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Paro R, Grossniklaus U, Santoro R, et al. Introduction to Epigenetics [Internet]. Cham (CH): Springer; 2021. doi: 10.1007/978-3-030-68670-3_9

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Introduction to Epigenetics [Internet].

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Fig. 9.6. One-carbon metabolism.

Fig. 9.6

One-carbon metabolism. SAM is produced by one-carbon metabolism, which combines the folate cycle and the methionine cycle. Nutrients that fuel one-carbon metabolism are folate, serine, and glycine. DHFR reduces folate to THF, which enters into the folate cycle and serves as scaffold that carries 1-carbon groups in a variety of reactions, including the production of mTHF. The folate cycle is coupled to the methionine cycle through Vitamin B12 that serves as cofactor for the demethylation of mTHF and the production of methionine by methionine synthase. MAT enzyme converts methionine into SAM, which is then demethylated to form SAH. Deadenylation of SAH by SAHH generates hCYS, resulting in a full turn of the methionine cycle. Dihydrofolate reductase (DHFR); tetrahydrofolate (THF); methyl-THF (mTHF); homocysteine (hCYS); methionine adenyltransferase (MAT); S-adenosyl homocysteine hydrolase (SAHH)

From: Chapter 9, Epigenetics and Metabolism

Copyright 2021, The Author(s)

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