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Gaynes BN, Lux LJ, Lloyd SW, et al. Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011 Sep. (Comparative Effectiveness Reviews, No. 33.)
This publication is provided for historical reference only and the information may be out of date.
Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults [Internet].
Show detailsTable JSummary of findings on nonpharmacologic treatment of adult treatment-resistant depression (TRD) with strength of evidence for Tier 1 (TRD) for KQ 6, health-related outcomes
| Comparison | Outcome | Number of Subjects | Strength of Evidence* | Findings† |
|---|---|---|---|---|
| ECT vs. ECT + rTMS | Health-related outcomes | 22 | Low | 1 fair trial: There were no differences between groups in improvements in daily functioning. |
| rTMS vs. sham | Health-related outcomes | 60 | Low | 1 fair trail: low rTMS had significantly greater improvement in health status and daily functioning than sham, while this relationship approached statistical significance when comparing high rTMS to sham. |
| VNS vs. sham | Health-related outcomes | 214 | Low | 1 fair trial: VNS and sham groups did not differ significantly in daily functioning. |
| CBT/DBT vs. control | Health-related outcomes | 0 | NA | No eligible studies identified. ‡ |
CBT = cognitive behavioral therapy; DBT = dialectical behavioral therapy; NA = not applicable; rTMS = repetitive transcranial magnetic stimulation; VNS = vagus nerve stimulation; vs. = versus
- *
Strength of evidence is based on the on guidance provided in the AHRQ Methods Guide for Comparative Effectiveness Reviews; see text.
- †
Good and fair designations relate to quality ratings for each study.
- ‡
At least one Tier 2 and/or Tier 3 study addressed this comparison.
- Table J, Summary of findings on nonpharmacologic treatment of adult treatment-re...Table J, Summary of findings on nonpharmacologic treatment of adult treatment-resistant depression (TRD) with strength of evidence for Tier 1 (TRD) for KQ 6, health-related outcomes - Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults
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