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Paro R, Grossniklaus U, Santoro R, et al. Introduction to Epigenetics [Internet]. Cham (CH): Springer; 2021. doi: 10.1007/978-3-030-68670-3_8

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Introduction to Epigenetics [Internet].

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Fig. 8.9. Alterations of HATs and HDACs in cancers.

Fig. 8.9

Alterations of HATs and HDACs in cancers. Alterations in the acetylation/deacetylation balance can influence the expression of tumor suppressor genes and oncogenes, favoring the tumorigenic process. High expression or the abnormal recruitment of HDACs or the reduced expression or activity of HATs can lead to the repression of tumor suppressor genes. In contrast, mutation or low expression of HDACs or high expression, oncogenic fusion, or aberrant recruitment of HATs can lead to the activation of oncogenes

From: Chapter 8, Epigenetics and Cancer

Copyright 2021, The Author(s)

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