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Newhouse K, Weaver A, Lee J, et al. Toxicological Review of Ethyl Tertiary Butyl Ether (CASRN 637-92-3). Washington (DC): U.S. Environmental Protection Agency; 2021 Jul.

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Toxicological Review of Ethyl Tertiary Butyl Ether (CASRN 637-92-3).

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Figure B-12. Comparison of the Borghoff et al. (2016) model predictions with measured amounts of tert-butanol in blood after repeated inhalation exposure to tert-butanol.

Figure B-12Comparison of the Borghoff et al. (2016) model predictions with measured amounts of tert-butanol in blood after repeated inhalation exposure to tert-butanol

Male rats were exposed to 239, 444, or 1,726 ppm and female rats were exposed to 256, 444, or 1,914 ppm tert-butanol for up to 8 consecutive days (Borghoff et al., 2001). tert-Butanol blood concentrations are better predicted by the model after 8 days of exposure with enzyme induction (right panels) than without enzyme induction (left panels).

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