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(A) The non-sclerotic hippocampus is from a temporal lobe epilepsy patient with an extrahippocampal mass lesion in the temporal lobe. The hippocampus appears similar to that from a neurologically normal autopsy control, even though neuronal counts show about a 20% loss of neurons in all fields. (B) This sclerotic hippocampus, also from a temporal lobe epilepsy patient, shows extensive neuronal loss in the hilus (H), almost total neuronal loss in area CA3 and CA1 with infiltration by glia. There is some preservation of neurons CA2. The neuronal density in the subiculum (SUB) is similar to that in the non-sclerotic hippocampus. The granule cell (GC) layer in B, also shows significant neuronal loss. The arrow heads denote the limits of the respective CA fields. Bar = 50 μm