Figure 5. In this diagram the pH regulatory mechanisms and the inhibitors used to acidify in a acute way the intracellular environment are illustrated.

Figure 5

In this diagram the pH regulatory mechanisms and the inhibitors used to acidify in a acute way the intracellular environment are illustrated. 1) vacuolar -type H+ ATP-ase ; 2) H+- lactate cotransport Na+/H* exchanger [MCT], 3) Na+ dependent Cl-/HCO3- exchanger [BCT], 4) Sodium-proton exchanger [NHE], 5,6) electrogenic Na+-HCO3- cotransport.

From: Influence of Tumor Microenvironment on Thermoresponse: Biologic and Clinical Implications

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