This is a work of the US government and distributed under the terms of the Public Domain
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
Note: The 15th Report on Carcinogens is a cumulative document that includes newly listed substances, as well as substances listed in prior editions.
The U.S. Department of Health and Human Services (HHS) released the 15th Report on Carcinogens on December 21, 2021. The Report on Carcinogens is a congressionally mandated, science-based public health document that NTP prepares for the HHS Secretary. This cumulative report now includes 256 listings of substances—chemical, physical, and biological agents; mixtures; and exposure circumstances—that are known or reasonably anticipated to cause cancer in humans.
Discover more details about the report and its new listings below. Also, check out the Data Exploration Dashboard, which provides an easy-to-understand visual breakdown of all substances listed in the document and their associated cancers.
Official Citation: NTP (National Toxicology Program). 2021. Report on Carcinogens, Fifteenth Edition. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service. https://ntp.niehs.nih.gov/go/roc15 (EndNote XML) DOI: https://doi.org/10.22427/NTP-OTHER-1003
Substance Profiles
A
- Acetaldehyde: CAS No. 75-07-0
- 2-Acetylaminofluorene: CAS No. 53-96-3
- Acrylamide: CAS No. 79-06-1
- Acrylonitrile: CAS No. 107-13-1
- Adriamycin: CAS No. 23214-92-8
- Aflatoxins: CAS No. 1402-68-2
- Alcoholic Beverage Consumption: CAS No.: none assigned
- 2-Aminoanthraquinone: CAS No. 117-79-3
- o-Aminoazotoluene: CAS No. 97-56-3
- 4-Aminobiphenyl: CAS No. 92-67-1
- 1-Amino-2,4-dibromoanthraquinone: CAS No. 81-49-2
- 1-Amino-2-methylanthraquinone: CAS No. 82-28-0
- Amitrole: CAS No. 61-82-5
- o-Anisidine and Its Hydrochloride: CAS Nos. 90-04-0 and 134-29-2
- Antimony Trioxide: CAS No. 1309-64-4
- Aristolochic Acids: CAS No.: none assigned
- Arsenic and Inorganic Arsenic Compounds: CAS No. 7440-38-2 (Arsenic)
- Asbestos: CAS No. 1332-21-4
- Azacitidine: CAS No. 320-67-2
- Azathioprine: CAS No. 446-86-6
B
- Basic Red 9 Monohydrochloride: CAS No. 569-61-9
- Benzene: CAS No. 71-43-2
- Benzidine and Dyes Metabolized to Benzidine
- Benzotrichloride: CAS No. 98-07-7
- Beryllium and Beryllium Compounds: CAS No. 7440-41-7 (Beryllium)
- 2,2-Bis(bromomethyl)-1,3-propanediol (Technical Grade): CAS No. 3296-90-0
- Bis(chloromethyl) Ether and Technical-Grade Chloromethyl Methyl Ether: CAS Nos. 542-88-1 and 107-30-2
- Bromodichloromethane: CAS No. 75-27-4
- 1-Bromopropane: CAS No. 106-94-5
- 1,3-Butadiene: CAS No. 106-99-0
- 1,4-Butanediol Dimethanesulfonate: CAS No. 55-98-1
- Butylated Hydroxyanisole: CAS No. 25013-16-5
C
- Cadmium and Cadmium Compounds: CAS No. 7440-43-9 (Cadmium)
- Captafol: CAS No. 2425-06-1
- Carbon Tetrachloride: CAS No. 56-23-5
- Ceramic Fibers (Respirable Size): CAS No.: none assigned
- Chlorambucil: CAS No. 305-03-3
- Chloramphenicol: CAS No. 56-75-7
- Chlorendic Acid: CAS No. 115-28-6
- Chlorinated Paraffins (C12, 60% Chlorine): CAS No. 108171-26-2
- Chloroform: CAS No. 67-66-3
- 3-Chloro-2-methylpropene: CAS No. 563-47-3
- 4-Chloro-o-phenylenediamine: CAS No. 95-83-0
- Chloroprene: CAS No. 126-99-8
- p-Chloro-o-toluidine and Its Hydrochloride: CAS Nos. 95-69-2 and 3165-93-3
- Chromium Hexavalent Compounds: CAS No. 18540-29-9
- Cisplatin: CAS No. 15663-27-1
- Coal Tars and Coal-Tar Pitches: CAS No. 8007-45-2 (Coal Tar)
- Cobalt-Related Exposures
- Coke-Oven Emissions: CAS No.: none assigned
- p-Cresidine: CAS No. 120-71-8
- Cumene: CAS No. 98-82-8
- Cupferron: CAS No. 135-20-6
- Cyclophosphamide: CAS No. 50-18-0
- Cyclosporin A: CAS No. 59865-13-3
D
- Dacarbazine: CAS No. 4342-03-4
- Danthron: CAS No. 117-10-2
- 2,4-Diaminoanisole Sulfate: CAS No. 39156-41-7
- 2,4-Diaminotoluene: CAS No. 95-80-7
- Diazoaminobenzene: CAS No. 136-35-6
- 1,2-Dibromo-3-chloropropane: CAS No. 96-12-8
- 1,2-Dibromoethane: CAS No. 106-93-4
- 2,3-Dibromo-1-propanol: CAS No. 96-13-9
- 1,4-Dichlorobenzene: CAS No. 106-46-7
- 3,3′-Dichlorobenzidine and Its Dihydrochloride: CAS Nos. 91-94-1 and 612-83-9
- Dichlorodiphenyltrichloroethane: CAS No. 50-29-3
- 1,2-Dichloroethane: CAS No. 107-06-2
- Dichloromethane: CAS No. 75-09-2
- 1,3-Dichloropropene (Technical Grade): CAS No. 542-75-6
- Diepoxybutane: CAS No. 1464-53-5
- Diesel Exhaust Particulates: CAS No.: none assigned
- Di(2-ethylhexyl) Phthalate: CAS No. 117-81-7
- Diethylstilbestrol: CAS No. 56-53-1
- Diethyl Sulfate: CAS No. 64-67-5
- Diglycidyl Resorcinol Ether: CAS No. 101-90-6
- 3,3′-Dimethoxybenzidine and Dyes Metabolized to 3,3′-Dimethoxybenzidine
- 4-Dimethylaminoazobenzene: CAS No. 60-11-7
- 3,3′-Dimethylbenzidine and Dyes Metabolized to 3,3′-Dimethylbenzidine
- Dimethylcarbamoyl Chloride: CAS No. 79-44-7
- 1,1-Dimethylhydrazine: CAS No. 57-14-7
- Dimethyl Sulfate: CAS No. 77-78-1
- Dimethylvinyl Chloride: CAS No. 513-37-1
- 1,4-Dioxane: CAS No. 123-91-1
- Disperse Blue 1: CAS No. 2475-45-8
E
- Epichlorohydrin: CAS No. 106-89-8
- Erionite: CAS No. 66733-21-9
- Estrogens, Steroidal: CAS No.: none assigned
- Ethylene Oxide: CAS No. 75-21-8
- Ethylene Thiourea: CAS No. 96-45-7
- Ethyl Methanesulfonate: CAS No. 62-50-0
F
- Formaldehyde: CAS No. 50-00-0
- Furan: CAS No. 110-00-9
G
- Certain Glass Wool Fibers (Inhalable): CAS No.: none assigned
- Glycidol: CAS No. 556-52-5
H
- Haloacetic Acids Found as Water Disinfection Byproducts (Selected)
- Helicobacter pylori (Chronic Infection): CAS No.: none assigned
- Heterocyclic Amines (Selected)
- Introduction
- 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline: CAS No. 77094-11-2
- 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline: CAS No. 77500-04-0
- 2-Amino-3-methylimidazo[4,5-f]quinoline: CAS No. 76180-96-6
- 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine: CAS No. 105650-23-5
- Heterocyclic Amines (Selected)
- References
- Hexachlorobenzene: CAS No. 118-74-1
- Hexachloroethane: CAS No. 67-72-1
- Hexamethylphosphoramide: CAS No. 680-31-9
- Hydrazine and Hydrazine Sulfate: CAS Nos. 302-01-2 and 10034-93-2
- Hydrazobenzene: CAS No. 122-66-7
I
- Ionizing Radiation
- Iron Dextran Complex: CAS No. 9004-66-4
- Isoprene: CAS No. 78-79-5
J
K
- Kepone: CAS No. 143-50-0
L
- Lead and Lead Compounds: CAS No. 7439-92-1 (Lead)
- Lindane, Hexachlorocyclohexane (Technical Grade), and Other Hexachlorocyclohexane Isomers: CAS No. 58-89-9 (Lindane)
M
- Melphalan: CAS No. 148-82-3
- Methoxsalen with Ultraviolet A Therapy: CAS No.: none assigned
- 2-Methylaziridine: CAS No. 75-55-8
- 4,4′-Methylenebis(2-chloroaniline): CAS No. 101-14-4
- 4,4′-Methylenebis(N,N-dimethyl)benzenamine: CAS No. 101-61-1
- 4,4′-Methylenedianiline and Its Dihydrochloride: CAS Nos. 101-77-9 and 13552-44-8
- Methyleugenol: CAS No. 93-15-2
- Methyl Methanesulfonate: CAS No. 66-27-3
- Metronidazole: CAS No. 443-48-1
- Michler’s Ketone: CAS No. 90-94-8
- Mineral Oils: Untreated and Mildly Treated: CAS No.: None assigned
- Mirex: CAS No. 2385-85-5
- Mustard Gas: CAS No. 505-60-2
N
- Naphthalene: CAS No. 91-20-3
- 2-Naphthylamine: CAS No. 91-59-8
- Nickel Compounds and Metallic Nickel
- Nitrilotriacetic Acid: CAS No. 139-13-9
- o-Nitroanisole: CAS No. 91-23-6
- Nitroarenes (Selected)
- Nitrobenzene: CAS No. 98-95-3
- Nitrofen: CAS No. 1836-75-5
- Nitrogen Mustard Hydrochloride: CAS No. 55-86-7
- Nitromethane: CAS No. 75-52-5
- 2-Nitropropane: CAS No. 79-46-9
- N-Nitrosamines: 15 Listings
- N-Methyl-N′-nitro-N-nitrosoguanidine: CAS No. 70-25-7
- N-Nitrosodi-n-butylamine: CAS No. 924-16-3
- N-Nitrosodiethanolamine: CAS No. 1116-54-7
- N-Nitrosodiethylamine: CAS No. 55-18-5
- N-Nitrosodimethylamine: CAS No. 62-75-9
- N-Nitrosodi-n-propylamine: CAS No. 621-64-7
- N-Nitroso-N-ethylurea: CAS No. 759-73-9
- 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone: CAS No. 64091-91-4
- N-Nitroso-N-methylurea: CAS No. 684-93-5
- N-Nitrosomethylvinylamine: CAS No. 4549-40-0
- N-Nitrosomorpholine: CAS No. 59-89-2
- N-Nitrosonornicotine: CAS No. 16543-55-8
- N-Nitrosopiperidine: CAS No. 100-75-4
- N-Nitrosopyrrolidine: CAS No. 930-55-2
- N-Nitrososarcosine: CAS No. 13256-22-9
- References
- Nitrosourea Chemotherapeutic Agents
- o-Nitrotoluene: CAS No. 88-72-2
- Norethisterone: CAS No. 68-22-4
O
- Ochratoxin A: CAS No. 303-47-9
- 4,4′-Oxydianiline: CAS No. 101-80-4
- Oxymetholone: CAS No. 434-07-1
P
- Pentachlorophenol and By-products of Its Synthesis: CAS No. 87-86-5 (Pentachlorophenol): CAS No. 131-52-2 (Pentachlorophenol, sodium salt)
- Phenacetin and Analgesic Mixtures Containing Phenacetin
- Phenazopyridine Hydrochloride: CAS No. 136-40-3
- Phenolphthalein: CAS No. 77-09-8
- Phenoxybenzamine Hydrochloride: CAS No. 63-92-3
- Phenytoin and Phenytoin Sodium: CAS Nos. 57-41-0 and 630-93-3
- Polybrominated Biphenyls
- Polychlorinated Biphenyls: CAS No. 1336-36-3
- Polycyclic Aromatic Hydrocarbons: 15 Listings
- Procarbazine and Its Hydrochloride: CAS Nos. 671-16-9 and 366-70-1
- Progesterone: CAS No. 57-83-0
- 1,3-Propane Sultone: CAS No. 1120-71-4
- β-Propiolactone: CAS No. 57-57-8
- Propylene Oxide: CAS No. 75-56-9
- Propylthiouracil: CAS No. 51-52-5
Q
R
- Reserpine: CAS No. 50-55-5
- Riddelliine: CAS No. 23246-96-0
S
- Safrole: CAS No. 94-59-7
- Selenium Sulfide: CAS No. 7446-34-6
- Silica, Crystalline (Respirable Size): CAS No.: none assigned
- Soots: CAS No.: none assigned
- Strong Inorganic Acid Mists Containing Sulfuric Acid: CAS No. 7664-93-9 (Sulfuric acid)
- Styrene: CAS No. 100-42-5
- Styrene-7,8-oxide: CAS No. 96-09-3
- Sulfallate: CAS No. 95-06-7
T
- Tamoxifen: CAS No. 10540-29-1
- 2,3,7,8-Tetrachlorodibenzo-p-dioxin: CAS No. 1746-01-6
- Tetrachloroethylene: CAS No. 127-18-4
- Tetrafluoroethylene: CAS No. 116-14-3
- Tetranitromethane: CAS No. 509-14-8
- Thioacetamide: CAS No. 62-55-5
- 4,4′-Thiodianiline: CAS No. 139-65-1
- Thiotepa: CAS No. 52-24-4
- Thiourea: CAS No. 62-56-6
- Tobacco-related Exposures
- Toluene Diisocyanates: CAS No. 26471-62-5
- o-Toluidine: CAS No. 95-53-4
- Toxaphene: CAS No. 8001-35-2
- Trichloroethylene: CAS No. 79-01-6
- 2,4,6-Trichlorophenol: CAS No. 88-06-2
- 1,2,3-Trichloropropane: CAS No. 96-18-4
- Tris(2,3-dibromopropyl) Phosphate: CAS No. 126-72-7
U
- Urethane: CAS No. 51-79-6
V
- Viruses: Eight Listings
- Epstein-Barr Virus: CAS No.: none assigned
- Hepatitis B Virus: CAS No.: none assigned
- Hepatitis C Virus: CAS No.: none assigned
- Human Immunodeficiency Virus Type 1: CAS No.: none assigned
- Human Papillomaviruses: Some Genital-Mucosal Types: CAS No.: none assigned
- Human T-Cell Lymphotropic Virus Type 1: CAS No.: none assigned
- Kaposi Sarcoma-Associated Herpesvirus: CAS No.: none assigned
- Merkel Cell Polyomavirus: CAS No.: none assigned
- References
- 4-Vinyl-1-cyclohexene Diepoxide: CAS No. 106-87-6
- Vinyl Halides (Selected)
W
- Wood Dust: CAS No.: none assigned
X
Y
Z
A · B · C · D · E · F · G · H · I · J · K · L · M · N · O · P · Q · R · S · T · U · V · W · X · Y · Z
- Glossary
- Acronyms and Abbreviations
- Units of Measurement
- Appendix A. Cancer Hazards Not Included in the NTP Report on Carcinogens
- Appendix B. Substances Delisted from the Report on Carcinogens
- Appendix C. Substances Reviewed but Not Recommended for Listing in the Report on Carcinogens
- Appendix D. 15th RoC and Monographs - Collaborators and Contributors
- Appendix E. Chemicals Nominated to the NTP for In-Depth Toxicological Evaluation
- Appendix F. Substance Names and Common Synonyms
- Appendix G. Listed Substances by CAS Number
- 15th Report on Carcinogens15th Report on Carcinogens
- Disposition and Toxicokinetics - Report on Carcinogens Monograph on Antimony Tri...Disposition and Toxicokinetics - Report on Carcinogens Monograph on Antimony Trioxide
Your browsing activity is empty.
Activity recording is turned off.
See more...