Original Report
Ovid MEDLINE Searches (1966 to July Week 3 2005)
I. Search Strategy: NSAIDs, focus on efficacy (OA)
- exp OSTEOARTHRITIS/ (26153)
- limit 1 to (humans and english language) (18162)
- celecoxib.mp. (1545)
- choline magnesium trisalicylate.mp. (38)
- DICLOFENAC/ (3399)
- DIFLUNISAL/ (380)
- ETODOLAC/ (284)
- FENOPROFEN/ (257)
- FLURBIPROFEN/ (1184)
- IBUPROFEN/ (4177)
- INDOMETHACIN/ (23527)
- KETOPROFEN/ (1443)
- KETOROLAC/ (723)
- meclofenamate sodium.mp. (51)
- Mefenamic Acid/ (764)
- meloxicam.mp. (522)
- nabumetone.mp. (350)
- NAPROXEN/ (2378)
- oxaprozin.mp. (121)
- PIROXICAM/ (1920)
- salsalate.mp. (74)
- SULINDAC/ (923)
- TOLMETIN/ (1255)
- valdecoxib.mp. (183)
- 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 (40472)
- limit 25 to (humans and english language) (17770)
- 2 and 26 (1094)
- Comparative Study/ (1202473)
- Cohort Studies/ (57012)
- Randomized Controlled Trials/ (38090)
- 27 and (28 or 29 or 30) (532)
- from 31 keep 1–532 (532)
II. Search Strategy: NSAIDs, focus on adverse events (OA & RA)
- Arthritis, Rheumatoid/ (53548)
- limit 1 to (humans and english language) (37493)
- celecoxib.mp. (1545)
- choline magnesium trisalicylate.mp. (38)
- *DICLOFENAC/ae [Adverse Effects] (374)
- *DIFLUNISAL/ae [Adverse Effects] (27)
- *ETODOLAC/ae [Adverse Effects] (19)
- *FENOPROFEN/ae [Adverse Effects] (41)
- *FLURBIPROFEN/ae [Adverse Effects] (41)
- *IBUPROFEN/ae [Adverse Effects] (356)
- *INDOMETHACIN/ae [Adverse Effects] (678)
- *KETOPROFEN/ae [Adverse Effects] (109)
- *KETOROLAC/ae [Adverse Effects] (16)
- meclofenamate sodium.mp. (51)
- *Mefenamic Acid/ae [Adverse Effects] (67)
- meloxicam.mp. (522)
- nabumetone.mp. (350)
- *NAPROXEN/ae [Adverse Effects] (269)
- oxaprozin.mp. (121)
- *PIROXICAM/ae [Adverse Effects] (130)
- salsalate.mp. (74)
- *SULINDAC/ae [Adverse Effects] (116)
- *TOLMETIN/ae [Adverse Effects] (74)
- valdecoxib.mp. (183)
- 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 (4875)
- limit 25 to (humans and english language) (3433)
- 2 and 26 (357)
- Cohort Studies/ (57012)
- Comparative Study/ (1202473)
- Randomized Controlled Trials/ (38090)
- 27 and (28 or 29 or 30) (128)
- from 31 keep 1–128 (128)
III. Search Strategy: Aspirin/acetaminophen
- exp OSTEOARTHRITIS/ (26153)
- limit 1 to (humans and english language) (18162)
- ASPIRIN/ (26642)
- ACETAMINOPHEN/ (8992)
- 2 and (3 or 4) (323)
- exp Arthritis, Rheumatoid/ (71858)
- limit 6 to (humans and english language) (50057)
- *ASPIRIN/ae [Adverse Effects] (2386)
- *ACETAMINOPHEN/ae [Adverse Effects] (719)
- 7 and (8 or 9) (81)
- 5 or 10 (400)
- Cohort Studies/ (57012)
- Comparative Study/ (1202473)
- Randomized Controlled Trials/ (38090)
- 11 and (12 or 13 or 14) (158)
- from 15 keep 1–158 (158)
IV. Search Strategy: Topical analgesics
- exp OSTEOARTHRITIS/ (26153)
- limit 1 to (humans and english language) (18162)
- (topical and capsaicin).mp. [mp=title, original title, abstract, name of substance word, subject heading word] (614)
- (topical and diclofenac).mp. [mp=title, original title, abstract, name of substance word, subject heading word] (356)
- (topical and ibuprofen).mp. [mp=title, original title, abstract, name of substance word, subject heading word] (137)
- (topical and ketoprofen).mp. [mp=title, original title, abstract, name of substance word, subject heading word] (114)
- (topical and salicylate).mp. [mp=title, original title, abstract, name of substance word, subject heading word] (160)
- 2 and (3 or 4 or 5 or 6 or 7) (40)
- exp Arthritis, Rheumatoid/ (71858)
- 9 and (3 or 4 or 5 or 6 or 7) (11)
- 8 or 10 (49)
- from 11 keep 1–49 (49)
CDSR/CRCT Searches (Through Third Quarter 2005)
I. Search Strategy: NSAIDs, focus on efficacy (OA)
- exp OSTEOARTHRITIS/ (1546)
- limit 1 to (humans and english language) (1546)
- celecoxib.mp. (219)
- choline magnesium trisalicylate.mp. (29)
- DICLOFENAC/ (878)
- DIFLUNISAL/ (90)
- ETODOLAC/ (70)
- FENOPROFEN/ (35)
- FLURBIPROFEN/ (272)
- IBUPROFEN/ (776)
- INDOMETHACIN/ (1224)
- KETOPROFEN/ (299)
- KETOROLAC/ (279)
- meclofenamate sodium.mp. (37)
- Mefenamic Acid/ (92)
- meloxicam.mp. (133)
- nabumetone.mp. (141)
- NAPROXEN/ (645)
- oxaprozin.mp. (47)
- PIROXICAM/ (447)
- salsalate.mp. (31)
- SULINDAC/ (119)
- TOLMETIN/ (360)
- valdecoxib.mp. (56)
- 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 (5040)
- limit 25 to (humans and english language)(5040)
- 2 and 26 (555)
- Comparative Study/ (96540)
- Cohort Studies/ (2139)
- Randomized Controlled Trials/ (4538)
- 27 and (28 or 29 or 30) (402)
II. Search Strategy: NSAIDs, focus on adverse events (OA & RA)
- Arthritis, Rheumatoid/ (2385)
- limit 1 to (humans and english language) (2385)
- celecoxib.mp. (219)
- choline magnesium trisalicylate.mp. (29)
- *DICLOFENAC/ae [Adverse Effects] (39)
- *DIFLUNISAL/ae [Adverse Effects] (6)
- *ETODOLAC/ae [Adverse Effects] (3)
- *FENOPROFEN/ae [Adverse Effects] (2)
- *FLURBIPROFEN/ae [Adverse Effects] (5)
- *IBUPROFEN/ae [Adverse Effects] (40)
- *INDOMETHACIN/ae [Adverse Effects] (61)
- *KETOPROFEN/ae [Adverse Effects] (9)
- *KETOROLAC/ae [Adverse Effects] (6)
- meclofenamate sodium.mp. (37)
- *Mefenamic Acid/ae [Adverse Effects] (0)
- meloxicam.mp. (133)
- nabumetone.mp. (141)
- *NAPROXEN/ae [Adverse Effects] (62)
- oxaprozin.mp. (47)
- *PIROXICAM/ae [Adverse Effects] (19)
- salsalate.mp. (31)
- *SULINDAC/ae [Adverse Effects] (11)
- *TOLMETIN/ae [Adverse Effects] (0)
- valdecoxib.mp. (56)
- 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 (846)
- limit 25 to (humans and english language) [Limit not valid in: CDSR,ACP Journal Club,DARE,CCTR; records were retained] (846)
- 2 and 26 (98)
- Cohort Studies/ (2139)
- Comparative Study/ (96540)
- Randomized Controlled Trials/ (4538)
- 27 and (28 or 29 or 30) (73)
III. Search Strategy: Aspirin/acetaminophen
- exp OSTEOARTHRITIS/ (1546)
- limit 1 to (humans and english language) (1546)
- ASPIRIN/ (3028)
- ACETAMINOPHEN/ (1128)
- 2 and (3 or 4) (115)
- exp Arthritis, Rheumatoid/ (2730)
- limit 6 to (humans and english language) (2730)
- *ASPIRIN/ae [Adverse Effects] (271)
- *ACETAMINOPHEN/ae [Adverse Effects] (32)
- 7 and (8 or 9) (10)
- 5 or 10 (124)
- Cohort Studies/ (2139)
- Comparative Study/ (96540)
- Randomized Controlled Trials/ (4538)
- 11 and (12 or 13 or 14) (90)
IV. Search Strategy: Topicals
- exp OSTEOARTHRITIS/ (1546)
- limit 1 to (humans and english language) (1546)
- (topical and capsaicin).mp. [mp=ti, ab, tx, kw, ct, ot, sh, hw] (123)
- (topical and diclofenac).mp. [mp=ti, ab, tx, kw, ct, ot, sh, hw] (199)
- (topical and ibuprofen).mp. [mp=ti, ab, tx, kw, ct, ot, sh, hw] (69)
- (topical and ketoprofen).mp. [mp=ti, ab, tx, kw, ct, ot, sh, hw] (46)
- (topical and salicylate).mp. [mp=ti, ab, tx, kw, ct, ot, sh, hw] (44)
- 2 and (3 or 4 or 5 or 6 or 7) (18)
- exp Arthritis, Rheumatoid/ (2730)
- 9 and (3 or 4 or 5 or 6 or 7) (6)
- 8 or 10 (22)
Current CER Update Search Strings
Database: Ovid MEDLINE 1996 to January week 2 2011
RCTs
- exp OSTEOARTHRITIS/ (18286)
- osteoarthriti$.mp. (23317)
- 1 or 2 (23317)
- Aspirin/ or aspirin.mp. (20844)
- acetaminophen.mp. or Acetaminophen/ (7386)
- Cyclooxygenase 2 Inhibitors/ or celecoxib.mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier] (7518)
- capsaicin.mp. or Capsaicin/ (6135)
- Chondroitin/or chondroitin.mp. (5835)
- diclofenac.mp. or Diclofenac/ (4611)
- diflunisal.mp. or Diflunisal/ (162)
- etodolac.mp. or Etodolac/ (295)
- fenoprofen.mp. or Fenoprofen/ (106)
- flurbiprofen.mp. or Flurbiprofen/ (813)
- Glucosamine/ or glucosamine.mp. (4146)
- ibuprofen.mp. or Ibuprofen/ (4484)
- indomethacin.mp. or Indomethacin/ (11590)
- ketoprofen.mp. or Ketoprofen/ (1574)
- Ketorolac/ or ketorolac.mp. (1209)
- meclofenamate.mp. (157)
- mefenamic acid.mp. or Mefenamic Acid/ (362)
- meloxicam.mp. (881)
- nabumetone.mp. (218)
- naproxen.mp. or Naproxen/ (2158)
- oxaprozin.mp. (59)
- piroxicam.mp. or Piroxicam/ (1288)
- salsalate.mp. (27)
- sulindac.mp. or Sulindac/ (878)
- tolmetin.mp. or Tolmetin/ (410)
- or/4–28 (71421)
- randomized controlled trial.mp. or exp Randomized Controlled Trial/ (189494)
- randomized controlled trial.pt. (186325)
- controlled clinical trial.mp. or exp Controlled Clinical Trial/ (38495)
- controlled clinical trial.pt. (34791)
- clinical trial.mp. or exp Clinical Trial/ (404159)
- clinical trial.pt. (252913)
- or/30–35 (406908)
- limit 36 to humans (397588)
- 3 and 29 and 37 (542)
- 38 and (200507$ or 200508$ or 200509$ or 20051$ or 2006$ or 2007$ or 2008$ or 2009$ or 2010$).ed. (211)
- limit 39 to english language (189)
- limit 39 to abstracts (202)
- 40 or 41 (210)
Systematic Reviews
- exp OSTEOARTHRITIS/ (18286)
- osteoarthriti$.mp. (23317)
- 1 or 2 (23317)
- Aspirin/ or aspirin.mp. (20844)
- acetaminophen.mp. or Acetaminophen/ (7386)
- Cyclooxygenase 2 Inhibitors/ or celecoxib.mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier] (7518)
- capsaicin.mp. or Capsaicin/ (6135)
- Chondroitin/ or chondroitin.mp. (5835)
- diclofenac.mp. or Diclofenac/ (4611)
- diflunisal.mp. or Diflunisal/ (162)
- etodolac.mp. or Etodolac/ (295)
- fenoprofen.mp. or Fenoprofen/ (106)
- flurbiprofen.mp. or Flurbiprofen/ (813)
- Glucosamine/ or glucosamine.mp. (4146)
- ibuprofen.mp. or Ibuprofen/ (4484)
- indomethacin.mp. or Indomethacin/ (11590)
- ketoprofen.mp. or Ketoprofen/ (1574)
- Ketorolac/ or ketorolac.mp. (1209)
- meclofenamate.mp. (157)
- mefenamic acid.mp. or Mefenamic Acid/ (362)
- meloxicam.mp. (881)
- nabumetone.mp. (218)
- naproxen.mp. or Naproxen/ (2158)
- oxaprozin.mp. (59)
- piroxicam.mp. or Piroxicam/ (1288)
- salsalate.mp. (27)
- sulindac.mp. or Sulindac/ (878)
- tolmetin.mp. or Tolmetin/ (410)
- or/4–28 (71421)
- meta-analysis.mp. or exp Meta-Analysis/ (33804)
- (cochrane or medline).tw. (33065)
- search$.tw. (112106)
- 30 or 31 or 32 (139975)
- “Review Literature as Topic”/ or systematic review.mp. (19084)
- 33 or 34 (146484)
- 3 and 29 and 35 (163)
- 36 and (200507$ or 200508$ or 200509$ or 20051$ or 2006$ or 2007$ or 2008$ or 2009$ or 2010$).ed. (77)
- limit 37 to humans (75)
- limit 38 to english language (72)
- limit 38 to abstracts (66)
Harms
- Aspirin/ or aspirin.mp. (20844)
- acetaminophen.mp. or Acetaminophen/ (7386)
- Cyclooxygenase 2 Inhibitors/ or celecoxib.mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier] (7518)
- capsaicin.mp. or Capsaicin/ (6135)
- Chondroitin/ or chondroitin.mp. (5835)
- diclofenac.mp. or Diclofenac/ (4611)
- diflunisal.mp. or Diflunisal/ (162)
- etodolac.mp. or Etodolac/ (295)
- fenoprofen.mp. or Fenoprofen/ (106)
- flurbiprofen.mp. or Flurbiprofen/ (813)
- Glucosamine/ or glucosamine.mp. (4146)
- ibuprofen.mp. or Ibuprofen/ (4484)
- indomethacin.mp. or Indomethacin/ (11590)
- ketoprofen.mp. or Ketoprofen/ (1574)
- Ketorolac/ or ketorolac.mp. (1209)
- meclofenamate.mp. (157)
- mefenamic acid.mp. or Mefenamic Acid/ (362)
- meloxicam.mp. (881)
- nabumetone.mp. (218)
- naproxen.mp. or Naproxen/ (2158)
- oxaprozin.mp. (59)
- piroxicam.mp. or Piroxicam/ (1288)
- salsalate.mp. (27)
- sulindac.mp. or Sulindac/ (878)
- tolmetin.mp. or Tolmetin/ (410)
- or/1–25 (71421)
- (ae or co or de).fs. (1917797)
- (adverse effect$ or adverse event$ or harm$).mp. (125151)
- 27 or 28 (1980478)
- rheumatoid arthritis.mp. or Arthritis, Rheumatoid/ (34754)
- Alzheimer Disease/pc [Prevention & Control] (1442)
- (alzheimer$ adj2 prevent$).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier] (267)
- 31 or 32 (1566)
- Neoplasms/pc [Prevention & Control] (6517)
- (cancer adj1 prevent$).mp. [mp=title, original title, abstract, name of substance word, subject heading word, unique identifier] (6643)
- 34 or 35 (11729)
- 30 or 33 or 36 (47989)
- 26 and 29 and 37 (1011)
- 38 and (200507$ or 200508$ or 200509$ or 20051$ or 2006$ or 2007$ or 2008$ or 2009$ or 2010$).ed. (332)
- limit 39 to humans (290)
- limit 40 to english language (264)
- limit 40 to abstracts (252)
- 41 or 42 (278)
Database: EBM Reviews - Cochrane Central Register of Controlled Trials (fourth quarter 2010)
- exp OSTEOARTHRITIS/ (2149)
- osteoarthriti$.mp. (3327)
- 1 or 2 (3327)
- Aspirin/ or aspirin.mp. (6044)
- acetaminophen.mp. or Acetaminophen/ (2083)
- Cyclooxygenase 2 Inhibitors/ or celecoxib.mp. [mp=title, original title, abstract, mesh headings, heading words, keyword] (639)
- capsaicin.mp. or Capsaicin/ (427)
- Chondroitin/ or chondroitin.mp. (212)
- diclofenac.mp. or Diclofenac/ (2245)
- diflunisal.mp. or Diflunisal/ (207)
- etodolac.mp. or Etodolac/ (154)
- fenoprofen.mp. or Fenoprofen/ (83)
- flurbiprofen.mp. or Flurbiprofen/ (499)
- Glucosamine/ or glucosamine.mp. (171)
- ibuprofen.mp. or Ibuprofen/ (1769)
- indomethacin.mp. or Indomethacin/ (2174)
- ketoprofen.mp. or Ketoprofen/ (687)
- Ketorolac/ or ketorolac.mp. (909)
- meclofenamate.mp. (69)
- mefenamic acid.mp. or Mefenamic Acid/ (196)
- meloxicam.mp. (160)
- nabumetone.mp. (137)
- naproxen.mp. or Naproxen/ (1268)
- oxaprozin.mp. (48)
- piroxicam.mp. or Piroxicam/ (900)
- salsalate.mp. (31)
- sulindac.mp. or Sulindac/ (249)
- tolmetin.mp. or Tolmetin/ (421)
- or/4–28 (17609)
- 3 and 29 (1357)
- limit 30 to yr=“2005 -Current” (192)
Database: EBM Reviews - Cochrane Database of Systematic Reviews (2005 to January 2011)
- osteoarthriti$.mp. (203)
- Aspirin/ or aspirin.mp. (303)
- acetaminophen.mp. or Acetaminophen/ (86)
- Cyclooxygenase 2 Inhibitors/ or celecoxib.mp. [mp=title, abstract, full text, keywords, caption text] (58)
- capsaicin.mp. or Capsaicin/ (37)
- Chondroitin/ or chondroitin.mp. (10)
- diclofenac.mp. or Diclofenac/ (99)
- diflunisal.mp. or Diflunisal/ (17)
- etodolac.mp. or Etodolac/ (17)
- fenoprofen.mp. or Fenoprofen/ (14)
- flurbiprofen.mp. or Flurbiprofen/ (24)
- Glucosamine/ or glucosamine.mp. (17)
- ibuprofen.mp. or Ibuprofen/ (126)
- indomethacin.mp. or Indomethacin/ (92)
- ketoprofen.mp. or Ketoprofen/ (40)
- Ketorolac/ or ketorolac.mp. (43)
- meclofenamate.mp. (8)
- mefenamic acid.mp. or Mefenamic Acid/ (27)
- meloxicam.mp. (14)
- nabumetone.mp. (9)
- naproxen.mp. or Naproxen/ (90)
- oxaprozin.mp. (5)
- piroxicam.mp. or Piroxicam/ (33)
- salsalate.mp. (2)
- sulindac.mp. or Sulindac/ (21)
- tolmetin.mp. or Tolmetin/ (8)
- or/2–26 (536)
- 1 and 27 (60)
- limit 28 to full systematic reviews (49)
Publication Details
Copyright
Publisher
Agency for Healthcare Research and Quality (US), Rockville (MD)
NLM Citation
Chou R, McDonagh MS, Nakamoto E, et al. Analgesics for Osteoarthritis: An Update of the 2006 Comparative Effectiveness Review [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011 Oct. (Comparative Effectiveness Reviews, No. 38.) Appendix C, Exact Search Strings.