Figure 5. Synchronous activity induced by bath application of 4AP in neocortical slices obtained from TLE (i.e., presenting with no architectural anomaly) and FCD patients.

Figure 5Synchronous activity induced by bath application of 4AP in neocortical slices obtained from TLE (i.e., presenting with no architectural anomaly) and FCD patients

A: Isolated field potentials (arrow) occur spontaneously in a TLE slice analyzed with field potential recording. . B: Spontaneous field potential discharges recorded in an FCD slice; note that in tnis experiment both isolated interictal field potentials (arrow) and an ictal discharge (dotted line) are shown in a. Note also that the onset of the ictal event is associated with the occurrence of a negative field potential ((arrowhead) that is followed by a slow negative event (asterisk) leading to ictal discharge oscillations. In b, superimposed interictal discharges (1) and ictal discharge onsets (2) are illustrated. C: Field potential activity and concomitant changes in [K+]o induced by 4AP in FCD tissue. Note that [K+]o increases up to 4.5 mM during the isolated negative field events (asterisk), reaches values of approx. 6.4 mM during the negative-going field potential leading to the ictal discharge onset (arrow), and levels to values of 12–14 mM during the ictal event..

From: Interictal Epileptiform Discharges in Partial Epilepsy

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Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition.
Noebels JL, Avoli M, Rogawski MA, et al., editors.
Copyright © 2012, Michael A Rogawski, Antonio V Delgado-Escueta, Jeffrey L Noebels, Massimo Avoli and Richard W Olsen.

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