NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Pancreatic adenocarcinoma is a highly lethal disease that is histologically characterized by a dense desmoplastic reaction (DR) surrounding malignant epithelial cells. The DR is composed of extracellular matrix (ECM) proteins, fibroblasts, stellate cells, endothelial cells, immune cells, and neurons. Accumulating evidence indicates that the epithelial and stromal compartments interact to enhance the aggressive nature of this disease. Pancreatic cancer cells release various factors that stimulate the stroma. Stromal cells, in turn, release mitogenic substances that stimulate tumor growth, invasion, and resistance to therapy. As we better understand the interactions between the stromal and epithelial cell compartments in pancreatic adenocarcinoma, it is becoming evident that anticancer therapies targeting the stroma, in addition to epithelial cells, may play a key role in improving clinical outcomes for patients with this deadly disease.
Contents
- PrefacePaul Grippo, PhD and Hidayatullah G. Munshi, MD.
- Foreward: It takes two to tango : Pancreatic cancer and its microenvironmentMinoti Apte, MBBS., MMedSci., PhD., AGAF.
- Contributors
- 1. Pathology of pancreatic stroma in PDACZeshaan A. Rasheed, William Matsui, and Anirban Maitra.
- 2. Imaging the pancreatic ECMPalamadai N. Venkatasubramanian.
- 3. Pancreatic stellate cells and fibrosisPhoebe Phillips.
- Introduction
- The microenvironment of pancreatic cancer
- The biology of pancreatic stellate cells
- Role of pancreatic stellate cells in pancreatic fibrosis
- The role of cancer-stellate cell interactions in tumor progression
- The hypoxia fibrosis cycle
- Role of pancreatic stellate cells and fibrosis in epithelial- mesenchymal transition
- Targeting pancreatic stellate cell mediated fibrosis: A potential therapy
- Summary Points
- Conclusion
- Acknowledgements
- References
- 4. Pancreatic cancer and the tumor microenvironment: Mesenchyme’s role in pancreatic carcinogenesisLaurent Bartholin.
- 5. Epithelial-mesenchymal transition and pancreatic cancer progressionSurabhi Dangi-Garimella, Seth B. Krantz, Mario A. Shields, Paul J. Grippo, and Hidayatullah G. Munshi.
- 1. Introduction
- 2. Epithelial-mesenchymal transition and PDAC
- 3. Role of microRNAs in modulating EMT in pancreatic cancer
- 4. Contribution of EMT to stem cells in pancreatic cancer
- 5. Importance of EMT in enhancing drug resistance in pancreatic cancer
- 6. Targeting EMT in pancreatic cancer
- Acknowledgements
- References
- 6. Pancreatic cancer stem cell and mesenchymal stem cellShin Hamada and Tooru Shimosegawa.
- Introduction
- Normal pancreatic stem cell and pancreatic CSC
- Marker of normal pancreatic stem cell and CSC
- Pancreatic cancer stem cell and therapy-resistance
- Interaction of cancer cells and stromal cells
- Role of MSC in pancreatic cancer
- Microenvironment of pancreatic cancer; Role of hypoxia
- Pancreatic cancer stromal cells as a possible CSC niche
- Closing remarks
- References
- 7. Signaling pathways mediating epithelial- mesenchymal crosstalk in pancreatic cancer: Hedgehog, Notch and TGFβJennifer M. Bailey and Steven D. Leach.
- 8. Desmoplasia and chemoresistance in pancreatic cancerClifford J. Whatcott, Richard G. Posner, Daniel D. Von Hoff, and Haiyong Han.
- Introduction
- Desmoplasia
- Cellular components
- Tumor-associated macrophages
- Neutrophils and regulatory T cells
- Non-cellular components
- Desmoplasia induced chemoresistance
- Biological chemoresistance
- Physiological chemoresistance
- Potential therapeutic approaches for reducing desmoplasia induced chemoresistance
- Conclusions
- Acknowledgements
- References
- 9. Therapeutic targeting of pancreatic stromaAndrew S. Liss and Sarah P. Thayer.
- Review Pathology of pancreatic stroma in PDAC.[Pancreatic Cancer and Tumor Mi...]Review Pathology of pancreatic stroma in PDAC.Rasheed ZA, Matsui W, Maitra A. Pancreatic Cancer and Tumor Microenvironment. 2012
- Review Key players in pancreatic cancer-stroma interaction: Cancer-associated fibroblasts, endothelial and inflammatory cells.[World J Gastroenterol. 2016]Review Key players in pancreatic cancer-stroma interaction: Cancer-associated fibroblasts, endothelial and inflammatory cells.Nielsen MF, Mortensen MB, Detlefsen S. World J Gastroenterol. 2016 Mar 7; 22(9):2678-700.
- Review Pancreatic cancer: the role of pancreatic stellate cells in tumor progression.[Pancreatology. 2010]Review Pancreatic cancer: the role of pancreatic stellate cells in tumor progression.Dunér S, Lopatko Lindman J, Ansari D, Gundewar C, Andersson R. Pancreatology. 2010; 10(6):673-81. Epub 2011 Jan 18.
- Hedgehog signaling stimulates Tenascin C to promote invasion of pancreatic ductal adenocarcinoma cells through Annexin A2.[Cell Adh Migr. 2017]Hedgehog signaling stimulates Tenascin C to promote invasion of pancreatic ductal adenocarcinoma cells through Annexin A2.Foley K, Muth S, Jaffee E, Zheng L. Cell Adh Migr. 2017 Sep 3; 11(5-6):514-523. Epub 2017 Feb 6.
- Review Pancreatic stellate cells and pancreas cancer: current perspectives and future strategies.[Eur J Cancer. 2014]Review Pancreatic stellate cells and pancreas cancer: current perspectives and future strategies.Haqq J, Howells LM, Garcea G, Metcalfe MS, Steward WP, Dennison AR. Eur J Cancer. 2014 Oct; 50(15):2570-82. Epub 2014 Aug 1.
- Pancreatic Cancer and Tumor MicroenvironmentPancreatic Cancer and Tumor Microenvironment
Your browsing activity is empty.
Activity recording is turned off.
See more...