From: DNA Damage-Independent Checkpoints from Yeast to Man
Copyright © 2000-2013, Landes Bioscience.
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Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-2013.
Figure 7Tension-sensitive kinetochore phosphorylation
The kinetochores of prometaphase chromosomes (a-c and the left cell in g) become phosphorylated forming a 3F3/2 antibody-reactive epitope (open circles). The phospho-epitope is lost (filled circles) as chromosomes attach to the mitotic spindle forming the metaphase plate (b-d). This inactivates the spindle assembly checkpoint and cells begin anaphase roughly 20 minutes later (e-f and the right cell in g). Micrographs show onion root meristematic cells. The left cell is represented schematically in c, in which one chromosome has not congressed (also see arrow in g).
- Figure 7, Tension-sensitive kinetochore phosphorylation - Madame Curie Bioscienc...Figure 7, Tension-sensitive kinetochore phosphorylation - Madame Curie Bioscience Database
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