Figure 3. Tonic GABAA receptor-mediated currents in interneurons of the hippocampus are relatively larger and more sensitive to low ambient GABA concentrations than are currents in pyramidal cells.

Figure 3Tonic GABAA receptor-mediated currents in interneurons of the hippocampus are relatively larger and more sensitive to low ambient GABA concentrations than are currents in pyramidal cells

As the GABA concentration increases, interneurons become less excitable and so phasic inhibition of pyramidal cells is “switched off”, whilst tonic inhibition of pyramidal cells increases.

From: Tonic GABAA Receptor-Mediated Signaling in Epilepsy

Cover of Jasper's Basic Mechanisms of the Epilepsies
Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition.
Noebels JL, Avoli M, Rogawski MA, et al., editors.
Copyright © 2012, Michael A Rogawski, Antonio V Delgado-Escueta, Jeffrey L Noebels, Massimo Avoli and Richard W Olsen.

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