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Chou R, McDonagh MS, Nakamoto E, et al. Analgesics for Osteoarthritis: An Update of the 2006 Comparative Effectiveness Review [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011 Oct. (Comparative Effectiveness Reviews, No. 38.)
Analgesics for Osteoarthritis: An Update of the 2006 Comparative Effectiveness Review [Internet].
Show detailsTable 3Risk of upper gastrointestinal bleeding or perforation with use of an NSAID compared with nonuse of NSAIDs, systematic review of observational studies97
| NSAID | Number of Studies | Pooled Estimate (95% CI) |
|---|---|---|
| Celecoxib | 4 | 1.4 (0.85 to 2.4) |
| Meloxicam | 4 | 4.2 (2.6 to 6.6) |
| Naproxen | 6 | 5.6 (3.8 to 8.3) |
| Ibuprofen | 5 | 2.7 (2.2 to 3.3) |
| Diclofenac | 6 | 4.0 (3.4 to 4.7) |
| Indomethacin | 5 | 5.4 (4.2 to 7.0) |
| Ketoprofen | 5 | 5.6 (3.9 to 7.9) |
| Piroxicam | 5 | 9.9 (6.0 to 16) |
| Ketorolac | 2 | 15 (5.9 to 36) |
CI = confidence interval; NSAID = nonsteroidal anti-inflammatory drug
- Table 3, Risk of upper gastrointestinal bleeding or perforation with use of an N...Table 3, Risk of upper gastrointestinal bleeding or perforation with use of an NSAID compared with nonuse of NSAIDs, systematic review of observational studies - Analgesics for Osteoarthritis
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