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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.

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Drugs and Lactation Database (LactMed®) [Internet].

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Lumasiran

Last Revision: August 15, 2025.

Estimated reading time: 1 minute

CASRN: 1834610-13-7

Drug Levels and Effects

Summary of Use during Lactation

No information is available on the clinical use of lumasiran during breastfeeding. Because lumasiran is 85% bound to plasma proteins and has a molecular weight of about 17,000 Da, the amount in milk is likely to be low. In addition, because lumasiran is poorly absorbed orally, it is not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. The drug is approved for use in children weighing less than 10 kg. If the mother requires lumasiran, it is not a reason to discontinue breastfeeding.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Substance Identification

Substance Name

Lumasiran

CAS Registry Number

1834610-13-7

Drug Class

Breast Feeding

Lactation

Milk, Human

RNA, Small Interfering

Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Copyright Notice

Attribution Statement: LactMed is a registered trademark of the U.S. Department of Health and Human Services.

Bookshelf ID: NBK617434PMID: 40864838

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