[Table, Table 3: Sample size necessary...] - Assay Guidance Manual

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Markossian S, Grossman A, Arkin M, et al., editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.

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Table 3: Sample size necessary to reduce the coefficient of variation (CV) to less than 10 or 20%, given a known CV when the sample size is one.

CV for Individual Subjects	Number of Subjects so that CV Mean < 10%	Number of Subjects so that CV Mean < 20%
<10	1	1
10.1-14.1	2	1
14.2-17.3	3	1
17.4-20.0	4	1
20.1-22.3	5	2
22.4-24.4	6	2
24.5-26.4	7	2
26.5-28.2	8	2
28.3-30	9	3
30.1-31.6	10	3
31.7-33.1	11	3
33.2-34.6	12	3
34.7-36.0	13	4
36.1-37.4	14	4
37.5-38.7	15	4
38.8-40.0	16	4

From: In Vivo Assay Guidelines

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Haas J, Manro J, Shannon H, et al. In Vivo Assay Guidelines. 2012 May 1 [Updated 2012 Oct 1]. In: Markossian S, Grossman A, Arkin M, et al., editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-. [Table, Table 3: Sample size necessary...]
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