From: Chapter 9, Glimpses of a Modern RNA World
© 2023 John Mattick and Paulo Amaral.
Open Access: This content is Open Access under the Creative Commons license CC-BY-NC-ND.
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Mattick J, Amaral P. RNA, the Epicenter of Genetic Information: A new understanding of molecular biology. Abingdon (UK): CRC Press; 2022 Sep 20. doi: 10.1201/9781003109242-9
RNA, the Epicenter of Genetic Information: A new understanding of molecular biology.
Show details%20riboswitch%20in%20the%205%02032%20untranslated%20region%20of%20the%20mRNA%20in%20the%20polycistronic%20met%20operon%20of%20Xanthomonas%20campestris%2C%20which%20encodes%20three%20enzymes%20for%20the%20biosynthesis%20of%20methionine%2C%20replaced%20here%20by%20the%20reporter%20gene%20gusA.&p=BOOKS&id=595929_Fig09_02.jpg "Click on image to zoom")
Figure 9.2
Structure and function of the S-adenosyl methionine (SAM) riboswitch in the 5′ untranslated region of the mRNA in the polycistronic met operon of Xanthomonas campestris, which encodes three enzymes for the biosynthesis of methionine, replaced here by the reporter gene gusA. Binding of SAM to the RNA aptamer in the riboswitch (boxed) causes an allosteric structural rearrangement that sequesters the Shine-Dalgarno sequence (purple) and AUG start codon (cyan) to inhibit translation. (Adapted from Tang et al.85 under license from Creative Commons.)
- Figure 9.2, [Structure and function of the...]. - RNA, the Epicenter of Genetic ...Figure 9.2, [Structure and function of the...]. - RNA, the Epicenter of Genetic Information
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