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Noebels JL, Avoli M, Rogawski MA, et al., editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.

  • This title is an author manuscript version first made accessible on the NCBI Bookshelf website July 2, 2012.

This title is an author manuscript version first made accessible on the NCBI Bookshelf website July 2, 2012.

Cover of Jasper's Basic Mechanisms of the Epilepsies

Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition.

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Figure 1. Alpha 5 subunit labeling is decreased in the hippocampus of pilocarpine-treated (Pilo) rats (A,B) and mice (C,D) compared to controls (Cont).

Figure 1Alpha 5 subunit labeling is decreased in the hippocampus of pilocarpine-treated (Pilo) rats (A,B) and mice (C,D) compared to controls (Cont)

A,B. In the rat, α5 subunit labeling is substantially decreased in dendritic layers of CA1 (arrow in B) and to an even greater extent in CA2. Less change is found in CA3 and the dentate gyrus (DG). C,D. In the mouse, a decrease in α5 subunit labeling is evident in dendritic regions (arrow in D) of the hippocampus (CA1-CA3). A slight decrease is also found in the dentate gyrus (DG). Scale bars: A,B, 500 μm; C,D, 500 μm. Panels A and B adapted from Houser CR and Esclapez M. Downregulation of the α5 subunit of the GABAA receptor in the pilocarpine model of temporal lobe epilepsy. Hippocampus 13:633–645, 2003, with permission.

From: Alterations in the Distribution of GABAA Receptors in Epilepsy

Copyright © 2012, Michael A Rogawski, Antonio V Delgado-Escueta, Jeffrey L Noebels, Massimo Avoli and Richard W Olsen.

All Jasper's Basic Mechanisms of the Epilepsies content, except where otherwise noted, is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported license, which permits copying, distribution and transmission of the work, provided the original work is properly cited, not used for commercial purposes, nor is altered or transformed.

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