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Auerbach SS, Behl MV, Collins BJ, et al. NIEHS Report on the In Vivo Repeat Dose Biological Potency Study of 2-Ethylhexyl Diphenyl Phosphate (CASRN 1241-94-7) in Male Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies): NIEHS Report 02 [Internet]. Research Triangle Park (NC): National Institute of Environmental Health Sciences; 2022 Oct. doi: 10.22427/NIEHS-02
NIEHS Report on the In Vivo Repeat Dose Biological Potency Study of 2-Ethylhexyl Diphenyl Phosphate (CASRN 1241-94-7) in Male Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies): NIEHS Report 02 [Internet].
Show detailsTable 2Organ Weights Summarya
| Endpoint | 0 mg/kgb,c n = 4 | 61 mg/kg n = 3 | 123 mg/kg n = 4 | 245 mg/kg n = 5 | 489 mg/kg n = 4 | 979 mg/kg n = 3 | BMD1Std (mg/kg) | BMDL1Std (mg/kg) |
|---|---|---|---|---|---|---|---|---|
| Terminal Body Weight (g) | 272.2 ± 0.4* | 275.5 ± 6.9 | 274.1 ± 7.8 | 270.2 ± 6.1 | 247.1 ± 6.7* | 258.0 ± 5.2 | NVM | NVM |
| Brain Weight Relatived (mg/g) | 6.14 ± 0.26** | 6.53 ± 0.11 | 6.44 ± 0.20 | 6.64 ± 0.16 | 7.19 ± 0.23** | 6.76 ± 0.17** | 123.7 | 43.3 |
| Liver Weight Relative (mg/g) | 38.21 ± 1.15** | 42.34 ± 2.46 | 45.20 ± 0.76** | 45.70 ± 1.68** | 48.20 ± 0.75** | 47.54 ± 2.86** | 39.4 | 17.2 |
Statistical significance for a dosed group indicates a significant pairwise test compared to the vehicle control group. Statistical significance for the vehicle control group indicates a significant trend test.
- *
Statistically significant at p ≤ 0.05; **p ≤ 0.01.
Benchmark response set at 1 standard deviation from the mean.
BMD = benchmark dose; BMDL = benchmark dose lower confidence limit; NVM = nonviable model.
- a
Descriptions of organ weight endpoints and changes are provided in Appendix E.
- b
Data are displayed as mean ± standard error of the mean.
- c
Statistical analysis performed by the Jonckheere (trend) and Williams or Dunnett (pairwise) tests.
- d
Relative organ weights (organ weight-to-body weight ratios) are given as mg organ weight/g body weight.
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