Figure 4. Potential mechanism by which inflammation could boost astrocytic glutamate release.

Figure 4Potential mechanism by which inflammation could boost astrocytic glutamate release

(Left) Scheme for control of astrocytic glutamate release by two G protein-coupled receptors. (Right) In the epileptic brain, mGluR5 is upregulated, and activated microglia as well as reactive astrocytes release TNFα, which acts on TNFR1 receptors in a pathway that promotes prostaglandin formation. Prostaglandin in turn activates a Gq-coupled prostanoid receptor that boosts intraastrocyte Ca2+ release and thus astrocytic glutamate release. From ref. 33.

From: Glutamatergic Mechanisms Related to Epilepsy

Cover of Jasper's Basic Mechanisms of the Epilepsies
Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition.
Noebels JL, Avoli M, Rogawski MA, et al., editors.
Copyright © 2012, Michael A Rogawski, Antonio V Delgado-Escueta, Jeffrey L Noebels, Massimo Avoli and Richard W Olsen.

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