NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Tobacco Use and Dependence Guideline Panel. Treating Tobacco Use and Dependence: 2008 Update. Rockville (MD): US Department of Health and Human Services; 2008 May.
Table 6.26Meta-analysis (2008): Effectiveness and abstinence rates for various medications and medication combinations compared to placebo at 6-months postquit (n = 83 studies)a
| Medication | Number of arms | Estimated odds ratio (95% C.I.) | Estimated abstinence rate (95% C.I.) |
|---|---|---|---|
| Placebo | 80 | 1.0 | 13.8 |
| Monotherapies | |||
| Varenicline (2 mg/day) | 5 | 3.1 (2.5–3.8) | 33.2 (28.9–37.8) |
| Nicotine Nasal Spray | 4 | 2.3 (1.7–3.0) | 26.7 (21.5–32.7) |
| High-Dose Nicotine Patch ( > 25 mg) (These included both standard or long-term duration) | 4 | 2.3 (1.7–3.0) | 26.5 (21.3–32.5) |
| Long-Term Nicotine Gum (> 14 weeks) | 6 | 2.2 (1.5–3.2) | 26.1 (19.7–33.6) |
| Varenicline (1 mg/day) | 3 | 2.1 (1.5–3.0) | 25.4 (19.6–32.2) |
| Nicotine Inhaler | 6 | 2.1 (1.5–2.9) | 24.8 (19.1–31.6) |
| Clonidine | 3 | 2.1 (1.2–3.7) | 25.0 (15.7–37.3) |
| Bupropion SR | 26 | 2.0 (1.8–2.2) | 24.2 (22.2–26.4) |
| Nicotine Patch (6–14 weeks) | 32 | 1.9 (1.7–2.2) | 23.4 (21.3–25.8) |
| Long-Term Nicotine Patch (> 14 weeks) | 10 | 1.9 (1.7–2.3) | 23.7 (21.0–26.6) |
| Nortriptyline | 5 | 1.8 (1.3–2.6) | 22.5 (16.8–29.4) |
| Nicotine Gum (6–14 weeks) | 15 | 1.5 (1.2–1.7) | 19.0 (16.5–21.9) |
| Combination therapies | |||
| Patch (long-term; > 14 weeks) + ad lib NRT (gum or spray) | 3 | 3.6 (2.5–5.2) | 36.5 (28.6–45.3) |
| Patch + Bupropion SR | 3 | 2.5 (1.9–3.4) | 28.9 (23.5–35.1) |
| Patch + Nortriptyline | 2 | 2.3 (1.3–4.2) | 27.3 (17.2–40.4) |
| Patch + Inhaler | 2 | 2.2 (1.3– 3.6) | 25.8 (17.4–36.5) |
| Patch + Second generation antidepressants (paroxetine, venlafaxine) | 3 | 2.0 (1.2–3.4) | 24.3 (16.1–35.0) |
| Medications not shown to be effective | |||
| Selective Serotonin Re-uptake Inhibitors (SSRIs) | 3 | 1.0 (0.7–1.4) | 13.7 (10.2–18.0) |
| Naltrexone | 2 | 0.5 (0.2–1.2) | 7.3 (3.1–16.2) |
- a
Go to www
.surgeongeneral.gov/tobacco/gdlnrefs .htm for the articles used in this meta-analysis.
- Table 6.26, Meta-analysis (2008): Effectiveness and abstinence rates for various...Table 6.26, Meta-analysis (2008): Effectiveness and abstinence rates for various medications and medication combinations compared to placebo at 6-months postquit (n = 83 studies)a - Treating Tobacco Use and Dependence: 2008 Update
Your browsing activity is empty.
Activity recording is turned off.
See more...