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Guthrie B, Rogers G, Livingstone S, et al. The implications of competing risks and direct treatment disutility in cardiovascular disease and osteoporotic fracture: risk prediction and cost effectiveness analysis. Southampton (UK): National Institute for Health and Care Research; 2024 Feb. (Health and Social Care Delivery Research, No. 12.04.)

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The implications of competing risks and direct treatment disutility in cardiovascular disease and osteoporotic fracture: risk prediction and cost effectiveness analysis.

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FIGURE 59. Payoff time for high-intensity statins (atorvastatin 20 mg/day) compared with no treatment, for different example populations under different DTD scenarios.
FIGURE 59. Payoff time for high-intensity statins (atorvastatin 20 mg/day) compared with no treatment, for different example populations under different DTD scenarios.
FIGURE 59. Payoff time for high-intensity statins (atorvastatin 20 mg/day) compared with no treatment, for different example populations under different DTD scenarios.

FIGURE 59

Payoff time for high-intensity statins (atorvastatin 20 mg/day) compared with no treatment, for different example populations under different DTD scenarios. (a) Undiscounted cumulative incremental QALYs for 50-year-olds, 50 : 50 men : women, 10-year cardiovascular risk = 5%; (b) undiscounted cumulative incremental NHB for 50-year-olds, 50 : 50 men : women, 10-year cardiovascular risk = 5%; (c) undiscounted cumulative incremental QALYs for 60-year-olds, 50 : 50 men : women, 10-year cardiovascular risk = 10%; and (d) undiscounted cumulative incremental NHB for 60-year-olds, 50 : 50 men : women, 10-year cardiovascular risk = 10%; (e) undiscounted cumulative incremental QALYs for 70-year-olds, 50 : 50 men : women, 10-year cardiovascular risk = 20%; (f) undiscounted cumulative incremental NHB for 70-year-olds, 50 : 50 men : women, 10-year cardiovascular risk= 20%; (g) undiscounted cumulative incremental QALYs for 80-year-olds, 50 : 50 men : women, 10-year cardiovascular risk = 30%; and (h) undiscounted cumulative incremental NHB for 80-year-olds, 50 : 50 men : women, 10-year cardiovascular risk = 30%.

From: Appendix 8, Full results from cost–utility model assessing statins for the primary prevention of cardiovascular disease including adjustment for competing risk

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This work was produced by Guthrie et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This is an Open Access publication distributed under the terms of the Creative Commons Attribution CC BY 4.0 licence, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. See: https://creativecommons.org/licenses/by/4.0/. For attribution the title, original author(s), the publication source – NIHR Journals Library, and the DOI of the publication must be cited.

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