Table 2-1, Cumene Metabolites in Rat and Mouse Urine (Oral Exposure) - Report on Carcinogens Monograph on Cumene

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National Toxicology Program. Report on Carcinogens Monograph on Cumene: RoC Monograph 02 [Internet]. Research Triangle Park (NC): National Toxicology Program; 2013 Sep.

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Table 2-1Cumene Metabolites in Rat and Mouse Urine (Oral Exposure)

Metabolite	Structure	% of Radiolabeled Peaks
		Male Rat	Mouse
		Male Rat	Male	Female
M1: (dihydrodiol?)	Not determined	N.D.	N.D.–trace	1.8–3.0
M2: 2-(2-hydroxy-2-propyl)phenylsulfate		trace	N.D.–trace	N.D.–4.4
M3: 4-(2-hydroxy-2-propyl)phenylsulfate		7–11.4	N.D.	N.D.–trace
M4: (unknown)	Not determined	5.2–5.6	N.D.	N.D.–trace
M5: 2-hydroxy-2-phenylpropylsulfate		2.2–2.6	3–8.4	5.8–19.1
M6: 2-phenyl-1,2-propandiol 2-glucuronide		N.D.–1.6	2.9–4.4	2.5–4.2
M7: 2-phenyl-1,2-propandiol 1-glucuronide		17.8–20.1	8.6–16.9	6.1–16.5
M8: 2-hydroxy-2-phenylpropionic acid		12.1–16.4	12.8–15.7	11.4–20.4
M9: 2-phenyl-2-propanol glucuronide		38.1–48.4^a	33.5–42.8	29.8–36.8
M10: 2-phenylpropionyl glucuronide		^b	N.D.	N.D.
M11: 2-phenylpropionyl glycine		N.D.	5.1–11	2.8–3.7
M12: S-(2-hydroxy-2-phenylpropyl)-N-acetylcysteine		4–4.9^c	trace	trace
M13: 2-phenyl-1-propanol glucuronide		4–4.9^c	1.6–5.8^c	1.5–2.3^c
M14: 2-phenyl-2-propanol		trace–1.8	N.D.–1.5	N.D.
M15: 2-phenyl-1-propanol		N.D.	N.D.–1.6	N.D.
M16: 2-phenylpropionic acid		trace–2.1	N.D.–trace	N.D.–trace

: Source: Chen et al. (2011).
: N.D. = not detected.
^a: Total of M9 and M10.
^b: M10 reported as a minor metabolite that coeluted with M9.
^c: Total of M12 and M13.

From: 2, Disposition and Toxicokinetics

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National Toxicology Program. Report on Carcinogens Monograph on Cumene: RoC Monograph 02 [Internet]. Research Triangle Park (NC): National Toxicology Program; 2013 Sep. Table 2-1, Cumene Metabolites in Rat and Mouse Urine (Oral Exposure)
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