Figure 8.11. Nuclear export.

Figure 8.11Nuclear export

Complexes between target proteins bearing nuclear export signals (NES), exportins, and Ran/ GTP form in the nucleus. Following transport through the nuclear pore complex, Ran GAP stimulates the hydrolysis of bound GTP, leading to formation of Ran/GDP and release of the target protein and exportin in the cytoplasm. Exportin is then transported back to the nucleus.

From: The Nuclear Envelope and Traffic between the Nucleus and Cytoplasm

Cover of The Cell
The Cell: A Molecular Approach. 2nd edition.
Cooper GM.
Sunderland (MA): Sinauer Associates; 2000.
Copyright © 2000, Geoffrey M Cooper.

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