Calcium transport in neurons. Influx of Ca2+ ions through receptor-operated channels (ROC) and voltage-dependent calcium channels (VDCC) activates extrusion mechanisms and calcium sequestration into mitochondria, endoplasmic reticulum (ER) and nucleus. Reproduced with permission from Murphy AN, Fiskum G. Bcl-2 and Ca2+-mediated mitochondrial dysfunction in neuronal cell death. Biochem Soc Symp 1999; 66:33-41, copyright 1999 the Biochemical Society.
From: Excitatory Amino Acid Neurotoxicity
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