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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
CASRN: 197922-42-2
Drug Levels and Effects
Summary of Use during Lactation
Because it is a large protein molecule with a molecular weight of 3752 Da, the amount in milk is likely to be very low. Teduglutide is also poorly absorbed orally so absorption by a breastfed infant is unlikely. Two breastfed infants apparently experienced no adverse effects during maternal use of teduglutide, but no long-term data are available. Until more data are available, teduglutide should be used with careful infant monitoring during breastfeeding.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
One mother used teduglutide during pregnancy and postpartum while breastfeeding. She breastfed her infant (extent not stated) for 6 months. No mention was made of any adverse effects in the infant.[1]
A woman taking teduglutide because of removal of a portion of her gastrointestinal tract became pregnant and delivered a healthy infant. She breastfed her infant and the drug was restarted 1 month after delivery. She breastfed (extent not stated) her infant for another 4 months during treatment. The infant experienced no side effects during breastfeeding.[2]
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Gentilini MV, Doeyo M, Ortega M, et al. Successful pregnancy in a patient with short bowel syndrome after surgical rehabilitation and sGLP-2 treatment: Novel report on endogenous GLP-2 levels at delivery and during breastfeeding. Therap Adv Gastroenterol 2022;15:17562848221129787. [PMC free article: PMC9706046] [PubMed: 36458051]
- 2.
- Lillienau J, Nilsson E, Vulcan A, Nilsson A. 90: Use of teduglutide during breast-feeding after pregnancy in a patient with severe intestinal failure. Transplantation 2023;107:53. doi:10.1097/01.tp.0000945816.46782.83 [CrossRef]
Substance Identification
Substance Name
Teduglutide
CAS Registry Number
197922-42-2
Drug Class
Breast Feeding
Lactation
Milk, Human
Incretins
Glucagon-Like Peptide-1 Agonists
GLP-1 Agonists
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- GCSH [Ovis aries]GCSH [Ovis aries]Gene ID:101120772Gene
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