Mental health conditions and traumatic brain injury (TBI) are common among Veterans and often negatively impact Veterans, their families, and their communities. The Department of Veterans Affairs (VA) devotes considerable resources to treating these conditions and improving diagnosis and treatment outcomes is an ongoing VA priority.

Contents

• PREFACE
• ACKNOWLEDGMENTS
• ABBREVIATIONS TABLE
• EXECUTIVE SUMMARY
  • INTRODUCTION
  • METHODS
  • RESULTS
  • DISCUSSION
• INTRODUCTION
• METHODS
  • TOPIC DEVELOPMENT
  • KEY QUESTION (KQ)
  • SEARCH STRATEGY
  • STUDY SELECTION
  • DATA ABSTRACTION
  • QUALITY ASSESSMENT AND SUMMARY OF RESULTS
  • PEER REVIEW
• RESULTS
  • OVERVIEW
  • DEPRESSION
  • BIPOLAR DISORDERS
  • POSTTRAUMATIC STRESS DISORDER
  • TRAUMATIC BRAIN INJURY
  • SUBSTANCE USE DISORDERS
  • OBSESSIVE COMPULSIVE DISORDER (OCD) AND ANXIETY DISORDERS
  • SYSTEMATIC REVIEWS
• DISCUSSION
  • SUMMARY OF KEY FINDINGS
  • IMPLICATIONS FOR VA POLICY
  • GAPS IN EVIDENCE AND FUTURE RESEARCH
  • LIMITATIONS
  • CONCLUSIONS
• REFERENCES
• APPENDIX A. SEARCH STRATEGY
• APPENDIX B. INCLUSION AND EXCLUSION CRITERIA
• APPENDIX C. PEER REVIEW DISPOSITION
• APPENDIX D. ELIGIBLE PRIMARY STUDIES
• APPENDIX E. ELIGIBLE SYSTEMATIC REVIEWS

Suggested citation:

Ullman K, Landsteiner A, Anthony M, et al. Neuroimaging and Neurophysiologic Biomarkers for Mental Health: An Evidence Map. Washington, DC: Evidence Synthesis Program, Health Services Research and Development Service, Office of Research and Development, Department of Veterans Affairs. VA ESP Project #09-009; 2022.

This report was prepared by the Evidence Synthesis Program Center located at the Minneapolis VA Health Care System, directed by Timothy J. Wilt, MD, MPH and Wei Duan-Porter, MD, PhD and funded by the Department of Veterans Affairs, Veterans Health Administration, Health Services Research and Development.

The findings and conclusions in this document are those of the author(s) who are responsible for its contents and do not necessarily represent the views of the Department of Veterans Affairs or the United States government. Therefore, no statement in this article should be construed as an official position of the Department of Veterans Affairs. No investigators have any affiliations or financial involvement (eg, employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties) that conflict with material presented in the report.