Figure 1. Group I metabotropic glutamate receptor (mGluR) activation induces persistent ictal-like discharges in the hippocampus.

Figure 1Group I metabotropic glutamate receptor (mGluR) activation induces persistent ictal-like discharges in the hippocampus

A, Summary histogram of mean duration of synchronized bursts elicited by picrotoxin (control) and maximum duration of prolonged bursts during application of the selective group I mGluR agonist (S)-3-hydroxyphenylglycine ((S)3HPG, 250–500 μM, n = 7 slices). Error bars: SEM. B, Intracellular recording from a CA3 pyramidal cell in a hippocampal slice before and during exposure to 250 μM (S)3HPG. C, Time course of synchronized burst prolongation; burst duration displayed before (1), during (bar), and after (2) group I mGluR stimulation with (R,S)-3,5-dihydroxyphenylglycine ((R,S)DHPG; 100 μM). Ictal-like discharges induced by (R,S)DHPG persisted for hours after washout of the agonist. Insets: Records before (1) and after (2) transient exposure to DHPG. (Modified from ref. 4.)

From: Glutamate Receptors in Epilepsy

Cover of Jasper's Basic Mechanisms of the Epilepsies
Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition.
Noebels JL, Avoli M, Rogawski MA, et al., editors.
Copyright © 2012, Michael A Rogawski, Antonio V Delgado-Escueta, Jeffrey L Noebels, Massimo Avoli and Richard W Olsen.

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