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Legend: CF=cystic fibrosis; FBG=fastng blood glucose; rhGH=recombinant human growth hormone

Note: The squares represent individual point estimates. The size of the square represents the weight given to each study in the meta-analysis. Horizontal lines through each square represent 95 percent confidence intervals. The diamond represents the combined results. The solid vertical line extending from 0 is the null value.

Uppercase letters represent study arms within the same trial, where A is the high dose and B is the low dose of rhGH.

Narrative: This figure depicts the meta-analysis of change from baseline in fasting blood glucose. The first trial by Hardin and colleagues in 2001 provided a mean difference of 9.00 mg/dl with a 95 percent confidence interval of 0.11 to 17.89 mg/dl. The second trial by Schnabel and colleagues in 2007 provided a mean difference of 3.70 mg/dl with a 95 percent confidence interval of −5.14 to 12.54 mg/dl with the higher dose of rhGH and a mean difference of 4.10 mg/dl with a 95 percent confidence interval of −5.77 to 13.97 mg/dl with the lower dose of rhGH. The combined effect of the studies showed a weighted mean difference of 5.68 mg/dl, with a 95 percent confidence interval of 0.43 to 10.93 mg/dl. The I-squared value was 0 percent and the Egger’s p-value was not applicable.