Figure 1. Correlation of pyramidal cell behavior during interical discharges with KCC2 expression in the human postoperative subiculum.

Figure 1Correlation of pyramidal cell behavior during interical discharges with KCC2 expression in the human postoperative subiculum

(A) Combined intracellular (top trace) and extracellular recordings (bottom trace) of a pyramidal cell inhibited by GABA(≈80%, upper recording) and a pyramidal cell depolarized and excited by GABA (≈20%, lower recording) during interictal events.

(B) Immunostaining for KCC2 (green) in cells identified by biocytin filling (red). All cells hyperpolarized during epileptiform events expressed KCC2 (yellow on merging, top cell). Most cells depolarized during interictal discharges did not express KCC2 (middle cell) but some of them have a clear staining for KCC2 (bottom cell).

Modified from7,8.

From: Chloride homeostasis and GABA signaling in temporal lobe epilepsy

Cover of Jasper's Basic Mechanisms of the Epilepsies
Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition.
Noebels JL, Avoli M, Rogawski MA, et al., editors.
Copyright © 2012, Michael A Rogawski, Antonio V Delgado-Escueta, Jeffrey L Noebels, Massimo Avoli and Richard W Olsen.

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