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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].
Show detailsCRD summary
The review concluded that dietary fibre can reduce glycosylated haemoglobin and fasting blood glucose in patients with type 2 diabetes mellitus. Potential for biases and the differences between trials mean that a degree of caution is required when interpreting the authors’ conclusions. The authors’ call for further research appears warranted.
Authors' objectives
To determine whether an increase in dietary fibre affects glycosylated haemoglobin and fasting blood glucose in patients with type 2 diabetes mellitus.
Searching
PubMed, CINAHL and Cochrane Central Register of Controlled Trials (CENTRAL) were searched from January 1980 to February 2011 for articles in English. Search terms were reported. Reference lists of retrieved articles were searched.
Study selection
Randomised controlled trials (RCTs) that involved an increase in dietary fibre as an intervention versus control in patients with type 2 diabetes mellitus were eligible for inclusion. Trials had to report on glycosylated haemoglobin or fasting blood glucose as an outcome. Trials in which two types of dietary fibre were compared or where diets were dissimilar between groups were excluded.
The included trials studied various forms of soluble and insoluble fibre (including cereal, guar gum, beet fibre and wheat fibre). The increase in dietary fibre compared with the control group ranged from 4g to 40g. Where reported, the mean age of patients ranged from 51.9 to 69.1 years. Trials were published between 1984 and 2007. More than half of the trials were randomised cross-over design.
The authors did not state how many reviewers undertook study selection.
Assessment of study quality
Quality assessment was undertaken using the GRADE tool to classify trial quality as high, moderate, low or very low.
The authors did not state how many reviewers undertook quality assessment.
Data extraction
Mean and standard deviation data were extracted on glycosylated haemoglobin or fasting blood glucose (standardised to mmol/L). Data on standard errors were converted to standard deviations.
The authors did not state how many reviewers extracted the data.
Methods of synthesis
A fixed-effect meta-analysis was undertaken to calculate pooled mean differences, with 95% confidence intervals (CIs). Statistical heterogeneity was assessed using the Χ² and Ι² statistics. A random-effects meta-analysis was used where there was evidence of significant statistical heterogeneity. Publication bias was assessed using funnel plots.
Results of the review
Fifteen RCTs were included (484 patients, range 10 to 58). Eleven trials were graded as high quality and four trials as moderate quality. The length of follow-up ranged from three to 12 weeks.
Compared with control, dietary fibre was associated with a statistically significantly lower fasting blood glucose (mean difference -0.85mml/L, 95% CI -1.25 to -0.46; 13 RCTs; Ι²=5%) and a reduced glycosylated haemoglobin (mean difference -0.26, 95% CI -0.51 to -0.02; 10 RCTs; Ι²=21%).
There was evidence of publication bias with the glycosylated haemoglobin outcome.
Authors' conclusions
Dietary fibre can reduce glycosylated haemoglobin and fasting blood glucose in patients with type 2 diabetes mellitus.
CRD commentary
Inclusion criteria for the review were clearly defined. Three relevant data sources were searched. There may have been the potential for language bias as only articles in English were included. Publication bias was assessed and was detected for one of the outcomes. The authors did not state whether they made any attempts to reduce reviewer error and bias during the review. Quality assessment indicated that all of the trials were of moderate to high quality; individual quality items were not reported and this made the quality assessment difficult to interpret. There were large differences in the amount and type of dietary fibre used in the studies. Data were pooled using appropriate meta-analysis techniques. Statistical heterogeneity was reported. The authors noted that the reduction in glycosylated haemoglobin may not have been clinically significant.
Potential for biases and the differences between trials mean that a degree of caution is required when interpreting the authors’ conclusions. The authors’ call for further research appears warranted.
Implications of the review for practice and research
Practice: The authors stated that increasing dietary fibre should be encouraged as a disease management strategy for patients with type 2 diabetes.
Research: The authors stated that further studies of more than 12 weeks were warranted to test the effect of fibre on glycosylated haemoglobin. Studies with larger doses of fibre were warranted to help support current recommendations for dietary fibre intake in type 2 diabetes.
Funding
None.
Bibliographic details
Post RE, Mainous AG, King DE, Simpson KN. Dietary fiber for the treatment of type 2 diabetes mellitus: a meta-analysis. Journal of the American Board of Family Medicine 2012; 25(1): 16-23. [PubMed: 22218620]
Original Paper URL
Indexing Status
Subject indexing assigned by NLM
MeSH
Aged; Blood Glucose /analysis; Diabetes Mellitus, Type 2 /diet therapy /physiopathology; Dietary Fiber /therapeutic use; Female; Hemoglobin A, Glycosylated /analysis; Humans; Male; Middle Aged; Outcome Assessment (Health Care)
AccessionNumber
Database entry date
06/11/2012
Record Status
This is a critical abstract of a systematic review that meets the criteria for inclusion on DARE. Each critical abstract contains a brief summary of the review methods, results and conclusions followed by a detailed critical assessment on the reliability of the review and the conclusions drawn.
- CRD summary
- Authors' objectives
- Searching
- Study selection
- Assessment of study quality
- Data extraction
- Methods of synthesis
- Results of the review
- Authors' conclusions
- CRD commentary
- Implications of the review for practice and research
- Funding
- Bibliographic details
- Original Paper URL
- Indexing Status
- MeSH
- AccessionNumber
- Database entry date
- Record Status
- Long-term effect of dietary fibre intake on glycosylated haemoglobin A1c level and glycaemic control status among Chinese patients with type 2 diabetes mellitus.[Public Health Nutr. 2014]Long-term effect of dietary fibre intake on glycosylated haemoglobin A1c level and glycaemic control status among Chinese patients with type 2 diabetes mellitus.Yang L, Shu L, Jiang J, Qiu H, Zhao G, Zhou Y, Jiang Q, Sun Q, Qin G, Wu H, et al. Public Health Nutr. 2014 Aug; 17(8):1858-64. Epub 2013 Jul 24.
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- Heterogeneous associations of insoluble dietary fibre intake with subsequent glycosylated Hb levels among Chinese adults with type 2 diabetes: a quantile regression approach.[Br J Nutr. 2014]Heterogeneous associations of insoluble dietary fibre intake with subsequent glycosylated Hb levels among Chinese adults with type 2 diabetes: a quantile regression approach.Tan Z, Ruan X, Chen Y, Jiang J, Zhou Y, Qiu H, Qin G, Xu WH. Br J Nutr. 2014 Sep 28; 112(6):958-63. Epub 2014 Jul 9.
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- Dietary fiber for the treatment of type 2 diabetes mellitus: a meta-analysis - D...Dietary fiber for the treatment of type 2 diabetes mellitus: a meta-analysis - Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews
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