Figure 2. Cortical interneurons are born in the subpallium and migrate tangentially to the cortex.

Figure 2Cortical interneurons are born in the subpallium and migrate tangentially to the cortex

The schema represents an E13.5 embryo brain hemisection. The arrows show representative migratory routes. POA-derived interneurons (blue) have a bias to invade the cortex through its rostral region, while CGE-derived interneurons (yellow) primarily reach the cortex by its caudal pole. LGE (red) is a major source for many olfactory bulb interneurons, although they are also produced in other regions. For simplicity, the septum and the thalamus are not depicted in the schema. ob, olfactory bulb; NCx, neocortex; PCx, paleocortex.

From: The Generation of Cortical Interneurons

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Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition.
Noebels JL, Avoli M, Rogawski MA, et al., editors.
Copyright © 2012, Michael A Rogawski, Antonio V Delgado-Escueta, Jeffrey L Noebels, Massimo Avoli and Richard W Olsen.

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