The objective of this report is to perform a systematic review of the beneficial and harmful effects of satralizumab as monotherapy or in combination with immunosuppressive therapy for the treatment of NMOSD in adult and adolescent patients who are AQP4 antibody positive.

Contents

• Abbreviations
• Executive Summary
• Introduction
  • Stakeholder Engagement
  • Clinical Evidence
  • Conclusions
• Introduction
  • Disease Background
  • Standards of Therapy
  • Drug
• Stakeholder Engagement
  • Patient Group Input
  • Clinician Input
• Clinical Evidence
  • Systematic Review (Pivotal and Protocol Selected Studies)
  • Findings From the Literature
  • Results
  • Indirect Evidence
  • Other Relevant Evidence
• Discussion
  • Summary of Available Evidence
  • Interpretation of Results
• Conclusions
• Appendix 1. Literature Search Strategy
• Appendix 2. Excluded Studies
• Appendix 3. Detailed Outcome Data
• Appendix 4. Description and Appraisal of Outcome Measures
• References

Version: Final (with redactions)

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