, conducted later in the COVID-19 era, addressed changes to practice as a facilitator to care. This study concerned people with opioid/substance use disorder and identified new procedures that limited patient exposure to others while providing the same level of service, including reduced requirements for in-person treatment, increased doses of medication to take home, and medication delivery systems.172 This was a new theme identified during the update for our review; we did not include surveys for the update.

We have low confidence that telehealth can lead to changes in practice that facilitate care. One small study of 37 individuals with opioid use disorder discussed changes in care. This study did not describe aims, recruitment, or data analysis sufficiently (Appendix C, Results C.4; Appendix D, Evidence Table D.22; Table 17).

3.4.2.1.12. Future of Telehealth

Information was also gathered regarding the future of telehealth in three qualitative studies. Obstetric patients were not interested in the continuation of telehealth.173 Patients receiving mental health noted that telehealth was convenient, but they were not interested in using it in the future.174, 175 This was a new theme identified during the update for our review; we did not include surveys for the update.

We have moderate confidence that patients do not consider telehealth in the future as a good option. The three included studies had minor methodologic concerns but, most importantly, only gathered information from patients receiving care for mental health or obstetrics, which may have biased opinions (Appendix C, Results C.4; Appendix D, Evidence Table D.22; Table 17).

3.4.2.2. Provider Perspective of Barriers and Facilitators to Telehealth

3.4.2.2.1. Telehealth Literacy

Eight qualitative studies discussed issues of telehealth literacy from the provider perspective. Four studies noted telehealth literacy as a barrier to using the telehealth platform that included connectivity issues,189 the initial setup of the telehealth platform,190 and patient knowledge.189, 191, 192 Providers across five studies noted various barriers in patients using telehealth, the most common of which were issues related to patient knowledge192 and digital literacy levels,189, 193 especially among specific geographic, aging, and racial/ethnic groups.194 Mitigating digital literacy barriers was noted as a concern.195 Suggested facilitators to implementing telehealth services were noted by providers in three studies and included online or paper modules for using and interacting with the telehealth platform,190 online modules that are specifically targeted to support staff,190 more training and time dedicated to learning to use telehealth,196 and calls made ahead of telehealth appointments to help patients navigate inside the portal.189

Six surveys190, 193, 196199 identified telehealth literacy as a barrier, with providers citing concern about patients’ ability to use telehealth193, 196, 197, 199 and concerns about their own ability or time to learn new systems.190 Three surveys identified telehealth literacy as a facilitator,197, 200, 201 with providers identifying their own telehealth ability as good to very good and noting their comfort using telehealth. The survey data are similar to the qualitative data in that the populations are predominantly based in the United States and the telehealth was primarily delivered via video. However, healthcare system data are lacking in both types of study and practice type/or specialty, and the timing of the studies was heterogeneous in both the qualitative and quantitative studies (Appendix C, Results Table C.5).

We have moderate confidence that providers find the telehealth literacy of their patients to be a barrier to care and that their own telehealth literacy can be increased through training. Our concerns with the studies were lack of transparency in data collection and limited presentations of findings. Additionally, there is overall heterogeneity of the populations studied (Appendix C, Results Table C.6; Appendix D, Evidence Table D.22; Table 18). Surveys identified additional barriers for patients from the provider perspective; however, surveys reported that providers were confident in their own telehealth literacy.

3.4.2.2.2. Cost

Nineteen qualitative studies elicited provider feedback about costs associated with telehealth. While providers found the telehealth model desirable and sustainable, the most consistently noted barrier was financial limitations related to charges for service delivery or reimbursements and revenue.190, 192, 202206 Conversely, some providers described the financial impact of converting to telehealth as minimal207 with an added benefit of reducing the financial burden to patients experiencing health disparities.208211 In addition, providers expressed concern that telehealth might be overused in the future as a cost- and time-saving measure, even if not in the best interest of patients.212, 213

Concerns about the time and work involved with checking each patient’s medical coverage were noted,189 as was the inability to conduct physical assessments.189 Opioid treatment programs in one study offered telehealth services either for medication management and/or psychosocial services only.202 Results from two studies questioned whether the telehealth model is sustainable.214, 215 A suggested facilitator was to designate one person to validate coverage/billings costs for certain visits (e.g., nutrition telehealth visits).189 Providers expressed a need for organizations to provide financial assistance in order to obtain adequate technologies necessary for successfully implementing telehealth services.210, 216 They also expressed concerns about the costs associated with staff workload pressures and lack of human connection for patients.217

Table 18. Summary of the evidence for provider perspectives of barriers and facilitators (N=60).

Table 18

Summary of the evidence for provider perspectives of barriers and facilitators (N=60).

Six surveys identified cost as a barrier to telehealth,245, 279282 with healthcare providers concerned about reimbursement245, 281, 282 and the general increase in the cost of business.279, 280 Two surveys reported benefits of telehealth in relation to cost: reduced travel burden283 and the ability to deliver care at the same cost via telehealth.284 Qualitative data were collected more often in the United States than surveys and more frequently included video as a mode of delivery. There were no common findings across the two types of studies in reference to healthcare system, clinical specialty, or time period that the data were collected (Appendix C, Results C.5).

We have moderate confidence that the cost of telehealth can be a barrier to care owing to limits to insurance reimbursement. Our confidence was lowered owing to concerns about insufficient details about recruitment and data collection. Three studies included a moderately detailed discussion of costs as a barrier; most of the studies that discussed cost as a possible facilitator included moderately detailed discussions. Additionally, there was overall heterogeneity of the populations studied (Appendix C, Results Table C.6; Appendix D, Evidence Table D.22; Table 18). The surveys echoed the concern about reimbursement, but providers also noted in the surveys that telehealth could reduce costs by reducing their travel burden.

3.4.2.2.3. Privacy

Ten qualitative studies described providers’ concerns about privacy in telehealth. Privacy concerns were related to maintaining confidentiality in the digital environment,219 especially if patients accessed telehealth in public places.218 Some providers noted that a benefit of telehealth was increased privacy, which supported greater comfort for patient disclosure and help-seeking,171, 220 while others cited difficulties ensuring privacy and confidentiality.221224 Difficulties ensuring privacy stemmed from patients having children and/or other housemates that made it difficult for them to express themselves freely, as they did not want their conversation overheard or had to work around the schedules of other people in the household.223, 224 In addition, inadequate privacy may limit the accessibility of remotely delivered services.225, 226

There were no surveys that collected data on privacy from a provider perspective.

We have moderate confidence that there are issues related to privacy in the context of confidentiality from a provider perspective. We had concerns related to transparency of data collection, recruitment, study design, and analysis in the two qualitative studies. We also have moderate confidence that privacy is a facilitator to telehealth. We had concerns about data collection, recruitment, and analysis, however, findings related to privacy were thoroughly described (Appendix C, Results C.6; Appendix D, Evidence Table D.22; Table 18).

3.4.2.2.4. Health Outcomes

Thirty-three qualitative studies discussed health outcomes associated with telehealth from the provider perspective. Providers in one study noted a preference for phone over video as lockdown eased, even though they were able to achieve physical assessments (e.g., gait and respiratory monitoring) via video.243 Providers’ most frequently cited limitation of telehealth was the lack of physical interaction/exam with patients.143, 192, 231, 239, 240, 244 Providers also noted concerns with telehealth appointments: less information to inform clinical decision-making,248 inadequate quality of care provided via the telehealth environment versus face-to-face,241 potential risks to patients and providers from virtual interactions,234 concerns about prescribing certain medications,247 the continuity of the rehab process and developing rapport,233, 240 and potential for patients to become distracted in the home environment.244 Providers noted telehealth as resulting in a lack of physical contact,143 being more exhausting than face-to-face therapy,237 and resulting in feelings of loneliness, all affecting therapists’ well-being at work.237 In addition, providers noted difficulties in providing a standard level of patient care, resulting from poor quality of technology; however, they also felt that the technology facilitated unexpected positive outcomes, such as being able to meet families and providing innovations for group therapy.229 Providers discussed a potential drop in their productivity.198

Improved outcomes associated with telehealth noted by providers were a more holistic view of the patient and their home environment,250 more opportunity for families/caregivers to be involved in telehealth visits,182, 231, 236 facilitated clinical assessment and treatment,191 patients being able to set up a relaxing experience in their home,182 improved client contact,231 and maintained or improved quality of care.218 In addition, video visits were described as advantageous, as they were convenient and saved patients time and money, particularly for older patients and those traveling long distances for in-person appointments.182, 245

Providing and facilitating access to video visits to all patients was reported as an important goal, which might be accomplished by engaging and empowering health system personnel to expand access.195 This action would help to streamline scheduling processes and video visit workflows196 and provide clinic staff support to prepare patients for visits.196 To be sustainable, “Patients’ suitability for video visits would need to be determined during scheduling based on several criteria (e.g., physical examination needs, patient’s technological capacity and demographics, new versus return).”245

Providers noted that the use of telehealth reduced travel time,240, 246 is more convenient,246, 248 and allows for time flexibility.182 Telehealth was noted as improving patient access to care230, 236 and facilitating continuity of care.245 Providers expressed that their experiences providing pain rehabilitation via telehealth were tightly linked to whether the methods could be used properly, related to technology, the environment, the patient, and the provider/care team.227 Providers expressed appreciation of continued care, facilitated through equitable patient access to required technology and devices (e.g., smart phones, tablet, e-mail).190, 228

Providers felt that telehealth facilitated access to colleagues with prior telehealth experience, accessible electronic medical record (EMR) data to plan telehealth care visits in advance of visits, and assistance for office staff in telehealth scheduling and administration.190 One group altered how they could use telehealth to triage or collect a medical history before an in-person visit, thereby minimizing exposure time.235 Having good technology setup279 and training were seen as necessary for successful implementation,238, 249 as were having a technology advocate242 and flexibility of telehealth platforms.232 In addition, providers felt it was important to provide technological access and support.196, 244

Limited and conflicting information regarding outcomes from the provider perspective was available in the survey data. One survey of psychiatrists found that providers thought that their video sessions were equivalent to face-to-face sessions;200 and, in another survey of neurosurgeons, providers felt that the quality of care via telehealth was inferior to face-to-face visits.285 Owing to the heterogeneity of data in the qualitative studies, we cannot point to any similarities across the groups (Appendix C, Results Table C.5).

We have moderate confidence that telehealth can be a barrier to health outcomes owing to a lack of physical interaction with patients. However, providers noted that telehealth can also give a more holistic view of patients and their environment and, in that way, could improve quality of care. We have concerns about transparency and sufficiency of data collection as well as analytic procedures.

Further, telehealth access impacts provider ability to deliver care which impacts patient outcomes. There is overall heterogeneity of the populations studied (Appendix C, Results Table C.6; Appendix D, Evidence Table D.22; Table 18). Information on outcomes was only found in two surveys and is not comparable to the qualitative data; the surveys only recorded provider impressions of the equivalence of telehealth to face-to-face visits.

3.4.2.2.5. Communication

Sixteen qualitative studies detailed the provider perspective of communication in telehealth. Providers noted barriers in communication and developing rapport, which they felt was not as effective in telehealth compared with in-person visits owing to technical limitations that exacerbated the lack of visual cues, eye contact, and body language (i.e., nonverbal limitations).191, 198, 215, 246, 248 In discussing technical limitations, providers noted Zoom fatigue251 and managing group dynamics,251 in addition to concerns about delays in examination, time to complete evaluation,244 privacy,214, 250 and lack of “water cooler” opportunities to collaborate with other therapists, caregivers, or patients.233 Providers noted concerns about how patients regard telehealth appointments, such as the formality with which patients do/do not regard the virtual appointment (e.g., driving during the appointment).252

Provider-noted facilitators included having a centralized patient call center to facilitate patient technological troubleshooting and scheduling;190 providing explicit orientation to etiquette expectations;251 offering individual coaching, as needed, to facilitate social competency with telehealth;251 and having good leadership and teamwork practices that support telehealth.253 Other facilitators noted by providers were to use end-of-day clinical debriefs among the care team, check-in with clients after already scheduled visits, and/or use text and phone for outreach.251

Providers felt that telehealth resulted in increased comfort for patients in their own home246 and described video visits as convenient and efficient231 and as facilitating better emotional connections.248 Of note, providers stated that telehealth resulted in their ability to use new strategies for connecting with patients,246 such as being able to add visual cues to aid to their discussions (e.g., during dietary conversations, holding up the actual food item).192 Findings of one study showed that telehealth services may not be appropriate for patients with complex diseases or situations that require a great variety of health services.237 Providers felt that telehealth facilitated easier connectivity to patients,250 in particular for teenage patients who tend to use telehealth visits more than in-person visits, offering increased insight into how patients/families manage their disorders at home.192

Six surveys collected information on telehealth and its impact on communication.196, 200, 245, 250, 282, 286 In one survey, providers noted that they had good rapport and were able to connect well with their patients via telehealth.200 The remainder of the surveys pointed to concerns about or barriers to communication between provider and patients: providers had concerns about sharing information with other healthcare teams and understanding patient preferences for care;250 expressed a desire for training in reference to telehealth communication, communicating post-visit instructions, or using interpreters on calls;196, 245, 282 had difficulty reaching patients and recognized patient preferences for face-to-face communication.286 Both the qualitative studies and surveys took place primarily in the United States but are not comparable to one another across mode of delivery, healthcare system, or provider specialty (Appendix C, Results C.5).

We have moderate confidence that telehealth can both impede and facilitate communication between provider and patient: barriers include telehealth platform fatigue and provider concerns about patients’ casual approach to telehealth care; facilitators include increased patient comfort and easier connectivity to patients. Concerns about this body of evidence include a lack of transparency in data collection and analysis and descriptions of communication issues that were not thorough in over one-third of included qualitative studies. Additionally, there is overall heterogeneity of the populations studied (Appendix C, Results C.6; Appendix D, Evidence Table D.22; Table 18). Survey data identified a different set of provider concerns about and benefits of telehealth for communication.

3.4.2.2.6. Inequity

Eighteen qualitative studies addressed inequity as a concern for providers. While providers felt that telehealth improved patient access to care,218, 230 access was described as potentially different for some populations (e.g., rural, disabled, those without reliable internet service) raising the issue of equity in access to healthcare.214, 231, 240, 248, 252, 255, 257 Providers highlighted issues with patients’ ability to access the technology and/or equipment,192, 228, 245, 250, 256 especially for remote/rural communities189, 198, 241, 242, 254, 257 or for those who have limited resources, such as limited internet access or equipment.228

Eight surveys of providers collected information on telehealth inequity.196, 199, 245, 253, 280, 282, 286, 287 Inequity was noted as connection (Wi-Fi or internet) access or issues280, 287 and the potential that patients’ limited financial resources could limit access.196, 199, 253, 280, 282 These surveys are not comparable to the qualitative studies in terms of where studies were conducted, mode of telehealth, clinical specialty area, or timing of data collection (Appendix C, Results C.5).

We have high confidence that inequity, in the context of access to telehealth, is a concern for providers across specialty areas. We had only minor concerns regarding data collection, accuracy, transparency, and analysis (Appendix C, Results C.6; Appendix D, Evidence Table D.22; Table 18). The survey information collected aligned with the qualitative data.

3.4.2.2.7. Technical Issues

Twenty-seven qualitative studies identified technology challenges, including digital literacy, experienced by many providers and their staff. Providers noted that technical difficulties sometimes resulted in missed appointments262 and that there were inadequate resources available to resolve these technical issues.192, 206, 255, 262, 265 Providers noted logistical challenges in accessing the telehealth technology.246 They also indicated that the swift transition to telehealth after March 2020, and the minimal use of it prior to that, greatly affected the ease of implementation.190, 215, 248 There were concerns about patients’ variable internet speeds, which could result in insufficient diagnostic ability.247 Providers noted difficulties accessing telehealth services in hospice care.260 The delivery of services through telehealth264 may be limited by patient, provider, and technological factors;230, 232, 244, 258, 259 the absence of desired functionalities, such as a virtual waiting room or a chat function, resulted in challenges in the workflow,143 and some providers found telehealth to be time consuming.192, 247 In addition, providers noted a potential loss of access to the electronic medical record when working remotely.242 Some providers described challenges that their opioid treatment providers faced in implementing telehealth services, citing clinic capacity.202 Likewise, some providers noted the time demands and costs associated with setup.241 Recent transitions to the electronic medical record exacerbated unfamiliarity with telehealth administration and scheduling.190

Digital literacy of both patients and providers was raised as a concern by providers.250 Providers described limited abilities to prevent technical difficulties as a barrier.182 Such difficulties disproportionately affected older and economically disadvantaged patients who may struggle to use laptops and tablets261, 263 and lack digital proficiency.240 Technological limitations also included ease of use and the learning curve of therapists and patients;233 while usability was considered high, usability/technical difficulties and lack of digital literacy affected implementation and ease of use, especially with logging on and maintaining continuous Wi-Fi or data connection throughout the visit.143

We identified 12 surveys of providers that addressed barriers to telehealth caused by technical issues.179, 182, 193, 196, 245, 250, 255, 280, 288291 There was a wide variety of concerns identified in the surveys: for example, connection issues encountered prior to consultation on both the provider and patient ends,182, 250, 280 concerns about implementation291 and provider training needs,196 and the quality of audio/video.250, 290 Most data in both qualitative studies and surveys were collected from a U.S. population, and about half of the included qualitative and survey studies evaluated video visits (Appendix C, Results C.5). There were no surveys that collected data on digital literacy from a provider perspective.

We have high confidence that providers feel that technical issues can negatively impact access to care across specialty areas. We had only minor concerns regarding data collection, accuracy, transparency, and analysis. Additionally, there is overall heterogeneity of the populations studied (Appendix C, Results C.6; Appendix D, Evidence Table D.22; Table 18). Information collected via surveys support this conclusion.

3.4.2.2.8. Appropriateness of Fit

We identified five qualitative studies that assessed appropriateness of fit (i.e., whether telehealth is a good fit for end users based on abilities and understanding) of telehealth from the provider perspective. Providers described the fit of telehealth modalities (i.e., phone and video) as variable, depending on the patient.202 In all, providers noted that telehealth is appropriate for some patients but not all.182, 196 Decisions for which patients should receive alternative consultations, telehealth versus face-to-face, were based on three main considerations: (1) minimization of risk, (2) adherence to guidelines, and (3) preference for face-to-face consultations.191 Providers felt that some patient groups, such as Indigenous people, simply did not like the idea of video interactions.264

There were no surveys that collected data on appropriateness of fit from a provider perspective.

We have high confidence that telehealth can be used appropriately, as long as alternative delivery of care is considered. We had only minor concerns regarding data collection, accuracy, transparency, and analysis (Appendix C, Results C.6; Appendix D, Evidence Table D.22; Table 18).

3.4.2.2.9. Future Use

Sixteen studies addressed the future use of telehealth services. Some providers reported a strong desire to return to in-person models, which some felt reflected best practices and facilitated peer interaction and support.272 Similarly, many providers stressed the need for flexible modes of delivery based on patient suitability and patient/provider preference, citing a blended/hybrid model as the best approach in the future of care delivery.266, 267, 269, 271274 Providers learned to be proactive and anticipate future challenges and difficulties and plan accordingly to reduce their negative impact.270 Providers suggested the need for information on adapting practice models for assessing patients via telehealth,223, 271 integrating EMRs,216 and educating and better integrating patients and families/caregivers, which they felt improved over time/with exposure to telehealth.216, 223, 267, 268 Increasing insurance coverage for telehealth was noted as a necessary component of successful future use.267, 269, 274

Some providers felt that telemedicine increased work/life balance because telemedicine allowed them greater ability to multi-task, take more breaks, and spend time with family while working from home.225, 273 However, physicians also noted that working from home invited more interruptions and pressed the need for clinicians to focus on telehealth sessions and manage their time.223, 225, 267 In addition, there were noted social concerns that included feelings of isolation and decreased informal communication with coworkers;225 providers noted higher levels of exhaustion from telemedicine sessions273 and stressed that future use is best suited in environments where there are adequate numbers of direct service providers to deliver quality telehealth.210

Successful future implementation relies on ensuring adequate staffing and time for virtual appointments.272, 275 One study noted that a threat to long-term sustainability was that several new and expanded programs did not have long-term staffing plans.249 Also, making sure that community interventions (such as Wi-Fi enhancers and universal broadband access) and education/training were implemented to ensure improved quality of and access to telehealth visits, especially for underserved populations.216, 223, 267, 276 There were also concerns about the lack of legal protections for those conducting appointments via telehealth.274 In addition, the cost of telehealth software was perceived as a barrier to future implementation of telehealth services.210 This was a new theme identified during the update for our review; we did not include surveys for the update.

We have high confidence that telehealth can be used in the future, as long as hybrid models are available based on patient preference and appropriateness of telehealth for certain conditions. We had minor to very minor concerns regarding data collection, accuracy, transparency, and analysis (Appendix C, Results C.6; Appendix D, Evidence Table D.22; Table 18).

3.4.2.2.10. Preparedness for Future Implementation

Three studies described preparedness for future implementation. “Preparedness” was operationalized to include both available equipment and adequate staff capacity to provide telehealth services.277 Clinics that already used telehealth in their practice, and had adequate resources (i.e., audio-visual technologies and instructional materials and procedures) and infrastructures to support its use, were better able to pivot to increasing telehealth use.277, 278 Those who were less well prepared, however, had a more difficult time. One study described attempts to mirror face-to-face appointments from each clinic setting for telehealth services to ease the transition and to ensure successful implementation.278 Institutional support was described as a key facilitator of telehealth implementation.209 The availability of equipment and the capacity of health professionals and patients to use audio-visual technologies resulted in most participants providing consultations via telephone.277 This was a new theme identified during the update for our review; we did not include surveys for the update.

We have moderate confidence that providers and their practices were prepared for telehealth and its future use. We had no to minor to very minor concerns related to the coherence and relevancy of our findings, and minor concerns regarding adequacy owing to the small sample size. We had moderate concerns about study methodology owing to insufficient information about data collection in all three studies, along with other minor issues (Appendix C, Results Table C.4; Appendix D, Evidence Table D.22; Table 18).

3.4.2.2.11. Changes in Practice

Seven studies described changes in practice necessary to implement telehealth in the future. Negative patient feedback prompted changes to practice models.270 Some regarded telehealth as a positive change172 but noted that it changed how they typically oriented patients and aligned expectations of therapy.223 Another study noted the need to build capacity and repurpose work roles to better integrate telehealth with in-person programs.217, 272, 275 To accommodate the changes and workload pressures necessitated by the virtual environment, practitioners described adaptations necessary to creating structure in their day to help mediate “Zoom fatigue” – these tactics included going for walks, taking lunch breaks, or even pretending to “go home” to help separate work from personal life.217, 223 In addition, providers described the need to align patients’ expectations of the telehealth environment, noting that when they were not on time, some patients left the videoconference.208 There were noted challenges with ensuring providers met appointment times.208 This was a new theme identified during the update for our review; we did not include surveys for the update.

We have high confidence that providers and their practices regard telehealth positively and that it necessitated needed changes in workflow and patient care. We had no to very minor concerns related to the coherence and relevancy of our findings, and minor concerns regarding adequacy owing to inconsistent findings. We had minor concerns about study methodology owing to insufficient information about data collection in most studies, along with other minor issues (Appendix C, Results Table C.6; Appendix D, Evidence Table D.22; Table 18).

3.4.2.3. Other Populations’ Perspectives of Barriers and Facilitators to Telehealth

3.4.2.3.1. Telehealth Literacy

One qualitative study of providers, patients, and caregivers recommended making telehealth platforms more amenable to older populations and those with cognitive impairments.292

Two surveys of patient/caregiver groups reported that telehealth was acceptable, they felt comfortable with the technology,293 and they experienced little to no difficulty with the telehealth platforms.294

3.4.2.3.2. Cost

No qualitative studies or surveys described cost from the perspective of other or mixed populations as a barrier or a facilitator to telehealth.

There were no surveys in other populations that addressed costs.

3.4.2.3.3. Privacy

No qualitative studies or surveys described privacy from the perspective of other or mixed groups as a barrier or a facilitator to telehealth.

There were no surveys in other populations that addressed privacy.

3.4.2.3.4. Health Outcomes

Five qualitative studies described health outcomes of telehealth from combined populations of patients, caregivers, and/or providers. For physical assessments via telehealth, groups reported issues with establishing continuity of care, the physical setting, focusing on available resources, the location of the care provider or child, and potential risks in the patient’s physical environment.233, 292 Concerns about the lack of physical exam/interaction were echoed by caregivers.295 Other concerns that emerged in provider and patient interviews included the logistics of the appointment296 and the need to confront new roles and workloads.297 Suggested facilitators included using a piecemeal approach to virtual care, which allowed providers to act rapidly and provided the flexibility needed for providers to select technologies based on their needs when technical challenges occurred.297 Another suggestion from patient/provider/caregiver perspectives was that tele-rehabilitation could be integrated as part of a hybrid delivery package, after initial visits are (ideally) home visits.292

There were no surveys in other populations that addressed health outcomes.

3.4.2.3.5. Communication

Six qualitative studies described communication from a combination of perspectives. Groups noted limitations of the virtual environment that prevent in-person evaluations, such as a physical exam or biological testing.244, 292, 298 Other difficulties were described as hearing difficulties, language barriers, and technical issues.296 Distractions in the home environment were also noted.298 Some patients were not able to engage during telehealth visits owing to sleeping, personal issues, or not being physically and emotionally available.299 Patients and caregivers expressed concerns about the maintenance of boundaries between patients and providers and between work/non-work hours.233

Two surveys of patient/caregiver groups reported that telehealth improved communication with their healthcare provider.300, 301

3.4.2.3.6. Access

Nine qualitative studies described perspectives related to access from mixed study populations. Telehealth may be a means to improve equity/expand access, but it comes with technical difficulties.298, 302 One critical barrier was the “paradoxical impact” on inequities, whereby virtual technologies could improve the distribution of healthcare services for those who already have access to healthcare.297 Patient/caregiver interviews noted technological difficulties,233, 244, 303 specifically regarding ease of use and learning curves for both therapists and patients;233 using tele-rehabilitation would depend on assessment of a person’s physical, and digital, ability.292 The telephone was seen as an effective method for obtaining a clinical history, but video appointments were necessary for examination of wounds; the overall preference was for an in-person evaluation.304 Review of patient medical records also highlighted technical difficulties accessing services, including ‘‘technicality,’’ ‘‘engagement,’’ and ‘‘scheduling,’’ or not specified.299 The barrier of scheduling issues was echoed in patient medical records, revealing that patient/caregivers who had other scheduled or unscheduled events, sometimes forgot the appointment or had conflicts.299 One study from the patient/caregiver perspective highlighted challenges using the online system.305 Telehealth worked better for some patients if a caregiver was present to facilitate/support video calling.292 Staff and patients chose the telephone as an easy and accessible platform for communicating and did not consider that there was any added benefit from having a video function.206

Two surveys of patient/caregiver groups reported that they had no problems accessing telehealth and, further, described telehealth as easy to use.301, 306

3.4.3. Satisfaction and Dissatisfaction With Telehealth

3.4.3.1. Patient Perspective of Satisfaction and Dissatisfaction With Telehealth

3.4.3.1.1. Ease of Use

Five qualitative studies described satisfaction with ease of use of telehealth from the patient perspective. Patients noted the convenience of telehealth159, 289, 307 and felt that telehealth appointments increased appointment flow289 and provided better access.307 “A further aspect to consider when evaluating the satisfaction with telehealth in this study is that many patients were grateful to receive care during the COVID-19 pandemic and considered telehealth to be the safest and only option.”142 In addition, a mixed-model clinic structure (i.e., telehealth and face-to-face clinic provided simultaneously) was reported as ideal, as long as patients were able to see a doctor if their condition deteriorated, as well as annually/biannually for examination and ‘check[ing]-in.’142 However, one group of patients expressed concerns about the necessity of having a quiet home environment, free of distractions, or any other factors preventing them from learning or performing the self-administered tasks/treatments.156

Ten surveys described satisfaction or dissatisfaction with ease of use of telehealth.149, 181, 184, 279, 302, 308312 A common theme across surveys was patients noting that telehealth was convenient.184, 279, 308, 310 Another theme was ease of scheduling, set up, and use of the systems for healthcare.149, 309, 311, 312 One study reported that patients found it very difficult to set up a telehealth appointment181 and another cited distractions in the home environment as an impediment to use.302 The survey and qualitative data were similar in that half of the included studies were U.S.-based, otherwise they were not similar in terms of mode of telehealth delivery, patient condition, or timing of the study (Appendix C, Results Table C.7).

We have moderate confidence that patients are satisfied with the ease of use of telehealth. Our confidence is limited owing to insufficient detail related to data collection and analysis and limited discussions of satisfaction in three of the five studies (Appendix C, Results Table C.8; Appendix D, Evidence Table D.22; Table 19). Information collected via surveys supports the findings that patients find telehealth easy to use.

Table 19. Summary of the evidence for patient satisfaction and dissatisfaction (N=30).

Table 19

Summary of the evidence for patient satisfaction and dissatisfaction (N=30).

3.4.3.1.2. Access

Five qualitative studies described satisfaction with access to telehealth from the patient perspective. Patients noted telehealth as a convenient method for accessing care.144, 313, 330 Access to care (i.e., attendance and engagement), especially for those who might be unable to travel to appointments, was facilitated by telehealth.330 When discussing access, patients also raised concerns about ethical issues, for which patient consent to use personal data and closed/password-protected online sessions were recommended to prevent uninvited interruptions.160 Suggestions for what would be helpful included simplifying the process of connecting to the virtual platform and improving Wi-Fi connectivity issues.140 Additional concerns regarding appointment scheduling were discovered in studies conducted later in the COVID-19 era. Patient portals for scheduling were cited as an issue,213 as well as portals for access to the clinicians: for instance, difficulty with the portal and video conferencing;138, 175 and administrative “gate-keeping,” where clinical support staff prevented contact with the providers.213, 314

Five surveys described satisfaction with access to telehealth.142, 176, 179, 239, 331 Satisfaction was rated for convenience and ease of access to care179, 239, 331, 332 and a desire to continue to use telehealth for care.142 Study populations in the qualitative studies and surveys were not comparable except for mode of telehealth delivery; both the qualitative studies and surveys collected information primarily from patients who received telehealth via video (Appendix C, Results Table C.7).

We have moderate confidence that patients express both satisfaction and dissatisfaction with access to telehealth care. There was a lack of detail about data collection and analyses in more than half of the studies, reducing our confidence in the findings (Appendix C, Results Table C.8; Appendix D, Evidence Table D.22; Table 19). The survey data support the finding that patients were satisfied with telehealth as a convenient way to access care; there were no survey data that recorded concerns about access.

3.4.3.1.3. Health Outcomes

Eleven qualitative studies described satisfaction with health outcomes associated with telehealth from the patient perspective. Patients generally described telehealth as positively impacting patient convenience and the overall experience.147 In one study, attendance was high and all parents stated that overall satisfaction with care was high; more than 90 percent of respondents reported satisfaction with telehealth consults and 100 percent reported satisfaction with treatment procedures via telehealth.315 Other studies cited satisfaction about the relaxed atmosphere of telehealth;316 and, in a study on exercise, the participants believed telehealth to be instrumental in their continuation of physical activity during the COVID-19 era.163 Online integrative oncology treatment was identified by patients to have beneficial effects that included increased feelings of caring, containment, support, calm, and empowerment.156

Challenges and dissatisfaction were noted in obstetrics and gynecology, specifically regarding pregnancy: patients felt that their health concerns were not adequately addressed during telehealth visits, and there was an overall sentiment that telehealth was inappropriate for this population.165, 173

Four surveys identified satisfaction or dissatisfaction with telehealth’s impact on health outcomes.179, 333335 Patients felt safer seeing their providers remotely333 and noted that they believed that the telehealth visit helped with their reported complaints. Patients also noted that they felt that a face-to-face exam would have been better, citing blood pressure cuffs and Doppler imaging as examples of things that would improve their care and outcomes.179, 335 Qualitative data on oncology patients were collected in three studies taking place in three different countries; survey data were also collected in multiple countries, otherwise they were not similar in terms of mode of telehealth delivery, patient condition, or timing of the study (Appendix C, Results Table C.7).

We have high confidence that patients are satisfied with the health outcomes from telehealth and find that it is beneficial to their overall care and receipt of treatment procedures. Our limited concerns are owing to insufficient data provided about data collection and analysis; however, sufficient descriptions of outcomes had a strong impact on our confidence. (Appendix C, Results Table C.8; Appendix D, Evidence Table D.22; Table 19). In general, the survey data agreed with the qualitative data. However, two surveys noted that face-to-face interactions would have been better for recording blood pressure or Doppler readings and could have improved outcomes in ways telehealth could not.

3.4.3.1.4. Communication

Nine qualitative studies described satisfaction with communication associated with telehealth from the patient perspective. Patients noted being satisfied with having access to see and discuss their health concerns with a telehealth nurse, whom they appreciated being the same telehealth nurse for each visit.140 This same group of patients perceived greater accessibility in scheduling visits.140 Other patient groups responded that the telehealth platform facilitated building and maintaining relationships between family and healthcare providers,318 resulting in retained independence and social connectedness throughout the COVID-19 pandemic,319 as well as maintaining ongoing treatment discussions when patients were not able to go to the office in person.156 Some patients felt that telehealth was comparable to in-patient visits and that appointments were less rushed.144 In addition, being at home provided an added layer of comfort and safety,144, 336 and the platform allowed them to ask more questions.144 Patients with specific healthcare needs (e.g., prostate check, intrauterine device removal) required in-person examination and care, resulting in increased peace-of-mind and confidence.159 Among a group of patients completing group teletherapy, participants preferred to have at least one in-person meeting to meet other patients and build relationships.322 Patients were generally understanding of the limitations resulting from the COVID-19 pandemic and the necessity to transition to an online platform, which they felt facilitated building and maintaining relationships/rapport.160

Several challenges in communicating via telehealth platforms were noted in three studies. Patients noted difficulties with masks and telehealth,315 difficulty hearing one another properly,160 and challenges with scheduling followups and other future appointments.315

To support and enhance communication, patients suggested user-centered technical features that included interactivity, were visually instructive and informative, and allowed connectivity through messaging.321 Other recommendations included using secure e-mail and video methods that facilitate remote connectivity and communication.152

More surveys than qualitative studies collected data on satisfaction and dissatisfaction with communication (N=19)140, 142, 148, 149, 181, 184, 185, 239, 279, 304, 309, 312, 315, 329, 334, 337340. Overall, patients expressed satisfaction with provider/staff understanding of patient concerns,148, 181, 184, 239, 337, 338, 340342 and they also felt their needs were being met in the telehealth exams.148, 181, 184, 343 Patients also noted that telehealth did not negatively impact their satisfaction with treatment explanation149, 181, 312, 315, 334 or overall experience.140, 185, 339 Although, in general, patients noted satisfaction with telehealth and did not note much difference between telehealth and in-person visits,142, 304, 329 one study found the opposite position among surveyed patients.142 Most of the surveys were conducted early in the era of COVID-19, whereas qualitative data were collected more commonly during the general period of COVID-19. Both qualitative studies and surveys were conducted in multiple countries, otherwise they were not similar in terms of mode of telehealth delivery, patient condition, or timing of the study (Appendix C, Results Table C.7).

We have moderate confidence that patients are satisfied with telehealth and its impacts on communication. Our concerns are owing to the lack of sufficiency of detail across studies regarding data collection and analyses. We are also concerned about the sufficiency of discussion about communication as it applies to telehealth (Appendix C, Results Table C.8; Appendix D, Evidence Table D.22; Table 19). The survey data support the findings of the qualitative studies in reference to satisfaction. While the qualitative studies found some dissatisfaction with communication via telehealth, a single survey noted that telehealth limited patient communication with their providers.

3.4.3.1.5. Privacy

Eight qualitative studies addressed patient satisfaction with privacy in telehealth. Two studies found that patients were satisfied with telehealth and privacy; one study of adolescents344 demonstrated that patients 13 years and older liked the ability to access their patient portals, and another of adults163 taking online exercise courses were less self-conscious in their groups. Two studies were neutral about any privacy issues that may exist during telehealth.169, 325 Five studies noted general dissatisfaction with telehealth privacy: patients perceived telephone counseling as more impersonal compared with in-person evaluations and noted inadequate privacy in the home environment to receive counseling services.336 Three studies gathered information pointing to lack of safety and privacy in the home environment.138, 174, 323 Finally, one study noted concerns about telehealth and privacy of information about self-harm and suicide.324

Three surveys addressed privacy as a measure of satisfaction among patients.142, 340, 345 Across these three surveys, patients noted that they felt that their privacy was protected during telehealth consultations. These surveys and qualitative studies are not comparable: the qualitative study took place in the United States via telephone-only administration of telehealth in an opioid treatment population later in the COVID-19 era, whereas the surveys were conducted in multiple countries with mixed modes of telehealth delivery (Appendix C, Results Table C.7).

We have high confidence that patients express both dissatisfaction and satisfaction related to privacy and telehealth. We had only minor concerns with the evidence owing to the lack of sufficiency of detail across studies regarding data collection and analyses (Appendix C, Results Table C.8; Appendix D, Evidence Table D.22; Table 19). The survey data do not support the finding that patients are dissatisfied or concerned about privacy issues with telehealth.

3.4.3.1.6. Benefits

Thirteen qualitative studies described patient-perceived benefits of telehealth. Telehealth was positively received by many patients,155, 315 especially as it provided a safe and contact-free alternative throughout the COVID-19 pandemic,307 which enabled continuity of care.145, 152, 159, 326, 327 Although some patients were skeptical of the quality of telehealth visits, especially for evaluations requiring physical assessment (e.g., eye exams), others were very satisfied and felt that the telehealth appointment was just as good as in-person, with the added benefits of convenience and ease of use.152, 166, 313 Telehealth was perceived to facilitate increased levels of communication, which translated into personalized care and positive health impacts.145 Patients also reported benefits of telehealth that included reduced hassle, time, and costs associated with traveling to appointments.326 Other patients described a positive experience associated with telehealth154 and telephone consultations,150 rating the experience as good as in-person care, especially in regards to communication, building rapport, and sharing information.145, 150 Patients reported being satisfied and having their needs met, stating they would likely choose telehealth over an in-person visit.144

There were no surveys that collected data about telehealth in the context of patient satisfaction as a benefit.

We have moderate confidence that patients are satisfied with telehealth and express their satisfaction by describing benefits. Our concerns are owing to a lack of information related to data collection and analyses. Further, discussions about the benefits of telehealth were only moderately described (Appendix C, Results Table C.8; Appendix D, Evidence Table D.22; Table 19).

3.4.3.1.7. Preferences

Ten qualitative studies described patients’ preferences regarding telehealth. Although patients described similarities between telehealth and in-person appointments,289 the preference was for face-to-face, in-person appointments.152, 166, 289 Patients felt that in-person evaluation facilitated easier conversations with providers, enhancing rapport.152 In addition, preferences for telehealth versus in-person evaluations were typically based on the health issues patients were presenting with (including severity of symptoms, likelihood of needing a physical exam, and whether they felt that they could explain themselves more clearly in-person),159, 307 in addition to the benefits provided by a virtual appointment (e.g., convenience and efficiency).152 This was especially true for patients who thought telehealth appointments were the best environment for discussing personal health problems.307 Video consultations were seen as more acceptable and were better received than telephone consultations;289, 307 however, the latter were preferred over video appointments in the case of a short followup appointment.143 Patients were apprehensive about the legitimacy of telehealth328 but were grateful for the added safety in light of the COVID-19 pandemic.146 In addition, patients expressed that telehealth was not well-suited for all groups, such as those who had recently undergone major surgery.329 Some felt that telehealth was acceptable after an initial, in-person evaluation307 and that an established relationship between patient and provider was critical.166 Other patient groups felt that telehealth was especially useful for triaging patients to in-person evaluation.143, 166 Patients preferred telehealth appointments that were less than one hour in length, to limit the tiring effect of looking at the computer screen.146 In one study, patients expressed wanting some customizable functionalities that encourage greater engagement and accountability.321

There were no surveys that collected data about telehealth in the context of preferences impacting patient satisfaction.

We have high confidence that, in general, patients prefer face-to-face visits with their healthcare provider but noted that telehealth was more convenient and may be better suited for some forms of care. We had minor concerns about data collection and analyses, but descriptions of preferences were thorough across the included studies (Appendix C, Results Table C.8; Appendix D, Evidence Table D.22; Table 19).

3.4.3.1.8. Concerns

Five qualitative studies described patients’ concerns about telehealth. Patients described the challenges in conducting a telehealth appointment in view of complex care needs;137 some had anxiety and skepticism regarding telehealth and setup166 and others stated a reduced confidence in providers.137 There were some sentiments that telehealth appointments were less personal than in-person appointments with physical exams.307 Patients sometimes found communication challenging, reporting difficulties hearing and challenges with followups and scheduling future appointments.315 In addition, the use of telehealth was less common when obtaining specialist care, which often required in-person evaluation (e.g., dentistry).327

There were no surveys that collected data about telehealth in the context of concerns impacting patient satisfaction.

We have moderate confidence that patients have concerns about telehealth use for complex care, as well as concerns about setup and the lack of personal care via telehealth. Our concerns about methodology were primarily about limited findings applicable to satisfaction with telehealth (Appendix C, Results Table C.8; Appendix D, Evidence Table D.22; Table 19).

3.4.3.1.9. Suggestions

Four qualitative studies focused on patient suggestions or facilitators to improve telehealth. In these studies, patients suggested several facilitators for successful implementation. Patients felt that telehealth consultations required mutual trust between the patient and their provider; this was seen as easier to accomplish for preexisting relationships with the healthcare provider, suggesting that developing rapport/relationships with the care team might be challenging for new patients.159 In one study, many patients reported a beneficial effect of telehealth, including a sense of caring and support, feeling empowered, and feeling that the appointment was calming. Telehealth facilitated patient self-efficacy and involvement in their own care.156 One study suggested additional training and technical support be provided to patients to better facilitate their telehealth visit,139 while another suggested that hybrid models of care be developed to better develop a therapeutic relationship and facilitate interpersonal connections.139

There were no surveys that collected data about telehealth in the context of suggestions or facilitators impacting patient satisfaction.

We have low confidence that patients’ suggestions of trust development, developing rapport, additional technical support, and hybrid models of care are facilitators to telehealth. We have serious concerns about the detail surrounding data collection, data analysis, and presentation of findings (Appendix C, Results Table C.8; Appendix D, Evidence Table D.22; Table 19).

3.4.3.2. Provider Perspective of Satisfaction and Dissatisfaction With Telehealth

3.4.3.2.1. Ease of Use

Five qualitative studies described provider satisfaction regarding ease of use of telehealth. Providers indicated advantages to telehealth, including that it is more convenient,194, 242 provides flexibility and greater access to patients,242 is more efficient in terms of time and utilization of office space,329 allows for remote work,255 and supports greater inclusion of caregivers.194 However, this same group of providers felt that, overall, while telehealth works well for their work schedule, there is a lack of internet access in rural settings, and it is a tedious system.194 To deal with the emergent nature of telehealth, providers reported leveraging existing systems, especially triage systems, to do the following: assess patient needs, communicate and support care-related decisions, ensure seamless transitions of care, and provide specialized support (e.g., bereavement and grief support services).241

Eleven surveys described provider satisfaction or dissatisfaction with ease of use of telehealth. 143, 181, 190, 201, 242, 280, 286, 287, 337, 346, 347 Providers noted that telehealth was convenient and easy to use for both their practices and their patients.143, 190, 201, 227, 242, 286, 337, 346 While ease of use was commonly noted, some providers noted that integrating telehealth into current practice was difficult,286 citing difficulty in coordination and setup.181, 280 Some providers also had difficulty in providing care and noted that consultations were uncomfortable.181, 242, 287, 347 Populations across the qualitative data and survey data were not comparable (Appendix C, Results Table C.9).

We have low confidence that providers are satisfied with telehealth, find it easy to use, more convenient, efficient, and perceive that it provides better access to patients. Our confidence is limited owing to a lack of sufficient details about qualitative methodology, which resulted in an inability to assess rigor. Additionally, there was a lack of detail in descriptions regarding ease of use in three of the five studies (Appendix C, Results Table C.10; Appendix D, Evidence Table D.22; Table 20). The survey data support the qualitative data.

3.4.3.2.2. Access

Four qualitative studies described provider perspectives regarding access to telehealth. Providers noted being generally satisfied with the telehealth platform, stating that telehealth provides benefits to both staff and patients.229 Perceived benefits to patients included patients not having to travel, find parking, or sit in waiting rooms, providing a level of convenience not comparable to in-person visits.189, 286 Providers noted that some patients are not well served by telehealth, such as those who are more difficult to reach and engage via telehealth (e.g., patients with mental health conditions).229 Some providers reported issues, for both themselves and their patients, with insufficient technological infrastructure (particularly related to internet connections), describing a lack of sufficient support from the organization to help with software or devices used to access the technology.231 In addition, providers felt that they needed a very user-friendly video call tool to ensure privacy standards are met, in addition to wanting features such as a digital white board, the ability to transfer files securely, and capacity for support group sessions.231

Five surveys described provider satisfaction with access to care.143, 179, 340, 348, 349 Surveys gathered information about providers’ general satisfaction with access to care via telehealth,143, 348, 350 as well as provider impressions that patients can access and use telehealth.143, 179 Results from one survey identified dissatisfaction with access as it applies to cost of telehealth to providers.349 Populations across the qualitative data and survey data were not comparable (Appendix C, Results Table C.9).

We have moderate confidence that providers are overall satisfied with telehealth and believe it can increase access to care for patients in terms of travel and time. However, we have the same level of confidence that providers were dissatisfied with telehealth owing to poor infrastructure and difficulty accessing technology for both providers and their patients, potentially limiting long-term implementation. While findings are well described, our confidence is limited owing to inadequate details about qualitative methodology, which limited our ability to address methodologic rigor (Appendix C, Results Table C.10; Appendix D, Evidence Table D.22; Table 20). The survey data support the qualitative data.

Table 20. Summary of the evidence for provider satisfaction and dissatisfaction (N=54).

Table 20

Summary of the evidence for provider satisfaction and dissatisfaction (N=54).

3.4.3.2.3. Health Outcomes

Fifteen qualitative studies described provider satisfaction or dissatisfaction with health outcomes of telehealth. Overall, providers described telehealth as increasing accountability,242 improving treatment accuracy and effectiveness,351 and increasing efficiency over face-to-face contact.241 Providers felt that telehealth was especially useful in triaging patients.259 The virtual environment meant that patients were more likely to keep appointments,189, 326 which resulted in greater compliance,242 increased patient comfort and safety,242 improved therapeutic relationships,242 and overall positive patient experiences.259 Providers noted that using telehealth services negates infection risk in hospital settings351 and minimizes the risk of COVID-19 transmission.287 Others noted positive outcomes that included opportunities for patients to learn treatment skills for use in home settings228 and opportunities for providers to gain additional information about the patient: for instance, a registered dietician may be able to “look into” a patient’s refrigerator/pantry to understand home environment and diet.189 One study reported that providers perceived that telehealth interactions resulted in increased focus on the topic, conciseness of the appointment, and an increased length of assessment; however, telehealth also resulted in less time or opportunity to manage all of the information.265 Providers felt more control over their schedules and a slowed pace, resulting in more peaceful and relaxing interactions with patients.214

When discussing negative outcomes associated with telehealth, providers described challenges delivering treatment protocols via telehealth,228 including a lack of physical exam,236, 259 which complicated their ability to diagnose and treat certain conditions.236 This negatively impacted both the quality202, 254 and continuity of care245 and represented reduced accountability.242 One example of this was unsupervised exercise and incorrect technique.279

Twelve surveys identified satisfaction or dissatisfaction with telehealth’s impact on health outcomes.179, 181, 219, 230, 242, 283, 284, 286, 304, 348, 355, 358 Providers noted that telehealth added value to treatment, in general,286, 304 and particularly during couple’s therapy.355 Further, providers expressed confidence that diagnoses were accurate, client concerns were addressed, and equality of telehealth were equivalent to in-person care.181, 242, 358 Contrary to those perceptions, some providers noted that they felt examinations suffered from lack of physical contact and the possibility to miss signs/indications of illness.179, 242, 284, 348 Providers did not notice a lower frequency of no-shows to therapy appointments,230 and did not observe positive patient outcomes compared with face-to-face care.219, 283 Populations across the qualitative studies and surveys were not comparable (Appendix C, Results Table C.9).

We have moderate confidence that providers were both satisfied and dissatisfied with telehealth’s impact on patient outcomes. Providers provided conflicting thoughts about accountability and treatment accuracy. Our confidence is limited owing to a lack of details about qualitative methodology, along with inadequate detail about outcomes in four of the 15 included studies (Appendix C, Results Table C.10; Appendix D, Evidence Table D.22; Table 20). The survey data support the qualitative data.

3.4.3.2.4. Communication

Twenty qualitative studies described communication via telehealth from the provider perspective. Some providers felt that telehealth facilitated conversations with and increased engagement of patients.214, 230, 242, 279 While providers agreed that clear, concise, and definitive communication was instrumental to efficient care and maintaining morale (of both staff and patients), the evolving nature of the COVID-19 pandemic made such definitive communication challenging.257 Providers perceived telephone conversations as more “business like,” enabling greater ability to run their clinic.259 Providers also discussed feeling more comfortable refusing patient requests during telehealth visits236 and sometimes used apps to draw attention to important aspects related to disease or treatment.286

Conducting services via telehealth, especially for those providing mental health services, made building rapport with patients more difficult,214, 219, 231, 242, 255, 259 which reduced the patient experience and resulted in an impersonal experience.242 Telehealth may be challenging for long, in-depth sessions255 for new patients or those who require a more thorough exam.202, 259 Providers noted the lack of personal connection and touch,236 the inability to fully assess patient status202 and provide a hands-on physical examination,245 and communication difficulties owing to sensory impairment, inadequate equipment, and uneven connectivity (e.g., in rural communities).262 Further, providers noted the inability of the virtual environment to fully support nonverbal communication231, 259, 326 or to convey visual cues (especially when using the telephone);264 providers also reported needing to use visual aids.245 These factors were associated with difficulties in providing emotional support for sensitive topics265 and sometimes resulted in providers having to reassure patients that the standard of care would be maintained.352

To facilitate outreach and assessment, providers described needing to proactively assess high-risk patients, screen for social determinants of health, keep up-to-date records, and consent patients to telehealth early or on admission.352 Further, providers felt that linking primary and secondary care could ease transitions of care.353 Providers suggested a timely in-person followup visit245 and efforts to build connectedness to counter less frequent in-person connections.352 Other issues noted by providers were poor availability of patients by telephone286 and legal issues, such as the indemnification between the patient and provider, potentially resulting from their virtual interaction.234 Despite these challenges, once adapted, some providers described being able to spend longer times with each patient and being able to connect well with them.214

Twelve surveys identified satisfaction or dissatisfaction with the effect of telehealth on communication.181, 198, 201, 219, 242, 284, 288, 333, 362365 Providers expressed general satisfaction with telehealth as it influences communication.362365 They noted that telehealth was equivalent to in-person care when establishing rapport and engagement with patients,363, 365 and they noted that patients were able to express themselves and understand their conditions during telehealth.201, 284, 363 They also noted that their communication was effective181, 219 and that their relationship with patients improved.242 Other groups of providers noted the opposite: video counseling was an impediment to communication and patient engagement.198, 219, 288, 364 Populations across the qualitative data and survey data were not comparable (Appendix C, Results Table C.9).

We have moderate confidence that providers are dissatisfied with telehealth: it can impede provider/patient communication owing to the impersonal nature. Findings regarding communication are well described, however, our confidence is limited owing to poor reporting of methods, which limited our evaluation of rigor (Appendix C, Results Table C.10; Appendix D, Evidence Table D.22; Table 20). The survey data are partially in agreement with the qualitative studies. While the qualitative studies point to telehealth as an impediment to communication, providers responding to surveys indicated that patients expressed themselves more freely and that telehealth was equivalent to in-person care in establishing rapport. Some surveys agreed with the qualitative studies in that telehealth was noted as an impediment to communication.

3.4.3.2.5. Benefits

Twenty-four qualitative studies focused on the benefits of telehealth from the provider perspective. Although some providers viewed in-person assessment as superior, telehealth was found to be beneficial and to increase accessibility during the time of limited in-person engagement.255, 258 Providers viewed telehealth as a sufficient alternative to in-person evaluation that resulted in risk reduction for patients and providers,238, 243, 253, 255, 257 shorter consultation lengths, and narrower gaps between need and demand (although there were concerns about access to services).287 Telehealth was seen as a tool to limit followup interruptions259, 354 and to ensure continuity of care and limit COVID-19 exposure.194, 203, 215, 354 Telehealth was viewed as inappropriate for new patients.259 Providers in one study noted an increase in remote healthcare delivery and acceptance since the start of the COVID-19 pandemic that they thought was facilitated by the availability of payments, the restructuring of policies to allow telehealth services, and the inclusion of remote consultations in appointment systems.253

Providers noted numerous benefits associated with video visits, including improvements to efficiency, capacity, and collaboration.232 With the added value of video to observe visual cues and assess physical status,143, 238, 259 clinical staff members were able to continue to see a full caseload of outpatients during pandemic quarantine.189 Telehealth appointments were particularly useful to see followup and post-operative patients and to more accurately triage and consult new referrals.239 Telehealth resulted in improved efficiency,232, 259 although not for all patient populations, such as patients requiring in-person assessment.230, 354 Noted benefits included continuation of services, increased availability, increased caregiver involvement, comfort of being at home, safety from COVID-19 exposure, increased flexibility, decreased travel time, preferred modality for some patients, and the integration of technology.258 Other noted benefits included more frequent use of telephone consultations,286 increased ability to collaborate,214 and convenience of and increased access to medical and counseling services.263 Also noted were increased ability to schedule appointments, the ability of patients to do more at home, and reduced barriers to telehealth use and care.357 Primary care visits conducted via telehealth visits tended to be shorter than in-person visits.236 Providers felt telehealth provided comparable care while preventing unnecessary travel, in addition to providing increased flexibility and convenience and enhanced connection.286 Providers in one study noted that the home environment promoted stronger therapeutic rapport and connections.355 Providers reported feeling favorably about the ability to work from home, which saved commuting time, increased capacity to see patients more efficiently, and facilitated issues related to childcare.356

There were no surveys that collected data about the satisfaction with benefits of telehealth from the perspective of the provider.

We have moderate confidence that providers are satisfied with telehealth and find it beneficial to patients and providers because it improves efficiency, capacity, and collaboration. Findings regarding benefits are well described; however, our confidence is limited owing to poor reporting of methods, which limited our evaluation of rigor (Appendix C, Results Table C.10; Appendix D, Evidence Table D.22; Table 20).

3.4.3.2.6. Preferences

Sixteen qualitative studies described provider preferences regarding telehealth. There was some preference for in-person assessments;255, 358 providers noted being generally satisfied with telehealth196, 255, 259 and perceived that patients found telehealth acceptable,202, 215 especially once they became familiar with the process.156, 218, 357 Providers felt that many components of in-person visits could be accomplished successfully via telehealth, including pain rehabilitation,227 and that telehealth was especially suitable for patients with less complex care needs.255 Telephone consultations were perceived as suitable for most patients;243 the telephone was seen as a primary alternative to video, either because it assuaged concerns about technical challenges with video consultations or because the general practitioner already saw most of their patients face-to-face.191 Providers did not feel there was any added benefit from having a video function.206 Other providers felt that telehealth should be a permanent option230 that could be integrated as a possible complement to in-person visits, reducing patient burden (e.g., travel time).354 As the pandemic waned, preferences for in-person visits replaced some of the initial appeal for telehealth appointments: “There was a strong feeling from respondents that they needed to catch up on concerns that patients had put on hold because they wanted to discuss them in person.”203

There were no surveys that collected data about telehealth in the context of preferences impacting provider satisfaction.

We have low confidence that providers are generally satisfied with telehealth and believe it can replace many aspects of in-person care. Providers noted that, over time, they needed to catch up on care put on hold during the pandemic. Our confidence is limited owing to a lack of details about qualitative methodology, along with inadequate detail about outcomes in 10 of the 16 included studies (Appendix C, Results Table C.10; Appendix D, Evidence Table D.22; Table 20).

3.4.3.2.7. Concerns

Seventeen qualitative studies discussed concerns with telehealth from the provider perspective. Overall, providers noted that, while telehealth was a good alternative, it should not replace in-person, face-to-face visits;219, 245, 258, 286, 357 they regarded telehealth as preventing a proper physical examination, necessary especially during initial medical evaluations and ongoing treatment phases.227, 259 In addition, providers felt that telehealth appointments are not well suited for all types of care, noting difficulty moving in-person appointments to patients’ homes.156, 359 While providers were generally dissatisfied with limited face-to-face, in-person contact,262, 279 video consultations were seen as “better than nothing.”360 Some providers felt that this choice depends on personal preference357 and expressed concerns about working remotely from their personal space.279, 357 Others felt that remotely-delivered care resulted in patients relying more heavily on them during off-hours.356 While many issues negatively impacted sustainability of the telehealth model, two primary issues stood out: not being able to conduct a physical exam and technical difficulties.238, 245, 258 Providers’ acceptance of video visits was similarly challenged by the technology and impact to workflow efficiency and communication.241, 245, 258 Providers were concerned about the sufficiency of telehealth in providing a long-term, successful outcome.227 They worried that patients who are critically ill and need to be seen in-person might fall through the cracks or be scheduled inappropriately for telehealth appointments.214 One way providers dealt with this was to request more investigations to clarify questions not answered in the virtual environment owing to the lack of physical examination.259 Some providers felt that more attention needed to be paid to understand relational processes in effectively communicating with patients via telehealth modalities.242 Many decision moments were present, however there was insufficient information available.286

There were no surveys that collected data about telehealth in the context of concerns impacting provider satisfaction.

We have high confidence that providers had some concerns leading to dissatisfaction of telehealth and felt that it should not replace face-to-face visits, as telehealth precludes physical exams and is not suited for all types of care. Findings regarding benefits are well described across all studies with a small percentage with poor reporting of methods, which limited our evaluation of rigor (Appendix C, Results Table C.10; Appendix D, Evidence Table D.22; Table 20).

3.4.3.2.8. Provider Suggestions

Eleven qualitative studies discussed provider suggestions for implementing telehealth services from the provider perspective. Providers felt that future use of telehealth should be considered in combination with traditional, in-person visits286 to ensure regular and appropriate followup, especially for particular patient populations (e.g., those who live far away from in-person care).351 Providers discussed the importance of stimulating the use of eHealth services to ensure successful and wide-spread implementation.357 Providers suggested that organizational readiness, engagement, and leadership are critical for successful telehealth implementation.361 Several factors to assess readiness to change and support the implementation of telehealth were suggested: (1) measuring awareness and acceptability among target groups; (2) providing safe, private, comfortable, and context-sensitive environments for patients; and (3) providing sufficient care across modalities.357

At the system level, facilitators to the implementation of telehealth included governmental or organizational supports, such as health reforms or strategies that facilitate the increased acceptance of telehealth services.253 At the organizational level, providers felt their ability to provide remote services was further enhanced by training and continuing education to achieve acuity in providing services via telehealth.219, 353 In addition, access to formal and informal inter-organizational networks and recognition of external policies and protocols were highlighted.361 Further, providing clinic staff with access to knowledge and information were seen as critical components to promoting provider and staff self-efficacy,361 and one study highlighted the need for careful consideration of providers’ workflows to avoid work overload and burnout.236 Regarding the latter, “It became easier when they found ways to introduce clients to the therapeutic frame, send intake forms via e-mail, and speak with their clients about the challenges that come with remote treatment.”219 Increased resolution of video images facilitated remote physical assessments.239 To mediate some of these issues, providers suggested: “(1) screen sharing to facilitate patient education and explain imaging results, (2) a waiting room function to replicate “stepping out of the room” when engaging with trainees, (3) a chat box for troubleshooting, (4) file sharing capabilities, (5) screenshot capabilities to support efficient charting, and (6) multi-person teleconferencing to include other members of the multidisciplinary team, interpreters, trainees, and family members in different physical locations.”245 Some providers noted that telehealth is here to stay and can no longer be ignored.257 To facilitate its sustainability, remote delivery of care was seen as needing equal payment structures and technological support.286 Social workers in one group noted that access to technology and other necessary supports facilitated their ability to complete their work, whether remotely or on-site via telehealth.257

There were no surveys that collected data about telehealth in the context of suggestions or facilitators impacting provider satisfaction.

We have moderate confidence that providers are satisfied with telehealth but suggested that telehealth in combination with in-person care should be considered for the future. Our confidence is limited owing to a lack of details about qualitative methodology, along with inadequate detail about outcomes in four of the 11 included studies (Appendix C, Results Table C.10; Appendix D, Evidence Table D.22; Table 20)

3.4.3.3. Other Populations’ Perspective of Satisfaction and Dissatisfaction With Telehealth

3.4.3.3.1. Ease of Use

One qualitative study of providers and hospital administrators noted that telehealth improved ease of completing visits.302

Two surveys of patients and their caregivers addressed ease of use. In one survey the respondents noted that the telehealth equipment worked well and it was easy to speak with the provider,366 and another survey noted some dissatisfaction of the patients and caregivers regarding the instructions for using telehealth.294

3.4.3.3.2. Access

Four qualitative studies of combined populations discussed telehealth access. One caregiver group noted being satisfied with not having to travel to appointments,295 and a group of patient and caregiver respondents noted the convenience of being able to complete testing at home.244 Patients and providers described reduced patient travel time and increased access owing to the ease of scheduling and accessing appointments.298 In another study, nurses and aides identified scenarios such as evaluating poor wound healing, signs and symptoms of infection, weight gain, and respiratory difficulties as issues for which telehealth (via video) would be especially useful.367 In this same study, patients and caregivers cited rashes, incisions, wounds, bleeding, and sore throat as issues for which the platform would be especially useful.367

Two surveys of patients and their caregivers identified positive aspects of access: one study noted that the respondents liked that the challenges of getting to their appointments were eliminated;295 another study noted the following benefits: no time away from work, no travel, and saved time.306

3.4.3.3.3. Health Outcomes

One study with both patients and hospital administrators concluded that telehealth improved patient comfort.302

There were no surveys that collected data about telehealth from other user groups in the context of impact on outcomes.

3.4.3.3.4. Communication

Four qualitative studies reported data regarding communication from combined populations. In a group of patient and hospital administrators, the majority of respondents felt that telehealth resulted in diminished human connection and rapport, resulting in part from an inability to read non-verbal communication.302 Patients and caregivers in one study noted telehealth as being subpar compared with in-person services, so telehealth was, therefore, not seen as a long-term solution or substitute for pre-COVID-19 era levels of care.368 One caregiver group described being able to receive a good level of care and compassion, even via telephone.369 Another patient/caregiver group provided generally negative feedback, citing technical difficulties (e.g., issues getting connected to the platform, losing internet connectivity), as well as limitations of evaluation within the virtual appointment.244 In most cases, staff and patients chose the telephone as an easy and accessible platform for communicating and did not consider that there was any added benefit from having a video function.206

Three surveys of patients and their caregivers addressed improved communication via telehealth. These groups noted that they were more comfortable about discussing their emotional health via telehealth,370 and they had the impression that providers were caring during the telehealth visit.371 Another survey identified overall satisfaction with/ease of communication via telehealth.301

3.4.3.3.5. Benefits

In general, users felt satisfied with their telehealth visit in terms of benefits.244, 304 Both patient/hospital administration groups,302 as well as patient/caregiver groups,305 noted the overall acceptability of telehealth and felt that it was especially adaptable to the COVID-19 pandemic.295 Joint provider/patient groups described telehealth as a “whole new way of working.”372 Patient/caregiver respondent groups were appreciative of clinics providing proactive care immediately after the onset of COVID-19 restrictions,303 noting that video calling was more valuable than receiving no support at all or only phone consultations.292

Telehealth was viewed as especially beneficial for certain types of patients, such as those with issues of mobility.373 Nurses and patients in one study identified a variety of benefits of using telehealth including convenience, saving time and money, and reducing stress.367 Caregivers/parents experienced good or improved communication with providers, highlighting enhanced feelings of connectedness, no waiting time or travel, not having to adjust work schedules/take time off, and not sitting in busy waiting rooms.369 Parent caregivers noted satisfying benefits of gaining time and not having to worry about their child missing school or having behavioral challenges at the hospital, for instance.295

There were no surveys that collected data about general benefits of telehealth from other user groups’ perspectives.

3.5. Results for Key Question 4

Key Question 4.

What strategies have been used to implement telehealth interventions during the COVID-19 era?

3.5.1. Key Points and Summary

  • No study compared implementation strategies for telehealth or provided a detailed description of their own implementation strategy, and fewer than half of the studies used a formal framework to design or evaluate their strategies.
  • Acceptability of telehealth services to patients varied considerably by the type of care and setting; for providers, acceptability was influenced by several factors, such as previous experience with telehealth and the type of care provided.
  • Adoption of telehealth among patients was variable across clinical settings and patient populations; whereas, adoption was generally accomplished in short timeframes among providers, but this seemed to be significantly affected by prior training in telehealth.
  • Feasibility of telehealth was sometimes limited by the availability of telehealth technologies for patients but was generally high among providers.
  • Fidelity of telehealth implementation, when measured, was generally positive (i.e., completed rate of the telehealth visits as planned).
  • We found insufficient evidence on implementation cost, penetration, and sustainability of telehealth services from the patient and provider perspectives.
  • Evidence on a health-system level was lacking for various outcomes of telehealth implementation (e.g., acceptability, adoption, appropriateness, feasibility, sustainability).

We identified 51 studies that assessed implementation of telehealth during the COVID-19 era (Appendix D, Evidence Tables D.23 through D.31). These studies aimed to develop a generalizable methodology to improve telehealth interventions during the COVID-19 era. None of the studies provided detailed descriptions of implementation strategies and only two of them compared strategies and/or patient groups. Only 18 of the studies used a formal and/or validated implementation framework to design and evaluate their implementation strategies (Table 21).

Most studies (N=23; 45.1 percent) were executed during the early COVID-19 era and were conducted in North America (N=37; 72.5 percent), with U.S. studies compromising 29 of those studies. Of the 51 studies, 35 (69 percent) reported using a mix of telephone and video to conduct the telehealth sessions, while 14 (27 percent) did not report details of their approach thus limiting the interpretation of findings.

Table 21. Implementation strategies and assessments with formal assessment frameworks (N=18).

Table 21

Implementation strategies and assessments with formal assessment frameworks (N=18).

3.5.2. Patient-Focused Studies

Twenty-five studies enrolled patients as participants to assess implementation strategies of telehealth in the COVID-19 era, with thirteen of these also including healthcare providers (Appendix D, Evidence Table D.24). Seventeen studies included adult patients, only; three studies focused on pediatric patients, only; four studies focused on a mix of adult and pediatric patients; and one study did not report the age group of the patients. Only half of the patient-focused studies (N=12) reported on the race/ethnicity of the patients and reported that 0 percent to 94 percent were White, and 0 percent to 67 percent were Black. Seven of these studies focused on mental health conditions, six studies concentrated on rehabilitation issues, and twelve studies targeted other medical conditions (e.g., obstetrics and gynecology, type 1 diabetes, cancer, orthopedics, Alzheimer’s and Parkinson’s diseases, and chronic pain). All of the studies, except one, implemented their telehealth intervention as planned. The planned implementation strategies varied from more traditional centralized telehealth services to mobile units offering telehealth services to patients living in rural areas.

3.5.3. Provider-Focused Studies

Thirty-nine studies targeted healthcare providers and health systems to evaluate the effectiveness of implementation strategies for rolling out telehealth services during the COVID-19 era (Appendix D, Evidence Table D.25). Nine studies assessed the feedback on the implementation strategies that were provided by mental health experts, six studies focused on rehabilitation experts, six studies enrolled primary care physicians, 17 studies included other types of specialties (e.g., neurology, obstetrics and gynecology, hepatology, ophthalmology, pediatrics), and one study did not specify the specialty of the providers. Twelve studies were conducted in large regional health systems, 18 studies were performed in single health systems, two studies were limited to specific clinics or centers, and seven studies either missed information on the type of the underlying health systems or included other types of health systems.

3.5.4. Implementation Strategies and Outcomes

Both patient-focused and provider-focused studies adopted a variety of strategies and different approaches/frameworks to assess the outcomes of telehealth implementation. All studies strategized to integrate and/or boost existing telehealth services into their routine clinical practices to minimize the negative effect of the COVID-19 pandemic. However, studies conducted different assessments to measure the effect of the telehealth implementation. The assessments ranged from descriptive statistics, surveys, interviews, to mixed-methods approaches. Only 18 of the studies (Table 22) used a validated assessment framework to measure the success of the implementation outcomes (e.g., Normalized Process Theory; Reach Effectiveness Adoption Implementation Maintenance/sustainment (RE-AIM); Normalization Process Theory). Studies with qualitative components extracted common themes from the patient and/or provider feedback. Overall, the qualitative themes suggested interest by patients in using telehealth services but also revealed potential barriers to the achievement of optimal outcomes of telehealth implementation (Appendix D, Evidence Table D.29).

Table 22. Implementation outcome categories covered by Key Question 4 studies (N=51).

Table 22

Implementation outcome categories covered by Key Question 4 studies (N=51).

3.5.4.1. Types of Implementation Outcomes

In most studies, healthcare systems did not have the time and resources to assess different approaches to telehealth implementation during the COVID-19 era. Indeed, no study evaluated implementation strategies directly, such as through comparison of implementation methods in a controlled study. We have thus described the measures commonly used to assess implementation outcomes and those results. We adopted the categories defined by Proctor et al. (2011) to summarize the implementation outcomes of the studies.29 Implementation outcomes were categorized and then summarized as acceptability, adoption, appropriateness, feasibility, fidelity, implementation cost, penetration, and sustainability (Appendix D, Evidence Tables D.30 and D.31). Acceptability describes the satisfaction among implementation stakeholders (e.g., patients, providers, healthcare organizations) with different aspects of the intervention (e.g., content, delivery). Adoption describes the rates of uptake or use of the intervention by the provider or healthcare organization. Appropriateness refers to the program suitability or compatibility at various levels of stakeholders (e.g., patient, provider, healthcare organization). Feasibility is the practicability of the intervention for everyday use by the providers or healthcare organization. Fidelity refers to the delivery of the intervention as designed. Implementation cost describes the assessment of marginal cost, cost-effectiveness, or cost benefit. Penetration is the degree to which the intervention was institutionalized. Sustainability is the continued delivery of the intervention beyond the study period.401

As Table 22 demonstrates, most studies focused on the acceptability, adoption, appropriateness, and feasibility outcomes of the implementation strategies. Fewer studies focused on fidelity, implementation cost, penetration, or sustainability of the telehealth implementation.

To assess the coverage of different types of implementation outcomes across studies, evidence was grouped using the implementation outcomes defined by Proctor et al. (2011)29 (Table 22, and Appendix D, Results Tables D.30 and D.31).

3.5.4.2. Acceptability

3.5.4.2.1. Patients

Patient satisfaction and confidence with telehealth services varied widely by the type of care and setting in which it was delivered. For example, telehealth for services that required physical manipulation were more burdensome on patients and caregivers than telehealth services that did not require physical manipulation (e.g., telerehabilitation versus teleconsultation). However, patients were satisfied if those healthcare interventions were meant to reduce isolation and improve interpersonal connection179, 251, 375, 377, 400, 402408 (Appendix D Table D.30).

3.5.4.2.2. Providers

Several factors appeared to influence provider satisfaction with telehealth services, such as the type of healthcare provided, availability of home health devices, previous experience with telehealth technology, and established workflows179, 245, 251, 324, 383, 392, 395, 403, 405, 406, 409416 (Appendix D Table D.31).

3.5.4.2.3. Patients and Providers

Telehealth interventions that increased access in target patient populations were acceptable to both patients and providers; however, patients and/or providers agreed that healthcare services requiring a physical exam, manipulation of the patient, or equipment for patient assessment were best supplemented with in-person visits245, 375, 379, 396, 404, 406, 409, 411, 412, 414, 416418 (Appendix D Tables D.30 and D.31).

3.5.4.2.4. Health System

No evidence.

3.5.4.3. Adoption

3.5.4.3.1. Patients

Adoption of telehealth services was variable across clinical setting, digital literacy of the patient population, and the urgency with which patients required healthcare services251, 374, 375, 377, 379, 397, 399, 402, 406, 419, 420 (Appendix D Table D.30).

3.5.4.3.2. Providers

Adoption of telehealth services was relatively quick among providers; however, the efficiency of adoption depended on prior training of the providers using telehealth services245, 251, 278, 290, 324, 383, 385, 387, 388, 392, 395, 400, 406, 414, 421 (Appendix D Table D.31).

3.5.4.3.3. Health System

No evidence.

3.5.4.4. Appropriateness

3.5.4.4.1. Patients

Telehealth showed varying levels of appropriateness across patients. For example, telehealth visits were found to be appropriate for patients requiring timely followups and continuity of care but not suitable for patient populations requiring physical examination, having acute illnesses, or requiring the collection of data from young children99, 251, 374, 375, 400, 402, 407, 414, 416, 417, 419 (Appendix D Table D.30).

3.5.4.4.2. Providers

Telehealth was assumed to be mostly appropriate for outpatient visits (e.g., prenatal care, COVID-19 visits); however, those services were found to be not appropriate for specific services (e.g., group therapy, physical examination, or services requiring assistance from a caregiver or participation of young children)179, 245, 251, 290, 385, 392, 393, 395, 396, 400, 403, 406, 408, 410, 411, 415, 416, 422, 423 (Appendix D Table D.31).

3.5.4.4.3. Health System

No evidence.

3.5.4.5. Feasibility

3.5.4.5.1. Patients

Feasibility of telehealth services was sometimes limited by technological challenges, lack of privacy, and missing medical equipment (e.g., thermometers, oximeters) at the patient’s residence99, 374, 381, 397, 400, 402, 414, 415 (Appendix D Table D.30).

3.5.4.5.2. Providers

Telehealth reduced the wait times (backlogs), as well as no-shows, hence increasing workplace flexibility; however, certain visit types took longer than planned (e.g., visits that required moving the camera for physical examination)278, 383, 392, 397, 399, 411, 413 (Appendix D Table D.31).

3.5.4.5.3. Health System

No evidence.

3.5.4.6. Fidelity

3.5.4.6.1. Patients

We identified three studies reporting completion of visits by patients375, 404, 414 (insufficient evidence).

3.5.4.6.2. Providers

One study discussed the fidelity of visits by providers416 (insufficient evidence).

3.5.4.6.3. Health System

Various health systems demonstrated the achievement of an acceptable rate of the planned telehealth visits as originally designed, with modest modifications179, 245, 387, 388, 397, 423, 424 (Appendix D Table D.31).

3.5.4.7. Implementation Cost and Penetration

3.5.4.7.1. Patients

Two studies calculated the saved costs associated with the receipt of telehealth by patients179, 414 (insufficient evidence). None of the studies assessed the penetration of the implementation strategy across other patient populations.

3.5.4.7.2. Providers

None of the studies focusing on providers calculated the incurred or saved costs associated with telehealth implementation. None of the studies assessed the penetration of the implementation strategy across other providers and/or health systems.

3.5.4.7.3. Health System

No evidence.

3.5.4.8. Sustainability

3.5.4.8.1. Patients and Providers

Sustainability of telehealth services was mostly assessed qualitatively (e.g., intention of patients or providers to use telehealth after the COVID-19 pandemic)179, 245, 392, 408, 414 (Appendix D Tables D.30 and D.31).

3.5.4.8.2. Health System

No evidence.

3.5.5. Summary of Findings

As shown in Table 23, we generally have low confidence in our conclusions about the outcomes from telehealth implementation (i.e., low strength of evidence). This was mainly because there were no trials and most studies did not have a comparison or control group, did not apply protection against bias, often did not compare telehealth with routine care, and were frequently single site studies.

Table 23. Summary of findings for implementation outcomes.

Table 23

Summary of findings for implementation outcomes.