From: Evidence review for CT and MRI indications for intervention
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Evidence review for CT and MRI indications for intervention: Heart valve disease presenting in adults: investigation and management: Evidence review F. London: National Institute for Health and Care Excellence (NICE); 2021 Nov. (NICE Guideline, No. 208.)
Evidence review for CT and MRI indications for intervention: Heart valve disease presenting in adults: investigation and management: Evidence review F.
Show detailsTable 6Clinical evidence summary: Aortic valve area on CT
|
Risk factor and outcome (population) | Number of studies | Effect (95% CI) | Risk of bias | Imprecision | Indirectness | GRADE Quality |
|---|---|---|---|---|---|---|
|
Aortic valve area ≤1.2 cm2 compared to >1.2 cm2 on CT for predicting mortality under medical management Mean follow-up 3.2 years (AS patients undergoing CT and echocardiography in same episode of care, 45% with NYHA class III/IV, mean aortic valve area 0.94 cm2; mean age 76 years) | 1 (n=269) | Adjusted HR: 3.16 (1.60 to 6.26)a | Seriousb | None | None | MODERATE |
|
Aortic valve area ≤1.0 cm2 compared to >1.0 cm2 on CT for predicting mortality under medical management Mean follow-up 3.2 years (AS patients undergoing CT and echocardiography in same episode of care, 45% with NYHA class III/IV, mean aortic valve area 0.94 cm2; mean age 76 years) | 1 (n=269) | Adjusted HR: 1.43 (0.77 to 2.64)a | Seriousb | Seriousc | None | LOW |
- (a)
Methods: multivariable analysis, adjusted for age-adjusted Charlson score index, sex, symptoms, mean gradient and LVEF (age prespecified in protocol was adjusted for but smoking was not)
- (b)
Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias
- (c)
95% CI crosses null line
- Magnetic resonance imaging (MRI) for the assessment of myocardial viability: an evidence-based analysis.[Ont Health Technol Assess Ser....]Magnetic resonance imaging (MRI) for the assessment of myocardial viability: an evidence-based analysis.Medical Advisory Secretariat. Ont Health Technol Assess Ser. 2010; 10(15):1-45. Epub 2010 Jul 1.
- Value of cardiac CT in comprehensive aortic valve and root evaluation before percutaneous aortic valve replacement.[Acta Radiol. 2013]Value of cardiac CT in comprehensive aortic valve and root evaluation before percutaneous aortic valve replacement.Bazeed MF, Rezk AI, Moselhy MS. Acta Radiol. 2013 Jun; 54(5):498-504. Epub 2013 Apr 30.
- Preprocedural Risk Assessment Prior to PPVI with CMR and Cardiac CT.[Pediatr Cardiol. 2017]Preprocedural Risk Assessment Prior to PPVI with CMR and Cardiac CT.Malone L, Fonseca B, Fagan T, Gralla J, Wilson N, Vargas D, DiMaria M, Truong U, Browne LP. Pediatr Cardiol. 2017 Apr; 38(4):746-753. Epub 2017 Feb 16.
- Review The effectiveness and cost-effectiveness of computed tomography screening for coronary artery disease: systematic review.[Health Technol Assess. 2006]Review The effectiveness and cost-effectiveness of computed tomography screening for coronary artery disease: systematic review.Waugh N, Black C, Walker S, McIntyre L, Cummins E, Hillis G. Health Technol Assess. 2006 Oct; 10(39):iii-iv, ix-x, 1-41.
- Review Tricuspid regurgitation: contemporary management of a neglected valvular lesion.[Postgrad Med J. 2010]Review Tricuspid regurgitation: contemporary management of a neglected valvular lesion.Irwin RB, Luckie M, Khattar RS. Postgrad Med J. 2010 Nov; 86(1021):648-55. Epub 2010 Oct 18.
- Table 6, Clinical evidence summary: Aortic valve area on CT - Evidence review fo...Table 6, Clinical evidence summary: Aortic valve area on CT - Evidence review for CT and MRI indications for intervention
- txid566550[Organism] (2)BioSample
- PMC Links for Gene (Select 91133) (13)PMC
- PREDICTED: Homo sapiens LIM homeobox 2 (LHX2), transcript variant X1, mRNAPREDICTED: Homo sapiens LIM homeobox 2 (LHX2), transcript variant X1, mRNAgi|2217382161|ref|XM_006717323.4|Nucleotide
- PREDICTED: Columba livia very long chain fatty acid elongase 4 (LOC102095164), t...PREDICTED: Columba livia very long chain fatty acid elongase 4 (LOC102095164), transcript variant X3, mRNAgi|2728158202|ref|XM_065034371.1|Nucleotide
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