Bookshelf

The initial exons of GABRB3 and UBE3A contain SP1 binding motifs in the proximal promoter region which are GC rich regions and are indicated by light blue painted squares. Green squares indicate exons of GABRB3 with exon numbers below. Orange squares indicate UBE3A exons. Bottom arrows indicate transcription direction. Both GABRB3 and UBE3A are transcribed in the same direction. One NRSF binding site lies at 350 bp upstream from exon 1A of GABRB3, the second NRSF binding site is in intron 3 and the third NRSF binding site is located 89 kb downstream from GABRB3 (Quest 2.4 data base).